CN105434880A - Traditional Chinese medicine preparation for treating Kaschin-Beck disease and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating Kaschin-Beck disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating Kaschin-Beck disease and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The effective ingredient of the preparation is prepared from the following raw materials: yam rhizome, eucommia ulmoides, licorice root, walking spleenwort, rhizoma cibotii, dendrolobium triangulare, glomeris, goldencup hypericum, achyranthes bidentata, parmelia tinctourium, cortex albiziae, folium eucalypti, winged laggera herb, rattlesnake plantain, salviae miltiorrhizae and phtheirospermum tenuisectum. The traditional Chinese medicine preparation is prepared from compatible medicinal materials according with traditional Chinese medicine and modern medicine theories, has the effects of strengthening tendons and bones, diminishing swelling, relieving pain, promoting qi to activate blood and invigorating health effectively. The traditional Chinese medicine preparation is convenient to use, has a good absorption effect and no negative, toxic or side effect. Clinical application verifies that the preparation has an extremely good effect of relieving Kaschin-Beck disease, and is applicable to clinical treatment and nursing popularization of the Kaschin-Beck disease.
Description
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation and the preparation method that are used for the treatment of Kaschin-Beck disease.
Background technology
Kaschin-Beck disease refers to a kind of endemicity, Osteoarthrosis deformans, domesticly cries again that short person is sick, abacus bead is sick.Each age group all can be fallen ill, multiple with Children and teenager, and adult seldom falls ill, sex no significant difference.
The symptom of Kaschin-Beck disease has following two aspects:
1. juvenile morbidity in period: because epiphyseal plate ossify in advance, make growth occur obstacle, show as d form.Build is short and small, and joint is thick, and has pain and limitation of activity, and with ankle joint morbidity the earliest, then order is finger-joint, knee joint, elbow, wrist, toes joint and hip.Because of epiphyseal plate, to merge speed inconsistent, and two lower limb often occur genu varum, in knee or coxa vara is lopsided.Stout-fingered little, foot is flat, and age of onset is lighter, and deformity is heavier.
2. postpubescence morbidity: deformity is not obvious, and main manifestations is osteoarthritis symptoms, and arthroncus has a small amount of hydrops, have friction sense, and with interlocking symptom, sometimes also can be checked through intraarticular has episome time movable.Adult cadaver lower limb morbidity is many, because of ankle, knee joint swelling pain, walks very inconvenient.
Kaschin-Beck disease easily causes degeneration, the necrosis of articular cartilage and growth plate cartilage.The lighter joint increases thick, pain, severe one is of short and small stature, joint deformity, life-long disabilities, disability, has had a strong impact on the life and work of adult normal, have a strong impact on the quality of life of people, therefore find a kind of effective medicine, to its treatment, there is significant meaning.Can ease the pain to Kaschin-Beck disease symptomatic treatment, have obvious joint deformity person can operative treatment, but postoperatively can cause row complication, have larger risk, and conservative medication more be conducive to the physical and mental health of patient.Chinese materia medica is as the traditional medicine of China, there is the advantages such as effect is strong, instant effect, lasting medicine, and there is no dependency, drug resistance and toxic and side effects, therefore select a kind of Chinese medicine preparation to be used for the treatment of Kaschin-Beck disease, for treatment Kaschin-Beck disease, there is very important clinical meaning.
Summary of the invention
The invention provides a kind of Chinese medicine preparation and the preparation method that are used for the treatment of Kaschin-Beck disease; Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine theory, there is effect of strengthening the tendons and bones, reducing swelling and alleviating pain, promoting flow of QI and blood, health invigorating, easy to use, good absorbing effect, without bad and toxic and side effects, through clinical verification, have fabulous alleviation and therapeutic effect to treatment Kaschin-Beck disease, the clinical treatment and the nursing that are suitable for Kaschin-Beck disease are applied.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Be used for the treatment of a Chinese medicine preparation for Kaschin-Beck disease, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Rhizoma Dioscoreae Septemlobae 50 ~ 80 parts of Cortexs Eucommiae 47 ~ 77 portions of Radix Glycyrrhizaes 45 ~ 75 parts of Herba asplenii prolongati 43 ~ 73 parts
Rhizoma Cibotii 40 ~ 70 parts of Radix dendrolobii triangulariss 35 ~ 65 parts of Prospiroboli joannsis 32 ~ 62 parts of Herba Hyperici Patulis 30 ~ 60 parts
Radix Achyranthis Bidentatae 28 ~ 58 parts of Parmelia saxatilis Ach. 25 ~ 55 portions of Cortex Albiziaes 23 ~ 53 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s 21 ~ 51 parts
Herba Laggerae Alatae 20 ~ 50 parts of Herba goodyearae repentis 16 ~ 46 parts of Radix Salviae Miltiorrhizaes 15 ~ 45 parts of Phtheirospermum tenuisectum Bur.et Franch.s 10 ~ 40 parts.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Rhizoma Dioscoreae Septemlobae 73 parts of Cortexs Eucommiae 70 portions of Radix Glycyrrhizaes 68 parts of Herba asplenii prolongati 66 parts
Rhizoma Cibotii 63 parts of Radix dendrolobii triangulariss 58 parts of Prospiroboli joannsis 56 parts of Herba Hyperici Patulis 54 parts
Radix Achyranthis Bidentatae 52 parts of Parmelia saxatilis Ach. 48 portions of Cortex Albiziaes 46 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s 44 parts
Herba Laggerae Alatae 43 parts of Herba goodyearae repentis 39 parts of Radix Salviae Miltiorrhizaes 38 parts of Phtheirospermum tenuisectum Bur.et Franch.s 33 parts.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Rhizoma Dioscoreae Septemlobae 66 parts of Cortexs Eucommiae 63 portions of Radix Glycyrrhizaes 61 parts of Herba asplenii prolongati 59 parts
Rhizoma Cibotii 56 parts of Radix dendrolobii triangulariss 51 parts of Prospiroboli joannsis 49 parts of Herba Hyperici Patulis 46 parts
Radix Achyranthis Bidentatae 45 parts of Parmelia saxatilis Ach. 41 portions of Cortex Albiziaes 39 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s 37 parts
Herba Laggerae Alatae 36 parts of Herba goodyearae repentis 32 parts of Radix Salviae Miltiorrhizaes 31 parts of Phtheirospermum tenuisectum Bur.et Franch.s 26 parts.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Rhizoma Dioscoreae Septemlobae 58 parts of Cortexs Eucommiae 54 portions of Radix Glycyrrhizaes 53 parts of Herba asplenii prolongati 52 parts
Rhizoma Cibotii 48 parts of Radix dendrolobii triangulariss 43 parts of Prospiroboli joannsis 40 parts of Herba Hyperici Patulis 39 parts
Radix Achyranthis Bidentatae 34 parts of Parmelia saxatilis Ach. 33 portions of Cortex Albiziaes 32 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s 29 parts
Herba Laggerae Alatae 28 parts of Herba goodyearae repentis 24 parts of Radix Salviae Miltiorrhizaes 23 parts of Phtheirospermum tenuisectum Bur.et Franch.s 18 parts.
Be used for the treatment of a preparation method for the Chinese medicine preparation of Kaschin-Beck disease, comprise following processing step:
(1) by Rhizoma Dioscoreae Septemlobae, the Cortex Eucommiae, Radix Glycyrrhizae, Radix Achyranthis Bidentatae and Radix Salviae Miltiorrhizae removing impurity, clean, section, mix thoroughly with yellow wine spray, after moistening, be placed in pot and fry to micro-dry, taking-up cools, and grinds into powder, must be 100 object fine powders, for subsequent use;
(2) Herba asplenii prolongati, Prospiroboli joannsi, Parmelia saxatilis Ach. and Herba Laggerae Alatae are removed impurity, clean, put into container, soak 12 hours with the alcoholic solution of volumetric concentration 70%, after add 3 times amount distilled water, decoct 2 hours, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(3) Rhizoma Cibotii, Radix dendrolobii triangularis, Cortex Albiziae and Phtheirospermum tenuisectum Bur.et Franch. are removed impurity, clean, put into container, add 5 times amount distilled water, decoct 3 hours, extract decoction liquor; Add 3 ~ 4 times amount distilled water again, decoct 2 hours, extract decoction liquor, finally merge the decoction liquor extracted for 2 times, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(4) by Herba Hyperici Patuli, Folium eucalypti globueli (Eucalyptus globulus Labill.) and Herba goodyearae repentis removing impurity, clean, sun dehydration, grinds into powder, must be 120 object fine powders, for subsequent use;
(5) make tablet after being mixed with the thick paste of step (2), step (3) gained by the fine powder of step (1), step (4) gained, be the described Chinese medicine preparation being used for the treatment of Kaschin-Beck disease.
The property of medicine of the present invention's Chinese medicine used is as follows:
Rhizoma Dioscoreae Septemlobae: bitter in the mouth, property is put down; Return liver, stomach, urinary bladder channel.Expelling wind and removing dampness.For rheumatoid arthritis stubborn, lumbocrural pain, dysuria, stranguria with turbid discharge is passed out semen, damp and hot sore." herbal classic " carries: " main lumbago and backache, bone strengthening saves, and wind and cold wetted perimeter numbness, malignant boil is recover not, steam.”
The Cortex Eucommiae: sweet in the mouth, warm in nature; Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement, hypertension." herbal classic " carries: " main pain along the spinal column, invigorating middle warmer benefit vital essence, hard muscles and bones, Qiang Zhi, wet except itching under the moon, dribbling urination.”
Radix Glycyrrhizae: sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity." herbal classic " carries: " longue meat, times power, incised wound swells, removing toxic substances for main the five internal organs six mansion cold and heat pathogen, hard muscles and bones.”
Herba asplenii prolongati: acrid in the mouth, hardship, property is put down.Promoting blood circulation to remove blood stasis, curing rheumatism, gets round by bribery.For hematemesis and epistaxis, cough with copious phlegm, general edema with yellowish skin, traumatic injury, bones and muscles pain." Tian Bao book on Chinese herbal medicine " carries: " bone and muscle strengthening.Treat traumatic injury, bones and muscles pain.”
Rhizoma Cibotii: bitter in the mouth, sweet, warm in nature; Return liver, kidney channel.Invigorating the liver and kidney, except rheumatism, strong waist foot, sharp joint.For back ache, gonalgia flaccidity of the lower limbs, cold-damp general arthralgia, loses frequent micturition of drowning, seminal emission leucorrhea." beautiful Chinese catalpa medicine solution " carries: " let out wet cold removing, play flaccidity pain relieving, let out kidney liver dampness, consciousness restoring, bone and muscle strengthening, control lumbago knee joint pain, the swollen lower limb of foot is weak, seminal emission foul leukorrhea.”
Radix dendrolobii triangularis: acrid in the mouth, sweet, cold in nature; Return lung, spleen, large intestine, kidney channel.Clearing away heat and cooling blood, bone and muscle strengthening, invigorating spleen to remove dampness.For diarrhoea of having sore throat, traumatic injury, fracture, hematmesis due to visceral injury." GUIHAIA register " carries: " clearing away heat and cooling blood, bone and muscle strengthening, invigorating spleen to remove dampness.Zhitan paralysis, laryngalgia, diarrhoea, internal traumatic injury, fracture, spits blood, spitting of blood.”
Prospiroboli joannsi: salty in the mouth, pungent, warm in nature; Return kidney channel.Dispelling wind and removing obstruction in the collateral, eliminating stasis to stop pain.For rheumatic arthralgia, the contracture of muscle arteries and veins, traumatic injury, fracture swells and ache." mountain of papers Chinese herbal medicine " carries: " relaxing muscles and tendons to promote blood circulation, detumescence dissipating blood stasis.”
Herba Hyperici Patuli: acrid in the mouth, hardship, cold in nature.Heat-clearing and toxic substances removing, diuresis clots absorbing.For hepatitis flu, dysentery gonorrhea, bones and muscles pain, throat moth is had a toothache, impetigo, traumatic injury." Yunnan Chinese herbal medicine " carries: " heat-clearing and toxic substances removing, relaxing muscles and tendons and activating QI and blood in the collateral, soothing liver-QI, hemostasis.”
Radix Achyranthis Bidentatae: bitter in the mouth, acid, property is put down; Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " only muscles and bones pain, strong muscle relaxing muscles and tendons, only waist knee joint is tingle, and removing blood stasis with potent drugs is had an abortion, and eliminating stagnation core, attacks scrofula, moves back carbuncle, mange, blood wind, psoriasis, pus nest.”
Parmelia saxatilis Ach.: sweet in the mouth, property is put down.Clearing away heat-damp and promoting diuresis, only metrorrhagia.For damp-heat in the urinary bladder, jaundice, lumbago due to pathogenic wind-dampness, metrorrhagia, skin pruritus, tinea pedis, oral aphthae in children, vitiligo." the conventional Chinese herbal medicine handbook in the north " carries: " strengthening bone and muscle, eliminate indigestion gathers for nourishing blood for improving eyesight, benefit essence.Control blurred vision, lumbago and skelalgia, enclosed mass in abdomen, hepatitis.”
Cortex Albiziae: sweet in the mouth, property is put down; GUIXIN, liver, lung meridian.Resolving depression and blood, mind calming is subsided a swelling.For irritability, melancholy insomnia, lung abscess carbuncle, injured bone." Japan hanako materia medica " carries: " soft extracts, subduing inflammation reuniting the fractured tendons and bones.”
Folium eucalypti globueli (Eucalyptus globulus Labill.): acrid in the mouth, hardship, cool in nature; Return lung, stomach, spleen, Liver Channel.Dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing, high dyspnea of heat type is coughed, pertussis, abdominal distention, burn and scald; Traumatic hemorrhage." Traditional Chinese Medicine in Sichuan will " carries: " control arthralgia and make the net for catching birds or fish bag of surgical site infections.”
Herba Laggerae Alatae: acrid in the mouth, property is put down; Return lung, spleen, urinary bladder channel.Expelling wind and removing dampness, changes stagnant dissipating blood stasis, subduing swelling and detoxicating.For cold cough body pain, stomachache dysentery, rheumatic arthritis, women's amenorrhea, traumatic injury, furuncle carbuncle scrofula, noxious dampness pruritus." Luchuan book on Chinese herbal medicine " carries: " wind dispelling pain relieving.Dispelling the wind and dampness pathogens osteodynia, dysentery, ophthalmic pruritus pain.”
Herba goodyearae repentis: sweet in the mouth, pungent, warm in nature.Nourishing the lung to arrest cough, tonifies Qi of the kidney, promoting flow of QI and blood, subduing swelling and detoxicating.For pulmonary tuberculosis cough, tracheitis, dizzy weak, neurasthenia, sexual impotence traumatic injury, arthralgia, laryngopharynx swelling and pain, acute mastitis furuncle, venom." Zhejiang conventional medical herbs among the people " carries: " heat-clearing and toxic substances removing, antiinflammatory detumescent.Control venom, carbuncle furuncle, pneumonopathy is coughed, tracheitis.”
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature; GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, evacuation of pus pain relieving.For angina pectoris, menoxenia, lump in the abdomen, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling." Japan hanako materia medica " carries: " sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; Evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood, mends new hemopoietic; Peaceful tire, fall stillborn fetus; Under hemostasis metrorrhagia and leukorrhagia, adjust married woman's passages through which vital energy circulates irregular, blood evil thought is tired of; Malignant boil scabies, wart is gone to live in the household of one's in-laws on getting married toxic swelling, erysipelas; Headache, acute conjunctivitis, hot temperature is mad vexed.”
Phtheirospermum tenuisectum Bur.et Franch.: acrid in the mouth, hardship, property is put down; GUIXIN warp.Heat-clearing and toxic substances removing, tranquilizing by nourishing the heart, pain relieving.For having a weak heart, cardiopalmus is coughed, sputum mixed with blood, laryngopharynx swelling and pain, fracture, Serpentis, lyssodexis.
The present invention compared with prior art, has following beneficial effect:
Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine theory, there is effect of strengthening the tendons and bones, reducing swelling and alleviating pain, promoting flow of QI and blood, health invigorating, easy to use, good absorbing effect, without bad and toxic and side effects, through clinical verification, have fabulous alleviation and therapeutic effect to treatment Kaschin-Beck disease, the clinical treatment and the nursing that are suitable for Kaschin-Beck disease are applied.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
Rhizoma Dioscoreae Septemlobae 79g Cortex Eucommiae 76g Radix Glycyrrhizae 74g Herba asplenii prolongati 72g
Rhizoma Cibotii 69g Radix dendrolobii triangularis 64g Prospiroboli joannsi 61g Herba Hyperici Patuli 59g
Radix Achyranthis Bidentatae 57g Parmelia saxatilis Ach. 54g Cortex Albiziae 52g Folium eucalypti globueli (Eucalyptus globulus Labill.) 50g
Herba Laggerae Alatae 49g Herba goodyearae repentis 45g Radix Salviae Miltiorrhizae 44g Phtheirospermum tenuisectum Bur.et Franch. 39g.
The processing step of Chinese medicine preparation preparation method of the present invention is:
(1) by Rhizoma Dioscoreae Septemlobae, the Cortex Eucommiae, Radix Glycyrrhizae, Radix Achyranthis Bidentatae and Radix Salviae Miltiorrhizae removing impurity, clean, section, mix thoroughly with yellow wine spray, after moistening, be placed in pot and fry to micro-dry, taking-up cools, and grinds into powder, must be 100 object fine powders, for subsequent use;
(2) Herba asplenii prolongati, Prospiroboli joannsi, Parmelia saxatilis Ach. and Herba Laggerae Alatae are removed impurity, clean, put into container, soak 12 hours with the alcoholic solution of volumetric concentration 70%, after add 3 times amount distilled water, decoct 2 hours, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(3) Rhizoma Cibotii, Radix dendrolobii triangularis, Cortex Albiziae and Phtheirospermum tenuisectum Bur.et Franch. are removed impurity, clean, put into container, add 5 times amount distilled water, decoct 3 hours, extract decoction liquor; Add 3 ~ 4 times amount distilled water again, decoct 2 hours, extract decoction liquor, finally merge the decoction liquor extracted for 2 times, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(4) by Herba Hyperici Patuli, Folium eucalypti globueli (Eucalyptus globulus Labill.) and Herba goodyearae repentis removing impurity, clean, sun dehydration, grinds into powder, must be 120 object fine powders, for subsequent use;
(5) make tablet after being mixed with the thick paste of step (2), step (3) gained by the fine powder of step (1), step (4) gained, be the described Chinese medicine preparation being used for the treatment of Kaschin-Beck disease.
Usage and dosage: oral, 2 times on the one, sooner or later each once, one time 3, a slice 40mg 20 days is 1 course for the treatment of, usual recovery from illness 1 ~ 3 course for the treatment of, and severe patient needs 4 ~ 6 recoveries from illness courses for the treatment of.
Embodiment 2
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
Rhizoma Dioscoreae Septemlobae 73g Cortex Eucommiae 70g Radix Glycyrrhizae 68g Herba asplenii prolongati 66g
Rhizoma Cibotii 63g Radix dendrolobii triangularis 58g Prospiroboli joannsi 56g Herba Hyperici Patuli 54g
Radix Achyranthis Bidentatae 52g Parmelia saxatilis Ach. 48g Cortex Albiziae 46g Folium eucalypti globueli (Eucalyptus globulus Labill.) 44g
Herba Laggerae Alatae 43g Herba goodyearae repentis 39g Radix Salviae Miltiorrhizae 38g Phtheirospermum tenuisectum Bur.et Franch. 33g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
Rhizoma Dioscoreae Septemlobae 66g Cortex Eucommiae 63g Radix Glycyrrhizae 61g Herba asplenii prolongati 59g
Rhizoma Cibotii 56g Radix dendrolobii triangularis 51g Prospiroboli joannsi 49g Herba Hyperici Patuli 46g
Radix Achyranthis Bidentatae 45g Parmelia saxatilis Ach. 41g Cortex Albiziae 39g Folium eucalypti globueli (Eucalyptus globulus Labill.) 37g
Herba Laggerae Alatae 36g Herba goodyearae repentis 32g Radix Salviae Miltiorrhizae 31g Phtheirospermum tenuisectum Bur.et Franch. 26g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
Rhizoma Dioscoreae Septemlobae 58g Cortex Eucommiae 54g Radix Glycyrrhizae 53g Herba asplenii prolongati 52g
Rhizoma Cibotii 48g Radix dendrolobii triangularis 43g Prospiroboli joannsi 40g Herba Hyperici Patuli 39g
Radix Achyranthis Bidentatae 34g Parmelia saxatilis Ach. 33g Cortex Albiziae 32g Folium eucalypti globueli (Eucalyptus globulus Labill.) 29g
Herba Laggerae Alatae 28g Herba goodyearae repentis 24g Radix Salviae Miltiorrhizae 23g Phtheirospermum tenuisectum Bur.et Franch. 18g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
Select the routine clinical observation of patients with Kashin-Beck Disease 600 that my institute or outer court make a definite diagnosis, patient is divided into two groups at random, treatment group 300 example, wherein male 150 example, women 150 example, 9 ~ 67 years old age, 50 years old mean age, the course of disease 1 year ~ 4 years, average 2 years.Matched group 300 example, wherein male 146 example, women 154 example, 11 ~ 70 years old age, 52 years old mean age, the course of disease 6 months ~ 3 years, average 1 year.The course of disease, the degrees of symptoms of two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group patient takes this Chinese medicine preparation, oral, 2 times on the one, sooner or later each once, one time 3, a slice 40mg 20 days is 1 course for the treatment of, usual recovery from illness 1 ~ 3 course for the treatment of, and severe patient needs 4 ~ 6 recoveries from illness courses for the treatment of.
Matched group takes Gujinwan tablet, oral, one time 3 ~ 4,3 times on the one.
3, efficacy determination:
(1) cure:, the transference cures such as bone surface is outwardly, genu varum is in knee, lurch, epiphysis increase; Skeleton recovery from illness, healthy.
(2) effective: above-mentioned symptom is alleviated to some extent, skeleton recovery from illness, healthy.
(3) invalid: disease is unchanged.
4, result:
Take in the treatment group of medicine of the present invention, cure 250 examples, effective 31 examples, invalid 19 examples, cure rate 83.3%, total effective rate 93.7%.
233 examples are cured, effective 29 examples, invalid 38 examples, cure rate 77.7%, total effective rate 87.3% in matched group.
Above result display, treatment group cure rate and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, all ××s, female, 12 years old, student, people from Changchun, Jilin.Patient points short and small, and articulations digitorum manus is thick, the bead that ancon and knee picture are heaved, and walks limping, after carrying out my institute's inspection, is diagnosed as Kaschin-Beck disease.After taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, symptom is obviously alleviated, and continues to take 1 course for the treatment of, and above symptom all disappears.Follow up a case by regular visits to and do not recur so far.
2, ×× is opened, man, 16 years old, student, Inner Mongol people from Chifeng.Patient's epiphyseal plate ossify in advance, and make growth occur obstacle, build is short and small, and joint is thick, and has the symptom such as pain and limitation of activity.After taking 1 course for the treatment of of Chinese medicine preparation of the present invention, health is rehabilitation gradually, and symptom is obviously alleviated, and continues to take 2 courses for the treatment of, above transference cure.Follow up a case by regular visits to and do not recur so far.
3, virgin ××, man, 21 years old, student, Jincheng, Shanxi people.The swelling of patient's osteoarthrosis, has a small amount of hydrops, have friction sense, and with interlocking symptom, intraarticular has episome on inspection, ankle, knee joint swelling pain, walks very inconvenient time movable.Be diagnosed as Kaschin-Beck disease.After taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, symptom is clearly better, and after continuing to take 3 courses for the treatment of, above transference cure, physical recovery is healthy.Follow up a case by regular visits to and do not recur so far.
4, white ××, female, 33 years old, profession, people from Shenyang, Liaoning.The swelling of patient's readme arthralgia, my institute checks then, and find that epiphysis starts to merge from middle body, gradually expand to edge, epiphysis itself is destroyed.Be diagnosed as Kaschin-Beck disease.Take Chinese medicine preparation of the present invention 2 the symptom course for the treatment of obviously to alleviate, after continuing to take 2 courses for the treatment of, transference cure.Follow up a case by regular visits to and do not recur so far.
5, ×× is tried to gain, female, 44 years old, peasant, people from Shijiazhuang, Hebei.Patient's epiphysis increases, and have pain, joint motions are limited, and the earliest, then finger-joint, knee joint, elbow, wrist, toes joint and hip are all limited, have a strong impact on life in originally ankle joint morbidity.After taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, above symptom takes a turn for the better, and after continuing to take 1 course for the treatment of, above transference cure, gets well.Follow up a case by regular visits to and do not recur so far.
6, her ××, man, 60 years old, unemployed, people from Lanzhou, Gansu.Suffering from osteoarthritis before patient, taking a turn for the better through curing, but recent knee joint, elbow, wrist, toes joint arthralgia, walking disorder.Check through my institute, the roomy distortion of patient's epiphysis, joint is thick, joint varus.Be diagnosed as Kaschin-Beck disease.After taking 3 courses for the treatment of of Chinese medicine preparation of the present invention, symptom takes a turn for the better, and after then taking 2 courses for the treatment of, physical recovery is normal, and activity freely.Follow up a case by regular visits to and do not recur so far.
Claims (5)
1. be used for the treatment of a Chinese medicine preparation for Kaschin-Beck disease, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Rhizoma Dioscoreae Septemlobae 50 ~ 80 parts of Cortexs Eucommiae 47 ~ 77 portions of Radix Glycyrrhizaes 45 ~ 75 parts of Herba asplenii prolongati 43 ~ 73 parts
Rhizoma Cibotii 40 ~ 70 parts of Radix dendrolobii triangulariss 35 ~ 65 parts of Prospiroboli joannsis 32 ~ 62 parts of Herba Hyperici Patulis 30 ~ 60 parts
Radix Achyranthis Bidentatae 28 ~ 58 parts of Parmelia saxatilis Ach. 25 ~ 55 portions of Cortex Albiziaes 23 ~ 53 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s 21 ~ 51 parts
Herba Laggerae Alatae 20 ~ 50 parts of Herba goodyearae repentis 16 ~ 46 parts of Radix Salviae Miltiorrhizaes 15 ~ 45 parts of Phtheirospermum tenuisectum Bur.et Franch.s 10 ~ 40 parts.
2. be used for the treatment of a Chinese medicine preparation for Kaschin-Beck disease, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Rhizoma Dioscoreae Septemlobae 73 parts of Cortexs Eucommiae 70 portions of Radix Glycyrrhizaes 68 parts of Herba asplenii prolongati 66 parts
Rhizoma Cibotii 63 parts of Radix dendrolobii triangulariss 58 parts of Prospiroboli joannsis 56 parts of Herba Hyperici Patulis 54 parts
Radix Achyranthis Bidentatae 52 parts of Parmelia saxatilis Ach. 48 portions of Cortex Albiziaes 46 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s 44 parts
Herba Laggerae Alatae 43 parts of Herba goodyearae repentis 39 parts of Radix Salviae Miltiorrhizaes 38 parts of Phtheirospermum tenuisectum Bur.et Franch.s 33 parts.
3. be used for the treatment of a Chinese medicine preparation for Kaschin-Beck disease, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Rhizoma Dioscoreae Septemlobae 66 parts of Cortexs Eucommiae 63 portions of Radix Glycyrrhizaes 61 parts of Herba asplenii prolongati 59 parts
Rhizoma Cibotii 56 parts of Radix dendrolobii triangulariss 51 parts of Prospiroboli joannsis 49 parts of Herba Hyperici Patulis 46 parts
Radix Achyranthis Bidentatae 45 parts of Parmelia saxatilis Ach. 41 portions of Cortex Albiziaes 39 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s 37 parts
Herba Laggerae Alatae 36 parts of Herba goodyearae repentis 32 parts of Radix Salviae Miltiorrhizaes 31 parts of Phtheirospermum tenuisectum Bur.et Franch.s 26 parts.
4. be used for the treatment of a Chinese medicine preparation for Kaschin-Beck disease, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Rhizoma Dioscoreae Septemlobae 58 parts of Cortexs Eucommiae 54 portions of Radix Glycyrrhizaes 53 parts of Herba asplenii prolongati 52 parts
Rhizoma Cibotii 48 parts of Radix dendrolobii triangulariss 43 parts of Prospiroboli joannsis 40 parts of Herba Hyperici Patulis 39 parts
Radix Achyranthis Bidentatae 34 parts of Parmelia saxatilis Ach. 33 portions of Cortex Albiziaes 32 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s 29 parts
Herba Laggerae Alatae 28 parts of Herba goodyearae repentis 24 parts of Radix Salviae Miltiorrhizaes 23 parts of Phtheirospermum tenuisectum Bur.et Franch.s 18 parts.
5. the preparation method being used for the treatment of the Chinese medicine preparation of Kaschin-Beck disease as described in any one of Claims 1 to 4, is characterized in that: comprise following processing step:
(1) by Rhizoma Dioscoreae Septemlobae, the Cortex Eucommiae, Radix Glycyrrhizae, Radix Achyranthis Bidentatae and Radix Salviae Miltiorrhizae removing impurity, clean, section, mix thoroughly with yellow wine spray, after moistening, be placed in pot and fry to micro-dry, taking-up cools, and grinds into powder, must be 100 object fine powders, for subsequent use;
(2) Herba asplenii prolongati, Prospiroboli joannsi, Parmelia saxatilis Ach. and Herba Laggerae Alatae are removed impurity, clean, put into container, soak 12 hours with the alcoholic solution of volumetric concentration 70%, after add 3 times amount distilled water, decoct 2 hours, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(3) Rhizoma Cibotii, Radix dendrolobii triangularis, Cortex Albiziae and Phtheirospermum tenuisectum Bur.et Franch. are removed impurity, clean, put into container, add 5 times amount distilled water, decoct 3 hours, extract decoction liquor; Add 3 ~ 4 times amount distilled water again, decoct 2 hours, extract decoction liquor, finally merge the decoction liquor extracted for 2 times, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(4) by Herba Hyperici Patuli, Folium eucalypti globueli (Eucalyptus globulus Labill.) and Herba goodyearae repentis removing impurity, clean, sun dehydration, grinds into powder, must be 120 object fine powders, for subsequent use;
(5) make tablet after being mixed with the thick paste of step (2), step (3) gained by the fine powder of step (1), step (4) gained, be the described Chinese medicine preparation being used for the treatment of Kaschin-Beck disease.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103860964A (en) * | 2014-03-28 | 2014-06-18 | 李国华 | Medicinal preparation for treating adult Kaschin-Beck disease |
| CN104189141A (en) * | 2014-08-07 | 2014-12-10 | 刘振标 | Health medicinal liquor for treating kaschin-beck disease |
| CN104547951A (en) * | 2015-01-29 | 2015-04-29 | 王东宝 | Traditional Chinese medicine preparation for treating cerebral apoplexy and preparation method of traditional Chinese medicine preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103860964A (en) * | 2014-03-28 | 2014-06-18 | 李国华 | Medicinal preparation for treating adult Kaschin-Beck disease |
| CN104189141A (en) * | 2014-08-07 | 2014-12-10 | 刘振标 | Health medicinal liquor for treating kaschin-beck disease |
| CN104547951A (en) * | 2015-01-29 | 2015-04-29 | 王东宝 | Traditional Chinese medicine preparation for treating cerebral apoplexy and preparation method of traditional Chinese medicine preparation |
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