CN105534887A - Female private part sterilizing care solution - Google Patents
Female private part sterilizing care solution Download PDFInfo
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- CN105534887A CN105534887A CN201511033380.XA CN201511033380A CN105534887A CN 105534887 A CN105534887 A CN 105534887A CN 201511033380 A CN201511033380 A CN 201511033380A CN 105534887 A CN105534887 A CN 105534887A
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- Prior art keywords
- chitosan
- private part
- deionized water
- care solution
- female private
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention belongs to the field of female daily necessities, and particularly relates to a female private part sterilizing care solution. The provided composition is prepared from chitosan, preservative, solubilizer and deionized water. Chitosan and the solubilizer are added into the composition, and chitosan with bactericidal performance can be fully dissolved in the deionized water. The problem that in the prior art, as chitosan is low in solubility, the female private part sterilizing care solution containing chitosan is defective in bactericidal performance is solved, private part bacteria are effectively killed, and private part homeostasis is stable. The female private part sterilizing care solution is simple in formula, low in cost and suitable for industrial production.
Description
Technical field
The invention belongs to women's daily necessities field, particularly relate to a kind of female private part sterilization care solution.
Background technology
Doctor trained in Western medicine is thought, the environment of vagina is owing to being often subject to the metabolite of host, the product of antibacterial itself and extrinsic factor (sexual intercourse, flushing and other interference) and unstable.Vaginal microbial flora is very complicated, and except protozoon, fungus, also comprise a lot of aerobe and anaerobe, these microorganisms can be divided into commensalism and pathologic, all grows in a common environment, may have the anti-effect of Fructus Citri tangerinae between each microorganism.What another affected its growth is hydrogen ion concentration, when pH3.8 ~ 4.2, be conducive to the breeding of commensalism bacterium, especially lactobacillus, this is that master 4.2 in healthy vagina wants strain, density in vaginal secretion can reach 105 ~ 108ml, after vagina is by infected by microbes, if lactobacillus is preponderated, still pH3.8 ~ 4.2 can be maintained, then can not cause a disease, and lactobacillus can also produce H202, suppress it to breed to the toxic effect of other microorganisms.Other are as common in vagina lower end in Streptococcus lactis (Lister) Lohnis 1909.554., enterobacteria, Bacillus proteus, Jia Fuji coccus, Wei Yong coccus etc., do not produce symptom at ordinary times.Restrict each other between vaginal microbial flora, pathological bacteria can not be acted on to some extent, if this balance is destroyed, condition each other event resolves, so hydrogen ion concentration declines, lactobacillus is lost ground, and bacterium is bred pathology, just produces symptom.Female private part conditioning liquid is Precerving liquid conventional in a kind of daily life, and primary efficacy is to regulate pH value, clean, and sterilization, the effect of some Feminine care solution also containing " beauty treatment ".
Chitosan is the product after chitin deacetylase base, is cationic high molecular polymer few in number in natural polysaccharide.The outward appearance of chitosan is white or faint yellow translucent chip solid, and slightly pearly luster, dissolves in most of diluted acid.Chitosan has a lot of unique function as natural cationic biopolymer, as moisture retention, wettability, film property, antistatic property, hair softness and protective effect etc.The fields such as textile printing and dyeing, medical science, food, cosmetics are widely used at present.Therefore, exploitation chitosan series effect product is more and more subject to people and pays close attention to, and has had in increasing female private part conditioning liquid and has added chitosan, made full use of the character that it can carry out gentle sterilization.Because chitosan is the regular linear macromolecule of molecular structure, degree of crystallinity is high, and make the chitosan of chitosan especially high molecular, the non-constant of dissolubility, water insoluble and majority of organic solvent, is only dissolved in part dilute acid solution.Therefore, in prior art, owing to being subject to the restriction of chitosan dissolubility, it is not good enough that the female private part sterilization care solution containing chitosan often also exists bactericidal effect, can not effectively kill pudendum antibacterial, maintains the homeostatic problem of pudendum.
Therefore, develop a kind of female private part sterilization care solution, for solving in prior art, owing to being subject to the restriction of chitosan dissolubility, it is not good enough that female private part sterilization care solution containing chitosan often also exists bactericidal effect, can not effectively kill pudendum antibacterial, maintain pudendum homeostasis, become those skilled in the art's problem demanding prompt solution.
Summary of the invention
In view of this, the invention provides a kind of female private part sterilization care solution, for solving in prior art, owing to being subject to the restriction of chitosan dissolubility, it is not good enough that female private part sterilization care solution containing chitosan often also exists bactericidal effect, can not effectively kill pudendum antibacterial, maintain the homeostatic problem of pudendum.
A kind of compositions provided by the invention, comprising: chitosan, antiseptic, solubilizing agent and deionized water.
Preferably, described antiseptic is Capmul MCM C8.
Preferably, described solubilizing agent is: lactic acid and/or propylene glycol.
Preferably, in mass parts, described compositions comprises: chitosan 0.8 ~ 1.2 part, Capmul MCM C8 0.2 ~ 0.5 part, lactic acid 0.8 ~ 1.2 part and deionized water 96.3 ~ 98.5 parts.
Preferably, in mass parts, described compositions comprises: chitosan 1 part, Capmul MCM C8 0.4 part, lactic acid 1 part and deionized water 97.6 parts.
Preferably, in mass parts, described compositions comprises: chitosan 0.8 ~ 1.2 part, Capmul MCM C8 0.2 ~ 0.5 part, propylene glycol 0.8 ~ 1.2 part and deionized water 96.3 ~ 98.5 parts.
Preferably, in mass parts, described compositions comprises: chitosan 1 part, Capmul MCM C8 0.4 part, propylene glycol 1 part and deionized water 97.6 parts.
Present invention also offers the application of compositions in sterilization field described in above any one.
Present invention also offers the application of compositions in female private part sterilization field described in above any one.
In sum, a kind of compositions provided by the invention, comprising: chitosan, antiseptic, solubilizing agent and deionized water.By adding chitosan and solubilizing agent in the composition, make to have microbe killing properties can chitosan can fully be dissolved in deionized water, solve in prior art, the problem that the female private part sterilization care solution sterilizing ability containing chitosan that is that cause is short of because chitosan dissolubility is low, can effectively kill pudendum antibacterial, maintain pudendum homeostasis.Meanwhile, formula of the present invention is simple, with low cost, is applicable to commercial production.
Detailed description of the invention
The invention provides a kind of female private part sterilization care solution, for solving in prior art, owing to being subject to the restriction of chitosan dissolubility, it is not good enough that the female private part sterilization care solution containing chitosan often also exists bactericidal effect, can not effectively kill pudendum antibacterial, maintain the homeostatic problem of pudendum.
Be clearly and completely described to the technical scheme in the embodiment of the present invention below, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
In order to be described in more detail the present invention, below in conjunction with embodiment to a kind of female private part sterilization care solution provided by the invention, describe particularly.
Embodiment 1
Take chitosan 1.2g, Capmul MCM C8 0.2g, lactic acid 0.8g, be dissolved in the deionized water of 98.5g, stir obtained conditioning liquid product 1.
Embodiment 2
Take chitosan 0.8g, Capmul MCM C8 0.5g, lactic acid 1.2g, be dissolved in the deionized water of 96.3g, stir obtained conditioning liquid product 2.
Embodiment 3
Take chitosan 1.0g, Capmul MCM C8 0.4g, lactic acid 1.0g, be dissolved in the deionized water of 97.6g, stir obtained conditioning liquid product 3.
Embodiment 4
Take chitosan 0.8g, Capmul MCM C8 0.5g, propylene glycol 1.2g, be dissolved in the deionized water of 96.3g, stir obtained conditioning liquid product 4.
Embodiment 5
Take chitosan 1.2g, Capmul MCM C8 0.2g, propylene glycol 0.8g, be dissolved in the deionized water of 98.5g, stir obtained conditioning liquid product 5.
Embodiment 6
Take chitosan 1.0g, Capmul MCM C8 0.4g, propylene glycol 1.0g, be dissolved in the deionized water of 97.6g, stir obtained conditioning liquid product 6.
Embodiment 7
The present embodiment is the bacteriostatic experiment of the private parts nursing liquid (hereinafter referred to as contrast conditioning liquid) of the obtained conditioning liquid product 1 ~ 6 of embodiment 1 ~ 6 and certain commercially available chitosan-containing.
(1), the activation of strain
Tested strain is (in the embodiment of the present invention, the escherichia coli selecting female private part common, bacillus subtilis, staphylococcus aureus and pseudomonas four kinds of strains are tested) be inoculated in liquid nutrient broth culture medium, 37 DEG C, rotating speed be 100r/min shaking table in activate 24h, make tested actication of culture.
(2), the preparation of culture medium
Conditioning liquid product 1 ~ 6 and contrast conditioning liquid add in liquid nutrient broth culture medium respectively, make the concentration of conditioning liquid in fluid medium be 0.1% (w/v), then the pH value of culture medium solution is adjusted to 6.0.Then 121 DEG C of sterilizing 15min.Meanwhile, the blank cultures of preparation not containing conditioning liquid product, the deionized water of the quality such as interpolation is prepared, and the steps such as sterilizing are all identical.
(3), inoculation, microorganism culture and count
Bacterium liquid (bacterial concentration is 107CFU/mL) is reached after aseptically getting 1.0mL activation, by bacterium liquid access 50.0mL in the cooled culture medium of sterilizing, then 37 DEG C, rotating speed be 100r/min shaking table in cultivate 24h, finally use dilution plate count method (this counting method can see GB GB4789.2-1994).
(4), the calculating of bacteriostasis rate
Bacteriostasis rate=(blank group bacterial number-experimental group bacterial number)/blank group bacterial number (bacterial number unit is CFU/mL).
The bacteriostasis rate recorded is arranged in table 1.
Table 1: product bacteriostasis rate
As can be drawn from Table 1, compared with contrast conditioning liquid, the obtained conditioning liquid product 1 ~ 6 of the embodiment of the present invention 1 ~ 6 the escherichia coli suppressing female private part common, bacillus subtilis, staphylococcus aureus and pseudomonas four kinds of strains time, bacteriostasis rate will obviously will with contrast conditioning liquid.And as can be seen from the formula of conditioning liquid, technical scheme provided by the invention, by adding solubilizing agent in formula, obviously can promote the dissolubility of chitosan, principle, also can explain that the obtained conditioning liquid product antibacterial effect of the embodiment of the present invention is more excellent.
In sum, a kind of compositions provided by the invention, comprising: chitosan, antiseptic, solubilizing agent and deionized water.By adding chitosan and solubilizing agent in the composition, make to have microbe killing properties can chitosan can fully be dissolved in deionized water, solve in prior art, the problem that the female private part sterilization care solution sterilizing ability containing chitosan that is that cause is short of because chitosan dissolubility is low, can effectively kill pudendum antibacterial, maintain pudendum homeostasis.Meanwhile, formula of the present invention is simple, with low cost, is applicable to commercial production.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (9)
1. a compositions, is characterized in that, described compositions comprises: chitosan, antiseptic, solubilizing agent and deionized water.
2. compositions according to claim 1, is characterized in that, described antiseptic is Capmul MCM C8.
3. compositions according to claim 1, is characterized in that, described solubilizing agent is: lactic acid and/or propylene glycol.
4. compositions according to claim 1, is characterized in that, in mass parts, described compositions comprises: chitosan 0.8 ~ 1.2 part, Capmul MCM C8 0.2 ~ 0.5 part, lactic acid 0.8 ~ 1.2 part and deionized water 96.3 ~ 98.5 parts.
5. compositions according to claim 4, is characterized in that, in mass parts, described compositions comprises: chitosan 1 part, Capmul MCM C8 0.4 part, lactic acid 1 part and deionized water 97.6 parts.
6. compositions according to claim 1, is characterized in that, in mass parts, described compositions comprises: chitosan 0.8 ~ 1.2 part, Capmul MCM C8 0.2 ~ 0.5 part, propylene glycol 0.8 ~ 1.2 part and deionized water 96.3 ~ 98.5 parts.
7. compositions according to claim 6, is characterized in that, in mass parts, described compositions comprises: chitosan 1 part, Capmul MCM C8 0.4 part, propylene glycol 1 part and deionized water 97.6 parts.
8. one kind comprises the application of compositions in sterilization field described in claim 1 to 7 any one.
9. one kind comprises the application of compositions in female private part sterilization field described in claim 1 to 7 any one.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511033380.XA CN105534887A (en) | 2015-12-31 | 2015-12-31 | Female private part sterilizing care solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511033380.XA CN105534887A (en) | 2015-12-31 | 2015-12-31 | Female private part sterilizing care solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105534887A true CN105534887A (en) | 2016-05-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201511033380.XA Pending CN105534887A (en) | 2015-12-31 | 2015-12-31 | Female private part sterilizing care solution |
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| CN (1) | CN105534887A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109395062A (en) * | 2018-12-29 | 2019-03-01 | 广州肽然生物科技有限公司 | A kind of female private part sterilization care solution |
-
2015
- 2015-12-31 CN CN201511033380.XA patent/CN105534887A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109395062A (en) * | 2018-12-29 | 2019-03-01 | 广州肽然生物科技有限公司 | A kind of female private part sterilization care solution |
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| CB02 | Change of applicant information |
Address after: 528000 Guicheng, Foshan, Nanhai District, East Street, No. 23 gem Applicant after: KINGDOM HEALTHCARE HOLDINGS CO., LTD., GUANGDONG Address before: 528200 Guicheng, Foshan, Nanhai District, East Street, No. 23 gem Applicant before: Kingdom Sanitary Products Co., Ltd. |
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Application publication date: 20160504 |