CN105535565A - Mouth ulcer treating pharmaceutical composition, preparation method and uses thereof - Google Patents
Mouth ulcer treating pharmaceutical composition, preparation method and uses thereof Download PDFInfo
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- CN105535565A CN105535565A CN201410582126.4A CN201410582126A CN105535565A CN 105535565 A CN105535565 A CN 105535565A CN 201410582126 A CN201410582126 A CN 201410582126A CN 105535565 A CN105535565 A CN 105535565A
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Abstract
The present invention provides a mouth ulcer treating pharmaceutical composition, which is an agent prepared by adopting polygonatum odoratum, adenophora stricta miq, ophiopogon japonicus, dendrobium nobile lindl, mulberry leaf, lophatherum gracile, asparagus cochinchinensis, pueraria lobata and the like as raw materials. The present invention further provides a preparation method and uses of the pharmaceutical composition, especially uses of the pharmaceutical composition in treatment of recurrent mouth ulcer. According to the present invention, the mouth ulcer treating pharmaceutical composition has characteristics of short treatment course, no adverse reaction, systemic and local action, treatment of concomitant symptoms such as bitter taste of mouth, dry mouth, halitosis and the like, recurrence reducing, safety, no side effect and low price, and provides a new selection for the clinic.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of oral ulcer, particularly, is take Chinese crude drug as the pharmaceutical composition that raw material is prepared from, and belongs to the field of Chinese medicines.
Background technology
The cause of disease of oral ulcer is more, and such as oral mucosal disease causes: as recurrent aphtha, herpetic stomatitis, hand-foot-mouth disease, pemphigus and pemphigoid secondary ulcer etc.; Traumatic ulcer: this is that a class irritates the directly relevant ulcer of factor with local, is caused by tumor " malignant ulcer ": this ulcer is the result of malignant tumor local infiltration sexual development, just may occur the general manifestation of malignant tumor before ulcer occurs.
Summary of the invention
In order to solve the problem, technical scheme of the present invention there is provided a kind of pharmaceutical composition for the treatment of recurrent oral ulceration, and another technical scheme of the present invention there is provided preparation method and the purposes of this pharmaceutical composition.
The invention provides a kind of pharmaceutical composition for the treatment of oral ulcer, it is the medicament that the raw material containing following weight proportioning is prepared from.
Rhizoma Polygonati Odorati 10-30 part, Radix Adenophorae (Radix Glehniae) 15-25 part, Radix Ophiopogonis 15-25 part, Herba Dendrobii 15-30 part, Folium Mori 15-25 part, Herba Lophatheri 15-30 part, Radix Asparagi 15-25 part, Pachyrhizua angulatus 10-30 part.
Further, also containing Fructus Ligustri Lucidi, the Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii in described raw material, its weight proportion is: Fructus Ligustri Lucidi 15-30 part, Radix Rehmanniae 15-30 part, Radix Rehmanniae Preparata 15-30 part, Fructus Lycii 15-30 part.Further, also contain in described raw material: Gypsum Fibrosum, Seem Lablab Album, Radix Glycyrrhizae Preparata, its weight proportion is: Gypsum Fibrosum 20-40 part, Seem Lablab Album 15-30 part, Radix Glycyrrhizae Preparata S-15 part.
Particularly, medicine of the present invention be prepared from by the raw material of following weight proportioning medicament-Rhizoma Polygonati Odorati 10-30 part, Radix Adenophorae (Radix Glehniae) 15-25 part, Radix Ophiopogonis 15-25 part, Herba Dendrobii 15-30 part, Folium Mori 15-25 part, Herba Lophatheri 15-30 part, Radix Asparagi 15-25 part, Fructus Ligustri Lucidi 15-30 part, Radix Rehmanniae 15-30 part, Radix Rehmanniae Preparata 15-30 part, Fructus Lycii 15-30 part, Gypsum Fibrosum 20-40 part, Seem Lablab Album 15-30 part, Pachyrhizua angulatus 10-30 part, Radix Glycyrrhizae Preparata 5-15 part.
Further, it is the medicament be prepared from by the raw material of following weight proportioning: Rhizoma Polygonati Odorati 10 parts, Radix Adenophorae (Radix Glehniae) 15 parts, Radix Ophiopogonis 15 parts, Herba Dendrobii 15 parts, 10 parts, Folium Mori, Herba Lophatheri 15 parts, Radix Asparagi 15 parts, Fructus Ligustri Lucidi 15 parts, 20 parts, the Radix Rehmanniae, 20 parts, Radix Rehmanniae Preparata, Fructus Lycii 15 parts, Gypsum Fibrosum 30 parts, 20 parts, Seem Lablab Album, Pachyrhizua angulatus 10 parts, Radix Glycyrrhizae Preparata 5 parts.
Pharmaceutical composition of the present invention is active component by the primary crude drug of Rhizoma Polygonati Odorati, Radix Adenophorae (Radix Glehniae), Radix Ophiopogonis, Herba Dendrobii, Folium Mori, Herba Lophatheri, Radix Asparagi, Fructus Ligustri Lucidi, the Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Gypsum Fibrosum, Seem Lablab Album, Pachyrhizua angulatus, Radix Glycyrrhizae Preparata or water or extractive with organic solvent, adds the medicament that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
Wherein, described medicament is powder, medicinal tea, oral liquid, capsule, tablet, pill, collutory, buccal lozenge.
Present invention also offers the method for this pharmaceutical composition, comprise the steps
:
A, take the raw material of following weight proportioning-
Rhizoma Polygonati Odorati 10-30 part, Radix Adenophorae (Radix Glehniae) 15-25 part, Radix Ophiopogonis 15-25 part, Herba Dendrobii 15-30 part, Folium Mori 15-25 part, Herba Lophatheri 15-30 part, Radix Asparagi 15-2S part, Fructus Ligustri Lucidi 15-30 part, Radix Rehmanniae 15-30 part, Radix Rehmanniae Preparata 15-30 part, Fructus Lycii 15-30 part, Gypsum Fibrosum 20-40 part, Seem Lablab Album 15-30 part, Pachyrhizua angulatus 10 parts, Radix Glycyrrhizae Preparata 5 parts;
B, above 15 taste medicines, be ground into coarse powder, mixing, decoct with water, concentrate, dry, granulate, add pharmaceutically acceptable adjuvant or complementary composition is prepared into the preparation pharmaceutically commonly used.
Present invention also offers the purposes of this pharmaceutical composition in the medicine of preparation treatment oral ulcer.Further, described medicine is the medicine for the treatment of recurrent oral ulceration.
Oral cavity is the door of digestive tract, and the stomach of the traditional Chinese medical science belongs to sun, preferring moisture to dryness, and gastric qi should be fallen; Clinical many deficiencies of stomach-Yin, adverse rising of stomach-QI.The raw interior-heat of the deficiency of YIN, hyperactivity of deficient fire, therefore see oral ulcer, thirst and liking drink, bitter taste, halitosis; Notably undermine Liver and kidney, companion sees xerosis cutis, soreness of the waist and knees, and the trick heart generates heat.Kidney yin is Kidney-Yin, is the basic of the cloudy liquid of human body, kidney storing essence, blood stored in the liver, " The liver and the kidney have a common source ", therefore controls deficiency of stomach-YIN and to hold concurrently nourishing the liver and kidney, intends controlling source.
Drug regimen raw material prescription of the present invention its in guidance of traditional Chinese medicine theory, wherein monarch drug: Rhizoma Polygonati Odorati, Radix Adenophorae (Radix Glehniae), Radix Ophiopogonis, Herba Dendrobii, Folium Mori, Herba Lophatheri, Radix Asparagi, enters stomach warp, cold nature, reinforcing stomach reg fluid, relieves heat and thirst; Ministerial drug. Fructus Ligustri Lucidi, the Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, enters kidney channel and Liver Channel, nourishing the liver and kidney, and benefit supports Kidney-Yin; Adjuvant drug: Gypsum Fibrosum, enters stomach warp, property Great Cold, clearing away heat-fire, treatment excessive thirst, aphtha of the mouth and tongue; Seem Lablab Album, slightly warm in nature, spleen invigorating dehumidifies, and share with cold medicine, anti-Great Cold impairment of YIN, Yin Yang balancing; Radix Glycyrrhizae Preparata coordinating the actions of various ingredients in a prescription.Courses of pharmaceuticals of the present invention is short, has no adverse reaction, and whole body and local act on simultaneously, and double simultaneous phenomenon of controlling, as bitter taste, xerostomia, halitosis etc., reduces recurrence, low price.Obviously, according to foregoing of the present invention, according to ordinary technical knowledge and the customary means of this area, not departing under the present invention's above-mentioned basic fundamental thought prerequisite, the amendment of other various ways, replacement or change can also be made.
The detailed description of the invention of form by the following examples, is described in further detail foregoing of the present invention again.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example.All technology realized based on foregoing of the present invention all belong to scope of the present invention.
Detailed description of the invention
Embodiment 1
The preparation a of medicine of the present invention, take the raw material of following weight proportioning:
Rhizoma Polygonati Odorati 10kg, Radix Adenophorae (Radix Glehniae) 15kg, Radix Ophiopogonis 15kg, Herba Dendrobii 15kg, Folium Mori 10kg, Herba Lophatheri 15kg, Radix Asparagi 15kg, Fructus Ligustri Lucidi 15kg, Radix Rehmanniae 20kg, Radix Rehmanniae Preparata 20kg, Fructus Lycii 15kg, Gypsum Fibrosum 30kg, Seem Lablab Album 20kg, Pachyrhizua angulatus 10kg, Radix Glycyrrhizae Preparata 5kg.
B, above 15 taste medicines, be ground into coarse powder, mixed Uniform, and high temperature is concentrated, spray-drying process.Usage and dosage: every day 1 one 2 wraps, and gradation buccal or boiled water are taken after mixing it with water, or follow the doctor's advice; Specification: often comprise crude drug in whole 10 grams.
Embodiment 2
The preparation of medicine of the present invention
A, take the raw material of following weight proportioning:
Rhizoma Polygonati Odorati 10kg, Radix Adenophorae (Radix Glehniae) 15kg, Radix Ophiopogonis ISkg, Herba Dendrobii 15kg, Folium Mori 15, Herba Lophatheri 15, Radix Asparagi 15kg, Fructus Ligustri Lucidi 15 ridge, the Radix Rehmanniae 15 he, Radix Rehmanniae Preparata 15kg, Fructus Lycii 15kg, Gypsum Fibrosum 20kg, Seem Lablab Album 15kg, Pachyrhizua angulatus 10kg, Radix Glycyrrhizae Preparata 5kg;
B, above 15 taste medicines, be ground into coarse powder, mixed Uniform, and high temperature is concentrated, sugar-free spray-drying process, encapsulated, obtains capsule.
Embodiment 3
The preparation a of medicine of the present invention, take the raw material of following weight proportioning:
Rhizoma Polygonati Odorati 30kg, Radix Adenophorae (Radix Glehniae) 25kg, Radix Ophiopogonis 25kg, Herba Dendrobii 30kg, Folium Mori 25kg, Herba Lophatheri 30kg, Radix Asparagi 2Skg, Fructus Ligustri Lucidi 30kg, Radix Rehmanniae 30kg, Radix Rehmanniae Preparata 30kg, Fructus Lycii 30kg, Gypsum Fibrosum 40kg, Seem Lablab Album 30kg, Pachyrhizua angulatus 30kg, Radix Glycyrrhizae Preparata 15k
g;
B, above 15 taste medicines, be ground into coarse powder, mixed Uniform, and high temperature is concentrated, spraying sugar-free drying and granulating, granulate, adds magnesium stearate, tabletting, obtains tablet.
Claims (5)
1. treat a pharmaceutical composition for oral ulcer, it is characterized in that: it is the medicament that the raw material containing following weight proportioning is prepared from:
Rhizoma Polygonati Odorati 10-30 part, Radix Adenophorae (Radix Glehniae) 15-25 part, Radix Ophiopogonis 15-25 part, Herba Dendrobii 15-30 part, Folium Mori 15-25 part, Herba Lophatheri 15-30 part, Radix Asparagi 15-25 part, Pachyrhizua angulatus 10-30 part.
2. the pharmaceutical composition for the treatment of oral ulcer according to claim 1, is characterized in that: also containing Fructus Ligustri Lucidi, the Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii in described raw material, its weight proportion is:
Fructus Ligustri Lucidi 15-30 part, Radix Rehmanniae 15-30 part, Radix Rehmanniae Preparata 15-30 part, Fructus Lycii 15-30 part.
3. the pharmaceutical composition for the treatment of oral ulcer according to claim 2, it is characterized in that: also contain in described raw material: Gypsum Fibrosum, Seem Lablab Album, Radix Glycyrrhizae Preparata, its weight proportion is
:
Gypsum Fibrosum 20-40 part, Seem Lablab Album 15-30 part, Radix Glycyrrhizae Preparata 5-15 part.
4. the pharmaceutical composition for the treatment of oral ulcer according to claim 3, is characterized in that: it is the medicament be prepared from by the raw material of following weight proportioning:
Rhizoma Polygonati Odorati 10-30 part, Radix Adenophorae (Radix Glehniae) 15-25 part, Radix Ophiopogonis 15-25 part, Herba Dendrobii 15-30 part, Folium Mori 15-25 part, Herba Lophatheri 15-30 part, Radix Asparagi 15-25 part, Fructus Ligustri Lucidi 15-30 part, Radix Rehmanniae 15-30 part, Radix Rehmanniae Preparata 15-30 part, Fructus Lycii 15-30 part, Gypsum Fibrosum 20-40 part, Seem Lablab Album 15-30 part, Pachyrhizua angulatus 10-30 part, Radix Glycyrrhizae Preparata 5-15 part.
5. the pharmaceutical composition for the treatment of oral ulcer according to claim 4, is characterized in that: it is the medicament be prepared from by the raw material of following weight proportioning:
Rhizoma Polygonati Odorati 10 parts, Radix Adenophorae (Radix Glehniae) 15 parts, Radix Ophiopogonis 15 parts, Herba Dendrobii 15 parts, 10 parts, Folium Mori, Herba Lophatheri 15 parts, Radix Asparagi 15 parts, Fructus Ligustri Lucidi 15 parts, 20 parts, the Radix Rehmanniae, 20 parts, Radix Rehmanniae Preparata, Fructus Lycii 15 parts, Gypsum Fibrosum 30 parts, 20 parts, Seem Lablab Album, Pachyrhizua angulatus 10 parts, Radix Glycyrrhizae Preparata 5 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410582126.4A CN105535565A (en) | 2014-10-28 | 2014-10-28 | Mouth ulcer treating pharmaceutical composition, preparation method and uses thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410582126.4A CN105535565A (en) | 2014-10-28 | 2014-10-28 | Mouth ulcer treating pharmaceutical composition, preparation method and uses thereof |
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| CN105535565A true CN105535565A (en) | 2016-05-04 |
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| CN201410582126.4A Pending CN105535565A (en) | 2014-10-28 | 2014-10-28 | Mouth ulcer treating pharmaceutical composition, preparation method and uses thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107569652A (en) * | 2017-09-18 | 2018-01-12 | 佛山市秸和科技有限公司 | A kind of Chinese medicine composition for being used to treat recurrent oral ulceration |
-
2014
- 2014-10-28 CN CN201410582126.4A patent/CN105535565A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107569652A (en) * | 2017-09-18 | 2018-01-12 | 佛山市秸和科技有限公司 | A kind of Chinese medicine composition for being used to treat recurrent oral ulceration |
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Application publication date: 20160504 |
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