CN105535485A

CN105535485A - Traditional Chinese medicine composition for treating senile duodenal ulcer

Info

Publication number: CN105535485A
Application number: CN201511035602.1A
Authority: CN
Inventors: 王明亮; 李春梅
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-12-29
Filing date: 2015-12-29
Publication date: 2016-05-04

Abstract

The invention discloses a traditional Chinese medicine composition for treating senile duodenal ulcer, and belongs to the technical field traditional Chinese medicines. Traditional Chinese medicines including roots of Nupharpumilum(Timm)DC. , Saussurea deltoidea, roots of Vernonia squarrosa (D. Don) Less. var. orientalis Kitam.[V. teres auct. non DC.], all grass of Aleuritopteris hopeana (C. Chr.) Ching, roots of Chinese honeysuckle, seeds of Castanopsis hystrix A.DC., all grass of Crepis turczaninowii C. A. Mey., Goodyera schlechtenda- liana Reichb.f G.repens(L.) B. Br, Adenophora paniculata, all grass of bieberstein carlina and roots or tender leaves of Vicia unijuga which have the functions of warming middle-jiao and tonifying deficiency and replenishing qi to invigorate spleens are selected for pathogenesis of senile duodenal ulcer according to the symptomatic treatment principle of traditional Chinese medicines and decocted into decoction, and it is proved through clinical tests that the total effective rate reaches 98%.

Description

A kind of Chinese medicine composition for the treatment of senile duodenal ulcer

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of senile duodenal ulcer.

Background technology

Duodenal ulcer belongs to peptic ulcer, is one of modal digestive tract disease clinically.Compared with the peptic ulcer of general population, peptic ulcer in elderly presents different features, first old people weakens due to gastrointestinal mucosa regeneration function, and cause easy disequilibrium between invasion and attack factor and mucosa self-defense-repair mechanism, therefore duodenum stain infections sickness rate is higher.Research in recent years shows that peptic ulcer is the different substantiality disease group that Different types of etiopathogenises causes, and the pathogenesis namely between patient is different and clinical manifestation is similar.Academic circles at present extensively thinks that peptic ulcer is caused by acid secretion exceedes normally, but it should be noted that acid secretion exceedes normal caused duodenal ulcer patients and only accounts for 40%, and therefore, the pathogenesis of duodenum stain infections still requires study.The many stimulating intestine and stomaches of Western medicine, the features such as Chinese medicine has property of medicine gentleness, treating both the principal and secondary aspects of a disease, and toxicity is low, untoward reaction is little, obtain good effect in recent years clinically.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for the treatment of senile duodenal ulcer.The cold and cool stimulation of old people Duo Yin, eating and drinking without temperance, disorder of emotion impairing the spleen and stomach, and cause caused by weakness of the spleen and stomach, cause ulcer and touching difficulty heals.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of the senile duodenal ulcer of this treatment is made up of the Chinese medicine of following weight portion: Rhizoma nupharis pumili 4-7 part, triangle leaf hieracioides 5-7 part, Herba Vernonia squarrosae 5-15 part, little 5-15 part of tackling all problems at once, Radix Quisqualis 3-5 part, Semen Castanopsis hickelii 15-30 part, Herba Crepidis croceae 3-8 part, Radix Coodyerae schlechtendalianae 10-15 part, fine leaf adenophora 3-7 part, Herba Carlinae biebersteinii 4-8 part, Radix seu Folium Viciae Unijugae 4-7 part.

Preferably, Rhizoma nupharis pumili 5 parts, triangle leaf hieracioides 6 parts, Herba Vernonia squarrosae 10 parts, little tackle all problems at once 10 parts, Radix Quisqualis 4 parts, Semen Castanopsis hickelii 22 parts, Herba Crepidis croceae 6 parts, Radix Coodyerae schlechtendalianae 12 parts, fine leaf adenophora 5 parts, Herba Carlinae biebersteinii 6 parts, Radix seu Folium Viciae Unijugae 6 parts.

More than preparation method all medicines traditionally decocting become decoction.

Fang Zhong: Rhizoma nupharis pumili tonify deficiency, stomach invigorating, regulating menstruation; The spleen invigorating of triangle leaf hieracioides disappears infantile malnutrition, the meridian dredging, wind-damp dispelling; Herba Vernonia squarrosae spleen invigorating, help digestion, pain relieving, antiinflammatory; Little invigorating the spleen and replenishing QI of tackling all problems at once, strengthening the spleen and stomach; Radix Quisqualis appetizing, spleen invigorating, parasite killing; Semen Castanopsis hickelii strengthening the spleen to promote digestion, strengthening by means of tonics; Herba Crepidis croceae resolving heat and reducing pathogenic fire, QI invigorating; Radix Coodyerae schlechtendalianae tonify deficiency; Fine leaf adenophora tonify deficiency, to induce sweat; Herba Carlinae biebersteinii strengthening by means of tonics taste, regulating menstruation and activating blood; Radix seu Folium Viciae Unijugae tonify deficiency.

Clinical data

1, physical data chooses in August ,-2013 in August, 2011 100 Patients is the patient of duodenal ulcer through electronic gastroscope and definitive pathological diagnosis, it is negative that rapid urease detects helicobacter pylori (Hp), 60 ~ 87 years old age, all patients are divided into treatment group and matched group when informed consent at random by random digits table, treatment group 50 example, man 27 example, female 23 example; 60 ~ 85 years old age, average 71 ± 2.6 years old; Matched group 50 example, man 24 example, female 26 example; 61 ~ 88 years old age, average 68 ± 4.2 years old.Two groups of patients, at sex, age, ulcer size isobase data no significant difference, have comparability (P > 0.05).

2, diagnostic criteria is with reference to the diagnostic criteria about peptic ulcer in " guideline of clinical investigations of new Chinese medicine treatment peptic ulcer ".

Inclusive criteria (1) age >=60 one full year of life; (2) the chronic course of disease, periodical attack and rhythm and pace of moving things Upper abdominal pain, Chinese medical discrimination (syndrome of deficient cold of spleen and stomach); (3) be the patient of duodenal ulcer through electronic gastroscope and definitive pathological diagnosis, it is negative that rapid urease detects helicobacter pylori (Hp); (4) patient signs Informed Consent Form.

Exclusion standard (1) age < 60 one full year of life; (2) gastric ulcer, compound ulcer, malignant ulcer and multiple stain infections; (3) helicobacter pylori (Hp) is positive; (4) active hemorrhage and pyloric obstruction; (5) gastrinoma patient; (6) other organic diseases patient (as patients such as hepatic and renal function exception, diabetes, severe cardiac cerebrovascular disease, hematopathy, tumors).

3, Therapeutic Method matched group: give rabeprazole 20mg, 1 time/d, period in a medicine is avoided drinking and irritative food; Treatment group: on the basis giving rabeprazole 20mg/d, take Rhizoma nupharis pumili 5g, triangle leaf hieracioides 6g, Herba Vernonia squarrosae 10g, the little 10g that tackles all problems at once, Radix Quisqualis 4g, Semen Castanopsis hickelii 22g, Herba Crepidis croceae 6g, Radix Coodyerae schlechtendalianae 12g, fine leaf adenophora 5g, Herba Carlinae biebersteinii 6g, Radix seu Folium Viciae Unijugae 6g, decocting makes decoction, every day, potion, took sooner or later.Treating all continuously for two groups 4 weeks is a course for the treatment of.

4, criterion of therapeutical effect gastroscopy effect evaluation criteria: (1) fully recovers: ulcer surface and inflammation all disappear; (2) effective: ulcer surface heals, but still has inflammation; (3) effective: ulcer area reduces > more than 50%; (4) invalid: the unchanged or area of ulcer reduces≤50%.

5, observe the curative effect after the course for the treatment of of therapeutic outcome patient treatment, the routine patient for the treatment of group 50 wherein fully recovers 25 examples (50%), effective 10 examples (20%), effective 14 examples (28%), invalid 1 example (2%), total effective rate 98%.Matched group 50 patient wherein fully recovers 8 examples (16%), effective 12 examples (24%), effective 23 examples (46%), invalid 7 examples (14%), total effective rate 86%.Two groups are compared, and treatment group cure rate, total effective rate are obviously better than matched group, have comparability (P < 0.05).

Detailed description of the invention

Embodiment one: take Rhizoma nupharis pumili 4g, triangle leaf hieracioides 5g, Herba Vernonia squarrosae 5g, the little 5g that tackles all problems at once, Radix Quisqualis 3g, Semen Castanopsis hickelii 15g, Herba Crepidis croceae 3g, Radix Coodyerae schlechtendalianae 10g, fine leaf adenophora 3g, Herba Carlinae biebersteinii 4g, Radix seu Folium Viciae Unijugae 4g, decocting makes decoction.

Embodiment two: take Rhizoma nupharis pumili 5g, triangle leaf hieracioides 6g, Herba Vernonia squarrosae 10g, the little 10g that tackles all problems at once, Radix Quisqualis 4g, Semen Castanopsis hickelii 22g, Herba Crepidis croceae 6g, Radix Coodyerae schlechtendalianae 12g, fine leaf adenophora 5g, Herba Carlinae biebersteinii 6g, Radix seu Folium Viciae Unijugae 6g, decocting makes decoction.

Embodiment three: take Rhizoma nupharis pumili 7g, triangle leaf hieracioides 7g, Herba Vernonia squarrosae 15g, the little 15g that tackles all problems at once, Radix Quisqualis 5g, Semen Castanopsis hickelii 30g, Herba Crepidis croceae 8g, Radix Coodyerae schlechtendalianae 15g, fine leaf adenophora 7g, Herba Carlinae biebersteinii 8g, Radix seu Folium Viciae Unijugae 7g, decocting makes decoction.

Claims

1. treat a Chinese medicine composition for senile duodenal ulcer, it is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma nupharis pumili 4-7 part, triangle leaf hieracioides 5-7 part, Herba Vernonia squarrosae 5-15 part, little 5-15 part of tackling all problems at once, Radix Quisqualis 3-5 part, Semen Castanopsis hickelii 15-30 part, Herba Crepidis croceae 3-8 part, Radix Coodyerae schlechtendalianae 10-15 part, fine leaf adenophora 3-7 part, Herba Carlinae biebersteinii 4-8 part, Radix seu Folium Viciae Unijugae 4-7 part.

2. a kind of Chinese medicine composition for the treatment of senile duodenal ulcer according to claim 1, is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma nupharis pumili 5 parts, triangle leaf hieracioides 6 parts, Herba Vernonia squarrosae 10 parts, little tackle all problems at once 10 parts, Radix Quisqualis 4 parts, Semen Castanopsis hickelii 22 parts, Herba Crepidis croceae 6 parts, Radix Coodyerae schlechtendalianae 12 parts, fine leaf adenophora 5 parts, Herba Carlinae biebersteinii 6 parts, Radix seu Folium Viciae Unijugae 6 parts.