CN103655606B - A kind of milch cow washes emulsion and preparation method thereof - Google Patents
A kind of milch cow washes emulsion and preparation method thereof Download PDFInfo
- Publication number
- CN103655606B CN103655606B CN201310681328.XA CN201310681328A CN103655606B CN 103655606 B CN103655606 B CN 103655606B CN 201310681328 A CN201310681328 A CN 201310681328A CN 103655606 B CN103655606 B CN 103655606B
- Authority
- CN
- China
- Prior art keywords
- weight portion
- emulsion
- milch cow
- washes
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention belongs to fine chemical product galenic pharmacy field, disclose a kind of milch cow and wash emulsion and preparation method thereof.Milch cow of the present invention is washed emulsion and includes chlorhexidine acetate, iodine class complex, surfactant, thickening agent, G & W.Milch cow of the present invention wash emulsion adopt surfactant and chlorhexidine acetate with the use of, chlorhexidine acetate is well dissolved in water, not easily precipitate out, affect without by other ions, keep the efficient bactericidal effect of chlorhexidine acetate, it is simultaneously introduced iodine class complex composite with chlorhexidine acetate, the two Synergistic, improve bactericidal effect further, and noresidue, skin is non-stimulated, on raw milk quality without impact. add glycerol moist cow breast skin effectively and reach good protected effect, it is suitable for most area pasture or dairy farmer uses and is effectively ensured cow breast health.Preparation method of the present invention is simple to operate, and raw material is easy to get, and is suitable for large-scale production.
Description
Technical field
The invention belongs to fine chemical product galenic pharmacy field, be specifically related to a kind of milch cow and wash emulsion and preparation method thereof.
Background technology
Milk is the food with significantly high nutritive value and physiological function, wherein contain the important nutrients of the necessary for human such as abundant lactoprotein, butter oil, lactose, mineral, vitamin, have the laudatory title of " improving food ", " the nurse mankind ", " white blood ".Milk is not only of fine quality, and inexpensive, when current national trophic level is also very low, greatly develops milk cattle cultivating and seems very necessary.The final purpose of Cow product is to give milk, and therefore protects cow breast most important.
In the feeding process of milch cow, breast inevitably touches various muck, feedstuff and earthfill rockfill concrete riprap RCC, and therefore cow breast surface easily grows a lot of microorganism, these antibacterials can enter in raw milk on the one hand, and contaminated milk affects the quality of milk, on the other hand, during owing to milking, the newborn hole of cow breast is opened, and therefore antibacterial is also easily accessible cow breast, causes mastitis, have a strong impact on lactogenic function, causing lactation amount to reduce, milk physicochemical property changes, Quality Down.The cleaning of cow breast before accordingly, it would be desirable to strengthen milking.
Wherein, washing emulsion be increasingly subject to liking of user with the milch cow that iodine and chlorhexidine are main component, because its broad-spectrum, efficiently, action time is short, can quickly kill various microorganism within the operating time, meet the operation requirement that dipping before milking sterilizes in short-term.But this kind of milch cow is washed product emulsion and commonly use ethanol as solvent, it is easy to stimulation cow breast skin, and the situation of defat occurs, and then affect milk yield and raw milk quality.
Summary of the invention
In view of this, present invention aims to the defect of prior art, it is provided that the milch cow that a kind of zest is little, bactericidal effect is good washes emulsion and preparation method thereof.
For realizing the purpose of the present invention, the present invention adopts the following technical scheme that
A kind of milch cow washes emulsion, including following raw material:
Preferably, described iodine class complex is polyethers iodine, quaternary amine chelated iodine or povidone iodine.
Preferably, described surfactant is nonionic surfactant.
Preferably, described surfactant is castor oil-base surfactant.
Preferably, described castor oil-base surfactant is one or more in castor oil hydrogenated, alkanolamide, undecylenic acid single ethanol amide sulfosuccinate acid disodium, ricinoleic alkyl alcohol amide borate, ammonium methyl ricinolcic acid sulfate.
Preferably, described thickening agent is one or more in starch, pectin, agar, gelatin, xanthan gum, methylcellulose, polyvinyl alcohol or polyvinylpyrrolidone.
Present invention also offers the preparation method that a kind of milch cow washes emulsion.
The preparation method that a kind of milch cow washes emulsion, for mixing homogeneously with the iodine class complex of 1 weight portion～10 weight portion, 0.1 weight portion～1 parts by weight of thickening agent, 5 weight portion～10 parts by weight of glycerin and 80 weight portion～85 weight parts waters and get final product after the chlorhexidine acetate hybrid reaction 20min of the surfactant and 0.1 weight portion～1 weight portion that take 1 weight portion～10 weight portion.
Milch cow of the present invention is washed emulsion and includes chlorhexidine acetate, iodine class complex, surfactant, thickening agent, G & W.Milch cow of the present invention wash emulsion adopt surfactant and chlorhexidine acetate with the use of, improve chlorhexidine acetate dissolubility in water, chlorhexidine acetate is well dissolved in water, not easily precipitate out, affect without by other ions, it is maintained with the efficient bactericidal effect of chlorhexidine acetate, it is simultaneously introduced iodine class complex composite with chlorhexidine acetate, the two Synergistic, improve bactericidal effect further, and noresidue, skin is non-stimulated, on raw milk quality without impact, it is simultaneously introduced glycerol moist cow breast skin effectively and reaches good protected effect, it is suitable for most area pasture or dairy farmer uses and is effectively ensured cow breast health.Preparation method of the present invention is simple to operate, and raw material is easy to get, and is suitable for large-scale production.
Detailed description of the invention
The embodiment of the invention discloses a kind of milch cow and wash emulsion and preparation method thereof.Those skilled in the art can use for reference present disclosure, is suitably modified technological parameter and realizes.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the art, they are considered as including in the present invention.Product and the method for the present invention are described already by preferred embodiment, product as herein described and method substantially can be modified or suitably change and combination by related personnel in without departing from present invention, spirit and scope, realize and apply the technology of the present invention.
For realizing the purpose of the present invention, the present invention adopts the following technical scheme that
A kind of milch cow washes emulsion, including following raw material:
Milch cow of the present invention is washed emulsion and includes chlorhexidine acetate, iodine class complex, surfactant, thickening agent, G & W.
Wherein, chlorhexidine acetate is also Robenidine Roripa, chlorhexidine acetate, Chlorhexidine, double; two benzyl chloride chlorhexidine, for cationic surfactant, has a broad antifungal spectrum, most Grain-positives and negative bacteria there is killing action, bacillus pyocyaneus is also effective, it is used for perform the operation remote holder, skin, planing surface and sterilization of instruments.
Chlorhexidine acetate dissolubility in water is only small, and to various ion-sensitives, it is easy to precipitating out, so needing to use ethanol as solvent, but ethanol is big to skin irritation, the easy defat of life-time service, makes xerosis cutis and is easily encroached on.Milch cow of the present invention wash emulsion option table surface-active agent and chlorhexidine acetate with the use of, improve chlorhexidine acetate dissolubility in water so that chlorhexidine acetate is well dissolved in water, not easily precipitates out, affect without by other ions, be maintained with the efficient bactericidal effect of chlorhexidine acetate.
In some embodiments, surfactant of the present invention is nonionic surfactant.
In some embodiments, surfactant of the present invention is castor oil-base surfactant.
In some specific embodiments, castor oil-base surfactant of the present invention is one or more in castor oil hydrogenated, alkanolamide, undecylenic acid single ethanol amide sulfosuccinate acid disodium, ricinoleic alkyl alcohol amide borate, ammonium methyl ricinolcic acid sulfate.
It is 0.1～1 weight portion that milch cow of the present invention washes the consumption of chlorhexidine acetate described in emulsion.It is 0.1 weight portion in certain embodiments, is 0.5 weight portion in certain embodiments, be 1 weight portion in further embodiments.
It is 1～10 weight portion that milch cow of the present invention washes the consumption of surfactant described in emulsion.It is 10 weight portions in certain embodiments, is 5 weight portions in certain embodiments, be 1 weight portion in further embodiments.
Iodine class complex is the product of iodine and surfactant or polymer substance complexation, and iodine class complex can improve the concentration of iodine.Milch cow of the present invention washes the iodine class complex in emulsion can kill the antibacterial of cow breast skin surface, and good antimicrobial effect, noresidue are simultaneously non-stimulated to skin, and its catabolite on raw milk quality without impact.Milch cow of the present invention washes the iodine class complex in emulsion and chlorhexidine acetate is composite, the two Synergistic, improves bactericidal effect further.
In some embodiments, iodine class complex of the present invention is polyethers iodine, quaternary amine chelated iodine or povidone iodine.
In some specific embodiments, iodine class complex of the present invention is povidone iodine.Povidone iodine (Povidone-iodine, PVP-I) is a kind of complex elementary composition by polyvinylpyrrolidone (PVP) and iodine (I), calculates (butt) according to dry product, comprises the available iodine of 9.0% to 12.0%.Milch cow of the present invention washes the povidone iodine in emulsion can kill the antibacterial of cow breast skin surface, and bactericidal effect is good, noresidue, simultaneously that skin is non-stimulated, and its catabolite on raw milk quality without impact.
It is 1～10 weight portion that milch cow of the present invention washes the consumption of the complex of iodine class described in emulsion.It is 1 weight portion in certain embodiments, is 5 weight portions in certain embodiments, be 10 weight portions in further embodiments.
Milch cow of the present invention is washed in emulsion possibly together with thickening agent.In some embodiments, thickening agent of the present invention is one or more in starch, pectin, agar, gelatin, xanthan gum, methylcellulose, polyvinyl alcohol or polyvinylpyrrolidone.
In some specific embodiments, thickening agent of the present invention is xanthan gum.Xanthan gum (Xanthangum, Xanthan gum is made in transliteration), is commonly called as Semen Maydis carbohydrate gum, HANSHENGJIAO.Xanthan gum is usually via manufactured by corn starch, by cabbage black rot xanthomonas campestris with carbohydrate for primary raw material, through aerobic fermentation biotechnology, cut off 1,6-glycosidic bond, after opening side chain, by the outer heteropolysaccharide of a kind of acid born of the same parents of Isosorbide-5-Nitrae-be bonded to straight chain composition.Xanthan gum is white or lurid powder, has excellent thickening property, suspension, emulsibility and a water solublity, and has good heat, soda acid, salt-stable and extremely strong antioxidation and resistance to enzymolysis ability.
It is 0.1～1 weight portion that milch cow of the present invention washes the consumption of thickening agent described in emulsion.It is 1 weight portion in certain embodiments, is 0.5 weight portion in certain embodiments, be 0.1 weight portion in further embodiments.
Glycerol has a skin protection moisture-keeping function, of the present invention washes in emulsion possibly together with trace glycerol, it is possible to moisten cow breast skin, it is to avoid often clean and cow breast is caused defat.
It is 5～10 weight portions that milch cow of the present invention washes the consumption of glycerol described in emulsion.It is 5 weight portions in certain embodiments, is 8 weight portions in certain embodiments, be 10 weight portions in further embodiments.
Milch cow of the present invention is washed in emulsion possibly together with 80 weight portion～85 weight parts waters.It is 85 weight portions in certain embodiments, is 80 weight portions in further embodiments.Preferably, described water is deionized water.
Milch cow of the present invention wash emulsion adopt surfactant and chlorhexidine acetate with the use of, improve chlorhexidine acetate dissolubility in water so that chlorhexidine acetate is well dissolved in water, not easily precipitates out, affect without by other ions, keep the efficient bactericidal effect of chlorhexidine acetate, be simultaneously introduced iodine class complex composite with chlorhexidine acetate, the two Synergistic, improve bactericidal effect further, and noresidue, skin is non-stimulated, on raw milk quality without impact.Add glycerol moist cow breast skin effectively and reach good protected effect, be suitable for most area pasture or dairy farmer uses, be effectively ensured cow breast health.
Present invention also offers the preparation method that a kind of milch cow washes emulsion, mix homogeneously with the iodine class complex of 1 weight portion～10 weight portion, 0.1 weight portion～1 parts by weight of thickening agent, 5 weight portion～10 parts by weight of glycerin and 80 weight portion～85 weight parts waters and get final product after taking the surfactant of 1 weight portion～10 weight portion and the chlorhexidine acetate hybrid reaction 20min of 0.1 weight portion～1 weight portion.
It is simple to operate that milch cow of the present invention washes emulsion preparation method, and raw material is easy to get, and is suitable for large-scale production.Milch cow of the present invention is washed the prepared milch cow of emulsion preparation method and washes the liquid that emulsion is clear, and low temperature, heat storage stability are qualified.
In order to be further appreciated by the present invention, below in conjunction with embodiment, the present invention is described in detail.
Embodiment 1:
A kind of milch cow washes emulsion, including following raw material:
Preparation method:
Mix homogeneously with the povidone iodine of 1 weight portion, 1 weight portion xanthan gum, 5 parts by weight of glycerin and 85 parts by weight of deionized water after taking the castor oil hydrogenated of 10 weight portions and the chlorhexidine acetate hybrid reaction 20min of 0.1 weight portion and obtain the milch cow of clear and wash emulsion.Low temperature, heat storage detection qualified stability.
Embodiment 2:
A kind of milch cow washes emulsion, including following raw material:
Preparation method:
Mix homogeneously with the povidone iodine of 5 weight portions, 0.5 weight portion xanthan gum, 8 parts by weight of glycerin and 85 parts by weight of deionized water after taking the ricinoleic alkyl alcohol amide borate of 5 weight portions and the chlorhexidine acetate hybrid reaction 20min of 0.5 weight portion and obtain the milch cow of clear and wash emulsion.Low temperature, heat storage detection qualified stability.
Embodiment 3:
A kind of milch cow washes emulsion, including following raw material:
Preparation method:
Mix homogeneously with the povidone iodine of 10 weight portions, 0.1 weight portion pectin, 10 parts by weight of glycerin and 80 parts by weight of deionized water after taking the undecylenic acid single ethanol amide sulfosuccinate acid disodium of 1 weight portion and the chlorhexidine acetate hybrid reaction 20min of 1 weight portion and obtain the milch cow of clear and wash emulsion.Low temperature, heat storage detection qualified stability.
Embodiment 4: bactericidal effect is tested
Preparation experiment bacteria suspension so that it is concentration is 1 × 108Cfu/mL～5 × 108It is 1 × 10 that cfu/mL(reclaims clump count7Cfu/mL～5 × 107Cfu/mL).
Experimental group (group B): take disinfection experiment sterile test tube, it is initially charged 0.5mL experiment bacteria suspension, add 0.5mL organic interfering substance matter, mixing, put in 20 DEG C ± 1 DEG C water-bath after 5min, the milch cow drawing above-described embodiment 3 with aseptic straw washes emulsion 4.0mL injection wherein, mixing timing immediately rapidly.Treat that experimental bacteria and milch cow are washed emulsion and interact to each scheduled time 30s, draw 0.5mL experimental bacteria respectively and milch cow is washed emulsion mixed liquor and is added in 4.5mL nertralizer, mixing.Each pipe experimental bacteria and milch cow wash emulsion mixed liquor after adding nertralizer effect 10min, draw 1.0mL sample liquid respectively, cultivate method of counting mensuration by viable bacteria and deposit viable count, often 2 plates of pipe sample liquid inoculation.As, when the clump count of growth is more on flat board, after series 10 times dilution can be carried out, then carried out viable bacteria cultivation counting.
Matched group (group A): replace milch cow to wash emulsion with standard hard water, carry out parallel laboratory test, as positive control.
All experiment samples are all cultivated in 37 DEG C of constant incubators, bacterial propagule is cultivated 48h and observes final result, calculate and kill logarithm, and result is in Table 1.The computing formula wherein killing logarithm is as follows:
Kill logarithm value (group A) (No)-experimental group viable bacteria concentration logarithm value (group B) (Nx) of logarithm value (KL)=matched group mean viable concentration
All kinds of killing bacteria logarithm of table 1
| Antibacterial | Escherichia coli | Yeast | Streptococcus |
| Killing bacteria logarithm | ≥5 | ≥5 | ≥5 |
Being washed emulsion bactericidal effect by visible embodiment 3 milch cow of the present invention of table 1 result notable, killing bacteria logarithm value is all higher than being equal to 5.
The bactericidal effect that embodiment 1 washes emulsion with milch cow described in embodiment 2 is similar to embodiment 3, and bactericidal effect is notable, and killing bacteria logarithm value is all higher than being equal to 5.
The explanation of above example is only intended to help to understand the product of the present invention and method and core concept thereof.It should be pointed out that, for those skilled in the art, under the premise without departing from the principles of the invention, it is also possible to the present invention carries out some improvement and modification, these improve and modify in the protection domain also falling into the claims in the present invention.
Claims (5)
1. a milch cow washes emulsion, it is characterised in that include following raw material:
Described surfactant is castor oil-base surfactant.
2. milch cow washes emulsion according to claim 1, it is characterised in that described iodine class complex is polyethers iodine, quaternary amine chelated iodine or povidone iodine.
3. milch cow washes emulsion according to claim 1, it is characterized in that, described castor oil-base surfactant is one or more in castor oil hydrogenated, alkanolamide, undecylenic acid single ethanol amide sulfosuccinate acid disodium, ricinoleic alkyl alcohol amide borate, ammonium methyl ricinolcic acid sulfate.
4. milch cow washes emulsion according to claim 1, it is characterised in that described thickening agent is one or more in starch, pectin, agar, gelatin, xanthan gum, methylcellulose, polyvinyl alcohol or polyvinylpyrrolidone.
5. the preparation method that a milch cow washes emulsion, it is characterized in that, mix homogeneously with the iodine class complex of 1 weight portion～10 weight portion, 0.1 weight portion～1 parts by weight of thickening agent, 5 weight portion～10 parts by weight of glycerin and 80 weight portion～85 weight parts waters and get final product after taking the surfactant of 1 weight portion～10 weight portion and the chlorhexidine acetate hybrid reaction 20min of 0.1 weight portion～1 weight portion；
Described surfactant is castor oil-base surfactant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310681328.XA CN103655606B (en) | 2013-12-12 | 2013-12-12 | A kind of milch cow washes emulsion and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310681328.XA CN103655606B (en) | 2013-12-12 | 2013-12-12 | A kind of milch cow washes emulsion and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103655606A CN103655606A (en) | 2014-03-26 |
| CN103655606B true CN103655606B (en) | 2016-07-06 |
Family
ID=50295168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310681328.XA Active CN103655606B (en) | 2013-12-12 | 2013-12-12 | A kind of milch cow washes emulsion and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103655606B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105582538A (en) * | 2016-03-24 | 2016-05-18 | 镇江威特药业有限责任公司 | Drip-proof type dairy cow teat dipping solution and preparation method thereof |
| CN106236772B (en) * | 2016-08-30 | 2018-08-17 | 北京安洁康生物科技有限公司 | Pasture disinfectant for nipples of dairy cows and its preparation method and application |
| CN106821974B (en) * | 2017-03-29 | 2021-04-02 | 佛山市南海东方澳龙制药有限公司 | Preparation method of povidone-iodine solution and povidone-iodine solution prepared by same |
| CN107582473A (en) * | 2017-11-01 | 2018-01-16 | 黄业钧 | A kind of milk cow Phytoremediation is antibacterial to wash emulsion and preparation method thereof |
| CN108992462B (en) * | 2018-09-21 | 2022-10-25 | 四川悦康源通药业有限公司 | Compound povidone iodine composition and preparation method thereof |
| CN110934800A (en) * | 2019-12-05 | 2020-03-31 | 上海康臣生物科技有限公司 | Multifunctional milk cow milk protecting agent and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1404811A (en) * | 2002-04-08 | 2003-03-26 | 高占奎 | Water soluble fragrant chlorhexidine iodine |
| CN102698358A (en) * | 2012-06-14 | 2012-10-03 | 杭州普瑞美克生物科技有限公司 | Preparation method for disposable compound iodine medical disinfecting large cotton bar |
-
2013
- 2013-12-12 CN CN201310681328.XA patent/CN103655606B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN103655606A (en) | 2014-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103655606B (en) | A kind of milch cow washes emulsion and preparation method thereof | |
| CN103766399B (en) | A kind of iodine-containing disinfectant and preparation method thereof | |
| CN107836466A (en) | A kind of tea tree ethereal oil natural disinfectant agent for animals and preparation method thereof | |
| CN106421217B (en) | A kind of solution of benzalkonium chloride and preparation method thereof | |
| CN105663158B (en) | A kind of high concentration iodic disinfecting liquid and preparation method thereof | |
| CN110013472A (en) | A kind of mammilla of milk cattle film forming Medicatedbath lotion, preparation method and its application method | |
| CN104940183A (en) | Disinfectant and preparation method thereof | |
| CN104622792A (en) | Film-forming papilla medicated bath preparation used for controlling recessive mastitis of dairy cattle | |
| CN101199319A (en) | Enzyme composite bactericide with broad-spectrum high-efficient bactericidal action and its preparation method | |
| CN101803611B (en) | Citric acid iodine disinfectant and method for preparing same | |
| CN104798775B (en) | A kind of cationic surfactant composite disinfectant for animals | |
| CN104524557A (en) | Lysostaphin compound disinfection gel | |
| CN102405935A (en) | Protamine compounded preparation, preparation method and application thereof | |
| CN104886110B (en) | A kind of multiduty composite cation surfactant disinfectants | |
| CN104304237B (en) | One is animal semen disinfectant and preparation method thereof safely and efficiently | |
| CN107412257B (en) | Medicated bath agent for nipples of dairy cows as well as preparation method and application of medicated bath agent | |
| CN104524558A (en) | Enzyme compounded preparation and preparation method thereof | |
| CN103655216B (en) | A kind of milch cow washes emulsion and preparation method thereof | |
| CN102939966B (en) | A kind of compound disinfectant, its preparation method and application | |
| CN102000092B (en) | New application of sulfadiazine sodium in preparing medicine for preventing or treating Bombyx mori septicemia | |
| CN102836247B (en) | Tangerine extract composition for feminite care | |
| CN104721812A (en) | Lysostaphin compound enzyme disinfectant and preparation method thereof | |
| CN105362287B (en) | One boar sterilization bath oil | |
| CN107773635A (en) | A kind of animal skin composite disinfectant and preparation method | |
| CN109820090A (en) | A kind of pig feed additive improving immunity and the pannage including it |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |