CN105531380B - 应答羧胺三唑乳清酸盐的方法和多个信号转导通路的分子药效学生物标志物 - Google Patents

应答羧胺三唑乳清酸盐的方法和多个信号转导通路的分子药效学生物标志物 Download PDF

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CN105531380B
CN105531380B CN201480050189.3A CN201480050189A CN105531380B CN 105531380 B CN105531380 B CN 105531380B CN 201480050189 A CN201480050189 A CN 201480050189A CN 105531380 B CN105531380 B CN 105531380B
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pharmacodynamic
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signaling pathway
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CN105531380A (zh
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拉希达·A·卡马利
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Tactical Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Life Sciences & Earth Sciences (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN201480050189.3A 2013-08-02 2014-07-30 应答羧胺三唑乳清酸盐的方法和多个信号转导通路的分子药效学生物标志物 Active CN105531380B (zh)

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Application Number Priority Date Filing Date Title
US13/957,720 2013-08-02
US13/957,720 US10378059B2 (en) 2013-08-02 2013-08-02 Methods and molecular pharmacodynamic biomarkers for multiple signaling pathways in response to carboxyamidotriazole orotate
PCT/US2014/048905 WO2015017545A1 (en) 2013-08-02 2014-07-30 Methods and molecular pharmacodynamic biomarkers for multiple signaling pathways in response to carboxyamidotriazole orotate

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CN105531380A CN105531380A (zh) 2016-04-27
CN105531380B true CN105531380B (zh) 2021-07-13

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US (1) US10378059B2 (https=)
EP (1) EP3027776B1 (https=)
JP (1) JP6913459B2 (https=)
KR (1) KR102389934B1 (https=)
CN (1) CN105531380B (https=)
AU (1) AU2014296212B2 (https=)
CA (1) CA2919690C (https=)
IL (1) IL243894B (https=)
WO (1) WO2015017545A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10882841B2 (en) 2016-03-01 2021-01-05 University Of Maryland, Baltimore Wnt signaling pathway inhibitors for treatments of disease
JP6889009B2 (ja) * 2017-04-13 2021-06-18 浜松ホトニクス株式会社 画像取得システム及び画像取得方法
US20220168276A1 (en) * 2020-08-05 2022-06-02 Tactical Therapeotics Inc. Mehods and Compositions for Treating SARS-CoV-2 Infection using Carboxyamidotriazole Orotate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69633566T2 (de) * 1995-07-21 2005-12-08 Savvipharm Inc. Orotatsalze von 5-amino- oder substituierten amino-1,2,3-triazolen zur behandlung von neoplasmen
US20030170720A1 (en) * 2001-01-23 2003-09-11 Van Der Kuyl Antoinette Cornelia Means and methods for treatment evaluation
US8137910B2 (en) 2002-05-03 2012-03-20 Duke University Method of regulating gene expression
US8450057B2 (en) 2006-08-14 2013-05-28 The Brigham And Women's Hospital, Inc. Diagnostic tests using gene expression ratios
US7750018B2 (en) * 2006-12-06 2010-07-06 Tactical Therapeutics, Inc Use of carboxiamidotriazole (CAI) orotate in macular degeneration
JP2010522567A (ja) 2007-03-28 2010-07-08 メダレックス インコーポレーティッド 遺伝子増幅および発現の方法
WO2009120561A2 (en) * 2008-03-22 2009-10-01 Merck & Co., Inc. Methods and gene expression signature for assessing growth factor signaling pathway regulation status
NZ598482A (en) * 2009-09-04 2014-05-30 Tactical Therapeutics Inc Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations
US8877785B2 (en) * 2009-09-04 2014-11-04 Tactical Therapeutics Inc Methods and compositions for enhancing sensitivity of cytotoxic drugs with timely combinatorial therapy with carboxyamidotriazole orotate
WO2012135845A1 (en) * 2011-04-01 2012-10-04 Qiagen Gene expression signature for wnt/b-catenin signaling pathway and use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Abstract 3350：Pluck hair as a biomarker platform for monitoring transcriptional consequences of clinical exposure to antagonism of the HDM2/P53 interaction in tumors;G Miele等;《Cancer Research》;20130415;第73卷;第3350页 *
Clinical pharmacogenomics：Applications in pharmaceutical R&D;M Norton等;《Drug Discovery Today》;20010101;第6卷(第4期);第180-185页 *

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EP3027776A4 (en) 2017-03-08
CA2919690C (en) 2021-11-02
EP3027776C0 (en) 2024-02-07
JP6913459B2 (ja) 2021-08-04
WO2015017545A1 (en) 2015-02-05
US20150038349A1 (en) 2015-02-05
EP3027776A1 (en) 2016-06-08
AU2014296212B2 (en) 2020-10-22
KR102389934B1 (ko) 2022-04-21
IL243894B (en) 2020-06-30
US10378059B2 (en) 2019-08-13
JP2016526908A (ja) 2016-09-08
HK1220493A1 (en) 2017-05-05
IL243894A0 (en) 2016-04-21
CA2919690A1 (en) 2015-02-05
EP3027776B1 (en) 2024-02-07
CN105531380A (zh) 2016-04-27
AU2014296212A1 (en) 2016-02-25
KR20160030535A (ko) 2016-03-18

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