CN105435377B - A kind of radiotherapy dosage measuring device and measuring method - Google Patents
A kind of radiotherapy dosage measuring device and measuring method Download PDFInfo
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- CN105435377B CN105435377B CN201510863610.9A CN201510863610A CN105435377B CN 105435377 B CN105435377 B CN 105435377B CN 201510863610 A CN201510863610 A CN 201510863610A CN 105435377 B CN105435377 B CN 105435377B
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- 238000001959 radiotherapy Methods 0.000 title claims abstract description 39
- 238000000034 method Methods 0.000 title claims abstract description 16
- 230000003287 optical effect Effects 0.000 claims abstract description 20
- 238000012545 processing Methods 0.000 claims abstract description 18
- 238000005259 measurement Methods 0.000 claims abstract description 14
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 13
- 230000002093 peripheral effect Effects 0.000 claims abstract description 11
- 230000008569 process Effects 0.000 claims abstract description 8
- 230000008021 deposition Effects 0.000 claims abstract description 6
- 230000005855 radiation Effects 0.000 claims description 12
- 238000000691 measurement method Methods 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 5
- 241001269238 Data Species 0.000 abstract 1
- 230000003595 spectral effect Effects 0.000 description 4
- 210000003484 anatomy Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000004744 fabric Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229940030792 clinac Drugs 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000004980 dosimetry Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000010503 organ complication Effects 0.000 description 1
- 238000000275 quality assurance Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
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Abstract
The invention discloses a kind of radiotherapy dosage measuring device and measuring method, belong to field of radiation therapy.The device includes three wide-angle lens, three EMCCD detectors, detector rotating device, multi-channel data registration collection module and computer processing unit.The present invention is based on the Cherenkov light light intensity datas generated in multi-angle acquisition radiation therapy process, it rebuilds to obtain the Cherenkov light light distribution of tumour and its peripheral region by optical fault, according to the quantitative relationship between Cherenkov light light intensity and dosage deposition, Dose Distribution in Radiotherapy Treatment is finally obtained.It can obtain that 3-dimensional dose distribution, real-time online be good, the simple radiotherapy dosage measuring device and measuring method of measurement the present invention provides one kind, can effectively ensure the curative effect of radiotherapy and ensure patient irradiation's safety.
Description
Technical field
The invention belongs to field of radiation therapy, and in particular to a kind of device for real-time measurement radiotherapy dose of radiation
And method.
Technical background
The factors such as anatomical structure variation, radiotherapy apparatus output parameter inaccuracy and patient's Set-up errors in radiation therapy process
Radiotherapy dosimetry inaccuracy will all be will cause, to influence the effect of radiation therapy or cause excessive exposure.ICRU 24 reports refer to
Out, the deviation of target dose ± 5% is possible to the probability for keeping primary tumor out of control or increasing normal organ complication.Radiotherapy
The Real-time Measuring Technique of dosage can the practical deviation authorized between dosage and intended dose of real-time verification, convenient in time discovery meter
It draws executive problem and modifies and be used for subsequent curative effect evaluation, truly accomplish the real-time quality assurance of dosage accuracy, have
Effect ensures Radiotherapy and ensures patient irradiation's safety.However, the difficulty and not of patient's body dosage distribution real-time measurement
Certainty is big, and real-time measurement means are still more single and not yet enough " ideal ", is always to restrict radiotherapy further to develop
Bottleneck.Therefore, it is badly in need of developing a kind of new equipment and new method for radiotherapy dosage real-time measurement, can be realized patient
The real-time measurement of internal dosage distribution.
Summary of the invention
The technical problem to be solved by the present invention is to be directed to prior art defect, 3-dimensional dose point can be obtained by providing one kind
Cloth, real-time online are good, measure simple radiotherapy dosage measuring device and measuring method.
The present invention uses following technical scheme to solve above-mentioned technical problem:
A kind of radiotherapy dose measuring device, including the rotation of three wide-angle lens, three EMCCD detectors, detector
Device, multi-channel data registration collection module and computer processing unit；The wide-angle lens is connected with EMCCD detector,
The detector rotating device and EMCCD detector are registrated collection module with multi-channel data respectively and are connected, multi-channel data
It is registrated collection module and connects computer processing unit.
The wide-angle lens is the adjustable focus wide-angle lens of large aperture.
The spectral response range of the EMCCD detector should with Cherenkov light Spectral matching, the EMCCD detector
Peak quantum efficiency should reach 90% or more, and reading noise should be as low as possible.
The EMCCD detector is fixed on detector rotating device, and 360 ° of detector can be realized by rotating device
All-directional rotation.
The computer processing unit can control the even speed-changing rotation of detector rotating device and fixed point remaining, while detector
Space angle information locating for EMCCD detector can be passed to multi-channel data registration collection module by rotating device.
The multi-channel data registration collection module can receive simultaneously and integrate the optical signalling of three EMCCD detectors
Space angle information when data and EMCCD detector measurement, and then pass to computer processing unit.
The computer processing unit, which has, realizes that background data deducts, optical fault is rebuild and Cherenkov light light intensity
Distribution is converted to the function of dosage distribution.
The present invention also provides the measurement methods of radiotherapy dose measuring device comprising the steps of:
1) according to knub position and size, the distributing position of detector rotating device position, EMCCD detector is adjusted
And wide-angle lens focal length size.
2) before radiation treatment, the measurement parameter setting according to radiotherapy dose measuring device in therapeutic process, utilizes
Wide-angle lens obtains the stray radiation background data and ambient light background data of single angle.
3) in radiation therapy process, computer processing unit control the even speed-changing rotation of EMCCD detector rotating device and
Fixed point remaining, multi-channel data registration collection module simultaneously receive and integrate three EMCCD detectors optical signal data and
Space angle information when EMCCD detector measurement, passes to computer processing unit.The information being collected into be tumour and
The multi-angle optical signal data of its peripheral region and corresponding space angle information.
4) optical signal data that each angle obtains is deducted into stray radiation background data and ambient light background data respectively,
Obtain the Cherenkov light light intensity data of each angle.
5) optical fault reconstruction is carried out using the Cherenkov light light intensity data of each angle and corresponding space angle information,
Obtain unit volume Cherenkov light the light distribution N(x, y, z of tumour and its peripheral region).
6) based on the quantitative ratio relation between Cherenkov light light intensity and dosage deposition, according to unit volume Cherenkov
Light light distribution N(x, y, z) obtain Dose Distribution in Radiotherapy Treatment D(x, y, z).
The beneficial effects of the present invention are: utilize the Cherenkov light generated during ray and matter interaction, benefit
It is rebuild to obtain the Cherenkov light light distribution of tumour and its peripheral region with multi-angle Cherenkov light light intensity data；Meanwhile
Based on the quantitative relationship between Cherenkov light light intensity and dosage deposition, and then patient in radiation therapy process can be obtained in real time
Intracorporal dosage distribution, to ensure the curative effect of radiotherapy and ensure patient irradiation's safety.
Detailed description of the invention
Fig. 1 is radiotherapy dose measuring device structural schematic diagram of the present invention；
Fig. 2 is the measurement method flow diagram of radiotherapy dose measuring device of the present invention.
Specific embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings.
As shown in Figure 1, this radiotherapy dose measuring device, including detector rotating device 1 and it is several be equipped with it is wide
The EMCCD detector 2 of angle mirror head 3, detector rotating device 1 and each EMCCD detector 2 are registrated by multi-channel data and are received
Collection module 4 connect 5 with computer processing unit；EMCCD detector 2 is fixed on detector rotating device 1, detector rotating dress
The EMCCD detector 2 of 1 control whole is set around the rotation of 360 ° of a certain center.
The wide-angle lens 3 is the adjustable focus wide-angle lens of large aperture, according to target area and can jeopardize organ size adjustment focal length.
The spectral response range of the EMCCD detector 2 should be with Cherenkov light Spectral matching, the peak volume of the EMCCD detector 2
Sub- efficiency should reach 90% or more, and reading noise should be as low as possible.The EMCCD detector 2 is fixed on detector rotating device 1
On, it can realize that the 360 ° omni-directional of detector is rotated by rotating device, the detector rotating device 1 passes through two support rods
It is fixed on right above tumor locus.The computer processing unit 5 can control the even speed-changing rotation of detector rotating device 1 and fixed point
It stops, while space angle information locating for EMCCD detector 2 can be passed to multi-channel data registration collection module 4.
The multi-channel data registration collection module 4 can receive simultaneously and integrate the optics letter of three EMCCD detectors
Space angle information when number and EMCCD detector measurement, and then pass to computer processing unit 5.The computer
Processing unit 5, which has, realizes that background data deducts, optical fault is rebuild and Cherenkov light light distribution is converted to dosage point
The function of cloth.
In radiation therapy process, the EMCCD detector 2 matches the multi-angle optical signal detected through multi-channel data
After quasi- collection module 4 is handled, the optical signal data after integration is passed into computer processing unit 5.The computer disposal
Optical signal data is deducted stray radiation background data and ambient light background data by unit 5, and combines EMCCD detector 2
Space angle information carries out optical fault reconstruction, and obtained optical tomographic image is registrated with original CT anatomical structure figure,
Obtain the unit volume Cherenkov light light distribution of tumour and its peripheral region.It is deposited according to Cherenkov light light intensity and dosage
Quantitative relationship, finally obtain Dose Distribution in Radiotherapy Treatment.
Fig. 2 is the measurement method flow diagram of radiotherapy dose measuring device of the present invention, detailed process are as follows:
Step 1) adjusts detector rotating device position and wide-angle lens focal length is big according to knub position and size
It is small, the rotation of clinac head when detector rotating device position should fully consider treatment；
Step 2 is based on digital equivalent body mould, in conjunction with the beam condition of TPS plan setting, utilizes Monte Carlo kit
Geant4 is calculated the Cherenkov light light distribution and dosage deposition distribution of tumour and its peripheral region, obtain tumour and its
The conversion coefficient that peripheral region any position is deposited from Cherenkov light light intensity to dosage；
Before radiation treatment, the measurement parameter according to radiotherapy dose measuring device in therapeutic process is arranged step 3),
The lens cap for covering wide-angle lens 3 obtains the stray radiation background data of single angle under identical beam condition irradiation；Meanwhile
Ambient light background data are obtained under lens cap opening and non-radiation situation；
Step 4) is carried out polygonal in radiation therapy process by the control detector rotating device 1 of computer processing unit 5
One-point measurement is spent, while space angle information and the optical signal transfer detected are registrated collection module 4 to multi-channel data
It is handled, finally passes data to computer processing unit 5；
The optical signal data that step 5) computer processing unit 5 obtains each angle deducts stray radiation background data
And ambient light background data, and the angle information obtained is combined to carry out optical fault reconstruction, the optical tomographic image that will be obtained
It is registrated with original CT anatomical structure figure, obtains the unit volume Cherenkov light light distribution N of tumour and its peripheral region
(x, y, z)；
The conversion coefficient obtained in step 6) combination step 2, according to unit volume Cherenkov light light distribution N(x, y,
Z) Dose Distribution in Radiotherapy Treatment D(x, y, z are converted to).
The present embodiment explains technical solution of the present invention with three EMCCD detectors and three wide-angle lens, can
According to actual needs and economic condition increases the number of detector and wide-angle lens, is no longer repeated herein.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, several improvement can also be made without departing from the principle of the present invention, these improvement also should be regarded as of the invention
Protection scope.
Claims (1)
1. a kind of measurement method of radiotherapy dose measuring device, it is characterised in that the following steps are included:
1) according to knub position and size, adjust detector rotating device position, EMCCD detector distributing position and
Wide-angle lens focal length size；
2) it is based on digital equivalent body mould, in conjunction with the beam condition of TPS plan setting, is calculated using Monte Carlo kit Geant4
The Cherenkov light light distribution and dosage deposition distribution of tumour and its peripheral region are obtained, tumour is obtained and its peripheral region is appointed
The conversion coefficient deposited from Cherenkov light light intensity to dosage at meaning position；
3) before radiation treatment, the measurement parameter setting according to radiotherapy dose measuring device in therapeutic process, utilizes wide-angle
Camera lens obtains the stray radiation background data and ambient light background data of single angle；
4) in radiation therapy process, computer processing unit controls the even speed-changing rotation of EMCCD detector rotating device and fixed point
It stops, multi-channel data registration collection module receives and integrate simultaneously the optical signal data and EMCCD of three EMCCD detectors
Space angle information when detector measurement, passes to computer processing unit；
5) optical signal data that each angle obtains is deducted into stray radiation background data and ambient light background data respectively, is obtained
The Cherenkov light light intensity data of each angle；
6) optical fault reconstruction is carried out using the Cherenkov light light intensity data of each angle and corresponding space angle information, obtained
Unit volume Cherenkov light the light distribution N(x, y, z of tumour and its peripheral region)；
7) based on the quantitative ratio relation between Cherenkov light light intensity and dosage deposition, according to unit volume Cherenkov light light
Strong distribution N(x, y, z) obtain Dose Distribution in Radiotherapy Treatment D(x, y, z).
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| CN106772529B (en) * | 2016-11-28 | 2019-03-29 | 北京格物时代科技发展有限公司 | A kind of dose of radiation residual activity value monitoring method and system |
| CN108169783A (en) * | 2018-02-26 | 2018-06-15 | 苏州大学 | A kind of real-time measurement apparatus and measuring method of the distribution of radiation space dosage |
| CN109893778B (en) * | 2019-03-15 | 2021-02-05 | 南京航空航天大学 | Particle radiotherapy beam real-time monitoring method |
| CN110465002A (en) * | 2019-07-09 | 2019-11-19 | 中国科学院西安光学精密机械研究所 | Tumor radiotherapy real-time monitoring synchronous acquisition device and monitoring instrument based on CLI |
| CN111991710B (en) * | 2020-08-24 | 2022-07-01 | 西安交通大学医学院第一附属医院 | Radiotherapy position and dose real-time monitoring and positioning device and tumor radiotherapy system |
| CN114984462B (en) * | 2022-04-15 | 2024-03-26 | 南京航空航天大学 | Cerenkov light dose monitoring method and device based on multichannel imaging |
| CN114887237A (en) * | 2022-04-15 | 2022-08-12 | 南京航空航天大学 | Method and system for enhancing Cerenkov effect dose imaging effect |
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Inventor after: Geng Changran Inventor after: Shu Diyun Inventor after: Tang Xiaobin Inventor after: Gong Pin Inventor after: Chen Da Inventor before: Tang Xiaobin Inventor before: Shu Diyun Inventor before: Gong Pin Inventor before: Geng Changran Inventor before: Chen Da |
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