CN105549141A - Fluorescent optical filter assembly for medical examination system - Google Patents
Fluorescent optical filter assembly for medical examination system Download PDFInfo
- Publication number
- CN105549141A CN105549141A CN201610045580.5A CN201610045580A CN105549141A CN 105549141 A CN105549141 A CN 105549141A CN 201610045580 A CN201610045580 A CN 201610045580A CN 105549141 A CN105549141 A CN 105549141A
- Authority
- CN
- China
- Prior art keywords
- refractive index
- rete
- glass substrate
- optical filter
- filter assembly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B5/00—Optical elements other than lenses
- G02B5/20—Filters
Abstract
The invention discloses a fluorescent optical filter assembly for a medical examination system, and the assembly comprises a first glass substrate, a second glass substrate, and a color glass piece, wherein the first and second glass substrates are glued together and the color glass piece is disposed between the first and second glass substrates. The inner surface or outer surface of the first glass substrate is provided with a main film layer, and the inner surface or outer surface of the second glass substrate is provided with a secondary film layer. The transmissivity of the color glass piece in the range from 200 nm to 550 nm is zero, and the transmissivity of the color glass piece in the range from 650 nm to 800 nm is greater than 90%. The assembly is advantageous in that the assembly can achieve the spectrum depth cut in the range from 200 nm to 625 nm through setting the specific main film layer and secondary film layer and employing the color glass piece to replace an optical filer, enables the transmissivity of spectrum in the range from 650 nm to 800 nm to be higher, cannot generate backward fluorescent light, and greatly reduces the cost; compared with an assembly formed by five optical filers, the assembly reduces the cost by more than 40%.
Description
Technical field
The present invention relates to a kind of optical element for medical test system, especially relate to a kind of fluorescent optical filter assembly for medical test system.
Background technology
Fluoroscopic examination is the detection technique generally used in biochemical, medical treatment and environmental analysis.Its ultimate principle is some specific composition of tested object under the exciting light of specific wavelength irradiates, and absorbs energy and produces transition, send the bioluminescence of specific wavelength.Undertaken by the fluorescence signal gathering this specific wavelength analyzing the various information such as composition, content, composition just can knowing tested object, thus reach testing goal.As a rule, the fluorescence be excited wants much weak relative to exciting light, needs to filter exciting light so gather before fluorescence in detection, is buried in strong optical excitation signal and excessively strong exciting light causes damage to detector to avoid fluorescence signal.At present conventional means choose suitable optical filter according to the wavelength of exciting light and fluorescence, as long wave pass filter or notch filtering light sheet exciting light is filtered while allow required fluorescence pass through.
Along with developing rapidly of biomedical detection technique, fluorescent probe technique, polarized fluorescence detection technique, multiphoton fluorescence detection technique, gene magnification fluorescent quantitation detection technique etc. to analyze sensitivity and accuracy requirement more and more higher.Fluorescent optical filter is as core detecting element, and the requirement in excitation light wave strong point cut off band width, cut-off degree of depth emitting fluorescence transmitance etc. is also more harsh.
On the biologic pharmacological science detecting instrument that the present invention relates to, needing wavelength is spectral depth cut-off (cutoff rate is 0) within the scope of 200 ~ 625nm, and is that spectrum within the scope of 650 ~ 800nm has higher transmitance (transmitance is for being greater than 90%) to wavelength.But in the technology produced in batches, the technical indicator of regulation be reached in existing being suitable for, must by more than at least 5 long-pass, the combining, so there is following shortcoming of short-pass or bandpass filter:
1, multiple optical filters gummed increases gummed part spatial volume, and the use difficulty of whole system increases;
2, for the optical filter of volume production, sheet number is more, and the yields of overall gummed is lower, and cost is also higher.
For above-mentioned defect, people attempt using coloured glass to carry out alternative corresponding optical filter, lead to effect, to reduce optical filter quantity with the filter of coloured glass self character Substitute For Partial optical filter combination.But find in actual use, although coloured glass can realize corresponding wave band cut-off and through, but fluoresce after also existing phenomenon: namely optical filter box reaches the effect of filtering exciting light and selecting specific fluorescent, but coloured glass itself produces fluorescence because absorbing exciting light, this fluorescence has been doped in the fluorescence that final detector detects, and has had a strong impact on instrument accuracy of detection and result.
Summary of the invention
Technical matters to be solved by this invention is to provide a kind of can the cut-off the spectral depth of 200 ~ 625nm wavelength, to the spectrum of 650 ~ 800nm wavelength, there is higher transmitance, the low and fluorescent optical filter assembly for medical test system of the phenomenon that do not fluoresce afterwards of cost.
The present invention solves the problems of the technologies described above adopted technical scheme: a kind of fluorescent optical filter assembly for medical test system, comprise the first glass substrate mutually glued together, second glass substrate and coloured glass sheet, described coloured glass sheet is arranged between the first described glass substrate and the second described glass substrate, inside surface or the outside surface of the first described glass substrate are provided with main rete, the inside surface of the second described glass substrate or outside surface are provided with time rete, described main rete is made up of 20 ~ 30 master unit layers, described master unit layer is 153 ~ 190nm by thickness, refractive index be 2.0 ~ 3.0 the first high refractive index layer and thickness be 63 ~ 132nm, refractive index is the first low-index film composition of 1.3 ~ 1.8, the first described glass substrate is adjacent with the first described high refractive index layer, described secondary rete is made up of 10 ~ 20 sub-cell layers, described sub-cell layer is 32 ~ 53nm by thickness, refractive index be 2.0 ~ 3.0 the second high refractive index layer and thickness be 66 ~ 116nm, refractive index is the second low-index film composition of 1.3 ~ 1.8, described coloured glass sheet transmitance in 200 ~ 550nm wavelength coverage is zero, and the transmitance in 650 ~ 800nm wavelength coverage is greater than 90%.
The material of described high refractive index layer is HfO
2, Ti
3o
5, Ta
2o
5, Nb
2o
5in one, the material of described low-index film is MgF
2or SiO
2.
Described main rete is made up of 27 master unit layers, described master unit layer by average thickness be 170nm, refractive index is the Ti of 2.41
3o
5the SiO rete composition that rete and average thickness are 95nm, refractive index is 1.47.
Described secondary rete is made up of 17 sub-cell layers, described sub-cell layer by average thickness be 48nm, refractive index is the Ti of 2.41
3o
5the SiO rete composition that rete and average thickness are 86nm, refractive index is 1.47.
Compared with prior art, the invention has the advantages that by arranging specific main rete and time rete, coloured glass sheet is adopted to carry out alternative filters, identical wavelength cut-off and transmitance can be realized, namely the spectral depth of 200 ~ 625nm wavelength is ended, to the spectrum of 650 ~ 800nm wavelength, there is higher transmitance, and fluoresce after can not occurring, cost then reduces greatly, and compared with the assembly formed with 5 tablet filters, cost of the present invention reduces by more than 40%.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention;
Fig. 2 is the micromechanism schematic diagram of the main rete of the present invention;
Fig. 3 is the present invention's time rete micromechanism schematic diagram;
Fig. 4 is that in the embodiment of the present invention one, first glass substrate plates 0 ° of incident angle transmittance curve schematic diagram after main rete;
Fig. 5 is 0 ° of incident angle transmittance curve schematic diagram of coloured glass sheet of the present invention;
Fig. 6 is that in the embodiment of the present invention one, second glass substrate plates 0 ° of incident angle transmittance curve schematic diagram after time rete;
The transmittance curve schematic diagram of fluorescent optical filter assembly under 0 ° of incident angle of Fig. 7 embodiment of the present invention one;
The OD of fluorescent optical filter assembly under 0 ° of incident angle (the cut-off degree of depth) curve synoptic diagram of Fig. 8 embodiment of the present invention one.
Embodiment
Below in conjunction with accompanying drawing embodiment, the present invention is described in further detail.
Embodiment one: as shown in Fig. 1 ~ Fig. 8, a kind of fluorescent optical filter assembly for medical test system, comprise the first glass substrate 1, second glass substrate 2 and coloured glass sheet 3 mutually glued together, coloured glass sheet 3 is arranged between the first glass substrate 1 and the second glass substrate 2, the inside surface of the first glass substrate 1 is provided with main rete 4, main rete 4 is made up of 27 master unit layers 41, master unit layer 41 by average thickness be 170nm, refractive index be 2.41 the first high refractive index layer Ti
3o
5the first low-index film SiO rete L1 that rete H1 and average thickness are 95nm, refractive index is 1.47 forms, the first glass substrate 1 and the first high refractive index layer Ti
3o
5rete H1 is adjacent, and the inside surface of the second glass substrate 2 is provided with time rete 5, and secondary rete 5 is made up of 17 sub-cell layers 51, sub-cell layer 51 by average thickness be 48nm, refractive index be 2.41 the second high refractive index layer Ti
3o
5the second low-index film SiO rete L2 that rete H2 and average thickness are 86nm, refractive index is 1.47 forms, and coloured glass sheet 3 transmitance in 200 ~ 550nm wavelength coverage is zero, and the transmitance in 650 ~ 800nm wavelength coverage is greater than 90%.
By the optical filter cost compare that the fluorescent optical filter assembly of above-described embodiment one and 5 glue together, the results are shown in Table 1.
Table 1 cost estimation contrasts
As can be seen from Table 1, fluorescent optical filter assembly of the present invention contrasts 5 tablet filter gummed part costs declines 42.9%
In above-described embodiment, the material Ti of high refractive index layer
3o
5also can by the HfO of refractive index between 2.0 ~ 3.0
2, Ta
2o
5, Nb
2o
5in one substitute, and the material SiO of low-index film
2also can by the MgF of refractive index between 1.3 ~ 1.8
2substitute, and the average thickness of the first high refractive index layer can be any thickness between 153 ~ 190nm, the average thickness of the first low-index film can be any thickness between 63 ~ 132nm, the average thickness of the second high refractive index layer can be any thickness between 32 ~ 53nm, and the average thickness of the second low-index film can be any thickness between 66 ~ 116nm.
Claims (4)
1. the fluorescent optical filter assembly for medical test system, it is characterized in that comprising the first glass substrate mutually glued together, second glass substrate and coloured glass sheet, described coloured glass sheet is arranged between the first described glass substrate and the second described glass substrate, inside surface or the outside surface of the first described glass substrate are provided with main rete, the inside surface of the second described glass substrate or outside surface are provided with time rete, described main rete is made up of 20 ~ 30 master unit layers, described master unit layer is 153 ~ 190nm by thickness, refractive index be 2.0 ~ 3.0 the first high refractive index layer and thickness be 63 ~ 132nm, refractive index is the first low-index film composition of 1.3 ~ 1.8, the first described glass substrate is adjacent with the first described high refractive index layer, described secondary rete is made up of 10 ~ 20 sub-cell layers, described sub-cell layer is 32 ~ 53nm by thickness, refractive index be 2.0 ~ 3.0 the second high refractive index layer and thickness be 66 ~ 116nm, refractive index is the second low-index film composition of 1.3 ~ 1.8, described coloured glass sheet transmitance in 200 ~ 550nm wavelength coverage is zero, and the transmitance in 650 ~ 800nm wavelength coverage is greater than 90%.
2. a kind of fluorescent optical filter assembly for medical test system as claimed in claim 1, is characterized in that the material of described high refractive index layer is HfO
2, Ti
3o
5, Ta
2o
5, Nb
2o
5in one, the material of described low-index film is MgF
2or SiO
2.
3. a kind of fluorescent optical filter assembly for medical test system as claimed in claim 2, is characterized in that described main rete is made up of 27 master unit layers, described master unit layer by average thickness be 170nm, refractive index is the Ti of 2.41
3o
5the SiO rete composition that rete and average thickness are 95nm, refractive index is 1.47.
4. a kind of fluorescent optical filter assembly for medical test system as claimed in claim 1, is characterized in that described described secondary rete is made up of 17 sub-cell layers, described sub-cell layer by average thickness be 48nm, refractive index is the Ti of 2.41
3o
5the SiO rete composition that rete and average thickness are 86nm, refractive index is 1.47.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610045580.5A CN105549141A (en) | 2016-01-22 | 2016-01-22 | Fluorescent optical filter assembly for medical examination system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610045580.5A CN105549141A (en) | 2016-01-22 | 2016-01-22 | Fluorescent optical filter assembly for medical examination system |
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| Publication Number | Publication Date |
|---|---|
| CN105549141A true CN105549141A (en) | 2016-05-04 |
Family
ID=55828438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610045580.5A Pending CN105549141A (en) | 2016-01-22 | 2016-01-22 | Fluorescent optical filter assembly for medical examination system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105549141A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107316275A (en) * | 2017-06-08 | 2017-11-03 | 宁波永新光学股份有限公司 | A kind of large scale Microscopic Image Mosaicing algorithm of light stream auxiliary |
| CN107479191A (en) * | 2017-08-15 | 2017-12-15 | 天津津航技术物理研究所 | A kind of the laser rectangle optical filter and design method of visible optical depth cut-off |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040027652A1 (en) * | 2002-07-31 | 2004-02-12 | Turan Erdogan | Optical filter and fluorescence spectroscopy system incorporating the same |
| CN1731226A (en) * | 2004-11-10 | 2006-02-08 | 中国科学院长春光学精密机械与物理研究所 | Digital X-ray image instrument narrow band pass filter |
| CN102736153A (en) * | 2012-07-05 | 2012-10-17 | 美德瑞光电科技（上海）有限公司 | Infrared cut-off filter with low-angle effect |
| CN103364859A (en) * | 2012-04-05 | 2013-10-23 | 信泰光学(深圳)有限公司 | Infrared cutoff filter structure |
| CN104049292A (en) * | 2014-06-27 | 2014-09-17 | 温岭市现代晶体有限公司 | Ultraviolet-infrared cut-off optical filter |
-
2016
- 2016-01-22 CN CN201610045580.5A patent/CN105549141A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040027652A1 (en) * | 2002-07-31 | 2004-02-12 | Turan Erdogan | Optical filter and fluorescence spectroscopy system incorporating the same |
| CN1731226A (en) * | 2004-11-10 | 2006-02-08 | 中国科学院长春光学精密机械与物理研究所 | Digital X-ray image instrument narrow band pass filter |
| CN103364859A (en) * | 2012-04-05 | 2013-10-23 | 信泰光学(深圳)有限公司 | Infrared cutoff filter structure |
| CN102736153A (en) * | 2012-07-05 | 2012-10-17 | 美德瑞光电科技（上海）有限公司 | Infrared cut-off filter with low-angle effect |
| CN104049292A (en) * | 2014-06-27 | 2014-09-17 | 温岭市现代晶体有限公司 | Ultraviolet-infrared cut-off optical filter |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107316275A (en) * | 2017-06-08 | 2017-11-03 | 宁波永新光学股份有限公司 | A kind of large scale Microscopic Image Mosaicing algorithm of light stream auxiliary |
| CN107479191A (en) * | 2017-08-15 | 2017-12-15 | 天津津航技术物理研究所 | A kind of the laser rectangle optical filter and design method of visible optical depth cut-off |
| CN107479191B (en) * | 2017-08-15 | 2020-04-28 | 天津津航技术物理研究所 | Laser rectangular filter for visible light deep cut-off and design method |
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