Summary of the invention
Purpose of the present invention just provides a kind of a kind of Chinese medicine composition of more efficiently treatment cerebral infarction.
Technical scheme of the present invention is: we are ground into the end with Hirudo, Pheretima, Radix Notoginseng, Bombyx Batryticatus, Scorpio, and the Radix Astragali, Ramulus Cinnamomi, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Caulis Piperis Kadsurae, Rhizoma Arisaematis, Fructus Trichosanthis, Bombyx Batryticatus are fried in shallow oil soup and melted and be mixture.
The consumption of medicine components of the present invention comes out through a large amount of practice summaries, and the each component consumption has effect preferably in the following weight parts scope:
Radix Notoginseng 4-6 part, Pheretima 4-6 part, Scorpio 5-8 part, Bombyx Batryticatus 5-8 one's share of expenses for a joint undertaking Hirudo 3-6 part, Radix Astragali 30-40 part, Ramulus Cinnamomi 8-10 part, Radix Angelicae Sinensis 10-13 part, Radix Salviae Miltiorrhizae 26-35 part, Rhizoma Chuanxiong 8-12 part, Caulis Piperis Kadsurae 12-16 part, Rhizoma Arisaematis 4-7 part, Fructus Trichosanthis 8-12 part.
In technical solution of the present invention, the salty hardship of Hirudo is gone into blood system, and merit is arrogated to oneself removing blood stasis; Pheretima is longer than current meridians, blood viscosity lowering; The Rhizoma Chuanxiong blood-activating and qi-promoting; Scorpio, Radix Notoginseng have the function of obvious anticoagulant embolism extinguishing; The Radix Astragali, Ramulus Cinnamomi, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Caulis Piperis Kadsurae compatibility have strengthened the effect of inrigorating qi and promoting blood circulation collateral dredging; Rhizoma Arisaematis, Fructus Trichosanthis, Bombyx Batryticatus are got its dissipating phlegm and removing blood stasis with collateral dredging.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to make various conventional oral preparations.Radix Notoginseng, Pheretima, Scorpio, Bombyx Batryticatus, Hirudo, above medicine is ground into powder.It is bottled that the Radix Astragali, Ramulus Cinnamomi, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Caulis Piperis Kadsurae, Rhizoma Arisaematis, Fructus Trichosanthis, medicine-feeding add the concentrated employing of water decoction.
The specific embodiment
Below further set forth the beneficial effect of medicine of the present invention by testing example.
The clinical observation of test example 1 Drug therapy cerebral infarction of the present invention
1, physical data
This research is observed the patient and is my institute's inpatient, all is diagnosed as cerebral infarction, divides this medicine treatment group and matched group at random.Diagnostic criteria and therapeutic evaluation standard meet " precious disconnected, the efficacy assessment standard of the apoplexy traditional Chinese medical science " that Society of Internal Medicine revises.The treatment group: Primary Care (reduce intracranial pressure, in good time use anticoagulant, prevent and treat complication and nutritional support etc.) in, add in order to this medicine and (grind into powder by Radix Notoginseng, Pheretima, Scorpio, Bombyx Batryticatus, Hirudo, frying in shallow oil soup with the Radix Astragali, Ramulus Cinnamomi, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Caulis Piperis Kadsurae, Rhizoma Arisaematis, Fructus Trichosanthis forms), day potion divides the secondary clothes.Matched group: on the basis of Primary Care, use troxerutin, aspirin, flunarizine etc.
(1) treatment group: in 288 examples, male 216 examples, women 72 examples.Age 38-60 year, 59.5 years old mean age.138 examples have hypertension, and sick 4--45 days, average 14,5 days.Blocking part, right side 102 examples, left side 87 examples, basal ganglia region lacuna 90 examples, Nie Ye 18 examples.Hemiplegia 225 examples, Ipsilateral muscular strength 0-1 level 87 examples, 2-3 rank 114 examples, 4 grade of 24 example.The mobility loses 78 examples, and mixed aphasia 36 examples are choked and coughed 36 examples.
(2) matched group: matched group 180 examples, male 114 examples, women 66 examples, age 40-70 year, average 59.4 years old.The course of disease 6 hours-36 days, average 16.5 days.Blocking part, right side 66 examples, left side 48 examples, basal ganglia region lacuna 51 examples, Nie Ye 6 examples, hemiplegia 144 examples, Ipsilateral muscular strength 0-1 level 18 examples, 2-3 level 63 examples, 4 grade of 12 example, motor aphasia 54 examples, mixed aphasia 18 examples are choked and are coughed 15 examples.
(3) the case inclusion criteria is: age 35-60 year, in the acute onset 72 hours: morbidity first or morbidity in the past do not stay the impairer of function of nervous system; The head CT Cerebral hemorrhage.
(4) standard that case is not selected is: clearly be heart source property cerebral thrombosis; Companion's atrial fibrillation or severe cardiac functional defect person; Companion's peptic ulcer or digestive tract hemorrhage person; Platelet is less than 60 * 10/L person; Using preparation persons such as anti-fibrinolytic, anticoagulation.
The equal no significant differences of logical statistical procedures such as point play in two groups of ages, sex, severity extent, traditional Chinese medical science typing, history of past illness integration, concomitant disease integration and function of nervous system.
2, research method
(1) diagnostic criteria:
" apoplexy tcm diagnosis, the efficacy assessment standard " that tcm diagnosis standard reference Society of Internal Medicine of the national association of traditional Chinese medicine in 1986 revises.The standard that the 4th national cerebrovascular academic conference of Western medicine diagnose standard reference nineteen ninety-five Chinese Medical Association revised: the clean state of Chang Yuan is morbidity down; Great majority do not have obviously headache and vomiting; Morbidity can be slower, progress gradually how, or be stage and carry out; Clear or the slight obstacle of consciousness in general morbidity back 1-2 day; Internal carotid artery systemic symptom and sign are arranged; Waist is worn cerebrospinal fluid and is not contained blood; CT examination is found cerebral location of lesions.
(2) efficacy assessment standard
The clinical efficacy evaluation criteria: (1) is basic complete: integration reaches 24 fens above persons.(2) produce effects: integration increases above going 10 fens persons.(3) effective: integration increases above 4 fens persons.(4) invalid; Integration increases by 4 fens persons of less than.(5) worsen: the state of an illness adds multiple integral and is reduced to dead person.Point system: 1, mind state: conscious 4 minutes; Mind realize all of a sudden (drowsy, wake up after can and people's words) 3 minutes; The mind mist (drowsiness, exhale answer imprecise) 2 minutes; Coma 1 minute; Muddle-headed 0 minute.2, language performance: normal 4 minutes; The general expression, name can not 3 minutes; Form a complete sentence in a minute and express not entirely and spend 2 fens; Not talkative word, phrase 1 minute; Language can not 0 minute.3, upper limb shoulder joint: normal 4 minutes; Last act is complete and muscular strength differed from 3 fens; Last act is flat takes on or crosses and takeed on 2 fens; Last act is less than takeing on 2 fens; Swing 0 minute is coughed up in inactive or front and back.4, upper limb articulations digitorum manus: normal 4 minutes; Finger movement effectively and muscular strength differed from 3 fens; Clench fist to stretch and refer to 2 fens; Count on one's fingers, can not hold fist, can not stretch 1 fen; Can not move 0 fen.5, lower limb hip joint: normal 4 minutes; Raised more than 45 ° 3 fens; 45 ° of less thaies 2 minutes; Swing energy translation 1 minute; Inactive 0 minute.6, lower limb toe joint: seldom 4 minutes; Stretch bend freely, weak 3 minutes of power; Stretch and bent incomplete 2 minutes; Slightly moving 1 minute; Can not move 0 fen.7, integration capability: life can be taken care of oneself, open lived on one's own life in 4 minutes simple work and some functional defecies energy 3 minutes; Can walk section processes, auxiliary 2 minutes of the people that still needs; Can stand and take a step, need the people to take care of at any time 1 fen; Liied in bed 0 fen.
3, Therapeutic Method
Treatment group: in Primary Care, add in order to change bolt post-equalization agent and (grind the end, fry in shallow oil soup with the Radix Astragali, Ramulus Cinnamomi, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Caulis Piperis Kadsurae, Rhizoma Arisaematis, Fructus Trichosanthis and concentrate and form by Radix Notoginseng, Pheretima, Scorpio, Bombyx Batryticatus, Hirudo, be packed as the 100ML/ bottle), day clothes 100ML, divide the secondary clothes, medicamental pulverata one bag of at every turn taking after mixing it with water.14 days is a course of treatment, 2-3 days at interval two courses of treatment, adds up curative effect two courses of treatment.
Matched group: on the basis of Primary Care, be a course of treatment in 14 days, 2-3 days at interval two courses of treatment, add up curative effect after two courses of treatment with XUESAITONG, aspirin etc.
4, statistical method
T check before and after the treatment, The data (± S) expression.
5, result and analysis
(1) curative effect
Treatment group: this medication therapy groups 288 examples, basic complete more 114 examples, produce effects 117 examples, 51 examples that take a turn for the better, invalid 6 examples, total effective rate 95.8%.Matched group: treat 180 examples, basic complete more 30 examples, produce effects power 24 examples, 78 examples that take a turn for the better, total effective rate 73.3%.Treatment group curative effect obviously is better than control tissue (P<0.05).
Clinical symptoms is improved relatively (seeing Table one) before and after (2) two groups of treatments
After two groups of treatments, except the curative effect of dizziness was preferable, the improvement of other each symptom was all not as good as the treatment group in the matched group.
Table one: two groups of treatment back clinical symptoms are improved relatively
Blood flow changes relatively (seeing Table two) before and after (3) two groups of treatments
Full specific viscosity, packed cell volume, Fibrinogen after the treatment of treatment group is starkly lower than treatment preceding (P<0.05~0.01).(P<0.05) other laboratory indexes treatment front and back difference does not have significance (P<0.05) before having only packed cell volume to be starkly lower than treatment after the treatment of control group.The improvement that explanation bolt post-equalization mixture is learned index to the hemorheology of Cerebral Infarction Patients is better than matched group.
Hemorheology changes relatively before and after the table two liang group treatment
6, toxicity
The clinical stage terminal is observed in 288 examples, 86 customary liver functions, blood routine examination, and all no abnormal variation, illustrating behind this medicine of application does not have systemic adverse reactions.5% patient is only arranged, the sensation of gastral cavilty portion discomfort is arranged after taking medicine, change one after each meal into, uncomfortable positive shape can obviously alleviate.
7, model case:
(1) Yin * *, man, 60 years old, cadre, first visit on May 10 in 2003.After patient's supper yesterday, dizzy suddenly, speech is not smoothgoing puckery, slobbering, and upper left numbness of lower limbs, weak, examine today.Disease is seen patient's emaciated physique, pale complexion, and Mental fatigue is drowsiness, and stiff tongue and retardation in speech, finger-joint are slightly active, but can not bend and stretch, and the left lower extremity swing is limited, incapable of flexing and extending, excessive phlegm between pharynx, it is soft to defecate, and day 2 times, pale tongue with white fur is greasy, thready and moderate pulse.Blood pressure 160/110MMHG, brain CT makes a definite diagnosis the right side cerebral infarction.The traditional Chinese medical science is examined and is apoplexy, belongs to syndrome of blood stasis due to qi deficiency.The benefiting QI for activating blood circulation collateral dredging adds the Rhizoma Atractylodis Macrocephalae 15 gram, Rhizoma Dioscoreae 15 grams with this medicine, obey 3 doses after conscious sialorrhea, expectorant minimizing, the left limb numbness is decrescence, can count on one's fingers and clench fist, still take treatment in 30 days with the top plus-minus, left side limb activity up and down recovers normal substantially, take care of oneself, language is unimpeded, the basic healing.
(2) Lee * *, the woman, 38 years old, Juxian County summer people from village, the peasant, on January 4th, 2005 was admitted to hospital.Patient's phenolics in 2004 is found hypertension, and October 16, the pressure holding of daily output bleeding from anus was continuous does not fall, and fluctuation is about 175/120MMHG, feel to have a dizzy spell 4 days puerperal, very dizzy, the left limb numbness, after local hospital gave quiet notes magnesium sulfate, blood pressure drops was 145/95MMHG.Once examined in local hospital and be " cerebral thrombosis ".Clothes Chinese medicine and western medicine poor effect was changeed my institute's treatment February 4.Disease sees that patient's body is fat slightly, face light yellow complexion, spiritlessness and weakness, lassitude, stiff tongue, slurred speech, slobbering, mouthful eye is to the left askew, and right upper extremity can not be praised, and front and back can not be swung, finger-joint is active slightly, but can not bend and stretch, right lower extremity swing incapable of flexing and extending, urinary incontinence.Pale tongue, white and thin fur, stringy and thready pulse.BP145/95MMHG, brain CT make a definite diagnosis the left side cerebral infarction.The traditional Chinese medical science is examined to apoplexy belongs to insufficiency of vital energy and blood, the blood stasis venation.Benefiting QI and nourishing blood, promoting blood circulation to remove obstruction in the collateral is selected this medicine, add Rhizoma Gastrodiae 10 gram, Concha Haliotidis 30 grams are obeyed conscious dizziness after 5 days, sialorrhea obviously alleviates, lower limb can be stood and be gone, it is flat that upper limb can be lifted to breast, and the incontinence sometimes of urinating is through taking 35 with the top plus-minus, limb activity is normal, cooperate limb functional exercise, the patient is healed entirely, recovers housework.
Come further to set forth the preparation method of medicine of the present invention by the following examples
Embodiment one:
Get Radix Notoginseng 5 grams, Pheretima 5 grams, Scorpio 6 grams, Bombyx Batryticatus 6 grams, Hirudo 5 grams, above medicine is ground even two bags that are divided into into powder.
Get the Radix Astragali 35 grams, Ramulus Cinnamomi 9 grams, Radix Angelicae Sinensis 12 grams, Radix Salviae Miltiorrhizae 30 grams, Rhizoma Chuanxiong 10 grams, Caulis Piperis Kadsurae 15 grams, Rhizoma Arisaematis 6 grams, Fructus Trichosanthis 10 grams, above Chinese medicine adds 100 milliliters of bottlings of 500 milliliters of decoct simmer down tos of water.Utilize medicinal liquid to take medicamental pulverata when taking.