CN105497680A - Medicine composition for treating sheep dry-sickness disease and preparation method of medicine composition - Google Patents

Medicine composition for treating sheep dry-sickness disease and preparation method of medicine composition Download PDF

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Publication number
CN105497680A
CN105497680A CN201510921768.7A CN201510921768A CN105497680A CN 105497680 A CN105497680 A CN 105497680A CN 201510921768 A CN201510921768 A CN 201510921768A CN 105497680 A CN105497680 A CN 105497680A
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Prior art keywords
parts
pharmaceutical composition
medicine composition
powder
sheep
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Pending
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CN201510921768.7A
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Chinese (zh)
Inventor
田卫东
唐世方
朱德建
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ANHUI TIANFENG LIVESTOCK TECHNOLOGY Co Ltd
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ANHUI TIANFENG LIVESTOCK TECHNOLOGY Co Ltd
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Priority to CN201510921768.7A priority Critical patent/CN105497680A/en
Publication of CN105497680A publication Critical patent/CN105497680A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention belongs to the technical field of animal remedy, and particularly relates to a medicine composition for treating the sheep dry-sickness disease and a preparation method of the medicine composition. The medicine composition is prepared from the following ingredients in parts by weight: 10 to 15 parts of dried immature fruit of citron orange, 20 to 30 parts of pumpkin seeds, 8 to 10 parts of areca-nut, 15 to 18 parts of cyrtomium fortunei, 15 to 20 parts of malt, 8 to 10 parts of cuscuta chinensis, 10 to 15 parts of medlar, 8 to 10 parts of wild chrysanthemum flowers, 30 to 40 parts of kelp powder and 3 to 5 parts of medical stone powder. The medicine composition provided by the invention can be used for radically curing the sheep dry-sickness disease; the medicine effect taking speed is high; the medicine effect maintaining time is long; no toxic or side effect exists; the growth and the development of sheep can be promoted; the immunity is improved. The yellow wine is used for extraction, so that the extraction rate of active ingredients is improved; meanwhile, a proper amount of sugar is contained in the yellow wine, and is cooperated with the medical stone to reduce the foreign odor and the bitter taste; the palatability is good; the intake quantity is increased.

Description

A kind ofly be used for the treatment of pharmaceutical composition of sheep dry-sickness and preparation method thereof
Technical field
The invention belongs to veterinary drug technical field, be specifically related to a kind ofly treat pharmaceutical composition of sheep dry-sickness and preparation method thereof.
Background technology
Sheep dry-sickness is because daily ration is single for a long time, and the reasons such as malnutrition cause digestion to be obstructed to stop eating, and cardinal symptom shows as disease sheep and becomes thin, and pasture material but do not put on flesh, and ruminate normal, the mental status is dispirited.At present, treatment sheep dry-sickness mainly takes Albendazole, calcium tablet, cod-liver oil etc., the higher and easy recurrent exerbation of cost.
Summary of the invention
For problems of the prior art, the invention provides a kind of pharmaceutical composition being used for the treatment of sheep dry-sickness, said composition cost is low and can effect a radical cure sheep dry-sickness, improves sheep immunity.
Present invention also offers a kind of preparation method being used for the treatment of sheep dry-sickness pharmaceutical composition.
The technical scheme that the present invention is adopted to achieve these goals is:
The invention provides a kind of pharmaceutical composition being used for the treatment of sheep dry-sickness, be prepared from by following raw material:
Fructus Aurantii Immaturus 10-15 part, Semen Cucurbitae 20-30 part, Bin youth 8-10 part, Rhizoma Osmundae 15-18 part, Fructus Hordei Germinatus 15-20 part, Semen Cuscutae 8-10 part, Fructus Lycii 10-15 part, Flos Chrysanthemi Indici 8-10 part, Kelp Powder 30-40 part, medical stone powder 3-5 part.
Further, the optimized raw material of the present invention is:
Fructus Aurantii Immaturus 12 parts, Semen Cucurbitae 25 parts, Bin youth 8 parts, Rhizoma Osmundae 16 parts, 20 parts, Fructus Hordei Germinatus, Semen Cuscutae 9 parts, Fructus Lycii 13 parts, Flos Chrysanthemi Indici 10 parts, Kelp Powder 36 parts, Maifanitum 4 parts.
Pharmaceutical composition provided by the invention adopts following methods to be prepared from:
(1) weight portion Fructus Aurantii Immaturus, Bin youth, Rhizoma Osmundae, Semen Cuscutae added and account for the water of four kinds of raw material gross weights 8 times and the mixed liquor of yellow wine, reflux, extract, 2 times under 80 DEG C of conditions, each 20min, then filters, and obtains filtrate for subsequent use;
(2) Semen Cucurbitae, Fructus Hordei Germinatus, Fructus Lycii, Flos Chrysanthemi Indici are mixed, be ground to 60 order powder, obtain mixed powder;
(3) by Kelp Powder, Maifanitum and mixed powder add in filtrate, and stir postlyophilization.
Further, in described mixed liquor, the volume ratio of water and yellow wine is 1:2.
Further, above-mentioned yellow wine is total sugar content is 60g/L.
The using method of pharmaceutical composition provided by the invention: directly make an addition to feedstuff, feeding after stirring.
In the present invention, the mutual synergism of each raw material, has the intestines and stomach coordinating, heat-clearing and toxic substances removing, the effects such as enhancing immunity.Said composition can increase the absorption of calcium, simultaneously containing abundant dietary fiber, promotes gastrointestinal peristalsis.Add Maifanitum in right amount, Chinese medicine bitter taste can be alleviated, improve palatability.Bin doctor contains abundant Arecoline hydrobromide, strengthens Semen Cucurbitae insect-expelling function, containing pectin in Semen Cucurbitae, can bond and eliminate Endophytic bacteria toxin and harmful substance, and can protect gastric mucosa, stimulate from coarse food; The zinc element contained promotes the growth promoter of sheep.
Advantage of the present invention is:
(1) pharmaceutical composition provided by the invention, can effect a radical cure sheep dry-sickness, and drug effect is fast and effective drug duration is long, has no side effect;
(2) each raw material is worked in coordination with mutually, promotes the growth promoter of sheep, improves immunity;
(3) by using yellow wine to extract, both improve the extraction ratio of effective ingredient, meanwhile, owing to containing appropriate sugar in yellow wine, collaborative Maifanitum alleviates abnormal flavour and bitter taste, good palatability, improves food-intake.
Detailed description of the invention
In order to understand essence of the present invention better, below by specific embodiment and clinical testing data, technical scheme of the present invention is further elaborated.
Embodiment 1
Be used for the treatment of a pharmaceutical composition for sheep dry-sickness, raw material is: Fructus Aurantii Immaturus 12 parts, Semen Cucurbitae 25 parts, Bin youth 8 parts, Rhizoma Osmundae 16 parts, 20 parts, Fructus Hordei Germinatus, Semen Cuscutae 9 parts, Fructus Lycii 13 parts, Flos Chrysanthemi Indici 10 parts, Kelp Powder 36 parts, Maifanitum 4 parts.
Preparation method is as follows:
(1) weight portion Fructus Aurantii Immaturus, Bin youth, Rhizoma Osmundae, Semen Cuscutae are added the mixed liquor (water is 1:2 with the volume ratio of yellow wine) of water and the yellow wine accounting for four kinds of raw material gross weights 8 times, reflux, extract, 2 times under temperature is 80 DEG C of conditions, each 20min, then filters, and obtains filtrate for subsequent use;
The total sugar content of described yellow wine is 60g/L;
(2) Semen Cucurbitae, Fructus Hordei Germinatus, Fructus Lycii, Flos Chrysanthemi Indici are mixed, be ground to 60 order powder, obtain mixed powder;
(3) by Kelp Powder, Maifanitum and mixed powder add in filtrate, and stir postlyophilization.
Embodiment 2
Be used for the treatment of a pharmaceutical composition for sheep dry-sickness, raw material is: Fructus Aurantii Immaturus 10 parts, Semen Cucurbitae 30 parts, Bin youth 9 parts, Rhizoma Osmundae 18 parts, 17 parts, Fructus Hordei Germinatus, Semen Cuscutae 8 parts, Fructus Lycii 10 parts, Flos Chrysanthemi Indici 9 parts, Kelp Powder 40 parts, medical stone powder 5 parts.
Preparation method is with embodiment 1.
Embodiment 3
Be used for the treatment of a pharmaceutical composition for sheep dry-sickness, raw material is: Fructus Aurantii Immaturus 15 parts, Semen Cucurbitae 20 parts, Bin youth 10 parts, Rhizoma Osmundae 15 parts, 15 parts, Fructus Hordei Germinatus, Semen Cuscutae 10 parts, Fructus Lycii 15 parts, Flos Chrysanthemi Indici 8 parts, Kelp Powder 30 parts, medical stone powder 3 parts.
Preparation method is with embodiment 1.
Comparative example 1
A kind of drug regimen raw material being used for the treatment of sheep dry-sickness forms with embodiment 1, and difference is: pulverize after directly being mixed by each composition.
Comparative example 2
This comparative example raw material composition is substantially identical with embodiment 1, and difference is: without Maifanitum, and other raw materials and composition are all with embodiment 1.
Preparation method is as follows:
(1) weight portion Fructus Aurantii Immaturus, Bin youth, Rhizoma Osmundae, Semen Cuscutae are added the water accounting for four kinds of raw material gross weights 8 times, reflux, extract, 2 times under temperature is 80 DEG C of conditions, each 20min, then filters, and obtains filtrate for subsequent use;
(2) Semen Cucurbitae, Fructus Hordei Germinatus, Fructus Lycii, Flos Chrysanthemi Indici are mixed, be ground to 60 order powder, obtain mixed powder;
(3) by Kelp Powder, Maifanitum and mixed powder add in filtrate, and stir postlyophilization.
Effect test
1. the existing sick sheep 70 suffering from dry-sickness, kind is Small-fat-tail sheep, about 3 monthly ages, the symptom of sick sheep is: become thin, pasture and expect but do not put on flesh, the sheep mental status is not good, is divided into 7 groups of S1-S7 at random, often organize 10, add pharmaceutical composition prepared by embodiment 1-3 in S1-S3 feeding feedstuff respectively, add pharmaceutical composition prepared by comparative example 1-2 in S4-S5 feeding feedstuff respectively, addition is 2.5g/kg body weight, once a day, make an addition in drinking water or feedstuff; S6 group is the drug regimen of existing treatment sheep dry-sickness: Albendazole 20mL/kg body weight, calcium tablet 0.4/kg body weight, cod-liver oil 2.5mL/kg body weight, compound vitamin B 0.55g/kg body weight; S7 group is blank group, does not carry out medicine elements addition, daily hello water and feedstuff.Daily management is all identical, and the equal successive administration of S1-S6 group 7 days, observed after 7 days, and to total effective rate statistics, observe the state of the sheep of recovery from illness or improvement, concrete outcome is in table 1.
Table 1
2. be spiked into by pharmaceutical composition prepared by embodiment 1 and comparative example 2 in feedstuff and feed 3 monthly ages suffering from dry-sickness sick Small-fat-tail sheep, feedstuff palatability carries out observation statistics, and eating rate (normal feed intake), the concrete outcome of feedstuff-meat ratio is in table 2.
Table 2
Described eating rate=on daily feed intake is without affecting sheep/sheep sum × 100% of normally searching for food.
Application test
1., in this plant, continue to occur that 3 monthly ages of trouble dry-sickness shut out and moor sheep, sick sheep feature: forage eating speed is slow, ruminating normal, but do not put on flesh, there is skinny phenomenon in the sick sheep that part is serious, after sick sheep isolation, average packet, uses the pharmaceutical composition of embodiment of the present invention 1-3, be spiked in feedstuff according to 2.5g/kg and carry out feeding, continuous feeding 7 days, then to cure rate, effective percentage, body weight is added up, and concrete outcome is in table 3.
Table 3
It should be noted last that; the technical staff of the industry should understand; above-described embodiment is only in order to illustrate technical scheme of the present invention and unrestricted; the present invention also has various changes and modifications without departing from the spirit and scope of the present invention, and these changes and improvements all fall in the claimed scope of the invention.

Claims (5)

1. be used for the treatment of a pharmaceutical composition for sheep dry-sickness, it is characterized in that, be prepared from by following raw material:
Fructus Aurantii Immaturus 10-15 part, Semen Cucurbitae 20-30 part, Bin youth 8-10 part, Rhizoma Osmundae 15-18 part, Fructus Hordei Germinatus 15-20 part, Semen Cuscutae 8-10 part, Fructus Lycii 10-15 part, Flos Chrysanthemi Indici 8-10 part, Kelp Powder 30-40 part, medical stone powder 3-5 part.
2. pharmaceutical composition according to claim 1, is characterized in that, described raw material is:
Fructus Aurantii Immaturus 12 parts, Semen Cucurbitae 25 parts, Bin youth 8 parts, Rhizoma Osmundae 16 parts, 20 parts, Fructus Hordei Germinatus, Semen Cuscutae 9 parts, Fructus Lycii 13 parts, Flos Chrysanthemi Indici 10 parts, Kelp Powder 36 parts, Maifanitum 4 parts.
3. pharmaceutical composition according to claim 1 and 2, is characterized in that, this pharmaceutical composition adopts following methods to be prepared from:
(1) weight portion Fructus Aurantii Immaturus, Bin youth, Rhizoma Osmundae, Semen Cuscutae added and account for the water of four kinds of raw material gross weights 8 times and the mixed liquor of yellow wine, reflux, extract, 2 times under 80 DEG C of conditions, each 20min, then filters, and obtains filtrate for subsequent use;
(2) Semen Cucurbitae, Fructus Hordei Germinatus, Fructus Lycii, Flos Chrysanthemi Indici are mixed, be ground to 60 order powder, obtain mixed powder;
(3) by Kelp Powder, Maifanitum and mixed powder add in filtrate, and stir postlyophilization.
4. pharmaceutical composition according to claim 3, is characterized in that, in described mixed liquor, the volume ratio of water and yellow wine is 1:2.
5. the pharmaceutical composition according to claim 3 or 4, is characterized in that, described yellow wine is total sugar content is 60g/L.
CN201510921768.7A 2015-12-14 2015-12-14 Medicine composition for treating sheep dry-sickness disease and preparation method of medicine composition Pending CN105497680A (en)

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CN201510921768.7A CN105497680A (en) 2015-12-14 2015-12-14 Medicine composition for treating sheep dry-sickness disease and preparation method of medicine composition

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Application Number Priority Date Filing Date Title
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1739372A (en) * 2004-08-23 2006-03-01 纪会谦 Aromatic compound feed and its production process
CN101934039A (en) * 2010-08-28 2011-01-05 穆志明 Medicament for treating spleen deficiency and dyspepsia stomach and intestine
CN103330088A (en) * 2013-07-12 2013-10-02 镇江万山红遍农业园 Traditional Chinese medicine additive for fattening goat and use method of traditional Chinese medicine additive

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1739372A (en) * 2004-08-23 2006-03-01 纪会谦 Aromatic compound feed and its production process
CN101934039A (en) * 2010-08-28 2011-01-05 穆志明 Medicament for treating spleen deficiency and dyspepsia stomach and intestine
CN103330088A (en) * 2013-07-12 2013-10-02 镇江万山红遍农业园 Traditional Chinese medicine additive for fattening goat and use method of traditional Chinese medicine additive

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
郑继方: "《兽医中药学》", 31 December 2012 *

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Application publication date: 20160420