CN105477518A - Traditional Chinese medicinal preparation for treating spleen-kidney deficiency type habitual abortion and preparation method of traditional Chinese medicinal preparation - Google Patents

Abstract

The invention relates to a traditional Chinese medicinal preparation for treating spleen-kidney deficiency type habitual abortion. The traditional Chinese medicinal preparation is characterized by being prepared from the following components: the seeds of Chinese dodder, radix angelica sinensis, polygala tenuifolia, morinda officinalis, root bark or bark of eucommia ulmoides, Chinese-dates, fructus amomi, codonopsis pilosula, roots of caragana sinica, fructus corni, the fruits of Chinese magnoliavine, raspberries, parasitic loranthus, teasel, caulis perllae, prepared rehmannia root, cornu cervi degelatinatum, the fruits of Chinese wolfberry, donkey-hide gelatin and bighead atractylodes rhizome. The traditional Chinese medicinal preparation for treating spleen-kidney deficiency type habitual abortion is prepared according to the theory of the traditional Chinese medicine, and is reasonable in compatibility of the medicinal materials, the traditional Chinese medicinal materials are mixed according to the monarch, minister, assistant and guide of the traditional Chinese medicine prescription, the maximal efficacies are exerted, and the traditional Chinese medicinal preparation is small in toxic and side effects and low in cost.

Description

A kind ofly treat Chinese medicine preparation of spleen kidney both deficiency type habitual abortion and preparation method thereof

Technical field

The invention belongs to medical art, be specifically related to a kind ofly treat Chinese medicine preparation of spleen kidney both deficiency type habitual abortion and preparation method thereof.

Background technology

Habitual abortion is mainly because of congenital defect, excess of sexual intercourse, pregnant rear fleshliness damage kidney qi, and tire is become homeless and is; Or ferritic insufficiency of vital energy and blood, serious disease prolonged illness is lost blood consumption gas, and tire is become homeless foster; Or ferritic yin asthenia generating intrinsic heat, collaterals of the uterus is solid etc. causes.Common pattern of syndrome has: 1. kidney qi deficiency habitual abortion.Pregnantly repeatly fall repeatly, soreness of the waist and knees, vertigo and tinnitus, spiritlessness and weakness, there is dim speckle in face, frequent urination at night, and light red tongue has indentation, deep and weak pulse.Controlling should the solid tire of the kidney invigorating.2. weak type of qi and blood habitual abortion.Pregnantly repeatly fall repeatly, spiritlessness and weakness, shortness of breath and palpitation, light red tongue, thready and weak pulse without strength, controlling should benefiting QI and nourishing blood.3. type of YIN-deficiency and interior-heat habitual abortion.Pregnantly repeatly fall repeatly, hectically flushed cheeks, feverish sensation in the palms and soles, agitation is peaceful, xerostomia, emaciated physique, red tongue, thready and rapid pulse.Controlling should replenishing YIN and removing heat.

For thousands of years, ancient Chinese medicine doctor, for habitual abortion, all there has been and fully realizes from the cause of disease to pathogenesis.Traditional Chinese medical science saying " kidney governing reproduction ", " tire lotus lies in spleen ", the traditional Chinese medical science think habitual abortion duty in congenital defect, many factors damages kidney qi again, so that can not sprout tire system tire; Or insufficiency of the spleen middle gas loss, change source feedback weary, so that can not feotus vitality be conserved one's health.Patient falls repeatly due to pregnant repeatly, and kidney qi is more empty, QI and blood consumption wound.Thus the sick position of habitual abortion is at kidney spleen, and kidney spleen virtual loss is one of its core pathogenesis, and deficiency of kidney-QI then rushes appoints more empty, and the sea of blood is vague and general, pregnant support unable, tire must slippage and under; The spleen being the foundation of acquired constitution, source of generating QI and blood, insufficiency of the spleen dysfunction of the spleen in transportation and transformation, deficiency of vital energy insufficiency of blood, QI-insufficiency with carry a tire, insufficiency of blood with fetus nourishing, then the easy slippage of tire and under.

Therefore theory of Chinese medical science is used, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, study effective Treated with Chinese Decoction habitual abortion and can not only overcome the untoward reaction that Western medicine causes, as infection, osteoporosis, thrombocytopenia, hemorrhage etc., more can effectively reduce its relapse rate, contribute to fetal development when again becoming pregnant good, there is good researching value and practical significance.

Summary of the invention

The invention provides a kind of new Chinese medicine preparation for the treatment of spleen kidney both deficiency type habitual abortion, overcome the deficiency of Chinese and western medicine preparation in the past, there is effect that relatively outstanding air making-up and spleen enlivening, kidney tonifying are antiabortive, have good curative effect to spleen kidney both deficiency type habitual abortion, and have no side effect.Described Chinese medicine preparation is obtained by following raw material: Semen Cuscutae, Radix Angelicae Sinensis, Radix Polygalae, Radix Morindae Officinalis, the Cortex Eucommiae, Fructus Jujubae, Fructus Amomi, Radix Codonopsis, Radix Caraganae Sinicae, Fructus Corni, Fructus Schisandrae Chinensis, Fructus Rubi, Herba Taxilli, Radix Dipsaci, Caulis Perillae, Radix Rehmanniae Preparata, Cornu Cervi Degelatinatum, Fructus Lycii, Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae.

The technical scheme adopted for solving its technical problem is the Chinese medicine preparation of described treatment spleen kidney both deficiency type habitual abortion, be made up of the medicine of following weight: Semen Cuscutae 5-15 part, Radix Angelicae Sinensis 5-15 part, Radix Polygalae 5-15 part, Radix Morindae Officinalis 5-15 part, Cortex Eucommiae 5-15 part, Fructus Jujubae 5-15 part, Fructus Amomi 5-15 part, Radix Codonopsis 10-20 part, Radix Caraganae Sinicae 10-20 part, Fructus Corni 10-20 part, Fructus Schisandrae Chinensis 10-20 part, Fructus Rubi 10-20 part, Herba Taxilli 10-20 part, Radix Dipsaci 10-20 part, Caulis Perillae 10-20 part, Radix Rehmanniae Preparata 10-20 part, Cornu Cervi Degelatinatum 10-20 part, Fructus Lycii 10-20 part, Colla Corii Asini 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part.

The preferred technical solution of the present invention is, described Chinese medicine preparation of the present invention, obtained by the raw material of following weight portion: Semen Cuscutae 10 parts, Radix Angelicae Sinensis 10 parts, Radix Polygalae 10 parts, Radix Morindae Officinalis 10 parts, the Cortex Eucommiae 10 parts, 10 parts, Fructus Jujubae, Fructus Amomi 10 parts, Radix Codonopsis 15 parts, Radix Caraganae Sinicae 15 parts, Fructus Corni 15 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Rubi 15 parts, Herba Taxilli 15 parts, Radix Dipsaci 15 parts, Caulis Perillae 15 parts, 15 parts, Radix Rehmanniae Preparata, Cornu Cervi Degelatinatum 15 parts, Fructus Lycii 15 parts, 15 parts, Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 15 parts.

Present invention also offers the preparation method of described Chinese medicine preparation, specifically comprise the steps:

(1) by the raw material Semen Cuscutae of above-mentioned weight portion, Radix Angelicae Sinensis, Radix Polygalae, Radix Morindae Officinalis, the Cortex Eucommiae, Fructus Jujubae, Fructus Amomi, Radix Caraganae Sinicae, Fructus Corni, Fructus Schisandrae Chinensis, Fructus Rubi, Herba Taxilli, Radix Dipsaci, Caulis Perillae, Radix Rehmanniae Preparata, after Cornu Cervi Degelatinatum, Fructus Lycii, Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae are pulverized respectively, add the water of 15 times amount of medical material gross weight, decoct 3 times, merge decoction liquor and filter, and when concentrating filtrate to 55 DEG C, its relative density is the thick paste of 1.15-1.20;

(2) adopt alcohol waterproof pulverization to extract separately above-mentioned Radix Codonopsis, first pulverize 3 times, 10min/ time with 5 times amount 85% ethanol, the medicinal residues after extraction pulverize extraction 3 times with 10 times amount hot water again, every 15min/ time, and the merging of extracted twice thing obtains Radix Codonopsis effective ingredient;

(3) ginseng effective component that step (2) is extracted is joined in thick paste prepared by step (1), to obtain final product.

Those skilled in the art directly can be used as medicine on obtained active constituents of medicine basis of the present invention to use or add on pharmaceutics acceptable adjuvant routinely technique be prepared into required preparation.As the oral drugs of the solid dosage form such as conventional tablet, capsule granule, pill, powder can be made, the oral drugs of the liquid forms such as syrup, oral liquid, water preparation, mixture, decoction also can be made.Therefore, in this Chinese medicine preparation except effective ingredient, pharmaceutically acceptable adjuvant can also be contained.Preferably, Chinese medicine preparation of the present invention conveniently preparation technology be prepared into granule, capsule, electuary or powder etc.

The side of Chinese medicine preparation of the present invention separates as follows:

The kidney being the origin of congenital constitution.The root of vigour, main store essential substances gas, be growth in humans, growth and reproduction basic, spleen is the source of QI and bloodization life, and interior foster the five internal organs, moisten skin outward, is maintain the human body life day after tomorrow basic.Chinese medicine preparation of the present invention is antiabortive for Therapeutic Principle with kidney and spleen invigorating, QI invigorating, and Semen Cuscutae, Radix Polygalae, Radix Dipsaci, Radix Morindae Officinalis, the Cortex Eucommiae, Cornu Cervi Degelatinatum the kidney invigorating and essence nourishing marrow in side, admittedly rush antiabortive; Radix Angelicae Sinensis, Fructus Corni, Fructus Schisandrae Chinensis, Fructus Rubi, Herba Taxilli, Radix Rehmanniae Preparata, Radix Caraganae Sinicae, Fructus Lycii, Colla Corii Asini Zishen fill fine nourish blood and antiabortive; Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Fructus Jujubae, invigorating the spleen and benefiting QI are as a means of change source; Fructus Amomi, Caulis Perillae are regulated the flow of vital energy antiabortive, make tonify without causing stagnation.Full side share, and make kidney qi healthy and vigorous, tire has direct bearing, carries and supports normally, then from the worry without induced abortion.

Chinese medicine preparation reasonable recipe of the present invention, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, effectively can cure the habitual abortion particularly habitual abortion disease that causes of asthenia of both the spleen and kidney.Through clinical practice checking, its determined curative effect, mild in medicine property and, do not occur toxic and side effects and untoward reaction, safety coefficient is high, and clinical observation total effective rate reaches more than 95%, can be used as clinical active drug and applies.

Detailed description of the invention

Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.

Embodiment 1: Semen Cuscutae 5 parts, Radix Angelicae Sinensis 5 parts, Radix Polygalae 5 parts, Radix Morindae Officinalis 5 parts, the Cortex Eucommiae 5 parts, 5 parts, Fructus Jujubae, Fructus Amomi 5 parts, Radix Codonopsis 10 parts, Radix Caraganae Sinicae 10 parts, Fructus Corni 10 parts, Fructus Schisandrae Chinensis 10 parts, Fructus Rubi 10 parts, Herba Taxilli 10 parts, Radix Dipsaci 10 parts, Caulis Perillae 10 parts, 10 parts, Radix Rehmanniae Preparata, Cornu Cervi Degelatinatum 10 parts, Fructus Lycii 10 parts, 10 parts, Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 10 parts.

(1) by the raw material Semen Cuscutae of above-mentioned weight portion, Radix Angelicae Sinensis, Radix Polygalae, Radix Morindae Officinalis, the Cortex Eucommiae, Fructus Jujubae, Fructus Amomi, Radix Caraganae Sinicae, Fructus Corni, Fructus Schisandrae Chinensis, Fructus Rubi, Herba Taxilli, Radix Dipsaci, Caulis Perillae, Radix Rehmanniae Preparata, after Cornu Cervi Degelatinatum, Fructus Lycii, Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae are pulverized respectively, add the water of 15 times amount of medical material gross weight, decoct 3 times, merge decoction liquor and filter, and when concentrating filtrate to 55 DEG C, its relative density is the thick paste of 1.15-1.20;

(2) adopt alcohol waterproof pulverization to extract separately above-mentioned Radix Codonopsis, first pulverize 3 times, 10min/ time with 5 times amount 85% ethanol, the medicinal residues after extraction pulverize extraction 3 times with 10 times amount hot water again, every 15min/ time, and the merging of extracted twice thing obtains Radix Codonopsis effective ingredient;

(3) ginseng effective component that step (2) is extracted is joined in thick paste prepared by step (1), to obtain final product.

(4) those skilled in the art directly can be used as medicine on this basis and be used or add adjuvant conventional formulation technique and obtain the conventional oral formulations such as granule, electuary, capsule or powder.

When using Chinese medicine preparation of the present invention to treat habitual abortion disease, take prepared granule, electuary or powder, containing crude drug amount 4g, every day 2 times, each 1 bag, take half an hour after meal for every bag.

Embodiment 2: Semen Cuscutae 10 parts, Radix Angelicae Sinensis 10 parts, Radix Polygalae 10 parts, Radix Morindae Officinalis 10 parts, the Cortex Eucommiae 10 parts, 10 parts, Fructus Jujubae, Fructus Amomi 10 parts, Radix Codonopsis 15 parts, Radix Caraganae Sinicae 15 parts, Fructus Corni 15 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Rubi 15 parts, Herba Taxilli 15 parts, Radix Dipsaci 15 parts, Caulis Perillae 15 parts, 15 parts, Radix Rehmanniae Preparata, Cornu Cervi Degelatinatum 15 parts, Fructus Lycii 15 parts, 15 parts, Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 15 parts.

Preparation technology is with embodiment 1.

Embodiment 3: Semen Cuscutae 15 parts, Radix Angelicae Sinensis 15 parts, Radix Polygalae 15 parts, Radix Morindae Officinalis 15 parts, the Cortex Eucommiae 15 parts, 15 parts, Fructus Jujubae, Fructus Amomi 15 parts, Radix Codonopsis 20 parts, Radix Caraganae Sinicae 20 parts, Fructus Corni 20 parts, Fructus Schisandrae Chinensis 20 parts, Fructus Rubi 20 parts, Herba Taxilli 20 parts, Radix Dipsaci 20 parts, Caulis Perillae 20 parts, 20 parts, Radix Rehmanniae Preparata, Cornu Cervi Degelatinatum 20 parts, Fructus Lycii 20 parts, 20 parts, Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 20 parts.

Preparation technology is with embodiment 1.

The clinical observation of embodiment 4 Chinese medicine preparation treatment of the present invention spleen kidney both deficiency type habitual abortion

1, case-data: that selects hospital ward and outpatient clinic meets spleen kidney both deficiency type habitual abortion patient 60 example.The method of employing random packet, parallel control is studied.Treatment group 30 example, at 22 years old ~ 33 years old age, average 26 years old, gravity flow parity mostly was 3 person 6 examples most, and all the other have been miscarried 2 times; Matched group 30 example, age 21-32 year, average 25.5 years old, gravity flow parity mostly was 3 persons 5 example most, and all the other have been miscarried 2 times.During first visit two groups pregnant age reckling be all pregnant 4 weeks, treatment group is pregnant 12 weeks to the maximum, and matched group is pregnant 14 weeks to the maximum.Two groups of Genders, age, the course of disease and abortion times, disease integration through statistical analysis no difference of science of statistics, equal tool comparability (P > 0.05).

2, tcm diagnosis standard:

1) pregnantly repeatly fall repeatly, the bridegroom's or husband's side checks normal person;

2) chromosome examination, gets rid of caused by inherited genetic factors;

3) gynecologial examination, understands uterus with or without deformity;

3, usage and dosage:

Treatment group: take Chinese medicine preparation of the present invention treatment, granule prepared by Example 1, every bag containing crude drug amount 4g, every day 2 times, each 1 bag, after meal half an hour warm water delivery service.Take 4 weeks at least continuously, eliminate as principle with clinical symptoms after taking medicine, symptom is not eliminated and is taken drug withdrawal after 3 months.

Matched group: zishenyutai pill eats three times in one day, and light salt brine is oral after meal, patient need take medicine 1-3 month, eliminates as principle with clinical symptoms after taking medicine, but clothes are to drug withdrawal after 3 months.

Patient's pregnancy period prohibits sexual life, avoids overworked, and special vaginal hemorrhage person lies up.After treatment in 3 months terminates, follow up a case by regular visits to and carry out efficacy evaluation to normal labor.

4, curative effect determinate standard: formulate with reference to " disease of tcm Standardization of diagnosis and curative effect "

Effective: normal labor;

Invalid: after treatment, abortion of still having an abortion.

5, therapeutic effect:

Without rejecting and coming off and stop case in therapeutic process, all complete clinical observation.

Two groups of patient treatment total effectses compare, and treatment group is successfully prevented miscarriage to normal labor person and is reached for 96.7%, and matched group is successfully prevented miscarriage to normal labor person and is reached for 90.0%, and total effective rate compares, and treatment group is apparently higher than matched group.

The comparitive study for the treatment of group and matched group

Group	Effectively	Invalid	Effective percentage
				Treatment group	29	1	29(96.7％)
Matched group	26	4	27(86.7％)

Claims (4)

1. treat a Chinese medicine preparation for spleen kidney both deficiency type habitual abortion, it is characterized in that composed of the following components:

Semen Cuscutae, Radix Angelicae Sinensis, Radix Polygalae, Radix Morindae Officinalis, the Cortex Eucommiae, Fructus Jujubae, Fructus Amomi, Radix Codonopsis, Radix Caraganae Sinicae, Fructus Corni, Fructus Schisandrae Chinensis, Fructus Rubi, Herba Taxilli, Radix Dipsaci, Caulis Perillae, Radix Rehmanniae Preparata, Cornu Cervi Degelatinatum, Fructus Lycii, Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae.

2. the Chinese medicine preparation for the treatment of spleen kidney both deficiency type according to claim 1 habitual abortion, is characterized in that being made up of according to parts by weight following component:

Semen Cuscutae 5-15 part, Radix Angelicae Sinensis 5-15 part, Radix Polygalae 5-15 part, Radix Morindae Officinalis 5-15 part, Cortex Eucommiae 5-15 part, Fructus Jujubae 5-15 part, Fructus Amomi 5-15 part, Radix Codonopsis 10-20 part, Radix Caraganae Sinicae 10-20 part, Fructus Corni 10-20 part, Fructus Schisandrae Chinensis 10-20 part, Fructus Rubi 10-20 part, Herba Taxilli 10-20 part, Radix Dipsaci 10-20 part, Caulis Perillae 10-20 part, Radix Rehmanniae Preparata 10-20 part, Cornu Cervi Degelatinatum 10-20 part, Fructus Lycii 10-20 part, Colla Corii Asini 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part.

3. the Chinese medicine preparation for the treatment of spleen kidney both deficiency type according to claim 1 and 2 habitual abortion, is characterized in that being made up of according to weight fraction following component:

Semen Cuscutae 10 parts, Radix Angelicae Sinensis 10 parts, Radix Polygalae 10 parts, Radix Morindae Officinalis 10 parts, the Cortex Eucommiae 10 parts, 10 parts, Fructus Jujubae, Fructus Amomi 10 parts, Radix Codonopsis 15 parts, Radix Caraganae Sinicae 15 parts, Fructus Corni 15 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Rubi 15 parts, Herba Taxilli 15 parts, Radix Dipsaci 15 parts, Caulis Perillae 15 parts, 15 parts, Radix Rehmanniae Preparata, Cornu Cervi Degelatinatum 15 parts, Fructus Lycii 15 parts, 15 parts, Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae 15 parts.

4. a preparation method for the Chinese medicine preparation for the treatment of spleen kidney both deficiency type as claimed in claim 1 or 2 habitual abortion, is characterized in that: concrete preparation method is as follows:

(1) by the raw material Semen Cuscutae of above-mentioned weight portion, Radix Angelicae Sinensis, Radix Polygalae, Radix Morindae Officinalis, the Cortex Eucommiae, Fructus Jujubae, Fructus Amomi, Radix Caraganae Sinicae, Fructus Corni, Fructus Schisandrae Chinensis, Fructus Rubi, Herba Taxilli, Radix Dipsaci, Caulis Perillae, Radix Rehmanniae Preparata, after Cornu Cervi Degelatinatum, Fructus Lycii, Colla Corii Asini, the Rhizoma Atractylodis Macrocephalae are pulverized respectively, add the water of 15 times amount of medical material gross weight, decoct 3 times, merge decoction liquor and filter, and when concentrating filtrate to 55 DEG C, its relative density is the thick paste of 1.15-1.20;

(2) adopt alcohol waterproof pulverization to extract separately above-mentioned Radix Codonopsis, first pulverize 3 times, 10min/ time with 5 times amount 85% ethanol, the medicinal residues after extraction pulverize extraction 3 times with 10 times amount hot water again, every 15min/ time, and the merging of extracted twice thing obtains Radix Codonopsis effective ingredient;

(3) ginseng effective component that step (2) is extracted is joined in thick paste prepared by step (1), to obtain final product.