CN105536292A - Method for removing impurities of radix paeoniae rubra and radix paeoniae alba - Google Patents
Method for removing impurities of radix paeoniae rubra and radix paeoniae alba Download PDFInfo
- Publication number
- CN105536292A CN105536292A CN201510988937.9A CN201510988937A CN105536292A CN 105536292 A CN105536292 A CN 105536292A CN 201510988937 A CN201510988937 A CN 201510988937A CN 105536292 A CN105536292 A CN 105536292A
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- China
- Prior art keywords
- resin
- water
- herbaceous peony
- solvent
- red root
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/12—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
- B01D15/203—Equilibration or regeneration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The invention provides a method for removing impurities of radix paeoniae rubra and radix paeoniae alba. The method comprises the following steps: before using resin, replacing water in a system by using an organic solvent; adding a small amount of water into a test tube, and slowly pouring a certain amount of the resin, which is sufficiently swollen with the water, into the test tube with the water; standing for stabilizing a bed layer. With the adoption of the method provided by the invention, the impurities are removed under the condition that components of the radix paeoniae rubra and the radix paeoniae alba are not influenced, and the method is not influenced by other chemical components.
Description
Technical field
The present invention relates to red root of herbaceous peony method field, particularly relate to a kind of field removing the method for red root of herbaceous peony impurity.
Background technology
Resin has network structure, its inner surface can adsorb different materials under different conditions selectively, and the stable in physicochemical property of polymeric adsorbent, chemical reaction can not be produced to adsorbate, and by any inorganic salts and strong ion low molecule chemical action, just by physical absorption from liquid according to the concentration of liquid adsorb organic compound matter selectively.So remove for the impurity of the red root of herbaceous peony, the resin of employing is the fabulous material that adsorptivity and screening property principle combine, and does not consider that non-polar macroporous resin is adsorbent in this way to removing of the red root of herbaceous peony in the past.
According to above problem, the present invention is compared to traditional approach in the past, and decontamination is more accurate, no longer relies on the method for artificial hand, consumes manual resource less, start and the response time almost nil, therefore, the present invention has more advantage at decontamination.
Summary of the invention
The technical problem to be solved in the present invention is: as why not affected the composition prerequisite removing impurities of the red root of herbaceous peony, not by the impact of other chemical analysis.
The invention provides following invention: a kind of method removing red root of herbaceous peony impurity, is characterized in that:
Resin before use must first with the water in organic solvent displacement system; Add a small amount of water in first in test tube, then fully slowly to pour into a certain amount of in test tube with water with water-soluble swollen resin, leave standstill, bed is stablized;
Pretreated resin, by aobvious intermediate value after rinsed with deionized water to efflux inspection PH=7, then replaces with the solvent same with preparation raw material liquid phase, the water in resin is replaced as corresponding solvent;
The red root of herbaceous peony is water-soluble, then carries out heat temperature raising, and form concentrate and be dissolved in suitable solvent, described suitable solvent can be ethanol, or adds some non-polar solvens in ethanol, to increase the solubility of red root of herbaceous peony concentrate;
The material liquid prepared is poured in separatory funnel, test tube is carried out the flow velocity of oblique regulates liquid of getting off, energy of adsorption is fully carried out; The red root of herbaceous peony is adsorbed on resin, and impurity flows out; When the material liquid passed into a certain extent after, beyond the adsorption capacity of resin, namely the red root of herbaceous peony flows out together with impurity; After adsorption step terminates, in bed space He in resin particle, go back residual quantities of contaminants, need to remove with solvent washing; With suitable strippant, the red root of herbaceous peony that resin adsorbs is desorbed; Strippant can be dissolved in the solvent same with preparation raw material liquid phase with acetic acid, is made into the solution of about 5%; Desorption procedure flow velocity can a little less than adsorption step flow velocity; Stripping liquid steams except after acetic acid and solvent, just obtains the red root of herbaceous peony concentrate of product; Finally by resin after aforesaid operations, reuse by it through certain reproducer; The regeneration of resin can use potassium hydroxide and alcohol mixed solution, avoids water to enter; Resin is after regeneration, then the liquid PH=7 being washed till outflow with ethanol is in neutral.
Accompanying drawing explanation
Fig. 1 is system assumption diagram of the present invention;
Detailed description of the invention
In order to make technical problem to be solved by this invention, technical scheme and beneficial effect clearly understand, below in conjunction with drawings and Examples, the present invention will be described in detail.It should be noted that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention, the product that can realize said function belongs to equivalent to be replaced and improves, and is all included within protection scope of the present invention.Concrete grammar is as follows:
Embodiment 1: in practice, whole remove red root of herbaceous peony impurity adopt anhydrous solvent, resin in general, need purify, if adopt polymer, in general wish to adopt suitable hole to adsorb according to the composition of the red root of herbaceous peony.Before use must first with the water in organic solvent displacement system; Add a small amount of water in first in test tube, then fully slowly to pour into a certain amount of in test tube with water with water-soluble swollen resin, leave standstill, bed is stablized;
Pretreated resin, by aobvious intermediate value after rinsed with deionized water to efflux inspection PH=7, then replaces with the solvent same with preparation raw material liquid phase, the water in resin is replaced as corresponding solvent;
The red root of herbaceous peony is water-soluble, then carries out heat temperature raising, and form concentrate and be dissolved in suitable solvent, described suitable solvent can be ethanol, or adds some non-polar solvens in ethanol, to increase the solubility of red root of herbaceous peony concentrate; The red root of herbaceous peony material liquid prepared is poured in separatory funnel, test tube is carried out the flow velocity of oblique regulates liquid of getting off, also can adopt certain valve that energy of adsorption is fully carried out; The red root of herbaceous peony is adsorbed on resin, and impurity flows out; When the material liquid passed into a certain extent after, beyond the adsorption capacity of resin, namely the red root of herbaceous peony flows out together with impurity; After adsorption step terminates, in bed space He in resin particle, go back residual quantities of contaminants, need to remove with solvent washing; With suitable strippant, the red root of herbaceous peony that resin adsorbs is desorbed; Strippant can be dissolved in the solvent same with preparation raw material liquid phase with acetic acid, is made into the solution of about 5%; Desorption procedure flow velocity can a little less than adsorption step flow velocity; Stripping liquid steams except after acetic acid and solvent, just obtains the red root of herbaceous peony concentrate of product; Finally by resin after aforesaid operations, reuse by it through certain reproducer; The regeneration of resin can use potassium hydroxide and alcohol mixed solution, avoids water to enter; Resin is after regeneration, then the liquid PH=7 being washed till outflow with ethanol is in neutral.
Design advantage of the present invention mainly contains: the composition prerequisite removing impurities affecting the red root of herbaceous peony, not by the impact of other chemical analysis.
Claims (1)
1. remove a method for red root of herbaceous peony impurity, it is characterized in that:
Resin before use must first with the water in organic solvent displacement system; Add a small amount of water in first in test tube, then fully slowly to pour into a certain amount of in test tube with water with water-soluble swollen resin, leave standstill, bed is stablized;
Pretreated resin, by aobvious intermediate value after rinsed with deionized water to efflux inspection PH=7, then replaces with the solvent same with preparation raw material liquid phase, the water in resin is replaced as corresponding solvent;
The red root of herbaceous peony is water-soluble, then carries out heat temperature raising, and form concentrate and be dissolved in suitable solvent, described suitable solvent can be ethanol, or adds some non-polar solvens in ethanol, to increase the solubility of red root of herbaceous peony concentrate;
The material liquid prepared is poured in separatory funnel, test tube is carried out the flow velocity of oblique regulates liquid of getting off, energy of adsorption is fully carried out; The red root of herbaceous peony is adsorbed on resin, and impurity flows out; When the material liquid passed into a certain extent after, beyond the adsorption capacity of resin, namely the red root of herbaceous peony flows out together with impurity; After adsorption step terminates, in bed space He in resin particle, go back residual quantities of contaminants, need to remove with solvent washing; With suitable strippant, the red root of herbaceous peony that resin adsorbs is desorbed; Strippant can be dissolved in the solvent same with preparation raw material liquid phase with acetic acid, is made into the solution of about 5%; Desorption procedure flow velocity can a little less than adsorption step flow velocity; Stripping liquid steams except after acetic acid and solvent, just obtains the red root of herbaceous peony concentrate of product; Finally by resin after aforesaid operations, reuse by it through certain reproducer; The regeneration of resin can use potassium hydroxide and alcohol mixed solution, avoids water to enter; Resin is after regeneration, then the liquid PH=7 being washed till outflow with ethanol is in neutral.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510988937.9A CN105536292A (en) | 2015-12-23 | 2015-12-23 | Method for removing impurities of radix paeoniae rubra and radix paeoniae alba |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510988937.9A CN105536292A (en) | 2015-12-23 | 2015-12-23 | Method for removing impurities of radix paeoniae rubra and radix paeoniae alba |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105536292A true CN105536292A (en) | 2016-05-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510988937.9A Pending CN105536292A (en) | 2015-12-23 | 2015-12-23 | Method for removing impurities of radix paeoniae rubra and radix paeoniae alba |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101297874A (en) * | 2008-06-13 | 2008-11-05 | 宁波立华制药有限公司 | Technique for extracting high-content effective composition from white peony root |
| JP2009186435A (en) * | 2008-02-08 | 2009-08-20 | Tsumura & Co | Method of purifying residual agricultural chemicals in herbal medicine sample |
| CN101628926A (en) * | 2009-08-11 | 2010-01-20 | 张守力 | Extraction process of paeoniflorin |
| CN102258588A (en) * | 2011-03-10 | 2011-11-30 | 张建军 | Preparation method of peony general glycoside |
| CN103044503A (en) * | 2012-12-24 | 2013-04-17 | 浙江工业大学 | Method for rapidly and efficiently extracting paeoniflorin and albiflorin |
-
2015
- 2015-12-23 CN CN201510988937.9A patent/CN105536292A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009186435A (en) * | 2008-02-08 | 2009-08-20 | Tsumura & Co | Method of purifying residual agricultural chemicals in herbal medicine sample |
| CN101297874A (en) * | 2008-06-13 | 2008-11-05 | 宁波立华制药有限公司 | Technique for extracting high-content effective composition from white peony root |
| CN101628926A (en) * | 2009-08-11 | 2010-01-20 | 张守力 | Extraction process of paeoniflorin |
| CN102258588A (en) * | 2011-03-10 | 2011-11-30 | 张建军 | Preparation method of peony general glycoside |
| CN103044503A (en) * | 2012-12-24 | 2013-04-17 | 浙江工业大学 | Method for rapidly and efficiently extracting paeoniflorin and albiflorin |
Non-Patent Citations (1)
| Title |
|---|
| 顾觉奋等: "《离子交换与吸附树脂在制药工业上的应用》", 30 April 2008, 中国医药科技出版社 * |
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Application publication date: 20160504 |