CN105496811A - Peeling dentifrice composition and use method thereof - Google Patents

Peeling dentifrice composition and use method thereof Download PDF

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Publication number
CN105496811A
CN105496811A CN201510920596.1A CN201510920596A CN105496811A CN 105496811 A CN105496811 A CN 105496811A CN 201510920596 A CN201510920596 A CN 201510920596A CN 105496811 A CN105496811 A CN 105496811A
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CN
China
Prior art keywords
dentifrice composition
granule
agent
dentifrice
certain embodiments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510920596.1A
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Chinese (zh)
Inventor
T.博伊德
E.阿瓦尼蒂多
J.瓦斯克斯
杨英
Q．C．何
M.霍尔乔斯
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Colgate Palmolive Co
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Colgate Palmolive Co
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Filing date
Publication date
Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co
Priority to CN201510920596.1A priority Critical patent/CN105496811A/en
Priority claimed from CN2009801585857A external-priority patent/CN102378621A/en
Publication of CN105496811A publication Critical patent/CN105496811A/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants

Abstract

The invention relates to a peeling dentifrice composition and a use method thereof. The invention describes a peeling dentifrice composition containing multiple particles and oral cavity-acceptable mediums. The particles contain at least one polymer binder. The composition contains at least one grinding agent with average particle size of 0.01-4mm. The invention further comprises a method using the composition to peel an oral cavity soft tissue.

Description

Fissility dentifrice composition and using method thereof
The application is the applying date is on April 2nd, 2009, application number is 200980158585.7 (international application no is PCT/US2009/039319), and denomination of invention is the divisional application of the application for a patent for invention of " fissility dentifrice composition and using method thereof ".
Background of invention
Mechanical stripping is used for the benefit of skin and epidermis known by personal care field.But the negative effect that the patent and the document that relate to mouth care are paid close attention to " come off (sloughing) " and peel off the sharply increase of speed.Propose the common surfactant that cleans one's teeth and made oral cavity and gastric mucosa discomfort, even thought that it facilitates periodontal disease, because it is said that it causes chronic inflammatory disease and oral mucosa to come off, thus promote the infection that pathogenic microorganism causes.
Chemical stripping known by skin health field, and usually relates to the material that employing can accelerate (desquamination) speed of peeling.Known pH is the activity that the α of 3-4 or beta hydroxy acid can increase the enzyme process in personal care product, but may too aggressivity to oral application.Also report proteolytic enzyme and reduce the purposes in oral biological film, but far away openly as the purposes of soft tissue remover (exfoliant).
Invention summary
Embodiment of the present invention comprise will be provided by the dentifrice composition peeling off the good effect that oral mucosa causes.
Described fissility dentifrice composition contains the acceptable vehicle of multiple granule and oral cavity.Granule comprises at least one polymer adhesive, and compositions comprises the grinding agent that at least one mean diameter is 0.01mm-4mm.Also comprise the method peeling off oral soft tissue by compositions.
Described oral soft tissue stripping system comprises compositions as above and realizes the oral care implement of stripping activity.
Detailed Description Of The Invention
Scope as used in text is write a Chinese character in simplified form as each numerical value be described within the scope of this and each numerical value.Any value within the scope of this can be selected as the end points of this scope.
In certain embodiments, fissility dentifrice composition of the present invention comprises the granule containing thickening agent and plasticity.In certain embodiments, dentifrice composition of the present invention can be applicable to the oral cavity of user, to peel off or to increase the desquamation (desquamation) in oral cavity.
Term " dentifrice " should comprise toothpaste, gutta-percha (gels) and purificant alone or in combination.Dentifrice composition can be any form wanted, such as but not limited to, (deepstriped) with dark striped, (surfacestriped) of belt surface striped, multilamellar or any combination of gutta-percha and toothpaste.The carrier of each component of dentifrice composition can comprise the as described below acceptable vehicle in any oral cavity being applicable to oral cavity.Dentifrice granule is hereafter describing with the vehicle of carrying granule.
In certain embodiments, dentifrice composition comprises granule.
In certain embodiments, granule can comprise at least one thickening agent.The example of thickening agent be suitable for include, but are not limited in hydroxypropyl emthylcellulose (HPMC), hydroxypropyl cellulose (HPC), methylcellulose and corn starch one or more.In certain embodiments, described granule comprises the thickening agent of the amount of 30-95% weight.In other embodiments, granule comprises the thickening agent of the amount of 50-85% weight.In one embodiment, granule comprises the thickening agent of the amount of 75% weight.
In certain embodiments, granule comprises at least one plasticizer.The example of the plasticizer be suitable for includes but not limited to propylene glycol, glycerol and glyceryl triacetate.In certain embodiments, granule comprises the plasticizer of the amount of 5-35% weight.In another embodiment, granule comprises the plasticizer of the amount of 10-20% weight.
In certain embodiments, granule is grinding agent.In certain embodiments, granule comprises physical grinding agent.In certain embodiments, physical grinding agent is silicon dioxide.In certain embodiments, granule comprises the physical grinding agent of the amount of 5-50% weight.In certain embodiments, granule comprises the physical grinding agent of the amount of 15-30% weight.
In certain embodiments, granule exists with the amount of the 1-5% weight of compositions.In certain embodiments, abrasive particles preparation exists with the amount of 1% weight of dentifrice composition.
As used herein, term " the acceptable vehicle in oral cavity " will comprise applicable vehicle, and it can be used to, with safety and effective mode, above-mentioned granule is applied to oral cavity.This kind of vehicle can comprise, but be not limited to, raw material is fluoride ion source, other anti-calculus agent (anti-calculusagents), buffer agent, other grinding-material, peroxide source, alkali metal hydrogencarbonate, thickening material, wetting agent, water, surfactant, taste masking system (navorsystem), sweetener, coloring agent such as, and their mixture.In certain embodiments, vehicle can comprise the usual component of toothpaste, dentifrice, prophylaxis pastes (prophylaxispastes), gutta-percha, purificant, lozenge, gum (gums) etc.
In certain embodiments, the acceptable vehicle in oral cavity comprises water.
The acceptable vehicle in oral cavity also can comprise wetting agent.In certain embodiments, wetting agent comprises glycerol or sorbitol or alkylene glycol such as Polyethylene Glycol or propylene glycol.In certain embodiments, wetting agent exists with the amount of the 15-80% weight of dentifrice composition.In other embodiments, wetting agent is with the existence of the amount of 54-70% weight.
The acceptable vehicle in oral cavity can comprise inorganic or natural or synthetic thickening agent or gellant.In certain embodiments, thickening agent or gellant exist with the amount of 3.5-7% weight.In certain embodiments, the thickening agent containing appropriate amount in dentifrice composition is with suspension abrasive grains or globule.In certain embodiments, the thickening agent containing appropriate amount in dentifrice composition can extrude, keep the product of shape to be formed, and it to be extruded on toothbrush and can not to fall between the bristles in pipe, and will substantially keep its shape thereon on the contrary.The thickening agent be suitable for of dentifrice composition or gellant can comprise inorganic thickening silicas (can trade name Zeodent165 derive from HuberCorporation), Irish moss, chondrus ocellatus Holmes, Tragacanth and polyvinylpyrrolidone.
In certain embodiments, the acceptable vehicle in oral cavity comprises at least one surfactant.The surfactant be suitable for can comprise, but be not limited to, the water soluble salt of higher fatty acids sulfate mono monoglyceride (fattyacidmonoglyceridemonosulfates), the sodium salt of monosulfated (monosulfated) monoglyceride of such as hydrogenated coconut fatty acid oil, cocoamidopropyl (cocamidopropylbetaine), higher alkyl sulfates is sodium lauryl sulfate such as, alkylaryl sulfonates is dodecylbenzene sodium sulfonate such as, higher alkyl sulfoacetates, lauryl sulfoacetate sodium, 1, the high-grade aliphatic ester of 2-dihydroxypropane sulfonate, with the substantially saturated higher aliphatic acylamide (acylamides) of lower aliphatic amino carboxylic acid compound, such as fatty acid, there are in the group such as alkyl or acyl group those amide of 12-16 carbon.The example of amide be suitable for can comprise the sodium of N-lauroyl sarcosine and N-lauroyl sarcosine, N-myristoy sarcosine or N-palmitoyl sarcosine, potassium and ethanolamine salt.
In certain embodiments, surfactant is present in dentifrice composition with the amount of 0.1-5.0% weight.In other embodiments, surfactant is present in dentifrice composition with the amount of 0.45-2.5% weight.In certain embodiments, surfactant is present in dentifrice composition with the amount of 0.45-2.5% weight.
Dentifrice composition also can contain binding agent.The example of the binding agent be suitable for can comprise, but be not limited to, sea rubber body (maiinecolloids), carboxy vinyl polymer, carrageenin, starch, water-soluble cellulose ether such as hydroxyethyl-cellulose, carboxymethyl cellulose (carmellose), hydroxypropyl emthylcellulose and their salt are (such as, carmethose), natural gum is karaya, xanthan gum, Radix Acaciae senegalis and Tragacanth such as, chitosan, colloidal magnesium aluminum silicate and colloidal silica.In certain embodiments, binding agent exists with the amount of the 0.1-0.70% weight of compositions.
Dentifrice composition also can comprise the mixture of correctives or correctives, comprises correctives that is natural or synthesis, such as taste masking oil, taste masking aldehyde, ester, alcohol, similar raw material, and combination.The example of the correctives be suitable for can comprise vanillin, Oleum Menthae Rotundifoliae, Oleum Cinnamomi, wintergreen oil (methyl salicylate), Oleum menthae, Oleum Caryophylli, Oleum Anisi Stellati, Oleum Eucalypti, citrus oils, fruit oil and quintessence oil.In certain embodiments, dentifrice composition comprises correctives such as limonene, menthone, carvone, methanol, anethole, Oleum Eucalypti, eucalyptol, eugenol, Cortex cinnamomi japonici (Ramulus Cinnamomi), oxanone, α-ionone, 1-ethoxy-2-hydroxy-4-propenyl benzene (propenylguaiethol), thymol, linalool, benzaldehyde, cinnamic aldehyde, N-ethyl-p-menthan-3-Methanamide, N-2, 3-trimethyl-2-butanamide, 3, 1-menthoxypropane (menthoxypropane)-1, 2-glycol, cinnamic aldehyde glycerine acetal (CGA), menthone (methone) glycerine acetal (MGA) and eucalyptole.
In certain embodiments, dentifrice composition also can comprise α and beta hydroxy acid.Hydroxy acid can strengthen the effect of the enzyme of the natural generation be present in oral cavity.In certain embodiments, dentifrice composition can comprise hydroxy acid, such as comprises at least one in the salicylic acid of lactic acid, glycolic and neutralization.In other embodiments, dentifrice composition can comprise the trypsin and protease undertaking and decompose ectoderm.
In certain embodiments, dentifrice composition comprises the hydroxy acid of the amount of 0.05-5% weight.In other embodiments, dentifrice composition comprises the hydroxy acid of the amount of 0.1-1% weight.
In certain embodiments, dentifrice composition also can comprise grinding agent.Grinding agent can play the machinery of stripping and the effect of physical instrument and increase coming off of oral mucosa.In certain embodiments, grinding agent distribution is in the acceptable vehicle in oral cavity, or it is present in granule.
In certain embodiments, dentifrice composition comprises silica abrasive.The example of the grinding agent be suitable for comprises, but be not limited to, silica abrasive is precipitated silica, Polymeric sodium metaphosphate., potassium metaphosphate, tricalcium phosphate, Tri-Compress, aluminium silicate, calcined alumina, bentonite or other siliceous material (siliceousmaterials), microgranular thermosetting resin such as tripolycyanamide, phenolic aldehyde and urea aldehyde such as, and crosslinked polyepoxide and polyester.
Grinding agent can exist by any appropriate amount.In certain embodiments, this kind of grinding agent exists with the amount of 1-40% weight.In other embodiments, this kind of grinding agent exists with the amount of 18-20% weight.
In certain embodiments, dentifrice composition comprises grinding globule.The example of the grinding globule obtained by commercial sources be suitable for comprise from those, such as 50.In certain embodiments, the diameter grinding globule is 0.1mm-5mm.In certain embodiments, the diameter grinding globule is 1mm-2mm.In certain embodiments, grind globule to exist with the amount of 0.1-10% weight.In other embodiments, grind globule to exist with the amount of 0.2-3% weight.
For reasons such as preparation, stability, aesthetic feeling, curative effect, consumer's requirements, other additive can be comprised in dentifrice composition.Exemplary additives comprises the dentifrice additives of other all routine, viscosity modifier, diluent, foam modifier, saliva stimulant, desensitizer, brightening agent, enzyme, pH adjusting agent, taste agent, sweeting agent, coloring agent, opacifier and flavorants.Other exemplary agents can comprise chlorite ion's reagent, triclosan, the chloro-2-of 5-(2,4-dichlorophenoxy)-phenol, chlorhexidine, alexidine, hexetidine, Sanguinarine, benzalkonium chloride, N-phenylsalicylamide, domiphen bromide, cetylpyridinium chloride, TPC , chlorination N-myristyl-4-ethylpyridine , octenidine, delmopinol, octapinol, sub-base derivatives of piperidine, nisin, zinc ion agent, stannous ion agent, quintessence oil, furanone, cell wall catabolic enzyme, lysozyme, plaque matrix inhibitors, glucanase, dental plaque glucanase, bacteriocin, people's histatins (histatins), sozin, cecropin, augmentin (augmentin), amoxicillin, tetracycline, doxycycline, minocycline, metronidazole, neomycin, kanamycin, clindamycin, strontium chloride, potassium nitrate, fluoride ion agent, Oleum menthae, chlorophyll, lignocaine, benzocaine, aminoacid and peroxide.
In certain embodiments, dentifrice composition is paste or gutta-percha agent.The thickening agent of appropriate amount can be comprised with particle or grinding globule in dentifrice composition.In certain embodiments, the thickening agent containing appropriate amount in dentifrice composition can extrude to be formed, keep the product of shape, and it can be expressed on toothbrush in pipe, and can not drop between bristle, can substantially keep its shape thereon on the contrary.
Dentifrice composition as above can be applicable to oral soft tissue.In certain embodiments, application dentifrice composition peels off oral mucosa, comprises interior cheek, tongue and gums cell.In certain embodiments, dentifrice composition is peeled off by machinery/physics mode.In certain embodiments, dentifrice composition is peeled off by the desquamation speed in chemical modification oral cavity.In certain embodiments, application dentifrice composition reduces the total bacterial load in saliva, and local cells colony will decline, and no matter is apply or brush teeth.
In certain embodiments, dentifrice composition is applied to oral cavity and below at least one result is provided: clinical minimizing volatile sulfur compounds (VSC) fresh breath that brings produced due to the proteoclastic bacterial metabolism of oral cavity anaerobium; Due to the antibacterial effect that the minimizing of whole oral cavity bacterium and tongue/interior cheek antibacterial brings; Because making relative cell age decline " the young oral cavity " of bringing by old and feeble technology; Inflammation alleviates; Chewing gum stimulation causes blood flow to increase to chewing gum, thus increases salivary flow; Reduce the formation of bacterial plaque on tongue rear portion; Improve " breathing " ability of mucosa; Improve the deposition of other composition; Increase the retention time of deposition activity; With alleviation halitosis/implication in morning.Therefore, available dentifrice composition keeps oral health and treatment and prevention oral disease.
In certain embodiments, dentifrice composition can comprise granule and α or beta hydroxy acid.In certain embodiments, the combination of granule and α or beta hydroxy acid is worked in coordination with and is peeled off and increase coming off of oral mucosa.
In certain embodiments, dentifrice composition is toothpaste and/or gutta-percha.
The stripping system of oral soft tissue is also included within embodiment of the present invention.This system can comprise the fissility dentifrice composition of any version as above, and dentifrice is applied to the oral care implement of oral soft tissue.Such as, oral care implement can be tongue cleaner, toothbrush, swab, sponge, fingerstall, cotton swab (stick), dens supporter and grinding belt (strip).Described instrument can by any material known in the art, and such as, plastics, resin, timber, fabric, polymer, sponge, paper, paper tinsel, thin film, metal and rubber are obtained.It is any known or exploitation that the oral care implement be contained in system can be this area.If wanted, people can wish to comprise such oral care implement, and it comprises peels off dentifrice and may be put in reservoir wherein or on it, cavity or other space.
EXPERIMENTAL EXAMPLESThe
embodiment 1: granular preparation
Table 1: peel off or increase the granular preparation come off
Composition Granule A, wt% Granule B, wt% Granule C, wt%
Particle mean size 1mm 0.75mm 0.1mm
Hydroxypropyl emthylcellulose 50 35 0
Hydroxypropyl cellulose (HPC) 0 0 60
Methylcellulose 0 20 0
Corn starch 0 30 15
Silicon dioxide, AC43 30 0 15
Plasticizer is as propylene glycol, glycerol, glyceryl triacetate etc. 20 15 10
Add up to 100 100 100
According to the granule that above formula is preparation following examples.
embodiment 2: the dentifrice composition containing 1% granule A
Dentifrice composition is prepared according to following formula:
Table 2: the sample containing 1% granule A
Composition % weight
Sodium CMC 0.65
Macrogol 600 (PEG-12) 3.0
Sorbitol 55.441
Saccharin sodium 0.3
Sodium fluoride 0.24
Tetrasodium pyrophosphate 0.5
Blue #1 dyestuff (1% in water) of FD&C 0.4
Silica abrasive (Zeodent 115) 20
Silicon dioxide thickening agents (Zeodent 165) 4.25
Taste masking oil 1.15
Sodium lauryl sulfate, 100% 1.5
Cocoamidopropyl 0.45
Granule A 1.0
Water Q.S.
embodiment 3: the dentifrice composition containing 3% granule B
Dentifrice composition is prepared according to following formula:
Table 3: the sample containing 3% granule B
embodiment 4: the dentifrice composition containing 5% granule C
Dentifrice composition is prepared according to the formula in table 4.
Table 4: the sample containing 5% granule C

Claims (10)

1. a fissility dentifrice composition, it comprises:
(A) multiple granule, granule wherein comprises at least one polymer adhesive and is selected from the plasticizer of propylene glycol, glycerol and glyceryl triacetate; With
(B) the acceptable vehicle in oral cavity,
At least one in the acceptable vehicle of wherein said granule and oral cavity also comprises the grinding agent that at least one has 0.01mm-4mm mean diameter, and wherein said compositions also comprises hydroxy acid,
Preferred granule wherein also comprises the thickening agent being selected from hydroxypropyl emthylcellulose, hydroxypropyl cellulose (HPC), methylcellulose and corn starch,
Preferred wherein said at least one grinding agent comprises silicon dioxide.
2. the dentifrice composition of claim 1, hydroxy acid is wherein selected from lactic acid and glycolic.
3. the dentifrice of claim 1, it also comprises proteolytic enzyme.
4. the dentifrice of claim 1, it also comprises and is selected from chlorite ion's reagent, triclosan, the chloro-2-of 5-(2,4-dichlorophenoxy)-phenol, chlorhexidine, alexidine, hexetidine, Sanguinarine, benzalkonium chloride, N-phenylsalicylamide, domiphen bromide, cetylpyridinium chloride, TPC chlorination N-myristyl-4-ethylpyridine the material of octenidine, delmopinol, octapinol, sub-base derivatives of piperidine, nisin, zinc ion agent, stannous ion agent, quintessence oil, furanone, cell wall catabolic enzyme and lysozyme.
5. the dentifrice of claim 1, it also comprises the material being selected from plaque matrix inhibitors, glucanase, change dextranase, bacteriocin, people's histatins, sozin, cecropin, augmentin, amoxicillin, tetracycline, doxycycline, minocycline, metronidazole, neomycin, kanamycin, clindamycin, strontium chloride, potassium nitrate, fluoride ion agent, Oleum menthae, chlorophyll, lignocaine, benzocaine, aminoacid and peroxide.
6. fissility dentifrice composition is preparing the purposes in medicine as defined in claim 1, and described medicine is for peeling off oral soft tissue.
7. peel off a system for oral soft tissue, it comprises:
(A) oral care implement, and
(B) fissility dentifrice composition according to claim 1.
8. the system of claim 7, oral care implement is wherein selected from tongue cleaner, toothbrush, swab, sponge, fingerstall, cotton swab, dens supporter and grinding belt.
9. the system of claim 7, oral care implement wherein comprises the reservoir putting into fissility dentifrice composition.
10. the system of claim 7, oral care implement wherein comprises the material being selected from plastics, resin, timber, fabric, polymer, sponge, paper, paper tinsel, thin film, metal and rubber.
CN201510920596.1A 2009-04-02 2009-04-02 Peeling dentifrice composition and use method thereof Pending CN105496811A (en)

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CN201510920596.1A CN105496811A (en) 2009-04-02 2009-04-02 Peeling dentifrice composition and use method thereof
CN2009801585857A CN102378621A (en) 2009-04-02 2009-04-02 Exfoliating dentifrice composition and method of use

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Publication number Priority date Publication date Assignee Title
CN108210376A (en) * 2018-04-04 2018-06-29 杭州纳美智康科技有限公司 A kind of tooth-caring toothpaste and preparation method thereof
WO2022062300A1 (en) * 2020-09-23 2022-03-31 Shandong Benzhen Cosmetics Co., Ltd Surfactant-free foamable oral care composition

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108210376A (en) * 2018-04-04 2018-06-29 杭州纳美智康科技有限公司 A kind of tooth-caring toothpaste and preparation method thereof
WO2022062300A1 (en) * 2020-09-23 2022-03-31 Shandong Benzhen Cosmetics Co., Ltd Surfactant-free foamable oral care composition

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Application publication date: 20160420