CN105535097A - Cow anestrus treating composition containing traditional Chinese medicines - Google Patents
Cow anestrus treating composition containing traditional Chinese medicines Download PDFInfo
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- CN105535097A CN105535097A CN201410604376.3A CN201410604376A CN105535097A CN 105535097 A CN105535097 A CN 105535097A CN 201410604376 A CN201410604376 A CN 201410604376A CN 105535097 A CN105535097 A CN 105535097A
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Abstract
The present invention discloses a composition containing traditional Chinese medicines used for cows and having effects of kidney reinforcing, yang strengthening, blood circulation activating and blood stasis dissipating, and sexual maturity promoting and conception. The composition comprises seven herbs such as epimedium, actinolite quenched with wine, angelica sinensis, herba Leonuri, safflower, licorice root, dodder and the like, trace sodium selenite, and vitamin E. According to the present invention, the composition has characteristics of rational formula and exact treatment effect, can clinically replace the hormone drugs for cows, and further has advantages of wide application range, high bioavailability, good treatment effect, no recurrence, and the like.
Description
Technical field
The invention belongs to herbal medicine technical field, particularly a kind of treat the weary feelings of cattle containing Chinese medicine composition, compositions takes full advantage of Chinese medicine and the effective compatibility of antioxidative.
Background technology
In actual milch cow, steer ration, the weary feelings of cattle are recurrent problems, and the cattle propagating system disease comprising weary feelings has accounted for about 18% of Niu Changfa disease.In Cow product, the weary feelings of cow can be caused by various factors, and directly cause Monitoring Ovarian Function to be upset, follicular development is obstructed, and sexual cycle stops.After weary feelings, cow can not breed in time, and cows breeding rate is declined, and then reduces pasture breeding potential, and the calving interval extends.That breeders loses symptom of estrus to replacement cattles more than 14 monthly ages and puerperal 60 days non-estrus cow, analysis and reproduction inspection should be carried out in time, and from improving feeding and management and application Chinese medicine, hormone are set about, make its restorative cycle.
The clinical manifestation of the weary feelings of milch cow has following four aspects: when 1, replacement cattle reaches age at sexual maturity, do not have the estrus cycle to occur; Or occur after reaching age at sexual maturity oestrusing for 1 ~ 2 time, long-time non-estrus again later; Or performance of oestrusing is not obvious.2, cow divides the puerperium to lose performance of oestrusing for a long time.3, cow divides the puerperium to occur oestrusing for 1 ~ 2 time, later non-return over a long time.4, the pregnant inspection of cow is without tire, and without oestrusing performance.
The weary feelings of milch cow cause many factors, one is trophic factor, and milch cow, in a liter newborn phase, needs a large amount of nutrition, and feedstuff feed quantity not sufficient, bad, causes nutrition negative balance, causes cow to become thin, and causes the weary feelings of milch cow.Two is cattle health factors.Cow suffers from the other diseases such as metabolic disease, hoof disease and parasitic disease, causes body constitution to decline.Three is uterus diseases, as pyometra, mummification, hysteromyoma, endometritis etc., makes endometrium can not discharge PG, caused by body, the mechanism of dissolving corpus luteum is destroyed.Four is that endocrine and neuroregulation are in disorder.Five is mismanagements, hypomotility, a cattle inbred etc.
In the breeding physiology function of milch cow, normally oestrusing and ovulating is the basis keeping normal reproductive capacity, because normally do not oestrus (ovulation), other reproductive physiology activity of cow just loses source.
In current cultivation situation, the weary feelings of cattle generally use hormone therapy.First time gives cattle intramuscular injection gonadotropin releasing hormone (GnRH) 20 μ g, and object is that the follicle in any FSH and LH Hormone Density of induction is ovulated and forms corpus luteum.Second time be after 7 days, inject prostaglandin analogue (PGF2 α) 25 ㎎, object be dissolve all corpus luteum, now ovary should exist one come from first time GnRH injection after, the dominant follicle of generation.Continuation, due to luteolysis, is grown and makes cow enter oestrus by this dominant follicle.Be inject GnRH20 μ g in a couple of days for the third time, object is that dominant follicle grows close to time ripe, induces this follicle to ovulate.This ripe treatment sequence, in oestrus, the optimum time of 5 ~ 12d starts, to weary feelings cow and recessive cow in estrus the most applicable.
For cow, no matter be with GnRH, PGF2 α, estradiol, or pregnant mare serum (PMSG), prostaglandin and analog (PG) etc., hormone can play a role clinical.But the injection sequence of each parahormone, delivery time are all very crucial, improper use, cow would not oestrus in your official hour.No matter use which kind of medicine, all must grasp suitable consumption, measure little inoperative, amount causes greatly endocrine regulation conception rate to reduce, and also may cause ovarian cyst.
Although the hormone therapy scheme of the weary feelings ovarian disease of international aquaculture accreditation cow, in milk, whether hormone remains, and whether trace hormone gives birth to impact to hair of children; Use after hormone, the service life of ovary has unchanged, equal no standard or systematic study, and milk cattle cultivating person is badly in need of the efficient genital tract mucosal agent of more pollution-free, noresidue, safety.
Have part Chinese medicine effective to cow retained corpus luteum at present, as common progestogenic infusion liquid preparation, the main component of this preparation is Herba Epimedii 200g, Flos Carthami 200g, Herba Leonuri 400g, cures mainly kidney invigorating and YANG supporting, blood circulation promoting and blood stasis dispelling, promoting the sexual maturity of animals and promoting gravidity.Herba Epimedii is the dry herb of Berberidaceae plant Epimedium sagittatum, and life is used or crisp use, acrid, sweet, warm.Enter liver, kidney channel.Be mainly used in kidney invigorating and YANG supporting, promote the sexual maturity, more obvious to the effect of male animal, treatment female animal non-estrus, not become pregnant, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Herba Leonuri.Promote the sexual maturity in addition in veterinary medical quality standard loose, standard is given for the reproduction conditioning of sow.Up to the present, that includes in veterinary medicine national standard is considerably less to the effective medicine of the weary feelings of cow.
Present inventor, through long term test, to grow growth-promoting in conjunction with plurality of Chinese, effect of QI and blood regulating, QI invigorating and hormone-like effect, develops with Chinese medicine as the weary feelings therapeutic combination of main cattle.Said composition focuses on compensate qi and blood, induced ovulation of promoting the sexual maturity, the present invention can promote the eliminating being trapped in afterbirth in female animal body, certain therapeutic effect is had to endometritis, therefore there is promoting the circulation of blood of enriching blood, warm palace blood, beneficial smart ovum, there is promotion follicle, Oviduct Development, accelerates the function of repairing genitals's pathological changes.
Chinese herbal medicine is a kind of medicine of environmental protection, have toxic and side effects little, the feature such as do not develop immunity to drugs, and the long-term reasonable employment of milch cow can be avoided in body and the drug residue problem of milk, ensure that the product of Cow product has reliable safety, Cow product has wide Utilization prospects.
Summary of the invention
Inventor through deeply, earnest experiments, successfully have developed a kind of be used for the treatment of the weary feelings of cattle containing Chinese medicine composition, and demonstrate its curative effect with experiment.Emphasis of the present invention is the efficient combination utilizing hormonelike Chinese medicine and antioxidant, effectively can solve the weary feelings problem of female animal.Noresidue of the present invention, have no adverse effects, to non-estrus of a specified duration, Repeat breeding cattle has good result.
Be used for the treatment of the weary feelings of cattle containing a Chinese medicine composition, each constituent is counted by weight: Herba Epimedii 1 ~ 4 part, wine are quenched Actinolitum 0.5 ~ 2 part, Radix Angelicae Sinensis 0.5 ~ 2 part, Herba Leonuri 1 ~ 10 part, 0.5 ~ 2 part, Flos Carthami, 1 ~ 4 part, Radix Glycyrrhizae, Semen Cuscutae 0.5 ~ 2 part, sodium selenite 0.01-0.05 part, vitamin E 0.1-1 part.
The each constituent of described compositions is counted by weight: Herba Epimedii 2 parts, wine are quenched Actinolitum 1 part, Radix Angelicae Sinensis 1 part, Herba Leonuri 5 parts, 1 part, Flos Carthami, 3 parts, Radix Glycyrrhizae, Semen Cuscutae 1 part, sodium selenite 0.02 part, vitamin E 0.5 part.
In component, wine Actinolitum of quenching cannot substitute with the Actinolitum of equivalent weight.
Described compositions can be prepared as the various dosage forms facilitating cattle to use, and comprises oral liquid, powder, granule, infusion liquid.
The invention has the beneficial effects as follows:
1, reasonable recipe, controls anti-combination, all medicine use in conjunction in side, and no drug residue, does not produce drug resistance, treating both the principal and secondary aspects of a disease;
2, described Chinese medicine composition, according to the custom of feeding of Niu Butong, can be made into oral liquid soluble in water, granule for cattle, makes powder for spice, can also make uterus perfusion and carry out perfusion administration.
Detailed description of the invention
Can observe beneficial property of the present invention with the following Examples, these embodiments are illustrative, can not be construed as limiting the present invention.
The preparation of embodiment 1 milch cow weary feelings treatment oral liquid
1. formula composition: Herba Epimedii 2 parts (2000g), wine are quenched Actinolitum 1 part (1000g), Radix Angelicae Sinensis 1 part (1000g), Herba Leonuri 5 parts (5000g), 1 part, Flos Carthami (1000g), 3 parts, Radix Glycyrrhizae (3000g), Semen Cuscutae 1 part (1000g), sodium selenite 0.02 part (20g), vitamin E 0.5 part (500g).
2. be prepared into oral liquid: first taken by formula by Chinese medicine composition, add 300L water soaking 12 hours, decoct twice, 4 hours first times, second time decocts 2 hours, keeps slight boiling condition after boiling at every turn, after twice liquid medicine mixing merges filtration, it is 1g/ml (every ml solution is containing 1g raw medicinal herbs) that concentrating under reduced pressure is recycled to solution concentration, cold preservation 24 hours, pulp board supplies loss amount after filtering, then cold preservation 24 hours, after filtration, flowing steam sterilization 30 minutes; Let cool the potassium sorbate that rear medicinal liquid adds sodium selenite, vitamin E and 3 ‰ amounts, mixing, fill, to obtain final product.
The preparation of embodiment 2 milch cow weary feelings treatment powder
1. formula composition: Herba Epimedii 1 part (1000g), wine are quenched Actinolitum 0.5 part (500g), Radix Angelicae Sinensis 0.5 part (500g), Herba Leonuri 1 part (1000g), 0.5 part, Flos Carthami (500g), 1 part, Radix Glycyrrhizae (1000g), Semen Cuscutae 0.5 part (500g), sodium selenite 0.01 part (10g), vitamin E 0.1 part (100g).
2. be prepared into powder: first taken by formula by Chinese medicine composition, pulverize respectively, cross 40 mesh sieves, after pulverizing, add sodium selenite and vitamin E mix homogeneously, cross 40 mesh sieves and get final product.
The preparation of embodiment 3 milch cow weary feelings treatment infusion liquid
1. formula composition: Herba Epimedii 4 parts (4000g), wine are quenched Actinolitum 2 parts (2000g), Radix Angelicae Sinensis 2 parts (2000g), Herba Leonuri 10 parts (10000g), 2 parts, Flos Carthami (2000g), 4 parts, Radix Glycyrrhizae (4000g), Semen Cuscutae 2 parts (2000g), sodium selenite 0.05 part (50g), vitamin e1 part (1000g).
2. be prepared into uterus perfusion: first taken by formula by Chinese medicine composition, add the water soaking 12 hours of ten times of weight, decoct twice, each 4 hours; Keep slight boiling condition after boiling, after twice liquid medicine mixing merges and filter, it was 1g/ml (every ml solution is containing 1g raw medicinal herbs) that concentrating under reduced pressure is recycled to solution concentration, supplies loss amount after 300 order filter-cloth filterings at every turn, with flowing steam sterilization 30 minutes; Let cool the propyl benzoate that rear medicinal liquid adds sodium selenite, vitamin E and 3 ‰ amounts, mixing, fill, to obtain final product.
Embodiment 4, the weary feelings medicine of a kind of cattle are to the clinical trial of non-estrus cow
Female animal non-estrus directly affects breeding of female animal and raise benefit.Above-described embodiment 2 product is used for cattle farm, Shandong, has screened 44 routine non-estrus cows, breed after taking medicine, Oestrus rate is joined rate and is reached 85.7%, achieves obvious economic benefit and therapeutic effect.
1 materials and methods
1.1 test material
1.1.1 the weary feelings treatment of cattle is provided by Tianjin Ringpu Bio-technology Co., Ltd. containing the compositions of Chinese medicine.
1.1.2 subjects and screening criteria:
In the adaptive cow of cattle farm, Zhucheng, select continuous more than two months non-estrus, the ill cattle that impact breeding is impregnated is subjects.
Judge disease criterion: in the adaptive cow of non-estrus, to without General Symptoms, rectum and examination per vagina, without obvious mutation, but do not show and oestrus, the ill cow that impact breeding is impregnated, and are judged to be weary feelings cow.
1.1.3 feedstuff, raising apparatus and other articles for use provide by vaccary.
1.1.4 record articles for use and related tests articles for use, provided by seminar.
1.2 test method
Test Niu Suiji is divided into 4 groups, often organizes 11 cattle.Experimental group 1 is low dosage administration group, suffers from cattle and takes embodiment 2 product every day, admix this product 100g in every concentrate; Experimental group 2 is clinical recommended dose administration group, suffers from cattle and takes embodiment 2 product every day, admix this product 150g in every concentrate; Respectively be used in conjunction 5d; 3rd group is progestogenic infusion liquid matched group, purchased from Guangzhou producer; 4th group is fall ill the positive controls of not administration.
1.3 efficacy determinations: performance in 15 days of taking medicine is oestrused and accepted to breed is effective, otherwise is invalid.
1.4 rearing conditions: test group cow all adopts identical trophic level, unified management system, unified raising program, unified feeding environment, and carries out prevention disinfection routinely.
2 results and analysis
Table 1 cattle weary feelings therapeutic combination is to weary feelings cow therapeutic effect
As seen from the above table: the weary feelings of product treatment cow in embodiment, have positive effect.Group 2 is each serving with 150g, and be used in conjunction 5d, therapeutic effect is best.
3. brief summary and discussion
Result shows, effectively can prevent and treat the weary feelings of milch cow containing Chinese medicine formula.Continuous more than two months non-estrus, the weary feelings cow that impact breeding is impregnated, adopt product of the present invention for oral administration, a 150g, be used in conjunction 5d, effective percentage reaches 90.9%, shows that the present invention treats cow non-estrus and has reliable curative effect.Suggestion, in order to effectively prevent the generation of weary feelings, taking above-mentioned medicament 100g every 1 week, to promote to oestrus, treating to take 1 dose again in 15-16 days of the second individual character cycle, effectively thoroughly changed weary situation condition.
Claims (5)
1. be used for the treatment of the weary feelings of cattle containing a Chinese medicine composition, it is characterized in that described compositions is made up of quench Actinolitum, Radix Angelicae Sinensis, Herba Leonuri, Flos Carthami, Radix Glycyrrhizae, Semen Cuscutae, sodium selenite, vitamin E of Herba Epimedii, wine.
2. according to claim 1 a kind of be used for the treatment of the weary feelings of cattle containing Chinese medicine composition, it is characterized in that each constituent of described compositions is counted by weight: Herba Epimedii 1 ~ 4 part, wine are quenched Actinolitum 0.5 ~ 2 part, Radix Angelicae Sinensis 0.5 ~ 2 part, Herba Leonuri 1 ~ 10 part, 0.5 ~ 2 part, Flos Carthami, 1 ~ 4 part, Radix Glycyrrhizae, Semen Cuscutae 0.5 ~ 2 part, sodium selenite 0.01-0.05 part, vitamin E 0.1-1 part.
3. according to claim 2 a kind of be used for the treatment of the weary feelings of cattle containing Chinese medicine composition, it is characterized in that each constituent of described compositions is counted by weight: Herba Epimedii 2 parts, wine are quenched Actinolitum 1 part, Radix Angelicae Sinensis 1 part, Herba Leonuri 5 parts, 1 part, Flos Carthami, 3 parts, Radix Glycyrrhizae, Semen Cuscutae 1 part, sodium selenite 0.02 part, vitamin E 0.5 part.
4. according to claim 1 a kind of be used for the treatment of the weary feelings of cattle containing Chinese medicine composition, to it is characterized in that in component that wine Actinolitum of quenching cannot substitute with the Actinolitum of equivalent weight.
5. a kind of according to claim 1 or 2 or 3 or 4 be used for the treatment of the weary feelings of cattle containing Chinese medicine composition, it is characterized in that described compositions is prepared as oral liquid, powder, granule, infusion liquid for cattle.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410604376.3A CN105535097A (en) | 2014-10-31 | 2014-10-31 | Cow anestrus treating composition containing traditional Chinese medicines |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106342753A (en) * | 2016-08-29 | 2017-01-25 | 贵州省正安县林下生态养殖有限责任公司 | Cattle expand breeding method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106342753A (en) * | 2016-08-29 | 2017-01-25 | 贵州省正安县林下生态养殖有限责任公司 | Cattle expand breeding method |
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Application publication date: 20160504 |
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