CN105497395A - Traditional Chinese medicine preparation for treating dysmenorrheal as well as preparation method and application of traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation for treating dysmenorrheal as well as preparation method and application of traditional Chinese medicine preparation Download PDFInfo
- Publication number
- CN105497395A CN105497395A CN201510977319.4A CN201510977319A CN105497395A CN 105497395 A CN105497395 A CN 105497395A CN 201510977319 A CN201510977319 A CN 201510977319A CN 105497395 A CN105497395 A CN 105497395A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- rhizoma
- preparation
- medicine preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 87
- 238000002360 preparation method Methods 0.000 title claims abstract description 68
- 239000000843 powder Substances 0.000 claims abstract description 48
- 241000218176 Corydalis Species 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 23
- 235000007034 Carum copticum Nutrition 0.000 claims abstract description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 206010013935 Dysmenorrhoea Diseases 0.000 claims description 60
- 210000000582 semen Anatomy 0.000 claims description 57
- 208000005171 Dysmenorrhea Diseases 0.000 claims description 54
- 238000011282 treatment Methods 0.000 claims description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- 239000012153 distilled water Substances 0.000 claims description 28
- 239000000706 filtrate Substances 0.000 claims description 27
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 27
- 241000903946 Clematidis Species 0.000 claims description 22
- 241000212376 Ammi Species 0.000 claims description 20
- 241000628997 Flos Species 0.000 claims description 20
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 13
- -1 boil 2-4h Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 238000007598 dipping method Methods 0.000 claims description 9
- 239000012535 impurity Substances 0.000 claims description 9
- 239000004570 mortar (masonry) Substances 0.000 claims description 9
- 238000002791 soaking Methods 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 8
- 239000002552 dosage form Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 3
- 239000006187 pill Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 2
- 208000002193 Pain Diseases 0.000 abstract description 19
- 230000036407 pain Effects 0.000 abstract description 19
- 208000024891 symptom Diseases 0.000 abstract description 17
- 229940079593 drug Drugs 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 13
- 210000001015 abdomen Anatomy 0.000 abstract description 9
- 206010009866 Cold sweat Diseases 0.000 abstract description 5
- 208000002173 dizziness Diseases 0.000 abstract description 5
- 230000008673 vomiting Effects 0.000 abstract description 4
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 210000004916 vomit Anatomy 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 244000302413 Carum copticum Species 0.000 abstract 2
- 241000218158 Clematis Species 0.000 abstract 2
- 244000150195 Cyperus longus Species 0.000 abstract 2
- 241000244355 Ligusticum Species 0.000 abstract 2
- 241000218378 Magnolia Species 0.000 abstract 2
- 244000197580 Poria cocos Species 0.000 abstract 2
- 235000008599 Poria cocos Nutrition 0.000 abstract 2
- 241001278830 Rosa banksiae Species 0.000 abstract 2
- 241001078983 Tetradium ruticarpum Species 0.000 abstract 2
- 241000301400 Trogopterus Species 0.000 abstract 2
- 244000178320 Vaccaria pyramidata Species 0.000 abstract 2
- 235000010587 Vaccaria pyramidata Nutrition 0.000 abstract 2
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 210000003608 fece Anatomy 0.000 abstract 2
- 206010028813 Nausea Diseases 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 230000008693 nausea Effects 0.000 abstract 1
- 230000001148 spastic effect Effects 0.000 abstract 1
- 238000003809 water extraction Methods 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 description 14
- 239000008280 blood Substances 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 10
- 241000700159 Rattus Species 0.000 description 9
- 230000010354 integration Effects 0.000 description 9
- 235000012054 meals Nutrition 0.000 description 8
- 210000004185 liver Anatomy 0.000 description 7
- 210000000056 organ Anatomy 0.000 description 7
- 230000001225 therapeutic effect Effects 0.000 description 7
- 206010000087 Abdominal pain upper Diseases 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 230000037396 body weight Effects 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 230000034994 death Effects 0.000 description 5
- 210000003734 kidney Anatomy 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- 230000027758 ovulation cycle Effects 0.000 description 5
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000002496 gastric effect Effects 0.000 description 4
- 210000002216 heart Anatomy 0.000 description 4
- 238000001802 infusion Methods 0.000 description 4
- 230000003821 menstrual periods Effects 0.000 description 4
- 230000005906 menstruation Effects 0.000 description 4
- 210000001672 ovary Anatomy 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 231100000915 pathological change Toxicity 0.000 description 3
- 230000036285 pathological change Effects 0.000 description 3
- 210000002381 plasma Anatomy 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 210000004291 uterus Anatomy 0.000 description 3
- 206010000084 Abdominal pain lower Diseases 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 210000004100 adrenal gland Anatomy 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002124 endocrine Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- 210000004392 genitalia Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 230000002175 menstrual effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 206010042772 syncope Diseases 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 210000001541 thymus gland Anatomy 0.000 description 2
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- 208000005641 Adenomyosis Diseases 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 201000009273 Endometriosis Diseases 0.000 description 1
- 206010016059 Facial pain Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241000521257 Hydrops Species 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000000450 Pelvic Pain Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 206010040007 Sense of oppression Diseases 0.000 description 1
- 206010063146 Uterine hypoplasia Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002547 anomalous effect Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 239000004490 capsule suspension Substances 0.000 description 1
- 210000001168 carotid artery common Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- 230000002498 deadly effect Effects 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000036267 drug metabolism Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000002357 endometrial effect Effects 0.000 description 1
- 201000009274 endometriosis of uterus Diseases 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000037308 hair color Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 231100001252 long-term toxicity Toxicity 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000036259 sexual stimuli Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000001113 umbilicus Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine preparation for treating dysmenorrheal as well as a preparation method and an application of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation for treating dysmenorrheal is prepared from platycladi seeds, clematis roots, corydalis tubers, rhizomes of featherleaf rodgersflower, poria cocos, seeds of Ajowan-caraway, trogopterus dung, Chinese ligusticum rhizomes, root-bark of wild banks roses, biond magnolia flowers, nutgrass galingale rhizomes, cowherb seeds and medcinal evodia fruits. During preparation, the root-bark of wild banks roses and the medcinal evodia fruits are juiced, the platycladi seeds, the clematis roots, the corydalis tubers, the seeds of Ajowan-caraway, the trogopterus dung and the Chinese ligusticum rhizomes are subjected to water extraction, the rhizomes of featherleaf rodgersflower, the biond magnolia flowers and the poria cocos are ground into fine powder, and the nutgrass galingale rhizomes and the cowherb seeds are subjected to alcohol extraction. The raw materials perform a synergistic function and have the effects of fast effects, definite curative effects, high safety and simple medication, the preparation process is simple and environment-friendly, and the traditional Chinese medicine preparation can effectively relieve symptoms such as spastic pains of the lower abdomen, fall-swell, nausea, dizziness, vomit, cold sweat, pale complexion and the like caused by dysmenorrheal, does not have toxic or side effects and provides a new choice for clinically pre-relieving various symptoms caused by dysmenorrheal.
Description
Technical field
The present invention relates to medical applications technical field, specifically a kind of Chinese medicine preparation for the treatment of dysmenorrhea and its production and use.
Background technology
Dysmenorrhea is common gynecological disease, show as before and after passing through clinically and occur that obvious lower abdomen spasmic pain, falling inflation are felt menstrual period, some patients also has soreness of waist pain sense of discomfort, with feeling sick, dizzy, vomiting phenomenon, the symptoms such as being in a cold sweat even appears in severe patient, pale complexion, deadly cold hand and foot and even severe pain faintness.
Dysmenorrhea is divided into primary dysmenorrhea (also claiming primary dysmenorrhea) and secondary dysmenorrhea two class according to pathogeny.The former refers to the dysmenorrhea that genitals produces without significant organic pathological changes, and the latter refers to produce due to genitals the dysmenorrhea that the pathological changes such as endometriosis, adenomyosis, pelvic inflammatory disease produce.
Show according to domestic sampling survey, in China's female population, dysmenorrhea incidence rate is 33.1%, main the young woman that colony is adolescent girls, unmarried or end is educated occurs, and wherein primary dysmenorrhea accounts for 53.2%.The pathogenic factor of primary dysmenorrhea mainly comprises endocrine factors, uterine factors and spirit, neural factors.Wherein endocrine factors comprises the R-endorphins content height etc. in endometrial prostaglandin height, patient body, uterine factors mainly refers to that uterine hypoplasia causes blood supply exception, uterus machine layer tissue hypoxic-ischemic etc., and spirit, neural factors refer to that the external or inherent threshold of pain that stress cause reduces, thought fear, anxiety and biochemical metabolism material all stimulate pelvic pain fiber by central nervous system.
From the Chinese point of view, the generation of primary dysmenorrhea is mainly because volt or essence and blood element lose in pathogen, and the QI and blood change be more worth before and after menstrual period is too fast, cause uterus QI-blood circulation smooth or lack moisten foster.At present, the medicine of commercially available treatment dysmenorrhea is more, but processing technology is comparatively complicated, and expensive, is difficult to effectively promote.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of dysmenorrhea and its production and use.
For achieving the above object, the invention provides following technical scheme:
Treat a Chinese medicine preparation for dysmenorrhea, be made up of the following raw material according to weight portion: Semen Platycladi 20-30 part, Radix Clematidis 10-20 part, Rhizoma Corydalis 10-20 part, Rhizoma Rodgersiae 8-12 part, Poria 8-12 part, Semen Trachyspermi Ammi 8-12 part, Oletum Trogopterori 5-10 part, Rhizoma Ligustici 5-10 part, Cortex Rosae Normalis Radicis 5-7 part, Flos Magnoliae 5-7 part, Rhizoma Cyperi 3-5 part, Semen Vaccariae 3-5 part, Fructus Evodiae 2-4 part.
As the present invention's further scheme: the Chinese medicine preparation of described treatment dysmenorrhea, be made up of the following raw material according to weight portion: Semen Platycladi 22-28 part, Radix Clematidis 12-18 part, Rhizoma Corydalis 12-18 part, Rhizoma Rodgersiae 9-11 part, Poria 9-11 part, Semen Trachyspermi Ammi 9-11 part, Oletum Trogopterori 6-9 part, Rhizoma Ligustici 6-9 part, Cortex Rosae Normalis Radicis 5.5-6.5 part, Flos Magnoliae 5.5-6.5 part, Rhizoma Cyperi 3.5-4.5 part, Semen Vaccariae 3.5-4.5 part, Fructus Evodiae 2.5-3.5 part.
As the present invention's further scheme: the Chinese medicine preparation of described treatment dysmenorrhea, be made up of the following raw material according to weight portion: Semen Platycladi 25 parts, Radix Clematidis 15 parts, Rhizoma Corydalis 15 parts, Rhizoma Rodgersiae 10 parts, 10 parts, Poria, Semen Trachyspermi Ammi 10 parts, Oletum Trogopterori 8 parts, Rhizoma Ligustici 8 parts, Cortex Rosae Normalis Radicis 6 parts, Flos Magnoliae 6 parts, Rhizoma Cyperi 4 parts, Semen Vaccariae 4 parts, Fructus Evodiae 3 parts.
The preparation method of the Chinese medicine preparation of described treatment dysmenorrhea, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Cortex Rosae Normalis Radicis and Fructus Evodiae are cleaned, chopping, strand juice, filter impurity, stays juice for subsequent use;
(3) get Semen Platycladi, Radix Clematidis, Rhizoma Corydalis, Semen Trachyspermi Ammi, Oletum Trogopterori and Rhizoma Ligustici to clean, put into container, add the distilled water of 8-10 times amount, after soaking 2-4h, boil 3-4h, extract; Again add 5-7 times amount distilled water, boil 2-4h, extract; Finally, add 3-5 times amount distilled water, heated and boiled 1-2h, extract; Merge three extracting solution, filter, reserved filtrate is for subsequent use;
(4) get Rhizoma Rodgersiae and Flos Magnoliae to clean, section, dries, puts into mortar, grind into powder, crosses 120-140 order fine powder, for subsequent use;
(5) get Rhizoma Cyperi and Semen Vaccariae is cleaned, immerse the alcohol solution dipping 2-3h of 65% of 5-7 times amount, heated and boiled 1-2h, extract, filter, obtain filtrate for subsequent use;
(6) Poria is pulverized, grind into powder, cross 200-220 order fine powder, for subsequent use;
(7) by juice made for above-mentioned steps (2)-(6), filtrate and fine powder mixing, make peroral dosage form through modern science technique, obtain medicine of the present invention.
As the present invention's further scheme: described peroral dosage form is pill, capsule, tablet, powder, granule or oral liquid.
As the present invention's further scheme: described peroral dosage form is capsule.
As the present invention's further scheme: the application of described Chinese medicine preparation in the anti-dysmenorrhea medicine of preparation treatment.
Compared with prior art, the invention has the beneficial effects as follows:
In the present invention, each crude drug synergism plays and has the high and medication of rapid-action, determined curative effect, safety and simply act on, preparation technology is simple, environmentally friendly, can effectively relieving dysmenorrhea cause lower abdomen spasmic pain, falling inflation, feel sick, dizzy, vomit, be in a cold sweat, the symptom such as pale complexion, do not have toxic and side effects, the various symptoms caused for clinical pre-relieving dysmenorrhea provide a newly selection.
Detailed description of the invention
Be described in more detail below in conjunction with the technical scheme of detailed description of the invention to this patent.
Embodiment 1
Treat a Chinese medicine preparation for dysmenorrhea, be made up of the following raw material according to weight portion: Semen Platycladi 20 parts, Radix Clematidis 10 parts, Rhizoma Corydalis 10 parts, Rhizoma Rodgersiae 8 parts, 8 parts, Poria, Semen Trachyspermi Ammi 8 parts, Oletum Trogopterori 5 parts, Rhizoma Ligustici 5 parts, Cortex Rosae Normalis Radicis 5 parts, Flos Magnoliae 5 parts, Rhizoma Cyperi 3 parts, Semen Vaccariae 3 parts, Fructus Evodiae 2 parts.
The preparation method of the Chinese medicine preparation of described treatment dysmenorrhea, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Cortex Rosae Normalis Radicis and Fructus Evodiae are cleaned, chopping, strand juice, filter impurity, stays juice for subsequent use;
(3) get Semen Platycladi, Radix Clematidis, Rhizoma Corydalis, Semen Trachyspermi Ammi, Oletum Trogopterori and Rhizoma Ligustici to clean, put into container, add the distilled water of 8 times amount, after soaking 2h, boil 3h, extract; Again add 5 times amount distilled water, boil 2h, extract; Finally, add 3 times amount distilled water, heated and boiled 1h, extract; Merge three extracting solution, filter, reserved filtrate is for subsequent use;
(4) get Rhizoma Rodgersiae and Flos Magnoliae to clean, section, dries, puts into mortar, grind into powder, crosses 120 order fine powders, for subsequent use;
(5) get Rhizoma Cyperi and Semen Vaccariae is cleaned, immerse the alcohol solution dipping 2h of 65% of 5 times amount, heated and boiled 1h, extract, filter, obtain filtrate for subsequent use;
(6) Poria is pulverized, grind into powder, cross 200 order fine powders, for subsequent use;
(7) by juice made for above-mentioned steps (2)-(6), filtrate and fine powder mixing, be made for pill through modern science technique, obtain medicine of the present invention.
Usage and dosage: half an hour is oral after meal.A 3-5g, 3 times on the one one month is a course for the treatment of.
Embodiment 2
Treat a Chinese medicine preparation for dysmenorrhea, be made up of the following raw material according to weight portion: Semen Platycladi 22 parts, Radix Clematidis 12 parts, Rhizoma Corydalis 12 parts, Rhizoma Rodgersiae 9 parts, 9 parts, Poria, Semen Trachyspermi Ammi 9 parts, Oletum Trogopterori 6 parts, Rhizoma Ligustici 6 parts, Cortex Rosae Normalis Radicis 5.5 parts, Flos Magnoliae 5.5 parts, Rhizoma Cyperi 3.5 parts, Semen Vaccariae 3.5 parts, Fructus Evodiae 2.5 parts.
The preparation method of the Chinese medicine preparation of described treatment dysmenorrhea, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Cortex Rosae Normalis Radicis and Fructus Evodiae are cleaned, chopping, strand juice, filter impurity, stays juice for subsequent use;
(3) get Semen Platycladi, Radix Clematidis, Rhizoma Corydalis, Semen Trachyspermi Ammi, Oletum Trogopterori and Rhizoma Ligustici to clean, put into container, add the distilled water of 8.5 times amount, after soaking 2.5h, boil 3.2h, extract; Again add 5.5 times amount distilled water, boil 2.5h, extract; Finally, add 3.5 times amount distilled water, heated and boiled 1.2h, extract; Merge three extracting solution, filter, reserved filtrate is for subsequent use;
(4) get Rhizoma Rodgersiae and Flos Magnoliae to clean, section, dries, puts into mortar, grind into powder, crosses 125 order fine powders, for subsequent use;
(5) get Rhizoma Cyperi and Semen Vaccariae is cleaned, immerse the alcohol solution dipping 2.2h of 65% of 5.5 times amount, heated and boiled 1.2h, extract, filter, obtain filtrate for subsequent use;
(6) Poria is pulverized, grind into powder, cross 205 order fine powders, for subsequent use;
(7) by juice made for above-mentioned steps (2)-(6), filtrate and fine powder mixing, be made for tablet through modern science technique, obtain medicine of the present invention.
Usage and dosage: half an hour is oral after meal.A 3-5g, 3 times on the one one month is a course for the treatment of.
Embodiment 3
Treat a Chinese medicine preparation for dysmenorrhea, be made up of the following raw material according to weight portion: Semen Platycladi 25 parts, Radix Clematidis 15 parts, Rhizoma Corydalis 15 parts, Rhizoma Rodgersiae 10 parts, 10 parts, Poria, Semen Trachyspermi Ammi 10 parts, Oletum Trogopterori 8 parts, Rhizoma Ligustici 8 parts, Cortex Rosae Normalis Radicis 6 parts, Flos Magnoliae 6 parts, Rhizoma Cyperi 4 parts, Semen Vaccariae 4 parts, Fructus Evodiae 3 parts.
The preparation method of the Chinese medicine preparation of described treatment dysmenorrhea, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Cortex Rosae Normalis Radicis and Fructus Evodiae are cleaned, chopping, strand juice, filter impurity, stays juice for subsequent use;
(3) get Semen Platycladi, Radix Clematidis, Rhizoma Corydalis, Semen Trachyspermi Ammi, Oletum Trogopterori and Rhizoma Ligustici to clean, put into container, add the distilled water of 9 times amount, after soaking 3h, boil 3.5h, extract; Again add 6 times amount distilled water, boil 3h, extract; Finally, add 4 times amount distilled water, heated and boiled 1.5h, extract; Merge three extracting solution, filter, reserved filtrate is for subsequent use;
(4) get Rhizoma Rodgersiae and Flos Magnoliae to clean, section, dries, puts into mortar, grind into powder, crosses 130 order fine powders, for subsequent use;
(5) get Rhizoma Cyperi and Semen Vaccariae is cleaned, immerse the alcohol solution dipping 2.5h of 65% of 6 times amount, heated and boiled 1.5h, extract, filter, obtain filtrate for subsequent use;
(6) Poria is pulverized, grind into powder, cross 210 order fine powders, for subsequent use;
(7) by juice made for above-mentioned steps (2)-(6), filtrate and fine powder mixing, be made for capsule through modern science technique, obtain medicine of the present invention.
Usage and dosage: half an hour is oral after meal.A 3-5g, 3 times on the one one month is a course for the treatment of.
Embodiment 4
Treat a Chinese medicine preparation for dysmenorrhea, be made up of the following raw material according to weight portion: Semen Platycladi 28 parts, Radix Clematidis 18 parts, Rhizoma Corydalis 18 parts, Rhizoma Rodgersiae 11 parts, 11 parts, Poria, Semen Trachyspermi Ammi-11 parts, Oletum Trogopterori 9 parts, Rhizoma Ligustici 9 parts, Cortex Rosae Normalis Radicis 6.5 parts, Flos Magnoliae 6.5 parts, Rhizoma Cyperi 4.5 parts, Semen Vaccariae 4.5 parts, Fructus Evodiae 3.5 parts.
The preparation method of the Chinese medicine preparation of described treatment dysmenorrhea, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Cortex Rosae Normalis Radicis and Fructus Evodiae are cleaned, chopping, strand juice, filter impurity, stays juice for subsequent use;
(3) get Semen Platycladi, Radix Clematidis, Rhizoma Corydalis, Semen Trachyspermi Ammi, Oletum Trogopterori and Rhizoma Ligustici to clean, put into container, add the distilled water of 9.5 times amount, after soaking 3.5h, boil 3.8h, extract; Again add 6.5 times amount distilled water, boil 3.5h, extract; Finally, add 4.5 times amount distilled water, heated and boiled 1.8h, extract; Merge three extracting solution, filter, reserved filtrate is for subsequent use;
(4) get Rhizoma Rodgersiae and Flos Magnoliae to clean, section, dries, puts into mortar, grind into powder, crosses 135 order fine powders, for subsequent use;
(5) get Rhizoma Cyperi and Semen Vaccariae is cleaned, immerse the alcohol solution dipping 2.8h of 65% of 6.5 times amount, heated and boiled 1.8h, extract, filter, obtain filtrate for subsequent use;
(6) Poria is pulverized, grind into powder, cross 215 order fine powders, for subsequent use;
(7) by juice made for above-mentioned steps (2)-(6), filtrate and fine powder mixing, be made for oral liquid through modern science technique, obtain medicine of the present invention.
Usage and dosage: half an hour is oral after meal.A 3-5g, 3 times on the one one month is a course for the treatment of.
Embodiment 5
Treat a Chinese medicine preparation for dysmenorrhea, be made up of the following raw material according to weight portion: Semen Platycladi 30 parts, Radix Clematidis 20 parts, Rhizoma Corydalis 20 parts, Rhizoma Rodgersiae 12 parts, 12 parts, Poria, Semen Trachyspermi Ammi 12 parts, Oletum Trogopterori 10 parts, Rhizoma Ligustici 10 parts, Cortex Rosae Normalis Radicis 7 parts, Flos Magnoliae 7 parts, Rhizoma Cyperi 5 parts, Semen Vaccariae 5 parts, Fructus Evodiae 4 parts.
The preparation method of the Chinese medicine preparation of described treatment dysmenorrhea, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Cortex Rosae Normalis Radicis and Fructus Evodiae are cleaned, chopping, strand juice, filter impurity, stays juice for subsequent use;
(3) get Semen Platycladi, Radix Clematidis, Rhizoma Corydalis, Semen Trachyspermi Ammi, Oletum Trogopterori and Rhizoma Ligustici to clean, put into container, add the distilled water of 10 times amount, after soaking 4h, boil 4h, extract; Again add 7 times amount distilled water, boil 4h, extract; Finally, add 5 times amount distilled water, heated and boiled 2h, extract; Merge three extracting solution, filter, reserved filtrate is for subsequent use;
(4) get Rhizoma Rodgersiae and Flos Magnoliae to clean, section, dries, puts into mortar, grind into powder, crosses 140 order fine powders, for subsequent use;
(5) get Rhizoma Cyperi and Semen Vaccariae is cleaned, immerse the alcohol solution dipping 3h of 65% of 7 times amount, heated and boiled 2h, extract, filter, obtain filtrate for subsequent use;
(6) Poria is pulverized, grind into powder, cross 220 order fine powders, for subsequent use;
(7) by juice made for above-mentioned steps (2)-(6), filtrate and fine powder mixing, be made for granule through modern science technique, obtain medicine of the present invention.
Usage and dosage: half an hour is oral after meal.A 3-5g, 3 times on the one one month is a course for the treatment of.
Comparative example 1
Treat a Chinese medicine preparation for dysmenorrhea, be made up of the following raw material according to weight portion: Semen Platycladi 22 parts, Radix Clematidis 12 parts, Rhizoma Corydalis 12 parts, 9 parts, Poria, Semen Trachyspermi Ammi 9 parts, Oletum Trogopterori 6 parts, Rhizoma Ligustici 6 parts, Cortex Rosae Normalis Radicis 5.5 parts, Flos Magnoliae 5.5 parts, Rhizoma Cyperi 3.5 parts, Semen Vaccariae 3.5 parts, Fructus Evodiae 2.5 parts.
The preparation method of the Chinese medicine preparation of described treatment dysmenorrhea, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Cortex Rosae Normalis Radicis and Fructus Evodiae are cleaned, chopping, strand juice, filter impurity, stays juice for subsequent use;
(3) get Semen Platycladi, Radix Clematidis, Rhizoma Corydalis, Semen Trachyspermi Ammi, Oletum Trogopterori and Rhizoma Ligustici to clean, put into container, add the distilled water of 8.5 times amount, after soaking 2.5h, boil 3.2h, extract; Again add 5.5 times amount distilled water, boil 2.5h, extract; Finally, add 3.5 times amount distilled water, heated and boiled 1.2h, extract; Merge three extracting solution, filter, reserved filtrate is for subsequent use;
(4) get Flos Magnoliae to clean, section, dries, puts into mortar, grind into powder, crosses 125 order fine powders, for subsequent use;
(5) get Rhizoma Cyperi and Semen Vaccariae is cleaned, immerse the alcohol solution dipping 2.2h of 65% of 5.5 times amount, heated and boiled 1.2h, extract, filter, obtain filtrate for subsequent use;
(6) Poria is pulverized, grind into powder, cross 205 order fine powders, for subsequent use;
(7) by juice made for above-mentioned steps (2)-(6), filtrate and fine powder mixing, be made for tablet through modern science technique, obtain medicine of the present invention.
Usage and dosage: half an hour is oral after meal.A 3-5g, 3 times on the one one month is a course for the treatment of.
Comparative example 2
Treat a Chinese medicine preparation for dysmenorrhea, be made up of the following raw material according to weight portion: Semen Platycladi 28 parts, Radix Clematidis 18 parts, Rhizoma Corydalis 18 parts, Rhizoma Rodgersiae 11 parts, 11 parts, Poria, Semen Trachyspermi Ammi-11 parts, Oletum Trogopterori 9 parts, Rhizoma Ligustici 9 parts, Cortex Rosae Normalis Radicis 6.5 parts, Rhizoma Cyperi 4.5 parts, Semen Vaccariae 4.5 parts, Fructus Evodiae 3.5 parts.
The preparation method of the Chinese medicine preparation of described treatment dysmenorrhea, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Cortex Rosae Normalis Radicis and Fructus Evodiae are cleaned, chopping, strand juice, filter impurity, stays juice for subsequent use;
(3) get Semen Platycladi, Radix Clematidis, Rhizoma Corydalis, Semen Trachyspermi Ammi, Oletum Trogopterori and Rhizoma Ligustici to clean, put into container, add the distilled water of 9.5 times amount, after soaking 3.5h, boil 3.8h, extract; Again add 6.5 times amount distilled water, boil 3.5h, extract; Finally, add 4.5 times amount distilled water, heated and boiled 1.8h, extract; Merge three extracting solution, filter, reserved filtrate is for subsequent use;
(4) get Rhizoma Rodgersiae to clean, section, dries, puts into mortar, grind into powder, crosses 135 order fine powders, for subsequent use;
(5) get Rhizoma Cyperi and Semen Vaccariae is cleaned, immerse the alcohol solution dipping 2.8h of 65% of 6.5 times amount, heated and boiled 1.8h, extract, filter, obtain filtrate for subsequent use;
(6) Poria is pulverized, grind into powder, cross 215 order fine powders, for subsequent use;
(7) by juice made for above-mentioned steps (2)-(6), filtrate and fine powder mixing, be made for oral liquid through modern science technique, obtain medicine of the present invention.
Usage and dosage: half an hour is oral after meal.A 3-5g, 3 times on the one one month is a course for the treatment of.
Embodiment 6
Clinical trial
(1) subjects: adopt the present invention to treat 300 examples altogether, the oldest person 32 years old, age reckling 14 years old;
(2) diagnostic criteria: Western medicine diagnose is according to " newly organized practical gynecology " (Su Yingkuan, Shandong science tech publishing house, 2005).Menstrual period or before and after row lower abdomen pain, pain and waist energy, very then faint, in periodical attack; Tcm diagnosis is according to " stomach faces card record by heavenly maiden section to be wanted " (stomach capital is raw, stomach ripple, Wang Maoni, etc., People's Health Publisher, 2010:193).
(3) exclusion standard: have significant organic pathological changes person through gynecologial examination; Those who are allergic to this drug; Be associated with cardiovascular; Severe primary disease, the psychotics such as liver, kidney and hemopoietic system; Menstrual cycle is irregular, and affect the treatment judgement person; Do not take medicine by regulation, cannot judge that curative effect or data are not congruent and affect the treatment or safety judgement person.
(4) Therapeutic Method: 300 routine patients are equally divided into five groups, often organize 60 examples, one group, two groups and three groups are test group, one group, two groups and three components do not take the Chinese medicine preparation of the treatment dysmenorrhea of the present invention that embodiment 1-embodiment 3 prepares, four groups and five groups is matched group, four groups and the five groups Chinese medicine preparation taken comparative example 1 and comparative example 2 respectively and prepare, usage and dosage: half an hour is oral after meal.A 3-5g, 3 times on the one one month is a course for the treatment of.After taking 3 courses for the treatment of continuously, add up the therapeutic outcome of five groups, observe the untoward reaction that treatments period patient occurs simultaneously.
(5) standard is observed: clinical symptoms, scoring situation, untoward reaction.
(6) criterion of therapeutical effect and tcm symptom improve situation:
Dysmenorrhea criterion of therapeutical effect formulates dysmenorrhea curative effect determinate standard with reference to " guideline of clinical investigations for the treatment of by Chinese herbs dysmenorrhea ": dysmenorrhea integration evaluation criteria is as shown in table 1:
Table 1: dysmenorrhea integration evaluation criteria
(7) therapeutic effect: curative effect determinate standard adopts in " guideline of clinical investigations for the treatment of by Chinese herbs dysmenorrhea ", therapeutic index=[before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100.
Recovery from illness: stomachache and other transference cures, drug withdrawal 3 non-recidivists of menstrual cycle, integration reduces >=95%;
Effective: stomachache obviously alleviates, all the other symptoms take a turn for the better, and drug withdrawal 3 menstrual cycle symptoms do not increase the weight of, and after 90% > treatment, integration reduces >=70%;
Effective: stomachache alleviates, other symptoms take a turn for the better, though symptom repeatedly, comparatively alleviates before treatment after drug withdrawal, after 70% > treatment, integration reduces >=30%;
Invalid: stomachache and other symptoms are without change or add severe one, and after treatment, integration reduces < 30%.
(8) therapeutic outcome: how to take effect after 5 days after taking medicine in Patients with 300 Cases case, 2-3 the course for the treatment of cures; Wherein cure 107 examples, effective 76 examples, effective 62 examples, invalid 55 examples, total effective rate reaches 81.6%, and therapeutic outcome is as shown in table 2:
Table 2: clinical trial therapeutic outcome
As shown in Table 2, the average effectiveness level adopting the Chinese medicine preparation for the treatment of dysmenorrhea of the present invention to carry out treating reaches 95%, and the effective percentage of the pharmaceutical composition adopting comparative example to prepare only has 61.7%, therefore, between medicine of the present invention, there is synergistic function, add the effective percentage of Chinese medicine preparation.
Model case:
(1) Zhu, 17 years old.Patient is from 15 the beginning of the year tides, and at every turn through row lower abdomen sharp ache, menoxenia, more or less, pain is radiated to waist and femoribus internus to amount, especially acute through row the 1st day pain, recovery after clean.After before in the period and use Chinese medicine preparation of the present invention menstrual period, pain obviously alleviates, and within second month, continues to use, and time in the period to three month, dysmenorrhea transference cure, after drug withdrawal, follows up a case by regular visits to and do not recur again.
(2) Zhang, 35 years old, oneself wedded, and closely over the past half year during menstrual onset, lower abdomen hurt like hell, the companion whole body is weak, and lower abdomen falling inflation is obvious, and many through measuring, color is dark red block.Ultrasound diagnosis is shown: left side attachment is shown in inflammatory mass.Examine as chronic pelvic inflammatory disease.Give invention formulation, take 2 courses for the treatment of continuously, the eumenorrhea, inflammation disappears, and pain disappears, and follows up a case by regular visits to have no and do not recur after half a year.
(3) grandson so-and-so, 26 years old, lower abdominal pain was examined for 4 hours.Be on tenterhooks, lusterless complexion, face pain, pitching must not.Tell lower abdominal pain violent unbearably, distending pain is main, and menstruation is fitted extremely, accompanies clot.The rule of menstruation usually, a folder clot, amount is many.Be in a very depressed state and do not dredge, often to menstruation, then hypogastralgia feeling of distension and oppression is uncomfortable, and medical history for many years.Body of the tongue is dark and gloomy livid purple, while there is tired purple, and thin fur and yellow, deep and hesitant pulse.Dialectical analysis: patient menstrual measures many, consumption impairment of YIN blood, deficiency of YIN-blood, Liver Channel loses supports, thus depressed joyless, and irritability is not dredged, the cloudy stagnation of QI of fainting, uterus insufficiency of vital energy and blood in addition tired stagnant obstructed so that sharp ache.Deficiency of YIN-blood is then shown in lusterless complexion.Menstruation accompanies clot, and picture of the tongue, pulse condition are outside deficiency of YIN-blood, the tired stagnation of QI of blood and resemble.Control with easing the affected liver yin nourishing, loose tired method of regulating the flow of vital energy.According to the prescription of above-described embodiment 3,1 dose of alleviation of pain of taking medicine, serve on 6 doses, and all cards are eliminated.
(4) bent certain, 32 years old, dysmenorrhea healed for a long time and not, stomachache pain lower abdomen under umbilicus, and first day of rising stomachache is very acute, and to finding that film sample is shown in again a burst of severe pain before coming off, clot falls then alleviation of pain then, red tongue, stringy pulse, is diagnosed as hot pain; Yu Jinghang starts to take Chinese medicine preparation of the present invention for first 5 days, and after taking 3 menstrual cycle, dysmenorrhea transference cure, continuous 3 menstrual cycle do not recur.
(5) Korea Spro so-and-so, female, 23 years old, the recent exacerbation of symptoms of the long-term dysmenorrhea of patient's readme, during dysmenorrhea complexion turn white, be in a cold sweat, general weakness, extreme cold of the limbs, within nearly two months, there is metrorrhagia symptom continuously.After three courses for the treatment of of patient consumes, during the physiology phase, dysmenorrhea symptom makes moderate progress, and after continuing again to take medicine one month, physiology phase glucose recovery is normal, after follow up a case by regular visits in this year without recurring.
The present invention is the good effect that has in treatment dysmenorrhea, below by animal efficacy data in addition further instruction:
One, Chinese medicine preparation animal acute toxicity test of the present invention:
1. trial drug: the Traditional Chinese medicine capsule preparation that in the present invention, embodiment 3 prepares.
2. experimental animal: regular grade NIH mice 12, body weight 19 ± 3g, male and female half and half.
3. test method: be divided into blank group at random, fasting was tested after 16 hours, administration group gives capsule suspension of the present invention (capsule 's content and water 1:1 are in harmonious proportion and form) by the dosage gavage of 0.4g/l0g, presses the dosage gastric infusion of 0.4g/l0g more once, twice totally after 6 hours.Meanwhile blank group gavage gives consubstantiality hydrops, raises seven days to observation post administration, the reaction of record mouse toxicity and death condition, and observes the change of its main organs and tissue.
4. result of the test: after seven days, mice is without death in administration, and behavior is active, and food ration is as usual, hair color light is without loose dirty, and without fainting from fear addicted to saliva, eye, mouth, nose, ear and crissum secretions without exception, without the rotten toe of docking.Put to death mice, dissect, observe the main organs such as its heart, liver, lung, kidney and organize and see exception, show the oral safety of this medicine.
Two, Chinese medicine preparation long-term toxicity test for animals of the present invention:
1. trial drug: the Traditional Chinese medicine capsule preparation that in the present invention, embodiment 3 prepares.
2. experimental animal: regular grade SD rat 36, body weight 175 scholar 16g, male and female half and half, are divided into 3 groups at random.
3. test method:
Pharmaceutical formulations: point high and low, blank three dosage groups, are respectively 100,50,0 times of clinical application amount.
Experiment adopts gastric infusion mode, all by the capacity gastric infusion of 1m1/100g, and successive administration 90 days; Give blank group every day the distilled water of the capacity of grade, then every treated animal puts to death 4, becomes celestial to carry out perusal to each organs and tissues of animal, and makes pathologic finding to organs such as the heart, liver, spleen, lung, kidney, adrenal gland, thymus.
4. result of the test:
1) each treated animal tested period feed, drinking-water, defecation are all normal, and sport health is active, by hair gloss, do not find death and other ANOMALOUS VARIATIONS.
2) each treated animal body weight increases normal, and administration group compares there was no significant difference (P>0.05) with matched group.
3) after experiment, each treated animal hepatic and renal function and serum biochemistry measurement result compare there was no significant difference with matched group.
4) after experiment, each treated animal hemogram checking compares there was no significant difference with matched group.
5) each treated animal heart, liver, spleen, lung, kidney, adrenal gland, thymus outward appearance and its organ index there are no significant difference.
6) each treated animal is the same with matched group, the size and form of the organs such as the heart, liver, spleen, lung, kidney is normal, smooth surface, without hemorrhage, adhesion or necrosis, histological examination is respectively organized internal organs and is showed no organic disease, cardiac muscle fiber is without degeneration or necrosis, and structure is normal, and lung tissue and spleen organize also no abnormality seen to change, hepatocyte and the change all without exception of the structure such as glomerule, renal tubules, namely relevant with drug metabolism important organ is all without obviously changing.
Three, Chinese medicine preparation of the present invention is on the impact of syndrome of qi stagnation and blood stasis rat ovary function:
1. trial drug: invention Chinese medicine preparation; Animals administer dosage is pressed body surface area conversion coefficient and is calculated: the multiple (the clinical every consumption per day of people calculates by 3g, and body weight gets 60kg) of animals administer dosage=people quantity × 0.018/200 × 1000 × clinical equivalent amount.
2. laboratory animal: female sd inbred rats, body weight 180-220g.
3. modeling and grouping: after rat adaptability raises 7d, be divided into matched group, model group, positive drug control group (aspirin 0.1g/kg), medicine high dose group (5.4g/kg of the present invention at random, be equivalent to 20 times of people's consumption), dosage group (2.7g/kg in medicine of the present invention, be equivalent to 10 times of people's consumption), medicine low dose group (1.35g/kg of the present invention, be equivalent to 5 times of people's consumption), often organize 8.Except matched group, all the other five groups, all inject hydrochloric acid epinephrine inj by 0.8mg/kgd, chronic unpredictable sexual stimulus (A: put upside down round the clock is accepted after 4h, B:0-4 DEG C of frozen water swimming 4min, C:50 DEG C of baking oven baking the affected part after applying some drugs l0min, D:60dB noise stimulation 3h, E: outstanding tail l0min, give a kind of stimulation at random) at every turn, continuous 14d, from 7d, this is not by the dosage gastric infusion of each group of regulation, continuous 7d, after the 15th day chloral hydrate anesthesia, common carotid artery gets blood, measures the content of plasma estradiol (E2), progesterone (P).
4. statistical method application SPSS16.0 statistical software statistics, all data represent with x ± s, compare and adopt t inspection between group.
5. result: Chinese medicine preparation of the present invention on syndrome of qi stagnation and blood stasis rat ovary function to affect result as shown in table 3;
Table 3: Chinese medicine preparation of the present invention is on the impact of syndrome of qi stagnation and blood stasis rat ovary function
| Group | E2（μg/L） | P（μg/L） |
| Matched group | 158.64±22.43 | 115.22±13.15 |
| Model group | 58.12±20.48** | 169.77±20.44** |
| Positive drug control group | 103.61±18.69** | 141.32±17.15** |
| High dose group of the present invention | 115.23±18.47**# | 130.69±18.24**## |
| Dosage group in the present invention | 107.36±17.41**# | 134.62±17.19**# |
| Low dose group of the present invention | 98.55±20.46**# | 143.54±18.91** |
Note: compared with matched group, * * P<0.01, compared with positive drug control group, #P<0.05, ##P<0.01.
As shown in Table 3, compared with matched group, model group rats blood plasma E2 content significantly reduces (P<0.01), and P content significantly raises, and ((P<0.01) shows modeling success.
After giving positive control drug and invention formulation, compared with model group, each administration group rat plasma E2 content significantly raises (P<0.01), and P content significantly reduces (P<0.01).Each administration group is compared, certain dose-effect relationship is there is between the dosage of pharmaceutical preparation of the present invention and E2 and P content, senior middle school's dosage group is compared with positive control drug group, E2 content and P content have significant difference (P<0.05), illustrate that medicine of the present invention can be treated qi stagnation and blood stasis type rat ovary and be had regulating action, make it regulate to normal level.
In the present invention, each crude drug synergism plays and has the high and medication of rapid-action, determined curative effect, safety and simply act on, preparation technology is simple, environmentally friendly, can effectively relieving dysmenorrhea cause lower abdomen spasmic pain, falling inflation, feel sick, dizzy, vomit, be in a cold sweat, the symptom such as pale complexion, do not have toxic and side effects, the various symptoms caused for clinical pre-relieving dysmenorrhea provide a newly selection.
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment, in the ken that one skilled in the relevant art possesses, various change can also be made under the prerequisite not departing from this patent aim.
Claims (7)
1. treat the Chinese medicine preparation of dysmenorrhea for one kind, it is characterized in that, be made up of the following raw material according to weight portion: Semen Platycladi 20-30 part, Radix Clematidis 10-20 part, Rhizoma Corydalis 10-20 part, Rhizoma Rodgersiae 8-12 part, Poria 8-12 part, Semen Trachyspermi Ammi 8-12 part, Oletum Trogopterori 5-10 part, Rhizoma Ligustici 5-10 part, Cortex Rosae Normalis Radicis 5-7 part, Flos Magnoliae 5-7 part, Rhizoma Cyperi 3-5 part, Semen Vaccariae 3-5 part, Fructus Evodiae 2-4 part.
2. the Chinese medicine preparation for the treatment of dysmenorrhea according to claim 1, it is characterized in that, be made up of the following raw material according to weight portion: Semen Platycladi 22-28 part, Radix Clematidis 12-18 part, Rhizoma Corydalis 12-18 part, Rhizoma Rodgersiae 9-11 part, Poria 9-11 part, Semen Trachyspermi Ammi 9-11 part, Oletum Trogopterori 6-9 part, Rhizoma Ligustici 6-9 part, Cortex Rosae Normalis Radicis 5.5-6.5 part, Flos Magnoliae 5.5-6.5 part, Rhizoma Cyperi 3.5-4.5 part, Semen Vaccariae 3.5-4.5 part, Fructus Evodiae 2.5-3.5 part.
3. according to the Chinese medicine preparation of the arbitrary described treatment dysmenorrhea of claim 1-2, it is characterized in that, be made up of the following raw material according to weight portion: Semen Platycladi 25 parts, Radix Clematidis 15 parts, Rhizoma Corydalis 15 parts, Rhizoma Rodgersiae 10 parts, 10 parts, Poria, Semen Trachyspermi Ammi 10 parts, Oletum Trogopterori 8 parts, Rhizoma Ligustici 8 parts, Cortex Rosae Normalis Radicis 6 parts, Flos Magnoliae 6 parts, Rhizoma Cyperi 4 parts, Semen Vaccariae 4 parts, Fructus Evodiae 3 parts.
4. a preparation method for the Chinese medicine preparation of the treatment dysmenorrhea as described in as arbitrary in claim 1-2, it is characterized in that, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2) Cortex Rosae Normalis Radicis and Fructus Evodiae are cleaned, chopping, strand juice, filter impurity, stays juice for subsequent use;
(3) get Semen Platycladi, Radix Clematidis, Rhizoma Corydalis, Semen Trachyspermi Ammi, Oletum Trogopterori and Rhizoma Ligustici to clean, put into container, add the distilled water of 8-10 times amount, after soaking 2-4h, boil 3-4h, extract; Again add 5-7 times amount distilled water, boil 2-4h, extract; Finally, add 3-5 times amount distilled water, heated and boiled 1-2h, extract; Merge three extracting solution, filter, reserved filtrate is for subsequent use;
(4) get Rhizoma Rodgersiae and Flos Magnoliae to clean, section, dries, puts into mortar, grind into powder, crosses 120-140 order fine powder, for subsequent use;
(5) get Rhizoma Cyperi and Semen Vaccariae is cleaned, immerse the alcohol solution dipping 2-3h of 65% of 5-7 times amount, heated and boiled 1-2h, extract, filter, obtain filtrate for subsequent use;
(6) Poria is pulverized, grind into powder, cross 200-220 order fine powder, for subsequent use;
(7) by juice made for above-mentioned steps (2)-(6), filtrate and fine powder mixing, make peroral dosage form through modern science technique, obtain medicine of the present invention.
5. the preparation method of the Chinese medicine preparation for the treatment of dysmenorrhea according to claim 4, is characterized in that, described peroral dosage form is pill, capsule, tablet, powder, granule or oral liquid.
6. the preparation method of the Chinese medicine preparation for the treatment of dysmenorrhea according to claim 5, is characterized in that, described peroral dosage form is capsule.
7. one kind as arbitrary in claim 1-2 as described in the application of Chinese medicine preparation in preparation treatment dysmenorrhea medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510977319.4A CN105497395A (en) | 2015-12-23 | 2015-12-23 | Traditional Chinese medicine preparation for treating dysmenorrheal as well as preparation method and application of traditional Chinese medicine preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510977319.4A CN105497395A (en) | 2015-12-23 | 2015-12-23 | Traditional Chinese medicine preparation for treating dysmenorrheal as well as preparation method and application of traditional Chinese medicine preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105497395A true CN105497395A (en) | 2016-04-20 |
Family
ID=55705956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510977319.4A Pending CN105497395A (en) | 2015-12-23 | 2015-12-23 | Traditional Chinese medicine preparation for treating dysmenorrheal as well as preparation method and application of traditional Chinese medicine preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105497395A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550339A (en) * | 2013-11-15 | 2014-02-05 | 初艳红 | Traditional Chinese medicine composition for treating primary dysmenorrheal caused by cold coagulation and blood stasis |
| CN103948903A (en) * | 2014-05-14 | 2014-07-30 | 张少林 | Traditional Chinese medicinal composition for treating gynaecological dysmenorrhea |
| CN104367919A (en) * | 2013-08-16 | 2015-02-25 | 李霞 | Menstruation regulating wine |
| CN104958691A (en) * | 2015-06-10 | 2015-10-07 | 张修斗 | Traditional Chinese medicinal composition for treating cold-damp stagnation type dysmenorrhoea, and preparation method thereof |
-
2015
- 2015-12-23 CN CN201510977319.4A patent/CN105497395A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367919A (en) * | 2013-08-16 | 2015-02-25 | 李霞 | Menstruation regulating wine |
| CN103550339A (en) * | 2013-11-15 | 2014-02-05 | 初艳红 | Traditional Chinese medicine composition for treating primary dysmenorrheal caused by cold coagulation and blood stasis |
| CN103948903A (en) * | 2014-05-14 | 2014-07-30 | 张少林 | Traditional Chinese medicinal composition for treating gynaecological dysmenorrhea |
| CN104958691A (en) * | 2015-06-10 | 2015-10-07 | 张修斗 | Traditional Chinese medicinal composition for treating cold-damp stagnation type dysmenorrhoea, and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 南京中医药大学: "《中药大辞典》", 31 March 2006, 上海科学技术出版社 * |
| 尹玲等: "痛经汤治疗原发性痛经83例", 《湖南中医杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101869691B (en) | Chinese medicinal composition for treating dysmenorrhea and preparation method thereof | |
| CN101810833B (en) | Chinese medicinal composition for treating edema and preparation method thereof | |
| CN101766774A (en) | Chinese medicine composite for treating duodenal ulcer and preparation method thereof | |
| CN101961480A (en) | Traditional Chinese medicinal composition for treating hematochezia and preparation method thereof | |
| CN104288426A (en) | Traditional Chinese medicine lotion for treating senile cutaneous pruritus and preparation method thereof | |
| CN102284049A (en) | Traditional Chinese medicine compound preparation for resisting ulcer and relieving chemoradiotherapeutic toxic and side effects, and preparation method and application thereof | |
| CN102793884A (en) | Chinese medical plaster for treating dysmenorrhea and preparation method thereof | |
| CN104491342A (en) | Medicament for treating diabetes and preparation method thereof | |
| CN102423423B (en) | Traditional Chinese medicine for treating urinary tract infection | |
| CN101002848B (en) | Medicine for treating recurrent uarthritis, and its preparing method | |
| CN103356932B (en) | A kind of pharmaceutical composition for the treatment of vulva squamous epithelial hyperplasia | |
| CN104758686A (en) | Traditional Chinese medicine preparation for treating poor sleep quality | |
| CN104547530A (en) | Chinese medicinal composition for treating diabetes | |
| CN104548029A (en) | Pharmaceutical composition for treating epigastric pain | |
| CN102940716A (en) | Traditional Chinese medicine for treatment of uterine prolapse | |
| CN104258074B (en) | A kind of Chinese medicine composition for the treatment of qi stagnation and blood stasis type primary dysmenorrhea | |
| CN103251901B (en) | Oral traditional Chinese medicine preparation for treating dysmenorrhea | |
| CN105343675A (en) | Traditional Chinese medicine preparation for treating adiposis and preparation method thereof | |
| CN102743686B (en) | The scorching clearing capsule of a kind of basin | |
| CN105056077A (en) | Traditional Chinese medicine composition for treating functional dyspepsia | |
| CN105497395A (en) | Traditional Chinese medicine preparation for treating dysmenorrheal as well as preparation method and application of traditional Chinese medicine preparation | |
| CN104906394A (en) | Traditional Chinese medicine for treating liver and kidney yin deficiency and qi and blood deficiency type hypertension | |
| CN104127787A (en) | Traditional Chinese medicinal plaster for treating constipations | |
| CN103720949A (en) | Capsule for relieving constipation and clearing bowels and preparation method thereof | |
| CN104491316B (en) | A kind of Chinese medicine preparation for the treatment of deficiency of QI in middle-JIAO type hyperplasia of prostate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160420 |
|
| RJ01 | Rejection of invention patent application after publication |