CN105520991A - Health product capable of preventing senile dementia and preparation method for health product - Google Patents
Health product capable of preventing senile dementia and preparation method for health product Download PDFInfo
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Abstract
The invention relates to a health product capable of preventing senile dementia and a preparation method for the health product, and belongs to the field of health products. The health product capable of preventing the senile dementia is a drink, particles or a capsule prepared from components of maca, chick embryo, caffeine, sodium glycerophosphate, nicotinic acid, phosphoric acid and vitamin B6. The health drink, particles or capable is used for preventing and improving the senile dementia, is small in side effect, and can enhance human immunity and physical quality, delay organism aging and improve life and survival quality of senile dementia patients.
Description
Technical field
The present invention relates to a kind of health product preventing and treating senile dementia and preparation method thereof, belong to field of health care products.
Background technology
Senile dementia means and occurs in senile various chronic brain syndrome, is a kind of with the degeneration of brain, and brain cell atrophy, cerebrovascular hemorrhage, cerebrovascular chronic hypoxia etc. are the dull-witted syndrome of pathologic basis.Show as hypomnesis caused by cognitive decrease, behavior postpones, exercise not harmony.Its main pathological characters occurs a large amount of senile plaque, neurofibrillary tangles, amyloid beta deposition and neuron vacuolar degeneration in brain and loses in a large number.
The medicament categories of current treatment senile dementia is also many, and a class increases brain Cholinergic nervous function, is mainly cholinesterase inhibitor and M-cholinergic receptor agonist.The another kind of cytoprotective for acting on neuronal transmission system, to delay neuronal degeneration process, comprises antioxidant, NSAID (non-steroidal anti-inflammatory drug), neurotrophic factor, anti-neuronal apoptosis agent and short neuron metabolism medicine, calcium channel blocking etc.Although above-mentioned this two large class medicine said can improve alleviate senile dementia clinical symptoms, disease can not be cured completely.
The aging increasingly of current China, so the sickness rate of senile dementia will improve constantly, also increasing on the impact of society, badly influence the development of society.Therefore, this disease is not when effecting a radical cure, and the health product that exploitation could prevent and improve senile dementia are particularly important.
At present, quite a few to the bibliographical information such as the health product comprising plant amedica, medicine, food for the treatment of senile dementia aspect, as the purposes (number of patent application 2011110044454.5) of caffeine in preparation treatment medicine for senile dementia discloses the treatment of 50mg-200mg caffeine for senile dementia; The health product (number of patent application 201410506188.7) preventing and treating senile dementia as a kind of are by nicotinic acid, vitamin B
6, vitamin C, 14 raw materials such as folic acid are prepared from.And prevention containing the component such as Maca, Embryo Gallus domesticus and the health care formula that improves senile dementia have no report.
Summary of the invention
The object of this invention is to provide a kind of health product preventing and treating senile dementia, the present invention also aims to provide above-mentioned health product for preventing and improve the purposes of senile dementia.
In order to achieve the above object, the invention provides a kind of health product preventing and treating senile dementia, these health product are made up of the component of following parts by weight: Maca 20 ~ 40 parts, Embryo Gallus domesticus 15 ~ 25 parts, caffeine 0.05 ~ 0.5 part, sodium glycerophosphate 0.1 ~ 0.5 part, 0.01 ~ 0.1 part, nicotinic acid, phosphoric acid 0.1 ~ 1 part, vitamin B
60.01 ~ 0.05 part.
Further, these health product are made up of the component of following parts by weight: Maca 30 parts, Embryo Gallus domesticus 20 parts, caffeine 0.2 part, sodium glycerophosphate 0.2 part, 0.04 part, nicotinic acid, phosphoric acid 0.5 part, vitamin B
60.03 part.
Described health product are beverage, granule or capsule.
Present invention also offers the preparation method of health product, its method comprises the following steps:
1) Traditional Chinese medicine composition formula amount component is taken respectively;
2) by Maca and Embryo Gallus domesticus extracting in water twice, collect extracting solution, filter, merging filtrate, when being concentrated into 70 DEG C, relative density is 1.15 ~ 1.20, for subsequent use;
3) caffeine, sodium glycerophosphate, nicotinic acid phosphoric acid, vitamin B is got
6be dissolved in water, mixing, and then add step 2) Maca of gained and Embryo Gallus domesticus extract, mixing, directly adds additive, or adds adjuvant, disintegrating agent, lubricant after drying and crushing, conventionally make beverage, granule or capsule.
Preferably: described step 2), it is 8 ~ 10 times of raw material weights that first time extracts water consumption, and extraction time first time is 1.5 ~ 2.5 hours; It is 6 ~ 8 times of raw material weights that second time extracts water consumption, and extraction time is 1 ~ 2 hour.
In aforementioned preparation process, the preparation method of beverage also comprises the step adding additive, and described additive is one or more in sucrose, sodium benzoate, sodium citrate, citric acid, pigment.
In aforementioned preparation process, the preparation method of granule also comprises the step adding adjuvant and lubricant, and described adjuvant is one or more in sucrose, dextrin, lactose, mannitol, and described lubricant is magnesium stearate or micropowder silica gel.
In aforementioned preparation process, the preparation method of capsule also comprises the step adding adjuvant, disintegrating agent, lubricant, described adjuvant is one or more in pregelatinized Starch, microcrystalline Cellulose, mannitol, described disintegrating agent be polyvinylpolypyrrolidone, corn starch, sodium carboxymethyl cellulose one or more, described lubricant is Pulvis Talci, magnesium stearate or micropowder silica gel.
The invention also discloses described health product in the application prevented and improve in senile dementia.
Beverage of the present invention is used for prevention and improves senile dementia, few side effects, can strengthen body immunity, strengthens body constitution, delays body aging, improves the life life quality of old dementia patients.
Detailed description of the invention
Further describe technical scheme of the present invention below, but described in claimed scope is not limited to.Below in conjunction with specific embodiment, elaboration detailed is further done to the present invention, but embodiments of the present invention are not limited to the scope that embodiment represents.These embodiments only for illustration of the present invention, but not for limiting the scope of the invention.In addition, after reading content of the present invention, those skilled in the art can do various amendment to the present invention, and these equivalent variations fall within appended claims limited range of the present invention equally.
Embodiment 1: beverage
Raw material is got according to following weight (gram) proportioning:
Maca 30 Embryo Gallus domesticus 20 caffeine 0.2 sodium glycerophosphate 0.2 nicotinic acid 0.04 phosphoric acid 0.5 vitamin B
60.03.
Get Maca, Embryo Gallus domesticus, extracting in water secondary, it is 8 times of raw material weights that first time extracts water consumption, extract 2 hours, it is 6 times of raw material weights that second time extracts water consumption, extracts 1.5 hours, merging filtrate, is concentrated into the extractum of relative density 1.15 (70 DEG C), for subsequent use; By sucrose, caffeine, sodium glycerophosphate, nicotinic acid, phosphoric acid, vitamin B
6, citric acid, sodium citrate, pigment be dissolved in water, then add Maca, Embryo Gallus domesticus extract, mixing, is settled to 1000ml, and filter, fill, obtains the beverage for preventing and improve senile dementia.
Embodiment 2: beverage
Raw material is got according to following weight (gram) proportioning:
Maca 40 Embryo Gallus domesticus 15 caffeine 0.5 sodium glycerophosphate 0.1 nicotinic acid 0.1 phosphoric acid 0.1 vitamin B
60.05.
Get Maca, Embryo Gallus domesticus, extracting in water secondary, it is 10 times of raw material weights that first time extracts water consumption, extract 2.5 hours, it is 8 times of raw material weights that second time extracts water consumption, extracts 2 hours, merging filtrate, is concentrated into the extractum of relative density 1.2 (70 DEG C), for subsequent use; By caffeine, sodium glycerophosphate, nicotinic acid, phosphoric acid, vitamin B
6with water dissolution, add 3 grams of sucrose, 3 grams of sodium benzoate, 1 gram of sodium citrate, 0.7 gram of citric acid, 0.2 gram of pigment, then add Maca, Embryo Gallus domesticus extract, mixing, is settled to 1000ml, and filter, fill, obtains the beverage for preventing and improve senile dementia.
Embodiment 3: granule
Raw material is got according to following weight (gram) proportioning:
Maca 20 Embryo Gallus domesticus 25 caffeine 0.05 sodium glycerophosphate 0.5 nicotinic acid 0.01 phosphatase 11 vitamin B
60.01.
Get Maca, Embryo Gallus domesticus, extracting in water secondary, it is 9 times of raw material weights that first time extracts water consumption, extract 2 hours, it is 7 times of raw material weights that second time extracts water consumption, extracts 2 hours, merging filtrate, is concentrated into the extractum of relative density 1.18 (70 DEG C), for subsequent use; By caffeine, sodium glycerophosphate, nicotinic acid, phosphoric acid, vitamin B
6with water dissolution, add Maca, Embryo Gallus domesticus extract, mixing, concentrated, dry, with sucrose and dextrin (1:2) to 200g, granulation, granulate, drying, obtain the granule for preventing and improve senile dementia.
Usage and dosage: oral, one time one bag, 2 times on the one.
Embodiment 4: granule
Raw material is got according to following weight (gram) proportioning:
Maca 20 Embryo Gallus domesticus 15 caffeine 0.05 sodium glycerophosphate 0.1 nicotinic acid 0.01 phosphoric acid 0.1 vitamin B
60.01.
Get Maca, Embryo Gallus domesticus, extracting in water secondary, it is 8 times of raw material weights that first time extracts water consumption, extract 1.5 hours, it is 8 times of raw material weights that second time extracts water consumption, extracts 1 hour, merging filtrate, is concentrated into the extractum of relative density 1.2 (70 DEG C), for subsequent use; By caffeine, sodium glycerophosphate, nicotinic acid, phosphoric acid, vitamin B
6with water dissolution, add Maca, Embryo Gallus domesticus extract, mixing, concentrated, dry, with sucrose and dextrin (1:1) to 200g, granulation, granulate, drying, obtain the granule for preventing and improve senile dementia.
Embodiment 5: capsule
Raw material is got according to following weight (gram) proportioning:
Maca 40 Embryo Gallus domesticus 25 caffeine 0.5 sodium glycerophosphate 0.5 nicotinic acid 0.1 phosphatase 11 vitamin B
60.05.
Get Maca, Embryo Gallus domesticus, extracting in water secondary, it is 9 times of raw material weights that first time extracts water consumption, extract 2.5 hours, it is 8 times of raw material weights that second time extracts water consumption, extracts 2 hours, merging filtrate, is concentrated into the extractum of relative density 1.2 (70 DEG C), for subsequent use; By caffeine, sodium glycerophosphate, nicotinic acid, phosphoric acid, vitamin B
6with water dissolution, add Maca, Embryo Gallus domesticus extract, mixing, mixing, concentrated, dry, add pregelatinized Starch and microcrystalline Cellulose (1.5:1) to 60g, granulation, granulate, drying, to incapsulate, obtain the capsule 120 for preventing and improve senile dementia.
Usage and dosage: oral, one time 3,2 times on the one.
Embodiment 6: low formula ratio beverage
Raw material is got according to following weight (gram) proportioning:
Maca 15 Embryo Gallus domesticus 10 caffeine 0.01 sodium glycerophosphate 0.5 nicotinic acid 0.008 phosphoric acid 0.05 vitamin B
60.008.
Preparation method is with embodiment 1.
Embodiment 7: high formula ratio beverage
Raw material is got according to following weight (gram) proportioning:
Maca 45 Embryo Gallus domesticus 30 caffeine 1 sodium glycerophosphate 1 nicotinic acid 0.2 phosphatase 11 .5 vitamin B
60.1.
Preparation method is with embodiment 1.
Test example 1: the present invention prevents and improves one of senile dementia beverage clinical research
1 data and method
1.1 clinical data
Random selecting 280 example suffers from the patient of senile dementia, wherein male account for 150 example, women account for 130 example, the age 60-90 year between, through 80 years old statistical average age; The clinical manifestation of patient is cognitive disorder 170 example, computing capability differs from 153 examples, apathetic expression, bradykinesia 133 example, speech disorder 102 is routine, and thought disturbance 107 example, disorientation 97 example, self care ability obstacle 214 example, personality disorder 57 are routine, night noisy 42 is routine, cardiopalmus dreaminess 31 example.The basic document of each group of patient, as the no significant difference such as age, sex (P > 0.05), has comparability.
1.2 method
Seven groups are divided into 280 routine patients of random selecting, often organize 40 people, embodiment of the present invention 1-5 prevents and improves the tablet in the beverage of senile dementia, patent application 2011110044454.5 embodiment 1, the health product in patent application 201410506188.7 embodiment 1 respectively, above-mentioned seven groups are sorted as A-G group successively, add up the living condition of seven groups of patients after taking medicament or health product, the curative effect of this six set product is analyzed.
1.3 statistical method
Adopt SPSS13.0 statistical software to analyze, statistics adopts t to check and X
2inspection, when P < 0.05 represents to there is significant difference, has statistical significance.
1.4 treatment standards
Effective: clinical symptom disappearance, basic living ability recovers normal, and severe patient disease has no and increases the weight of and be improved.
Effective: clinical symptom relief, stable disease, observes more than 1 month, and nothing repeatedly.
Invalid: clinical symptoms is not improved.
2 results
By test, we find, seven groups of patients after carrying out drug administration or health product without death, embodiment of the present invention 1-5 prevention and the successful improving senile dementia are better than F, G group, wherein the beverage curative effect of embodiment 1 is the most remarkable, have the case scenario of 92.5% to be clearly better, and beverage of the present invention have no adverse reaction; Patent application 2011110044454.5,201410506188.7 prevents and treats senile dementia therapeutic effect lower than the present invention.Illustrate that prescription proportioning of the present invention is respond well, and safety.Clinical effectiveness compares in table 1.
The clinical effectiveness of table 1 seven set product compares
| Group | Number of cases | Significantly | Effectively | Invalid | Total effective rate |
| A group | 40 | 20 | 17 | 3 | 92.5％ |
| B group | 40 | 18 | 18 | 4 | 90％ |
| C group | 40 | 17 | 18 | 5 | 85％ |
| D group | 40 | 17 | 17 | 6 | 85％ |
| E group | 40 | 19 | 17 | 4 | 90％ |
| F group | 40 | 15 | 17 | 8 | 80％ |
| G group | 40 | 14 | 16 | 10 | 75％ |
Note: P < 0.05
Test example 2: the present invention prevents and improves the beverage clinical research situation two of senile dementia
1 case selection
Three groups of totally 100 examples, first group of 40 people, second and third group respectively 30 people, wherein man 64 example, female 36 example, age 58-87 year between, course of disease 4-22, all meets AD diagnostic criteria.
2 application processes
First, second and third group gives the prevention of the present embodiment 1,6,7 respectively and improves the beverage of senile dementia, every day 50 milliliters, and taking 3 courses for the treatment of, 3 months is a course for the treatment of.
3 curative effects are as follows
First group: possessiveness recuperator 24 example, anxiety state alleviation person 15 example, be slow in action and improve 16, hallucination vain hope minimizing 18 example, the thought disturbance person of making moderate progress 27 example, the apathy person of making moderate progress 30 example, behavior disorder improver 35 example, sensitive person 27 example of readme brain response, depressed mood turns day by day optimistic person 22 example, lack energy person and improve 32 examples, without obvious changer 1 example.
Second group: possessiveness recuperator 12 example, anxiety state alleviation person 6 example, be slow in action and improve 8, hallucination vain hope minimizing 9 example, the thought disturbance person of making moderate progress 15 example, the apathy person of making moderate progress 17 example, behavior disorder improver 19 example, sensitive person 13 example of readme brain response, depressed mood turns day by day optimistic person 11 example, lack energy person and improve 16 examples, without obvious changer 3 example.
3rd group: possessiveness recuperator 16 example, anxiety state alleviation person 10 example, be slow in action and improve 13, hallucination vain hope minimizing 14 example, the thought disturbance person of making moderate progress 20 example, the apathy person of making moderate progress 22 example, behavior disorder improver 25 example, sensitive person 19 example of readme brain response, depressed mood turns day by day optimistic person 16 example, lack energy person and improve 23 examples, without obvious changer 1 example.
More than can find out, the present invention's low formula ratio dosage is lower, does not reach effect; High recipe quantity drug effect of comparing with the formula of embodiment 2 is not significantly increased, consider that after increasing raw material, cost increases, and excessive after also have certain security risk, drug dose also can affect beverage flavor after increasing in addition, therefore limited prescription consumption of the present invention, curative effect, safety, mouthfeel are all satisfied.
Test example 3: model case
Land, female, 60 years old, cardiopalmus dreaminess, hypomnesis, frequent tinnitus, hyperhidrosis, limbs fatigue, listless, take the prevention of the present embodiment 1 and improve the beverage of senile dementia, above transference cure after 3 courses for the treatment of, energetic, dynamic, have rosy cheeks, sleep quality is good, appetite strengthens, and mood is optimistic, and memory obviously strengthens.
Not certain, female, 62 years old, spirit significantly failed, and Blunting, liked to be disgruntled, to have the tendency put upside down of sleeping, and take the beverage that the present embodiment 2 prevents and improves senile dementia, after the course for the treatment of, symptom is clearly better, and after 2 courses for the treatment of, symptom disappears substantially.
Clock, man, 56 years old, vocabulary reduced, speech is dull, soliloquy, maybe can not tell object names or total aphasia, to time, personage and orientation force generation obstacle, do not recognize door, migration everywhere, takes the prevention of the present embodiment 4 and improves the granule of senile dementia, and after 2 courses for the treatment of, symptom is clearly better.
Week certain, female, 70 years old, long-term bed, hypomnesis, clothing, food, lodging and transportion--basic necessities of life were looked after by people, confusion of thinking, irritability, and emotion control ability is more weak, and mental status is unstable.Take the prevention of the present embodiment 5 and improve the capsule of senile dementia, after 4 courses for the treatment of, symptom is clearly better, and can leave the bed and walk about, and mental status is comparatively stable, thinking and express substantially clear, can with people's normal communication of surrounding.
Claims (9)
1. prevent and treat the health product of senile dementia for one kind, it is characterized in that, these health product are made up of the component of following parts by weight: Maca 20 ~ 40 parts, Embryo Gallus domesticus 15 ~ 25 parts, caffeine 0.05 ~ 0.5 part, sodium glycerophosphate 0.1 ~ 0.5 part, 0.01 ~ 0.1 part, nicotinic acid, phosphoric acid 0.1 ~ 1 part, vitamin B
60.01 ~ 0.05 part.
2. the health product of control senile dementia according to claim 1, it is characterized in that, these health product are made up of the component of following parts by weight: Maca 30 parts, Embryo Gallus domesticus 20 parts, caffeine 0.2 part, sodium glycerophosphate 0.2 part, 0.04 part, nicotinic acid, phosphoric acid 0.5 part, vitamin B
60.03 part.
3. the health product of control senile dementia according to claim 1 and 2, is characterized in that, described health product are beverage, granule or capsule.
4. prevent and treat the preparation method of the health product of senile dementia described in claim 1 or 2, comprise the following steps:
1) Traditional Chinese medicine composition formula amount component is taken respectively;
2) by Maca and Embryo Gallus domesticus extracting in water twice, collect extracting solution, filter, merging filtrate, when being concentrated into 70 DEG C, relative density is 1.15 ~ 1.20, for subsequent use;
3) caffeine, sodium glycerophosphate, nicotinic acid phosphoric acid, vitamin B is got
6be dissolved in water, mixing, and then add step 2) Maca of gained and Embryo Gallus domesticus extract, mixing, directly adds additive, or adds adjuvant, disintegrating agent, lubricant after drying and crushing, conventionally make beverage, granule or capsule.
5. prevent and treat the preparation method of the health product of senile dementia according to claim 4, it is characterized in that, described step 2) in, it is 8 ~ 10 times of raw material weights that first time extracts water consumption, and extraction time first time is 1.5 ~ 2.5 hours; It is 6 ~ 8 times of raw material weights that second time extracts water consumption, and extraction time is 1 ~ 2 hour.
6. prevent and treat the preparation method of the health product of senile dementia according to claim 4, it is characterized in that, the preparation method of described beverage also comprises the step adding additive, and described additive is one or more in sucrose, sodium benzoate, sodium citrate, citric acid, pigment.
7. prevent and treat the preparation method of the health product of senile dementia according to claim 4, it is characterized in that, the preparation method of described granule also comprises the step adding adjuvant and lubricant, described adjuvant is one or more in sucrose, dextrin, lactose, mannitol, and described lubricant is magnesium stearate or micropowder silica gel.
8. prevent and treat the preparation method of the health product of senile dementia according to claim 4, it is characterized in that, the preparation method of described capsule also comprises the step adding adjuvant, disintegrating agent, lubricant, described adjuvant is one or more in pregelatinized Starch, microcrystalline Cellulose, mannitol, described disintegrating agent be polyvinylpolypyrrolidone, corn starch, sodium carboxymethyl cellulose one or more, described lubricant is Pulvis Talci, magnesium stearate or micropowder silica gel.
9. health product described in claim 1 or 2 are in the application prevented and improve in senile dementia.
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| CN105918754A (en) * | 2016-05-10 | 2016-09-07 | 雷正新 | Multifunctional solid beverage and preparation process thereof |
| CN107897935A (en) * | 2017-11-24 | 2018-04-13 | 南京圣诺生物科技实业有限公司 | Nervonic acid composition and preparation method thereof and health products |
| CN108392510A (en) * | 2018-05-30 | 2018-08-14 | 湖南农业大学 | Application in the dyskinesia caused by alleviating alcohol of maca water extract |
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Application publication date: 20160427 |