CN105536037A - Antibacterial medical adhesive and preparation method thereof - Google Patents
Antibacterial medical adhesive and preparation method thereof Download PDFInfo
- Publication number
- CN105536037A CN105536037A CN201610044761.6A CN201610044761A CN105536037A CN 105536037 A CN105536037 A CN 105536037A CN 201610044761 A CN201610044761 A CN 201610044761A CN 105536037 A CN105536037 A CN 105536037A
- Authority
- CN
- China
- Prior art keywords
- parts
- antibacterial medical
- binding agent
- gelatin
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/104—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to an antibacterial medical adhesive and a preparation method thereof. The antibacterial medical adhesive is prepared from, by weight, 5-10 parts of hydroxypropyl methacrylate, 5-10 parts of tert-butyl methacrylate, 3-5 parts of isopropyl acrylate, 3-5 parts of isobutyl acrylate, 10-20 parts of gelatin, 10-15 parts of glycerinum, 2-5 parts of degreased silkworm chrysalis meal, 10-15 parts of fibrin glue, 5-10 parts of sodium alga acid, 2-5 parts of L-glutamic acid and 20-50 parts of deionized water. The adhesive has the high adhesive strength and compressive strength, has small stimulation to organism tissue, has no added harmful reagent, and is suitable for being used in surgical operations, particularly soft tissue adhering.
Description
Technical field
The present invention relates to adhesive field, be specifically related to a kind of antibacterial medical binding agent and preparation method thereof.
Background technology
Along with the progress of medical science level, more and more higher to the requirement of operation technique and auxiliary material clinically, the raising of clinical requirement facilitates the research and development of adhesive of medical.Adhesive of medical is a branch of medical high polymer, and it take biological tissue as bonding object, and human body overwhelming majority tissue, organ can be applied adhering technique replacement part over the course for the treatment of and sew up, and ligation operates, and need not anaesthetize; Automatic-falling after wound healing, adhesive of medical self is aseptic, and has bacteriostasis, and infection conditions seldom occurs.Because it is remarkable to some curative effect of disease, show unique characteristics, easy to operate, be subject to the welcome of clinician.
Desirable adhesive of medical should possess following character (1) safety, reliable, avirulence, without three causing (carcinogenic, teratogenesis, mutagenesis); (2) there is good biocompatibility, do not hinder self healing of tissue; (3) aseptic and can keep aseptic over a period to come; (4) quick-binding can be realized under room temperature, normal pressure; (5) have good bonding strength and persistency, stick portion has certain elasticity and toughness; (6) in use to tissue nonirritant; (7) can degrade gradually after reaching result of use, Absorption And Metabolism; (8) there is good using state and be easy to preserve.But still do not work out all ideal adhesive of medical product of various aspects of performance at present.
Still applicable with the cyanoacrylate adhesive of comparatively early exploitation at present.It is a kind of based on the chemical glue of highly purified cyanoacrylate, histocompatibility is good, to human non-toxic, harmless, under the anionic species contained in tissue and blood etc. during use exists, thin film can be formed by rapid solidification, reach the effect of quick bonding, hemostasis, wound closure, analgesic antiphlogistic.Patent CN103585671 discloses that a kind of concentration of formaldehyde is low, adhesive strength is high, adhesive film good toughness, the medical cyanoacrylate adhesive little to tissue irritation, its formula is made up of cyanoacrylate, citrate, formaldehyde inhibitor, hydroquinone, sulfur dioxide.Patent CN103432623A disclose a kind ofly to solidify rapidly, adhesive strength is large, medical cyanoacrylate adhesive to human non-toxic's side effect, it is made up of a-alpha-cyanoacrylate n-octyl, polymethyl methacrylate, dibutyl phthalate, dioctyl phthalate, p-methyl benzenesulfonic acid and hydroquinone.Above-mentioned patent is owing to containing the materials such as sulfur dioxide, hydroquinone, polymethyl methacrylate in formula technique, product is caused to prepare and in use procedure, there is weak point more or less, therefore, there is formula ratio in product preparation process is difficult to accurately control and the not degradation problem of some component of formula, when may use causing shaped article further, curing rate is undesirable, bonding strength is not enough, some problems such as degradation property difference and poor stability.
Summary of the invention
Based on problems of the prior art, the invention provides a kind of antibacterial medical binding agent and preparation method thereof, by weight, comprise following component: Hydroxypropyl methacrylate 5-10 part, Tert-butyl Methacrylate 5-10 part, isopropyl acrylate 3-5 part, Isobutyl 2-propenoate 3-5 part, 10 ~ 20 parts, gelatin, glycerol 10-15 part, degreased pupa powder 2-5 part, Fibrin Glue 10-15 part, sodium alginate 5-10 part, Pidolidone 2 ~ 5 parts and deionized water 20-50 part.
Preferably, by weight, comprise following component: Hydroxypropyl methacrylate 8-10 part, Tert-butyl Methacrylate 8-10 part, isopropyl acrylate 4-5 part, Isobutyl 2-propenoate 4-5 part, 16 ~ 18 parts, gelatin, glycerol 12-15 part, degreased pupa powder 4-5 part, Fibrin Glue 10-12 part, sodium alginate 8-10 part, Pidolidone 2 ~ 3 parts and water 40-50 part.
More preferably, by weight, comprise following component: Hydroxypropyl methacrylate 10 parts, Tert-butyl Methacrylate 10 parts, isopropyl acrylate 4 parts, Isobutyl 2-propenoate 4 parts, 16 parts, gelatin, glycerol 15 parts, degreased pupa powder 5 parts, Fibrin Glue 10 parts, sodium alginate 10 parts, Pidolidone 3 parts and deionized water 45 parts.
Preferably, the molecular weight of described gelatin is 30000-40000.
Preferably, the water content of described degreased pupa powder is lower than 8%.
The present invention also protects the preparation method of above-mentioned antibacterial medical binding agent, comprises the steps: to take each raw material by weight, is added by raw material in container; be heated to 50-70 DEG C; be stirred to and dissolve completely, under being room temperature after ultrasonic 4-6h, then disinfection obtains.
Preferably, employing radiosterilization is disinfected described in.
Compared with prior art, tool has the following advantages and beneficial effect in the present invention:
(1) the present invention adopts the components such as gelatin, glycerol, degreased pupa powder, Pidolidone to substitute poisonous component used in the prior art, by the formula of adjustment antibacterial medical binding agent, achieve higher adhesion strength and comprcssive strength, stimulate little to bio-tissue, do not add any harmful reagent, be suitable in surgical operation, be especially applicable to the bonding of soft tissue.
(2) adhesion strength of antibacterial medical binding agent prepared of the present invention and comprcssive strength are improved largely, and wherein comprcssive strength is higher than 60N, comprcssive strength higher than 65Mpa, far above binding agent conventional in prior art.
(3) preparation method of the present invention is simple, and raw material is easy to get, and is applicable to large-scale production.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with specific embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, and be not construed as limiting the invention.
Embodiment 1
Take following raw material by weight, raw material is added in container, be heated to 70 DEG C, be stirred to and dissolve completely, under being room temperature after ultrasonic 4h, then carrying out radiosterilization process and obtain antibacterial medical adhesive A 1.
Raw material comprises: Hydroxypropyl methacrylate 5 parts, Tert-butyl Methacrylate 5 parts, isopropyl acrylate 3 parts, Isobutyl 2-propenoate 3 parts, 12 parts, gelatin, glycerol 10 parts, degreased pupa powder 3 parts, Fibrin Glue 15 parts, sodium alginate 5 parts, Pidolidone 5 parts and deionized water 50 parts.
Embodiment 2
Take following raw material by weight, raw material is added in container, be heated to 60 DEG C, be stirred to and dissolve completely, under being room temperature after ultrasonic 5h, then carrying out radiosterilization process and obtain antibacterial medical adhesive A 2.
Raw material comprises: Hydroxypropyl methacrylate 10 parts, Tert-butyl Methacrylate 10 parts, isopropyl acrylate 4 parts, Isobutyl 2-propenoate 4 parts, molecular weight is 16 parts, the gelatin of about 35000, glycerol 15 parts, degreased pupa powder (water content is 5%) 5 parts, Fibrin Glue 10 parts, sodium alginate 10 parts, Pidolidone 3 parts and deionized water 45 parts.
Embodiment 3
Take following raw material by weight, raw material is added in container, be heated to 60 DEG C, be stirred to and dissolve completely, under being room temperature after ultrasonic 5h, then carrying out radiosterilization process and obtain antibacterial medical adhesive A 3.
Raw material comprises: Hydroxypropyl methacrylate 8 parts, Tert-butyl Methacrylate 8 parts, isopropyl acrylate 5 parts, Isobutyl 2-propenoate 5 parts, molecular weight is 18 parts, the gelatin of about 35000, glycerol 13 parts, degreased pupa powder (water content is 5%) 4 parts, Fibrin Glue 12 parts, sodium alginate 9 parts, Pidolidone 2 parts and 40 parts, water.
Performance test:
Measure the performance of binding agent prepared by the embodiment of the present invention 1 ~ 2 respectively, comprise adhesion strength and 24h, 72h intensity test, result is as shown in table 1.Wherein the assay method of adhesion strength is as follows: according to YY/T0729.1 tissue adhesive adhesive property test method part 1: overlap joint-shear tension bearing strength is tested.
Table 1
| A1 | A2 | A3 | |
| Adhesion strength (N) | 58.4 | 61.3 | 60.2 |
| 24h comprcssive strength (MPa) | 64.1 | 66.1 | 65.0 |
| 72h comprcssive strength (MPa) | 63.6 | 66.0 | 64.5 |
As shown in Table 1, the adhesion strength of the antibacterial medical binding agent that the present invention prepares and comprcssive strength have had and have increased substantially, and stimulate little, the requirement of Complex Clinical adhesive of medical to bio-tissue.
Above embodiment display and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; instead of limit the scope of the invention by any way; without departing from the scope of the invention; the present invention also has various changes and modifications, and these changes and improvements all fall in claimed scope.
Claims (6)
1. antibacterial medical binding agent and preparation method thereof, is characterized in that, by weight, comprise following component: Hydroxypropyl methacrylate 5-10 part, Tert-butyl Methacrylate 5-10 part, isopropyl acrylate 3-5 part, Isobutyl 2-propenoate 3-5 part, 10 ~ 20 parts, gelatin, glycerol 10-15 part, degreased pupa powder 2-5 part, Fibrin Glue 10-15 part, sodium alginate 5-10 part, Pidolidone 2 ~ 5 parts and deionized water 20-50 part.
2. antibacterial medical binding agent according to claim 1, is characterized in that, by weight, comprise following component: Hydroxypropyl methacrylate 8-10 part, Tert-butyl Methacrylate 8-10 part, isopropyl acrylate 4-5 part, Isobutyl 2-propenoate 4-5 part, 16 ~ 18 parts, gelatin, glycerol 12-15 part, degreased pupa powder 4-5 part, Fibrin Glue 10-12 part, sodium alginate 8-10 part, Pidolidone 2 ~ 3 parts and water 40-50 part; Be more preferably, by weight, comprise following component: Hydroxypropyl methacrylate 10 parts, Tert-butyl Methacrylate 10 parts, isopropyl acrylate 4 parts, Isobutyl 2-propenoate 4 parts, 16 parts, gelatin, glycerol 15 parts, degreased pupa powder 5 parts, Fibrin Glue 10 parts, sodium alginate 10 parts, Pidolidone 3 parts and deionized water 45 parts.
3. the antibacterial medical binding agent according to claim 1-2, is characterized in that, the molecular weight of described gelatin is 30000-40000.
4. the antibacterial medical binding agent according to claim 1-3, is characterized in that, the water content of described degreased pupa powder is lower than 8%.
5. the preparation method of the antibacterial medical binding agent according to claim 1-4, is characterized in that, comprises the steps: to take each raw material by weight, raw material is added in container, be heated to 50-70 DEG C, be stirred to and dissolve completely, under being room temperature after ultrasonic 4-6h, then disinfection obtains.
6. preparation method according to claim 5, is characterized in that, described in disinfect employing radiosterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610044761.6A CN105536037A (en) | 2016-01-22 | 2016-01-22 | Antibacterial medical adhesive and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610044761.6A CN105536037A (en) | 2016-01-22 | 2016-01-22 | Antibacterial medical adhesive and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105536037A true CN105536037A (en) | 2016-05-04 |
Family
ID=55815908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610044761.6A Withdrawn CN105536037A (en) | 2016-01-22 | 2016-01-22 | Antibacterial medical adhesive and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105536037A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075545A (en) * | 2016-06-15 | 2016-11-09 | 湖州科达化工燃料有限公司 | A kind of soft tissue binding agent with antibacterial anti hemorrhagic effect |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070071800A1 (en) * | 2005-09-29 | 2007-03-29 | National Starch And Chemical Investment Holding Company | Acrylic pressure sensitive adhesives |
| CN101875828A (en) * | 2009-04-28 | 2010-11-03 | 中国科学院过程工程研究所 | Medicinal hydrophilic polyacrylic ester pressure-sensitive adhesive and preparation method |
| CN102008743A (en) * | 2009-09-08 | 2011-04-13 | 张元元 | Adhesive for bones and teeth |
| CA2795282A1 (en) * | 2010-04-03 | 2011-10-06 | Lohmann Gmbh & Co. Kg | Acrylate adhesive for use on the skin |
-
2016
- 2016-01-22 CN CN201610044761.6A patent/CN105536037A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070071800A1 (en) * | 2005-09-29 | 2007-03-29 | National Starch And Chemical Investment Holding Company | Acrylic pressure sensitive adhesives |
| CN101875828A (en) * | 2009-04-28 | 2010-11-03 | 中国科学院过程工程研究所 | Medicinal hydrophilic polyacrylic ester pressure-sensitive adhesive and preparation method |
| CN102008743A (en) * | 2009-09-08 | 2011-04-13 | 张元元 | Adhesive for bones and teeth |
| CA2795282A1 (en) * | 2010-04-03 | 2011-10-06 | Lohmann Gmbh & Co. Kg | Acrylate adhesive for use on the skin |
Non-Patent Citations (1)
| Title |
|---|
| 董忠良 主编: "《胶黏剂最新设计制备手册》", 31 July 2010, 化学工业出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075545A (en) * | 2016-06-15 | 2016-11-09 | 湖州科达化工燃料有限公司 | A kind of soft tissue binding agent with antibacterial anti hemorrhagic effect |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Williams et al. | The Williams dictionary of biomaterials | |
| DE69333286T2 (en) | A THROMBIN BLOOD FRACTION FOR USE IN A MEDICAL PROCEDURE | |
| JP2014532458A (en) | Collagen-polysaccharide materials mimicking blood vessels, tissues and bones for medical, pharmaceutical and orthopedic applications and processes for their production | |
| CN102247617A (en) | Medical adhesive or hemostatic | |
| WO2006092798A3 (en) | Novel adhesive materials, manufacturing thereof, and applications thereof | |
| CN114369441A (en) | Polyphenol-based medical tissue adhesive, and preparation method and application thereof | |
| CN106075545A (en) | A kind of soft tissue binding agent with antibacterial anti hemorrhagic effect | |
| CN105727347A (en) | Composite hemostatic sponge and preparation method thereof | |
| Bhattacharya et al. | Collagen sheet dressings for cutaneous lesions of toxic epidermal necrolysis | |
| CN105326535B (en) | Medical anastomosis nail and preparation method thereof | |
| CN109806438B (en) | Orthopedic adhesive with function of promoting bone growth and preparation method thereof | |
| CN105536037A (en) | Antibacterial medical adhesive and preparation method thereof | |
| RU2010102090A (en) | COMPOSITIONS FOR ANTIFIBRINOLYTIC TREATMENT | |
| CN208876658U (en) | Internal Medicine-Cardiovascular Dept. hemostasis compressorium | |
| CN109847093B (en) | Antibacterial orthopedic adhesive and preparation method thereof | |
| CN110420347A (en) | A kind of adhesive of medical and preparation method thereof | |
| CN106178087A (en) | Human body soft tissue bonding special bio medical material and preparation method thereof | |
| CN105727345A (en) | Absorbable hemostasis membrane material and preparation method thereof | |
| CN108714242A (en) | A kind of preparation method of nanometer of medical adhesive | |
| CN108042845A (en) | A kind of albumin based aquagel dressing and preparation method thereof | |
| CN104921775A (en) | Postoperative tourniquet for percutaneous coronary intervention treatment | |
| CN1297323C (en) | Glue for medical use | |
| CN107469142A (en) | A kind of antibacterial modified nano composite material for promoting osteogenic growth and preparation method thereof | |
| CN113209360B (en) | Medical adhesive for promoting wound healing and preparation method thereof | |
| CN1795933A (en) | Preparation and application of anti blocking biomembrane for tendon and ligament |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160504 |