CN105434649A - Traditional Chinese medicine composition treating blood-stasis collateral-obstruction type diabetic foot - Google Patents
Traditional Chinese medicine composition treating blood-stasis collateral-obstruction type diabetic foot Download PDFInfo
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- CN105434649A CN105434649A CN201410459973.1A CN201410459973A CN105434649A CN 105434649 A CN105434649 A CN 105434649A CN 201410459973 A CN201410459973 A CN 201410459973A CN 105434649 A CN105434649 A CN 105434649A
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Abstract
A disclosed traditional Chinese medicine composition treating blood-stasis collateral-obstruction type diabetic foot is prepared from the following traditional Chinese medicine raw materials in parts by weight: 55-64 parts of radix astragali, 5-14 parts of mulberry/cassia twig, 12-18 parts of radix angelicae sinensis, 12-18 parts of radix paeoniae rubra, 12-18 parts of szechuan lovage rhizome, 25-33 parts of radix salviae miltiorrhizae, 12-18 parts of raw radix rehmanniae, 12-18 parts of radix cyathulae, 12-18 parts of raw pheretima, 25-33 parts of caulis spatholobi, and 5-14 parts of white silkworm. Most of the raw materials in the formula possess the efficacies of tonifying qi and unblocking vessels, activating blood and resolving stasis. The total effective rate is 90.4%. The traditional Chinese medicine composition is capable of improving clinic symptoms and shortening the treatment course.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and application thereof for the treatment of diabetic foot, particularly relate to a kind of Chinese medicine composition for the treatment of blood stasis resistance network patients with type Ⅰ DM foot.
Background technology
Diabetic foot (DF) is one of chronic complicating diseases of diabetes, destroy to Lower Distal Extremities dysautonomia and peripheral angiopathy is relevant in various degree foot ulcers, infection and (or) deep tissues, the lighter show as foot deformity, xerosis cutis and send out cool, callus, foot ulcers, gangrene can be there is in severe one, be the main cause causing diabetics limbs maimed person, drastically influence the quality of life of patient.
Diabetic foot, also known as diabetic gangrene, belongs to the traditional Chinese medical science " necrosis " category together with thromboangiitis obliterans, atherosclerotic occlusive disease.Chinese medicine thinks that this disease is mainly deficiency of both QI and YIN, obstruction of collaterals by blood stasis, and QI and blood can not caused by sensible extremity.But chemical drugs does not also have the special medicine for diabetic foot, general treatment method is conservative symptomatic treatment, and simultaneously conventional chemicals has obvious side effect, and diabetics needs lifelong medication, and long-term prescription can exert an adverse impact to health.
Summary of the invention
For above-mentioned prior art, the invention provides a kind of Chinese medicine composition for the treatment of blood stasis resistance network patients with type Ⅰ DM foot, this Chinese medicine composition has supplementing qi and invigorating vasculum, effect of blood circulation promoting and blood stasis dispelling, and easy to operation.
The present invention is achieved by the following technical solutions:
Treat a Chinese medicine composition for blood stasis resistance network patients with type Ⅰ DM foot, be made up of the raw material of Chinese medicine of following weight:
The Radix Astragali 55 ~ 64 parts, Sang Guizhi 5 ~ 14 parts, Radix Angelicae Sinensis 12 ~ 18 parts, Radix Paeoniae Rubra 12 ~ 18 parts, Rhizoma Chuanxiong 12 ~ 18 parts, Radix Salviae Miltiorrhizae 25 ~ 33 parts, 12 ~ 18 parts, the Radix Rehmanniae, Radix Cyathulae 12 ~ 18 parts, Pheretima 12 ~ 18 parts, Caulis Spatholobi 25 ~ 33 parts, Bombyx Batryticatus 5 ~ 14 parts.
Preferably, be made up of the raw material of Chinese medicine of following weight:
The Radix Astragali 57 parts, Sang Guizhi 8 parts, Radix Angelicae Sinensis 13 parts, Radix Paeoniae Rubra 13 parts, Rhizoma Chuanxiong 13 parts, Radix Salviae Miltiorrhizae 27 parts, 13 parts, the Radix Rehmanniae, Radix Cyathulae 13 parts, Pheretima 13 parts, Caulis Spatholobi 27 parts, Bombyx Batryticatus 8 parts.
More preferably, be made up of the raw material of Chinese medicine of following weight:
The Radix Astragali 60 parts, Sang Guizhi l0 part, Radix Angelicae Sinensis 15 parts, Radix Paeoniae Rubra 15 parts, Rhizoma Chuanxiong 15 parts, Radix Salviae Miltiorrhizae 30 parts, 15 parts, the Radix Rehmanniae, Radix Cyathulae 15 parts, Pheretima 15 parts, Caulis Spatholobi 30 parts, Bombyx Batryticatus l0 part.
Above-mentioned medical material is put into marmite, adds the water soaking 2 hours of 4 times of dose weight multiples, decoct 1 hour, filter to obtain medicinal liquid and medicinal residues, in medicinal residues, add the water of 2 times of doses again, decoct 0.5 hour, filter to obtain medicinal liquid, merge the medicinal liquid of twice, to obtain final product.
Diabetic foot is one of chronic complicating diseases of diabetes, should belong to the traditional Chinese medical science " arthromyodynia " category according to its clinical manifestation.With the passing of time the diabetes deficiency of YIN scorching, and Tianjin blood depletion exhausts into the stasis of blood, numbness resistance blood network, and passages through which vital energy circulates is obstructed, the symptom such as occur pain, numbness, amyotrophy, send out cool to be afraid of cold.Raw many tools supplementing qi and invigorating vasculum of the present invention, blood circulation invigorating efficacies, total effective rate is 90.48%, can improve clinical symptoms, shortens and treats the course for the treatment of.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment 1:
Treat a Chinese medicine composition for blood stasis resistance network patients with type Ⅰ DM foot, be made up of the raw material of Chinese medicine of following weight proportion:
The Radix Astragali 55 grams, Sang Guizhi 5 grams, Radix Angelicae Sinensis 12 grams, Radix Paeoniae Rubra 12 grams, Rhizoma Chuanxiong 12 grams, Radix Salviae Miltiorrhizae 25 grams, 12 grams, the Radix Rehmanniae, Radix Cyathulae 12 grams, Pheretima 12 grams, Caulis Spatholobi 25 grams, Bombyx Batryticatus 5 grams.
Embodiment 2:
Treat a Chinese medicine composition for blood stasis resistance network patients with type Ⅰ DM foot, be made up of the raw material of Chinese medicine of following weight proportion:
The Radix Astragali 64 grams, Sang Guizhi 14 grams, Radix Angelicae Sinensis 18 grams, Radix Paeoniae Rubra 18 grams, Rhizoma Chuanxiong 18 grams, Radix Salviae Miltiorrhizae 33 grams, 18 grams, the Radix Rehmanniae, Radix Cyathulae 18 grams, Pheretima 18 grams, Caulis Spatholobi 33 grams, Bombyx Batryticatus 14 grams.
Embodiment 3:
Treat a Chinese medicine composition for blood stasis resistance network patients with type Ⅰ DM foot, be made up of the raw material of Chinese medicine of following weight proportion:
The Radix Astragali 57 grams, Sang Guizhi 8 grams, Radix Angelicae Sinensis 13 grams, Radix Paeoniae Rubra 13 grams, Rhizoma Chuanxiong 13 grams, Radix Salviae Miltiorrhizae 27 grams, 13 grams, the Radix Rehmanniae, Radix Cyathulae 13 grams, Pheretima 13 grams, Caulis Spatholobi 27 grams, Bombyx Batryticatus 8 grams.
Embodiment 4:
Treat a Chinese medicine composition for blood stasis resistance network patients with type Ⅰ DM foot, be made up of the raw material of Chinese medicine of following weight proportion:
The Radix Astragali 60 grams, Sang Guizhi l0 gram, Radix Angelicae Sinensis 15 grams, Radix Paeoniae Rubra 15 grams, Rhizoma Chuanxiong 15 grams, Radix Salviae Miltiorrhizae 30 grams, 15 grams, the Radix Rehmanniae, Radix Cyathulae 15 grams, Pheretima 15 grams, Caulis Spatholobi 30 grams, Bombyx Batryticatus l0 gram.
Clinical data
1.1 physical data:
All cases all meets diabetic foot clinical criteria.Clinically divide two groups by random digits table by 82 routine patients, wherein treatment group 42 example, 41 ~ 62 years old age, the course of disease 2 ~ 15 years; Matched group is 40 examples, 40 ~ 69 years old age, course of disease 1-14; Treatment group and matched group patient compare in sex, age, the course of disease, the state of an illness, and no significant difference (P > 0.05), has comparability.
1.2 clinical criterias:
All patients all meets WHO(1999) diabetes diagnostic criterion, the diagnostic criteria of blood stasis resistance network patients with type Ⅰ DM foot: weakness of the lower extremities, be afraid of cool, intermittent limping; Skin pruritus, dry and lossless, biped xerosis cutis, be full of cracks, parallel Zhi are formed, and foot pallor or obfuscation have ecchymosis, and hair comes off, and toenail thickens; Acra twinge, causalgia, numbness, insensitive or forfeiture, foot steps on cotton-wool sense or foreign body sensation.Pale tongue is dark, white and thin fur, deep-thready pulse or heavy.
1.3 cases are included in and exclusion standard:
(1) inclusive criteria:
meet WHO(1999) diabetes diagnostic criterion;
meet diabetic foot (Wagner classification 0 grade) diagnostic criteria.(2) exclusion standard:
type 1 diabetes patient;
diabetic foot (Wagner classification) 1 grade and above patient;
the diabetic complication person having other serious.
1.4 Therapeutic Method:
Two groups of patients all carry out diabetes education and appropriate exercise, all should insulinize, control blood sugar level.Wherein, matched group patient gives intravenous drip thioctic acid 450mg/ day (Yabao Group Taiyuan Pharmaceutical Co., Ltd. produces, the accurate word H20055869 of traditional Chinese medicines); Treatment group patient gives the Chinese medicine composition foot bath of the embodiment of the present invention 4 on treatment of control group basis; get every agent medicine in the embodiment of the present invention 4 and decoct twice; extracting juice 200 ~ 300ml altogether; point early, evening twice warmly takes; period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing; fry, fire are burned and stodgy food should not be eaten more, within two weeks, are a course for the treatment of.
1.5 curative effect determinate standards:
" diabetes (diabetes) traditional Chinese medical science TCM Differentiation of Clinical Stages and efficacy assessment standard " that " the new Chinese medicine guideline of clinical investigations " issued according to Ministry of Health of the People's Republic of China and diabetes Professional Committee of Chinese Chinese medicine association formulate is formulated.
Effective: clinical symptoms is clearly better, patients feet's skin color obviously improves, and limbs are without twinge feeling of numbness;
Effective: clinical symptoms takes a turn for the better, patients feet's skin color improves, and limbs are even twinge feeling of numbness, and other symptoms are slightly improved;
Invalid: symptom has no improvement.
1.6 statistical procedures:
Application SPSS10.0 software carries out statistical procedures, continuous data adopt mean ± standard deviation with
represent, enumeration data adopts
inspection, compare between group and adopt t inspection, P < 0.05 has statistical significance.
2 results
2.1 Clinical efficacy comparisons:
After the course for the treatment of, effective 27 examples for the treatment of group, account for 64.29%, and effective 11 examples, account for 26.19%, invalid 4 examples, and total effective rate is 90.48%; Effective 10 examples of matched group, account for 25.0%, and effective 13 examples, account for 32.5%, invalid 12 examples, and total effective rate is 57.5%; Two groups of total effective rates compare, and difference has statistical significance (P < 0.05).
2.3 untoward reaction:
Untoward reaction is there is in treatment group without patient.
Claims (4)
1. treat a Chinese medicine composition for blood stasis resistance network patients with type Ⅰ DM foot, it is characterized in that, be made up of the raw material of Chinese medicine of following weight:
The Radix Astragali 55 ~ 64 parts, Sang Guizhi 5 ~ 14 parts, Radix Angelicae Sinensis 12 ~ 18 parts, Radix Paeoniae Rubra 12 ~ 18 parts, Rhizoma Chuanxiong 12 ~ 18 parts, Radix Salviae Miltiorrhizae 25 ~ 33 parts, 12 ~ 18 parts, the Radix Rehmanniae, Radix Cyathulae 12 ~ 18 parts, Pheretima 12 ~ 18 parts, Caulis Spatholobi 25 ~ 33 parts, Bombyx Batryticatus 5 ~ 14 parts.
2. a kind of Chinese medicine composition for the treatment of blood stasis resistance network patients with type Ⅰ DM foot as claimed in claim 1, is characterized in that, be made up of the raw material of Chinese medicine of following weight:
The Radix Astragali 57 parts, Sang Guizhi 8 parts, Radix Angelicae Sinensis 13 parts, Radix Paeoniae Rubra 13 parts, Rhizoma Chuanxiong 13 parts, Radix Salviae Miltiorrhizae 27 parts, 13 parts, the Radix Rehmanniae, Radix Cyathulae 13 parts, Pheretima 13 parts, Caulis Spatholobi 27 parts, Bombyx Batryticatus 8 parts.
3. a kind of Chinese medicine composition for the treatment of blood stasis resistance network patients with type Ⅰ DM foot as claimed in claim 1, is characterized in that, be made up of the raw material of Chinese medicine of following weight:
The Radix Astragali 60 parts, Sang Guizhi l0 part, Radix Angelicae Sinensis 15 parts, Radix Paeoniae Rubra 15 parts, Rhizoma Chuanxiong 15 parts, Radix Salviae Miltiorrhizae 30 parts, 15 parts, the Radix Rehmanniae, Radix Cyathulae 15 parts, Pheretima 15 parts, Caulis Spatholobi 30 parts, Bombyx Batryticatus l0 part.
4. the Chinese medicine composition described in any one of claim 1-3, it is characterized in that, preparation method is: above-mentioned medical material is put into marmite, adds the water soaking 2 hours of 4 times of dose weight multiples, decocts 1 hour, filter to obtain medicinal liquid and medicinal residues, in medicinal residues, add the water of 2 times of doses again, decoct 0.5 hour, filter to obtain medicinal liquid, merge the medicinal liquid of twice, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410459973.1A CN105434649A (en) | 2014-09-11 | 2014-09-11 | Traditional Chinese medicine composition treating blood-stasis collateral-obstruction type diabetic foot |
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| CN201410459973.1A CN105434649A (en) | 2014-09-11 | 2014-09-11 | Traditional Chinese medicine composition treating blood-stasis collateral-obstruction type diabetic foot |
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| CN105434649A true CN105434649A (en) | 2016-03-30 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825635A (en) * | 2015-05-15 | 2015-08-12 | 济南科纳信息科技有限公司 | Traditional Chinese medicine composition for treating diabetic feet |
| CN113082115A (en) * | 2021-04-16 | 2021-07-09 | 辽宁中医药大学 | Traditional Chinese medicine composition for treating diabetic peripheral neuropathy and preparation method thereof |
-
2014
- 2014-09-11 CN CN201410459973.1A patent/CN105434649A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825635A (en) * | 2015-05-15 | 2015-08-12 | 济南科纳信息科技有限公司 | Traditional Chinese medicine composition for treating diabetic feet |
| CN113082115A (en) * | 2021-04-16 | 2021-07-09 | 辽宁中医药大学 | Traditional Chinese medicine composition for treating diabetic peripheral neuropathy and preparation method thereof |
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Application publication date: 20160330 |