CN105486683A - Mycobacterium tuberculosis screening system and method - Google Patents
Mycobacterium tuberculosis screening system and method Download PDFInfo
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- CN105486683A CN105486683A CN201511005737.3A CN201511005737A CN105486683A CN 105486683 A CN105486683 A CN 105486683A CN 201511005737 A CN201511005737 A CN 201511005737A CN 105486683 A CN105486683 A CN 105486683A
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Abstract
The invention provides a mycobacterium tuberculosis screening system and a mycobacterium tuberculosis screening method. The system comprises a microscopic scanner and a control terminal, wherein the microscopic scanner comprises a scanner body, a controller group and a main controller; each controller in the controller group is connected with the main controller; a light path is formed by a light source device in the scanner body, a platform for storing slices, an objective lens group, a third reflection mirror group, a second auxiliary lens group and a microscopic camera; a platform movement controller in the controller group is connected with the platform and is used for controlling the movement of the platform; an objective lens switching or up-down movement controller in the controller group is connected with the objective lens group and is used for controlling the switching of all objective lenses in the objective lens group, and the up-down movement of all the objective lenses, so that the mycobacterium tuberculosis screening system can be used for automatically scanning and imaging the slices with phlegm of patients, and automatically analyzing images to determine whether the patients have tuberculosis or not; and the participation of a large number of basic detection personnel is avoided, the detection efficiency is improved and the detection cost is reduced.
Description
Technical field
The present invention relates to light technical field, particularly relate to a kind of tubercle bacillus screening system and method.
Background technology
China is that 22 tuberculosis height bear one of country in the world, and the population of China about 1/3rd has infected tubercle bacillus.According to the study, by the crowd of mycobacterium tuberculosis infection, the people of 10 can develop into tuberculosis.Therefore, tuberculosis effectively verified, diagnose, treat and prevention is current problems faced.
It is make a definite diagnosis method lungy that tubercle bacillus checks, finds tubercle bacillus to be make a definite diagnosis Main Basis lungy in phlegm.At present, the microscope that mainly employing is traditional is coated with section to phlegm and observes, and checks phlegm is coated with in section whether have tubercle bacillus, and more than 300 the phlegm painting section through observation patient determines whether patient is tuberculosis patient.
But in prior art, adopt traditional microscope to be coated with section to phlegm by basic unit testing staff and observe, working strength is large, and easily undetected, checking efficiency is low and cost is high.
Summary of the invention
The invention provides a kind of tubercle bacillus screening system and method, for solving the low and problem that cost is high of tubercle bacillus screening efficiency in prior art.
First aspect of the present invention is to provide a kind of tubercle bacillus screening system, comprising:
Microscan instrument and control terminal; Described microscan instrument is connected with described control terminal; Described control terminal is used for described microscan instrument sending controling instruction, and scans according to described microscan instrument the sectioning image obtained and carry out tubercle bacillus examination;
Wherein, described microscan instrument comprises: scanner body, controller group and master controller; Each controller in described controller group is connected with described master controller;
Described scanner body comprises: light supply apparatus, for placing the platform of section, objective lens, the 3rd reflective mirror group, the second auxiliary mirror group and micro-camera; Described micro-camera is connected with described control terminal;
Wherein, by described light supply apparatus, form light path for placing the platform of section, objective lens, the 3rd reflective mirror group, the second auxiliary mirror group and micro-camera;
Described controller group comprises: platform movement controller, object lens switch or the controller that moves up and down;
Described platform movement controller is connected with described platform, for controlling the movement of described platform according to the steering order of described master controller;
Described object lens switch or the controller that moves up and down is connected with described objective lens, for controlling the switching in described objective lens between each object lens according to the steering order of described master controller, and the moving up and down of each object lens in described objective lens.
Further, described microscan instrument also comprises: the first attachment lens group and the second attachment lens group;
Described controller group also comprises: lens switch controller;
By described light supply apparatus, for placing the platform of section, objective lens, the 3rd reflective mirror group, the second auxiliary mirror group, the first attachment lens group or the second attachment lens group, micro-camera forms light path;
Described lens switch controller is connected with described master controller, described first attachment lens group and described second attachment lens group, controls described first attachment lens group and described second switching of attachment lens group in described light path for the steering order according to described master controller.
Further, described microscan instrument also comprises: be arranged on the first Slide Group in described first attachment lens group, the second Slide Group, the transmission group be arranged in described second attachment lens group;
Described transmission group is connected with described first Slide Group, described second Slide Group and described lens switch controller, for driving described first Slide Group to drive described first attachment lens group to slide under the control of described lens switch controller, or described second Slide Group is driven to drive described second attachment lens group to slide.
Further, described microscan instrument also comprises: the 4th reflective mirror group and eyepiece device;
Described eyepiece device comprises: the first reflective mirror group, the first auxiliary mirror group, the second reflective mirror group, turn to prism and eyepiece;
By described light supply apparatus, for place section platform, objective lens, the 3rd reflective mirror group, the second auxiliary mirror group, the 4th reflective mirror group, the first reflective mirror group, the first auxiliary mirror group, the second reflective mirror group, turn to prism and eyepiece to form light path;
Described lens switch controller is connected with described 4th reflective mirror group, controls described 4th switching of reflective mirror group in light path for the steering order according to described master controller.
Further, described microscan instrument also comprises: be arranged on the 3rd Slide Group in described 4th reflective mirror group;
Described transmission group is connected with described 3rd Slide Group, drives described 4th reflective mirror group to slide for driving described 3rd Slide Group under the control of described lens switch controller.
Further, described microscan instrument also comprises: fluorescent apparatus;
Described controller group also comprises: light source switch controller;
Described light source switch controller is connected with described fluorescent apparatus, described light supply apparatus, described master controller, for controlling unlatching or the closedown of described fluorescent apparatus and described light supply apparatus according to the steering order of described master controller.
Further, described microscan instrument also comprises: section box, automatic threading device that at least one section is housed;
Described automatic threading device is connected with described section box and described master controller, cuts into slices for capturing from described section box and is placed into described platform.
Further, described microscan instrument also comprises: panorama camera;
Described panorama camera is arranged on the top of described platform, is connected with described control terminal, and for taking pictures to the panorama camera on described platform, and the image obtained taking pictures is sent to described control terminal.
In the present invention, a kind of tubercle bacillus screening system is provided, comprises: microscan instrument and control terminal; Microscan instrument is connected with control terminal; Control terminal is used for microscan instrument sending controling instruction, and scans according to microscan instrument the sectioning image obtained and carry out tubercle bacillus examination; Wherein, microscan instrument comprises: scanner body, controller group and master controller; Each controller in controller is connected with master controller; By the light supply apparatus in scanner body, form light path for placing the platform of section, objective lens, the 3rd reflective mirror group, the second auxiliary mirror group and micro-camera; Controller group comprises: platform movement controller, object lens switch or the controller that moves up and down; Platform movement controller is connected with platform, for the movement of the steering order parametric controller according to master controller; Object lens switch or the controller that moves up and down is connected with objective lens, for controlling the switching in objective lens between each object lens according to the steering order of master controller, and the moving up and down of each object lens in objective lens, thus realize tubercle bacillus screening system and autoscan imaging is carried out to the section be coated with patient's phlegm and image is carried out to automatic analysis to determine whether patient suffers from tuberculosis, avoid a large amount of participations of basic unit testing staff, improve checking efficiency and reduce check cost.
Second aspect of the present invention is to provide a kind of tubercle bacillus screening method, comprising:
Control terminal is to the master controller sending controling instruction in microscan instrument;
Described master controller switches or the controller sending controling instruction that moves up and down to the platform movement controller in microscan instrument, object lens;
Described platform movement controller drives described platform movement according to described steering order, makes the objective lens above the slice alignment platform on described platform;
Described object lens switch or the controller that moves up and down drives the object lens in described objective lens to carry out switching or moving up and down according to described steering order, focus, with make the micro-camera in described microscan instrument to through focusing and amplify section scan, obtain sectioning image;
Control terminal identifies described sectioning image, obtains the tubercle bacillus quantity in described sectioning image, determines whether patient suffers from tuberculosis according to the tubercle bacillus quantity in described sectioning image.
Further, described method also comprises:
Described control terminal sends lens switching command according to the operation of user to the master controller in microscan instrument;
Described master controller according to described lens switching command to the lens switch controller sending controling instruction in microscan instrument;
Described lens switch controller drives the attachment lens group on the light path path between micro-camera and objective lens to switch according to described steering order, scans the switching of multiple to realize cutting into slices.
In the present invention, control terminal is to the master controller sending controling instruction in microscan instrument; Master controller switches or the controller sending controling instruction that moves up and down to the platform movement controller in microscan instrument, object lens; Platform movement controller drives platform movement according to steering order, makes the objective lens above the slice alignment platform on platform; Object lens switch or the controller that moves up and down drives the object lens in objective lens to carry out switching or moving up and down according to steering order, focus, with make the micro-camera in microscan instrument to through focusing and the section of amplifying scan, obtain sectioning image; Control terminal identifies sectioning image, obtain the tubercle bacillus quantity in sectioning image, determine whether patient suffers from tuberculosis according to the tubercle bacillus quantity in sectioning image, thus realize tubercle bacillus screening system and autoscan imaging is carried out to the section be coated with patient's phlegm and image is carried out to automatic analysis to determine whether patient suffers from tuberculosis, avoid a large amount of participations of basic unit testing staff, improve checking efficiency, reduce check cost.
Accompanying drawing explanation
Fig. 1 is the structural representation of a tubercle bacillus screening system provided by the invention embodiment;
Fig. 2 is the vertical view of microscan instrument in tubercle bacillus screening system provided by the invention;
Fig. 3 is the partial schematic diagram of lens switch controller in microscan instrument;
Fig. 4 is the front elevation of microscan instrument in tubercle bacillus screening system provided by the invention;
Fig. 5 is the side view of microscan instrument in tubercle bacillus screening system provided by the invention;
Fig. 6 is the process flow diagram of a tubercle bacillus screening method provided by the invention embodiment;
Fig. 7 is the process flow diagram of another embodiment of tubercle bacillus screening method provided by the invention.
Reference numeral:
1-microscan instrument; 2-control terminal; 11-scanner body; 12-controller group; 13-master controller; 14-first attachment lens group; 15-second attachment lens group; 16-first Slide Group; 17-second Slide Group; 18-transmission group; 19-the 4th reflective mirror group; 20-eyepiece device; 21-the 3rd Slide Group; 22-fluorescent apparatus; 23-cuts into slices box; 24-automatic threading device; 25-panorama camera; 111-light supply apparatus; 112-is for placing the platform of section; 113-objective lens; 114-the 3rd reflective mirror group; 115-second auxiliary mirror group; The micro-camera of 116-; 201-first reflective mirror group; 202-first auxiliary mirror group; 203-second reflective mirror group; 204-turns to prism; 205-eyepiece; 121-platform movement controller; 122-object lens switch or the controller that moves up and down; 123-lens switch controller; 124-light source switch controller.
Embodiment
For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with the accompanying drawing in the embodiment of the present invention, technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Fig. 1 is the structural representation of a tubercle bacillus screening system provided by the invention embodiment, as shown in Figure 1, comprising:
Microscan instrument 1 and control terminal 2; Microscan instrument 1 is connected with control terminal 2; Control terminal 2 for microscan instrument 1 sending controling instruction, and scans according to microscan instrument 1 sectioning image obtained and carries out tubercle bacillus examination;
Wherein, microscan instrument 1 comprises: scanner body 11, controller group 12 and master controller 13; Each controller in controller group 12 is connected with master controller 13;
Scanner body 11 comprises: light supply apparatus 111, for placing platform 112, objective lens 113, the 3rd reflective mirror group 114, second auxiliary mirror group 115 and the micro-camera 116 of section; Micro-camera 116 is connected with control terminal 2;
Wherein, by light supply apparatus 111, form light path for placing the platform 112 of section, objective lens 113, the 3rd reflective mirror group 114, second auxiliary mirror group 115 and micro-camera 116;
Controller group 12 comprises: platform movement controller 121, object lens switch or the controller 122 that moves up and down;
Platform movement controller 121 is connected with platform 112, for the movement of the steering order parametric controller 112 according to master controller 13;
Object lens switch or the controller 122 that moves up and down is connected with objective lens 113, for according to the switching in the steering order of master controller 13 control objective lens 113 between each object lens, and the moving up and down of each object lens in objective lens 113.
Further, in conjunction with the vertical view with reference to figure 2, Fig. 2 being microscan instrument in tubercle bacillus screening system provided by the invention, microscan instrument also comprises: the first attachment lens group 14 and the second attachment lens group 15; Controller group 12 also comprises: lens switch controller 123;
By light supply apparatus 111, for placing the platform 112 of section, objective lens 113, the 3rd reflective mirror group 114, second auxiliary mirror group 115, first attachment lens group 14 or the second attachment lens group 15, micro-camera 116 forms light path;
Lens switch controller 123 is connected with master controller 13, first attachment lens group 14 and the second attachment lens group 15, for controlling the first attachment lens group 14 and the second switching of attachment lens group 15 in light path according to the steering order of master controller 13.
Wherein, in conjunction with reference to figure 3, Fig. 3 is the partial schematic diagram of lens switch controller in microscan instrument, and as shown in Figure 3, microscan instrument also comprises: be arranged on the first Slide Group 16 in the first attachment lens group, the second Slide Group 17, the transmission group 18 be arranged in the second attachment lens group;
Transmission group 18 is connected with the first Slide Group 16, second Slide Group 17 and lens switch controller 123, for driving the first Slide Group 16 to drive the first attachment lens group 14 to slide under the control of lens switch controller 123, or the second Slide Group 17 is driven to drive the second attachment lens group 15 to slide.
Further, in conjunction with the front elevation with reference to figure 2, Fig. 3 and Fig. 4, Fig. 4 being microscan instrument in tubercle bacillus screening system provided by the invention, microscan instrument also comprises: the 4th reflective mirror group 19 and eyepiece device 20;
Eyepiece device comprises: the first reflective mirror group 201, first auxiliary mirror group 202, second reflective mirror group 203, turn to prism 204 and eyepiece 205;
By light supply apparatus 111, for place section platform 112, objective lens 113, the 3rd reflective mirror group 114, second auxiliary mirror group 115, the 4th reflective mirror group 19, first reflective mirror group 201, first auxiliary mirror group 202, second reflective mirror group 203, turn to prism 204 and eyepiece 205 to form light path;
Lens switch controller 123 is connected with the 4th reflective mirror group 19, controls the 4th switching of reflective mirror group 19 in light path for the steering order according to master controller 13.
Wherein, control terminal can be provided with operation interface, so that user selects enlargement factor or microscan instrument use-pattern on operation interface, control terminal is determined to select the 4th reflective mirror group, the first attachment lens group or the second attachment lens group according to the selection of user, and to lens switch controller sending controling instruction, so that lens switch controller carries out the switching of the 4th reflective mirror group, the first attachment lens group or the second attachment lens group.
Further, in conjunction with reference to figure 3, microscan instrument 1 also comprises: be arranged on the 3rd Slide Group 21 in the 4th reflective mirror group;
Transmission group 18 is connected with the 3rd Slide Group 21, drives the 4th reflective mirror group 19 to slide for driving the 3rd Slide Group 21 under the control of lens switch controller 123.
Further, in conjunction with reference to figure 2, microscan instrument also comprises: fluorescent apparatus 22;
Controller group also comprises: light source switch controller 124;
Light source switch controller 124 is connected with fluorescent apparatus 22, light supply apparatus 111, master controller 13, for controlling unlatching or the closedown of fluorescent apparatus 22 and light supply apparatus 111 according to the steering order of master controller 13.
Further, in conjunction with reference to figure 2, microscan instrument 1 also comprises: section box 23, automatic threading device 24 that at least one section is housed;
Automatic threading device 24 is connected with section box 23 and master controller 13, cuts into slices for capturing from section box 23 and is placed into platform 112.
Wherein, in section box 23, a large amount of section can be placed, such as more than 400 section, so that automatic threading device 24 captures.The setting of section box 23 and automatic threading device 24, makes the tubercle bacillus screening system of the present embodiment automatically can carry out examination one by one to a large amount of section, improves screening efficiency.
Wherein, light supply apparatus 111 is arranged on the below of platform; The light emission direction of light supply apparatus 111 can object platform.When cutting into slices for acid-fast stain when cutting into slices, light supply apparatus is that the section be placed on platform is thrown light on, and light reflexes to the second auxiliary mirror group by objective lens through the 3rd reflective mirror group; Light is passed to micro-camera through the 4th reflective mirror group, the first attachment lens group or the second attachment lens group by the second auxiliary mirror group, carries out section amplify capture to make micro-camera by light; Or light is reflexed to the first reflective mirror group through the 4th reflective mirror group by the second auxiliary mirror group, first reflective mirror group is by light reflection to the first auxiliary mirror group, and reflex to through the second reflective mirror group and turn to prism, through turning to the scattering of prism to arrive eyepiece, so that user observes.
The light emission direction of fluorescent apparatus 22 can towards the 3rd reflective mirror group.When cutting into slices for fluorescent dye when cutting into slices, 3rd reflective mirror group can by the light reflection of fluorescent apparatus to objective lens, by objective lens light is sent to the section on platform, light is passed to the 4th reflective mirror group, the first attachment lens group or the second attachment lens group by objective lens and the 3rd reflective mirror group, the second auxiliary mirror group by the fluorescent dye part of the section on platform, and then arrives eyepiece or micro-camera.
Further, in conjunction with the side view with reference to figure 5, Fig. 5 being microscan instrument in tubercle bacillus screening system provided by the invention, as shown in Figure 5, microscan instrument also comprises: panorama camera 25;
Panorama camera 25 is arranged on the top of platform 112, is connected with control terminal 2, and for taking pictures to the panorama camera 25 on platform 112, and the image obtained taking pictures is sent to control terminal 2.
Wherein, panorama camera can under the control of master controller fast fetching picture, the image of section is presented on the operation interface of control terminal by master controller, so that according to the image of section, user determines that section is for acid-fast stain section or fluorescent dye section, and then select the unlatching of fluorescent apparatus or light supply apparatus; Or sectioning image can be sent to control terminal by master controller, sectioning image mates with the sectioning image prestored by control terminal, determine that section is for acid-fast stain section or fluorescent dye section, and then send switching command by master controller to light source switch controller according to matching result, so that light source switch controller selects the unlatching of fluorescent apparatus or light supply apparatus.
In the present embodiment, a kind of tubercle bacillus screening system is provided, comprises: microscan instrument and control terminal; Microscan instrument is connected with control terminal; Control terminal is used for microscan instrument sending controling instruction, and scans according to microscan instrument the sectioning image obtained and carry out tubercle bacillus examination; Wherein, microscan instrument comprises: scanner body, controller group and master controller; Each controller in controller is connected with master controller; By the light supply apparatus in scanner body, form light path for placing the platform of section, objective lens, the 3rd reflective mirror group, the second auxiliary mirror group and micro-camera; Controller group comprises: platform movement controller, object lens switch or the controller that moves up and down; Platform movement controller is connected with platform, for the movement of the steering order parametric controller according to master controller; Object lens switch or the controller that moves up and down is connected with objective lens, for controlling the switching in objective lens between each object lens according to the steering order of master controller, and the moving up and down of each object lens in objective lens, thus realize tubercle bacillus screening system and autoscan imaging is carried out to the section be coated with patient's phlegm and image is carried out to automatic analysis to determine whether patient suffers from tuberculosis, avoid a large amount of participations of basic unit testing staff, improve checking efficiency and reduce check cost.
Fig. 6 is the process flow diagram of a tubercle bacillus screening method provided by the invention embodiment, as shown in Figure 6, comprising:
601, control terminal is to the master controller sending controling instruction in microscan instrument.
602, master controller switches or the controller sending controling instruction that moves up and down to the platform movement controller in microscan instrument, object lens.
603, platform movement controller drives platform movement according to steering order, makes the objective lens above the slice alignment platform on platform.
604, object lens switching or the controller that moves up and down drive the object lens in objective lens to carry out switching or moving up and down according to steering order, focus, with make the micro-camera in microscan instrument to through focusing and amplify section scan, obtain sectioning image.
605, control terminal identifies sectioning image, obtains the tubercle bacillus quantity in sectioning image, determines whether patient suffers from tuberculosis according to the tubercle bacillus quantity in sectioning image.
Further, described method also comprises: control terminal sends lens switching command according to the operation of user to the master controller in microscan instrument;
Master controller according to lens switching command to the lens switch controller sending controling instruction in microscan instrument;
Lens switch controller drives the attachment lens group on the light path path between micro-camera and objective lens to switch according to steering order, scans the switching of multiple to realize cutting into slices.
In the present embodiment, control terminal is to the master controller sending controling instruction in microscan instrument; Master controller switches or the controller sending controling instruction that moves up and down to the platform movement controller in microscan instrument, object lens; Platform movement controller drives platform movement according to steering order, makes the objective lens above the slice alignment platform on platform; Object lens switch or the controller that moves up and down drives the object lens in objective lens to carry out switching or moving up and down according to steering order, focus, with make the micro-camera in microscan instrument to through focusing and the section of amplifying scan, obtain sectioning image; Control terminal identifies sectioning image, obtain the tubercle bacillus quantity in sectioning image, determine whether patient suffers from tuberculosis according to the tubercle bacillus quantity in sectioning image, thus realize tubercle bacillus screening system and autoscan imaging is carried out to the section be coated with patient's phlegm and image is carried out to automatic analysis to determine whether patient suffers from tuberculosis, avoid a large amount of participations of basic unit testing staff, improve checking efficiency and reduce check cost.
Fig. 7 is the process flow diagram of another embodiment of tubercle bacillus screening method provided by the invention, as shown in Figure 7, comprising:
701, make phlegm and be coated with section.
702,400 multiple phlegm are coated with section to be placed in section box, section box are placed in automatic threading device or automatic threading machine.
703, automatic threading device or automatic threading machine automatically load individual phlegm and are coated with section on the platform in microscan instrument.
704, the panorama camera be placed in above platform is coated with section to the phlegm on platform and takes.
705, the image of shooting is sent to control terminal by panorama camera.
706, control terminal adopts barcode scanner to scan the bar code that phlegm is coated with slicing edge setting, obtains the relevant information that phlegm is coated with patient corresponding to section.
707, control terminal adopts image recognizer to identify phlegm painting section, and determining that phlegm is coated with section is fluorescent dye section or acid-fast stain section, if fluorescent dye section, performs step 708; If acid-fast stain is cut into slices, perform step 709.
708, adopt micro-camera to be coated with section to phlegm and carry out fluorescent scanning; Perform step 710.
Wherein, adopt micro-camera to be coated with to phlegm the process of carrying out fluorescent scanning of cutting into slices and be specifically as follows, the enlargement factor of attachment lens is switched to 20 times; The object lens of objective lens carry out auto-focusing; Micro-camera carries out coarse scan or tubercle bacillus identification under 20 times of enlargement factors; Add up suspicious tubercle bacillus quantity; If tubercle bacillus quantity is greater than zero, then the enlargement factor of attachment lens is switched to 40 times; Scan present viewing field or carry out bacillus identification; If tubercle bacillus quantity is more than or equal to designated value, be then diagnosed as tuberculosis; If tubercle bacillus is less than designated value, then move to the next visual field, rescan present viewing field or carry out bacillus identification.
In addition, if the suspicious tubercle bacillus quantity of statistics is zero, then non-tuberculosis is diagnosed as.
709, adopt micro-camera to be coated with section to phlegm and carry out light field scanning; Perform step 710.
Wherein, adopt micro-camera to be coated with to phlegm the process of carrying out light field scanning of cutting into slices and be specifically as follows, auto-focusing, adopts 100 times and scans or carry out bacillus identification; If tubercle bacillus quantity is more than or equal to designated value, be then diagnosed as tuberculosis; If tubercle bacillus quantity is less than designated value, then change the visual field, re-start 100 times and scan or carry out bacillus identification.
710, be coated with the quantity of the tubercle bacillus in section according to microscan image determination phlegm, the quantity according to tubercle bacillus is diagnosed.
If the quantity of 711 tubercle bacilluses is greater than preset value, then patient diagnosed suffers from tuberculosis; If the quantity of tubercle bacillus is less than preset value, be then defined as doubtful bacillus.
712, set up bacillus database, bacillus database comprises: phlegm is coated with microscan image and the diagnostic result of section.
713, automatic threading machine or automatic threading device carry out section recovery, and judge whether to proceed scanning; If proceed scanning, then perform step 703; If do not proceed scanning, then auxiliary diagosis can be carried out.
Wherein, the process of carrying out auxiliary diagosis can be, for local user or long-distance user, relevant information according to local user or long-distance user inquires about bacillus database, obtain local user or phlegm corresponding to long-distance user is coated with section scan image, be coated with section scan image according to phlegm and carry out bacillus confirmation.If can not confirm, then automatically load relevant phlegm and be coated with section from entering sheet machine and carry out eyepiece location and eyepiece and observe, confirm; After having confirmed, control terminal carries out intelligent learning, upgrades diagnostic result; Judge whether to proceed diagosis; If proceed, then open local user or other phlegm corresponding to long-distance user is coated with section scan image, and carry out bacillus confirmation; If do not proceed, then complete auxiliary diagosis.
In the present embodiment, automatic threading device or automatic threading machine automatically load individual phlegm and are coated with section on the platform in microscan instrument, the panorama camera be placed in above platform is coated with section to the phlegm on platform and takes and send to control terminal, control terminal adopts image recognizer to be coated with section to phlegm and identifies, determining that phlegm is coated with section is fluorescent dye section or acid-fast stain section, and carry out fluorescent scanning or light field scanning according to determination result, the quantity of the tubercle bacillus in section is coated with according to microscan image determination phlegm, quantity according to tubercle bacillus is diagnosed, thus realize tubercle bacillus screening system and autoscan imaging is carried out to the section be coated with patient's phlegm and image is carried out to automatic analysis to determine whether patient suffers from tuberculosis, avoid a large amount of participations of basic unit testing staff, improve checking efficiency and reduce check cost.
One of ordinary skill in the art will appreciate that: all or part of step realizing above-mentioned each embodiment of the method can have been come by the hardware that programmed instruction is relevant.Aforesaid program can be stored in a computer read/write memory medium.This program, when performing, performs the step comprising above-mentioned each embodiment of the method; And aforesaid storage medium comprises: ROM, RAM, magnetic disc or CD etc. various can be program code stored medium.
Last it is noted that above each embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to foregoing embodiments to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein some or all of technical characteristic; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.
Claims (10)
1. a tubercle bacillus screening system, is characterized in that, comprising:
Microscan instrument and control terminal; Described microscan instrument is connected with described control terminal; Described control terminal is used for described microscan instrument sending controling instruction, and scans according to described microscan instrument the sectioning image obtained and carry out tubercle bacillus examination;
Wherein, described microscan instrument comprises: scanner body, controller group and master controller; Each controller in described controller group is connected with described master controller;
Described scanner body comprises: light supply apparatus, for placing the platform of section, objective lens, the 3rd reflective mirror group, the second auxiliary mirror group and micro-camera; Described micro-camera is connected with described control terminal;
Wherein, by described light supply apparatus, form light path for placing the platform of section, objective lens, the 3rd reflective mirror group, the second auxiliary mirror group and micro-camera;
Described controller group comprises: platform movement controller, object lens switch or the controller that moves up and down;
Described platform movement controller is connected with described platform, for controlling the movement of described platform according to the steering order of described master controller;
Described object lens switch or the controller that moves up and down is connected with described objective lens, for controlling the switching in described objective lens between each object lens according to the steering order of described master controller, and the moving up and down of each object lens in described objective lens.
2. system according to claim 1, is characterized in that, described microscan instrument also comprises: the first attachment lens group and the second attachment lens group;
Described controller group also comprises: lens switch controller;
By described light supply apparatus, for placing the platform of section, objective lens, the 3rd reflective mirror group, the second auxiliary mirror group, the first attachment lens group or the second attachment lens group, micro-camera forms light path;
Described lens switch controller is connected with described master controller, described first attachment lens group and described second attachment lens group, controls described first attachment lens group and described second switching of attachment lens group in described light path for the steering order according to described master controller.
3. system according to claim 2, is characterized in that, described microscan instrument also comprises: be arranged on the first Slide Group in described first attachment lens group, the second Slide Group, the transmission group be arranged in described second attachment lens group;
Described transmission group is connected with described first Slide Group, described second Slide Group and described lens switch controller, for driving described first Slide Group to drive described first attachment lens group to slide under the control of described lens switch controller, or described second Slide Group is driven to drive described second attachment lens group to slide.
4. system according to claim 3, is characterized in that, described microscan instrument also comprises: the 4th reflective mirror group and eyepiece device;
Described eyepiece device comprises: the first reflective mirror group, the first auxiliary mirror group, the second reflective mirror group, turn to prism and eyepiece;
By described light supply apparatus, for place section platform, objective lens, the 3rd reflective mirror group, the second auxiliary mirror group, the 4th reflective mirror group, the first reflective mirror group, the first auxiliary mirror group, the second reflective mirror group, turn to prism and eyepiece to form light path;
Described lens switch controller is connected with described 4th reflective mirror group, controls described 4th switching of reflective mirror group in light path for the steering order according to described master controller.
5. system according to claim 4, is characterized in that, described microscan instrument also comprises: be arranged on the 3rd Slide Group in described 4th reflective mirror group;
Described transmission group is connected with described 3rd Slide Group, drives described 4th reflective mirror group to slide for driving described 3rd Slide Group under the control of described lens switch controller.
6. system according to claim 1, is characterized in that, described microscan instrument also comprises: fluorescent apparatus;
Described controller group also comprises: light source switch controller;
Described light source switch controller is connected with described fluorescent apparatus, described light supply apparatus, described master controller, for controlling unlatching or the closedown of described fluorescent apparatus and described light supply apparatus according to the steering order of described master controller.
7. system according to claim 1, is characterized in that, described microscan instrument also comprises: section box, automatic threading device that at least one section is housed;
Described automatic threading device is connected with described section box and described master controller, cuts into slices for capturing from described section box and is placed into described platform.
8. system according to claim 1, is characterized in that, described microscan instrument also comprises: panorama camera;
Described panorama camera is arranged on the top of described platform, is connected with described control terminal, and for taking pictures to the panorama camera on described platform, and the image obtained taking pictures is sent to described control terminal.
9. a tubercle bacillus screening method, is characterized in that, comprising:
Control terminal is to the master controller sending controling instruction in microscan instrument;
Described master controller switches or the controller sending controling instruction that moves up and down to the platform movement controller in microscan instrument, object lens;
Described platform movement controller drives described platform movement according to described steering order, makes the objective lens above the slice alignment platform on described platform;
Described object lens switch or the controller that moves up and down drives the object lens in described objective lens to carry out switching or moving up and down according to described steering order, focus, with make the micro-camera in described microscan instrument to through focusing and amplify section scan, obtain sectioning image;
Control terminal identifies described sectioning image, obtains the tubercle bacillus quantity in described sectioning image, determines whether patient suffers from tuberculosis according to the tubercle bacillus quantity in described sectioning image.
10. method according to claim 9, is characterized in that, also comprises:
Described control terminal sends lens switching command according to the operation of user to the master controller in microscan instrument;
Described master controller according to described lens switching command to the lens switch controller sending controling instruction in microscan instrument;
Described lens switch controller drives the attachment lens group on the light path path between micro-camera and objective lens to switch according to described steering order, scans the switching of multiple to realize cutting into slices.
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| CN201511005737.3A CN105486683A (en) | 2015-12-28 | 2015-12-28 | Mycobacterium tuberculosis screening system and method |
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| CN201511005737.3A CN105486683A (en) | 2015-12-28 | 2015-12-28 | Mycobacterium tuberculosis screening system and method |
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