CN105434396B - A kind of Capsules and preparation method thereof containing nano-ZnO - Google Patents
A kind of Capsules and preparation method thereof containing nano-ZnO Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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Abstract
The present invention relates to Capsules technical fields, and in particular to a kind of Capsules and preparation method thereof containing nano-ZnO are made of the raw material of following parts by weight：50-60 portions of major ingredients, 2-8 parts of plasticizer, 2-8 parts of tweens, 15-25 parts of titanium dioxides, 3-8 parts of pigments, 2-10 parts of nano-ZnOs and 30-40 parts of water.The major ingredient is one or both of gelatin, hydroxypropyl methyl cellulose；The plasticizer is one or both of glycerine, polyethylene glycol.The preparation method of the Capsules of the present invention, simple for process, Capsules moisture controls between 10-18%, and Capsules obtained have uvioresistant Anti-tarnish property and from antibacterial functions, long shelf-life.
Description
Technical field
The present invention relates to Capsules technical fields, and in particular to a kind of containing the Capsules of nano-ZnO and its preparation side
Method.
Background technology
In the prior art, capsule has bioavilability height, good airproof performance, medicine stability good compared with other dosage forms
Good, the features such as content is accurate, good appearance, it can play the role of increasing stability, improve bioavilability and taste masking.
Existing capsule is mostly using gelatin as capsule material, using glycerine as plasticizer, due to the property of gelatin itself and the height of glycerine
Permeability, there is also some stability problems for capsule, as unqualified in being disintegrated in storage period, and it is existing that material transport etc. occurs in capsule
As making formulation development encounter difficulties.
Research finds that strong ultraviolet light or radiation of visible light can accelerate gelatin variation, and dissolution rate in vitro is caused to reduce,
Humidity is higher while such as illumination, and gelatine capsule when containing orchil, and the influence is especially notable.Many dyestuffs can be logical with gelatin
Hydrophobic bond and Hydrogenbond are crossed, therefore existing capsule is preferably stored under the conditions of being protected from light.In addition, traditional capsule does not have from anti-
The storage life of bacterium function, capsule is considerably reduced.
Invention content
The purpose of the present invention is being directed to above-mentioned deficiency in the prior art, a kind of Capsules containing nano-ZnO are provided,
With uvioresistant Anti-tarnish property and from antibacterial functions, long shelf-life.
The purpose of the present invention is being directed to above-mentioned deficiency in the prior art, a kind of Capsules containing nano-ZnO are provided
Preparation method, simple for process, Capsules moisture controls between 10-18%, and the uvioresistant that can significantly improve Capsules is preapred for an unfavorable turn of events
Color function and from antibacterial functions.
The purpose of the present invention is achieved through the following technical solutions.
A kind of Capsules containing nano-ZnO, are made of the raw material of following parts by weight：
50-60 parts of major ingredient
2-8 parts of plasticizer
2-8 parts of tween
15-25 parts of titanium dioxide
3-8 parts of pigment
2-10 parts of nano-ZnO
30-40 parts of water
Wherein, the major ingredient is one or both of gelatin, hydroxypropyl methyl cellulose；
Wherein, the plasticizer is one or both of glycerine, polyethylene glycol.
Preferably, the major ingredient be gelatin, hydroxypropyl methyl cellulose with mass ratio for 2-3:1 mixture；Preferably,
The plasticizer be glycerine, polyethylene glycol with mass ratio for 2-3:The mixture of 1-1.5.
The titanium dioxide of the present invention is rutile type titanium white, and whiteness L values are more than 97, B values and are less than 0, and it is micro- that grain size is less than 4
Rice.The shading of rutile type titanium white, weatherability, gloss retention, tinting strength, tinting power are excellent, the good weatherability of Capsules obtained, hide
Optical property is good.Specifically, the grain size of the rutile type titanium white is 3.25 microns, and whiteness 99, which is the German worlds Kang Nuosi, to be had
The product that the trade mark of limit company production is K2233.
Preferably, a kind of Capsules containing nano-ZnO, are made of the raw material of following parts by weight：
50-55 parts of major ingredient
3-5 parts of plasticizer
3-5 parts of tween
15-20 parts of titanium dioxide
3-5 parts of pigment
2-5 parts of nano-ZnO
30-40 parts of water.
Wherein, the grain size of the nano-ZnO is 20-100nm.Preferably, grain size 40-80nm.
Wherein, the pigment is at least one of brilliant blue, lemon yellow, iron oxide；
The tween is at least one of Tween-20, Tween-40, Tween-60, Tween-80.
Wherein, in the gelatin imino acid content be gelatin gross mass 10-20%.
Gelation is the most important functional character of gelatin, it refers to gelatin molecule under certain condition by random coil state
Orderly triple-helix structure is gradually reverted to, this process mainly divides three phases：First, when temperature is down to solidification point about（35℃）With
When lower, the polypeptide chain of random coil revolves into left hand helix again in gelatin solution, and the intersegmental effect of adjacent left hand helix chain generates
Hydrogen bond crosslinks re-form the nucleus of class collagen helix body, this process is known as " renaturation "；Second, class collagen helix body is poly-
Conjunction forms microgel；Third, aggregation are further formed the network gel with certain rigidity.
Class triple-helix structure in gelatin gel is maintained mainly by intramolecular oxygen key and oxygen key hydration, in imino acid
- the NH of the Pro ,-OH of Hyp can form oxygen key with other amino acid side groups and hydrone, be conducive to class triple-helix structure
Stablize.The imino acid content of the present invention is up to 10-20%, and the gelling performance of gelatin is superior, and the gelation of colloidal sol is good, obtained
The performance of Capsules is stablized.
Wherein, the molecular weight of the gelatin is 20000~250000Da, and the molecular weight of gelatin is big, and steric hindrance is small, has
Help be promoted the stability of its triple-helix structure.
Wherein, the methoxyl content in the hydroxypropyl methyl cellulose be 20-25%, hydroxypropyl content 8%-12%, and
And the aqueous solution that mass concentration is 2% at 20 DEG C（I.e. the mass concentration of hydroxypropyl methyl cellulose in aqueous solution is 2%）
Medium viscosity is 10-20mPa .s.
Hydroxypropyl methyl cellulose abbreviation HPMC has thermal gels property, hydroxypropyl methyl cellulose of the invention, first
Oxygroup content is 20-25%, hydroxypropyl content 8%-12%, and the aqueous solution medium viscosity that mass concentration is 2% at 20 DEG C is
10-20mPa .s, gelling temp (0.2%) are 60-90 DEG C, and there are preferable thickening capabilities, salt discharge PH stability, to protect
The features such as aqueous, dimensional stability, excellent film forming and extensive resistance to enzymatic, dispersibility and caking property.
The aqueous solution of hydroxypropyl methyl cellulose has surface-active, the advantage that transparency is high, performance is stablized, with gelatin
It is used in mixed way, gelling performance is better, greatly improves the dispersibility and stability of nano material dispersion, Capsules obtained
Stability it is good.
Wherein, the polyethylene glycol is one or both of PEG 400, PEG 4000.
Polyethylene glycol abbreviation PEG, PEG400 are liquid, it has the extensive compatibility with various solvents, are molten well
Agent and solubilizer are widely used in liquid preparation, such as oral solution, eye drops.The PEG4000 of high molecular weight is in medicine, makeup
It is used as matrix in product industrial production, plays a part of to adjust viscosity, fusing point.Preferably, the polyethylene glycol is PEG 400, PEG
4000 with mass ratio be 3-5:The mixture of 1-2.PEG400 and the PEG4000 of high molecular weight are mixed, and mixture has very
Good dissolubility and good and drug compatibility, can prevent from being bonded between Capsules and between medicine bottle it is be bonded.
A kind of preparation method of the Capsules containing nano-ZnO, includes the following steps：
（1）It weighs：Major ingredient, plasticizer, tween, titanium dioxide, pigment, nano-ZnO, the water for weighing formula ratio are spare；
（2）Prepare nano material dispersion：By plasticizer, tween, nano-ZnO and water, nanometer is dispersed by ultrasonic wave
Material dispersion；
（3）Colloidal sol：Major ingredient, titanium dioxide, pigment are uniformly mixed, above-mentioned nano material dispersion is added, at 50-75 DEG C
Under the conditions of colloidal sol；
（4）Prepare Capsules：After mixing, carried out dipping in glue glue capsule base, glue with the stainless steel mould of predetermined size
Dry hardening under the conditions of 50-90 DEG C of capsule base, through pulling out shell, Capsules, the moisture control of Capsules is made with after arrangement in cutting
System is in 10-18%.
Wherein, the step（2）In, the vibration frequency of ultrasonic wave is 20-35KHz.
Wherein, the step（3）In, collosol temperature is 55-65 DEG C.
Wherein, the step（4）In, the moisture control of dry hardening under the conditions of 60-80 DEG C of capsule base, Capsules exists
12.5-17.5%。
Beneficial effects of the present invention：
When size is suitable with ultraviolet light wave wavelength or smaller of the nano-ZnO particle of the present invention, small-size effect causes light
Influx and translocation, and generate the uvioresistant Anti- tarnishing function that light shield effect improves material；Meanwhile nano-ZnO is illuminated by the light generation electricity
Son --- hole pair, and highly active free radical and superoxide ion can be formed, microorganism killing is generated to antibacterial functions.
Capsules system of the present invention containing nano-ZnO is made using safe and non-toxic medicinal raw material is processed, it
The not only characteristic with general capsule, but also with uvioresistant Anti-tarnish property and from antibacterial functions, make product stability it is good,
Storage period is long.The preparation method of Capsules, it is simple for process, be conducive to promote and apply.
Through the capsule to capsule and control containing nano-ZnO carry out superior function experiment, it is of the invention containing nano-ZnO
Capsules items are investigated result and are basically unchanged compared with 0 month, and the capsule items without nano-ZnO are investigated result and compared with 0 month
Larger variation relatively has occurred.The result shows that the Capsules containing nano-ZnO of the present invention have stronger superiority, anti-purple
Outer Anti-tarnish property is good, good from antibacterial functions.
Specific implementation mode
The invention will be further described with the following Examples.
Embodiment 1
A kind of Capsules containing nano-ZnO of the present embodiment, are made of the raw material of following parts by weight：
Major ingredient：50 parts, plasticizer：2 parts, Tween-20：2 parts, titanium dioxide：15 parts, pigment：3 parts, nano-ZnO：2- parts, water
：30 parts.
Wherein, the major ingredient is gelatin；The content of imino acid is the 15% of gelatin gross mass in the gelatin.
Wherein, the plasticizer is glycerine.
The grain size of the nano-ZnO is 50nm.
The pigment is brilliant blue.
A kind of preparation method of Capsules containing nano-ZnO of the present embodiment, includes the following steps：
（1）It weighs：Major ingredient, plasticizer, Tween-20, titanium dioxide, pigment, nano-ZnO, the water for weighing formula ratio are spare；
（2）Prepare nano material dispersion：By plasticizer, Tween-20, nano-ZnO and water, it is dispersed into and is received by ultrasonic wave
Rice material dispersion, the vibration frequency of ultrasonic wave is 20KHz；
（3）Colloidal sol：Major ingredient, titanium dioxide, pigment are uniformly mixed, above-mentioned nano material dispersion is added, in 50 DEG C of items
Colloidal sol under part；
（4）Prepare Capsules：After mixing, carried out dipping in glue glue capsule base with mold, capsule base is under the conditions of 50 DEG C
Dry hardening, through pulling out shell, cutting is controlled with Capsules, the moisture of Capsules after arrangement, is made 18%.
Embodiment 2
A kind of Capsules containing nano-ZnO of the present embodiment, are made of the raw material of following parts by weight：
Major ingredient：52 parts, plasticizer：3 parts, Tween-40：3 parts, titanium dioxide：18 parts, pigment：4 parts, nano-ZnO：3 parts, water
：32 parts.
Wherein, the major ingredient is hydroxypropyl methyl cellulose；Methoxyl content in the hydroxypropyl methyl cellulose is
23%, hydroxypropyl content 10%, and the aqueous solution medium viscosity that mass concentration is 2% at 20 DEG C is 18mPa .s.
Wherein, the plasticizer polyethylene glycol.The polyethylene glycol is PEG 400, PEG 4000 with mass ratio is 3:1
Mixture.
The grain size of the nano-ZnO is 20nm.
The pigment is lemon yellow.
A kind of preparation method of Capsules containing nano-ZnO of the present embodiment, includes the following steps：
（1）It weighs：Major ingredient, plasticizer, Tween-40, titanium dioxide, pigment, nano-ZnO, the water for weighing formula ratio are spare；
（2）Prepare nano material dispersion：By plasticizer, Tween-40, nano-ZnO and water, it is dispersed into and is received by ultrasonic wave
Rice material dispersion, the vibration frequency of ultrasonic wave is 35KHz；
（3）Colloidal sol：Major ingredient, titanium dioxide, pigment are uniformly mixed, above-mentioned nano material dispersion is added, in 55 DEG C of items
Colloidal sol under part；
（4）Prepare Capsules：After mixing, carried out dipping in glue glue capsule base with mold, capsule base is under the conditions of 60 DEG C
Dry hardening, through pulling out shell, cutting is controlled with Capsules, the moisture of Capsules after arrangement, is made 17.5%.
Embodiment 3
A kind of Capsules containing nano-ZnO of the present embodiment, are made of the raw material of following parts by weight：
Major ingredient：55 parts, plasticizer：5 parts, Tween-80：5 parts, titanium dioxide：20 parts, pigment：5 parts, nano-ZnO：5 parts, water
：35 parts.
Wherein, it with mass ratio is 2 that the major ingredient, which is gelatin, hydroxypropyl methyl cellulose,:1 mixture；
The content of imino acid is the 12% of gelatin gross mass in the gelatin.
Methoxyl content in the hydroxypropyl methyl cellulose is 20%, hydroxypropyl content 12%, and at 20 DEG C
The aqueous solution medium viscosity that mass concentration is 2% is 15mPa .s.
Wherein, the plasticizer is polyethylene glycol.The polyethylene glycol is PEG 400, PEG 4000 with mass ratio is 4:
1.5 mixture.
The grain size of the nano-ZnO is 40nm.
The pigment is iron oxide.
A kind of preparation method of Capsules containing nano-ZnO of the present embodiment, includes the following steps：
（1）It weighs：Major ingredient, plasticizer, Tween-80, titanium dioxide, pigment, nano-ZnO, the water for weighing formula ratio are spare；
（2）Prepare nano material dispersion：By plasticizer, Tween-80, nano-ZnO and water, it is dispersed into and is received by ultrasonic wave
Rice material dispersion, the vibration frequency of ultrasonic wave is 30KHz；
（3）Colloidal sol：Major ingredient, titanium dioxide, pigment are uniformly mixed, above-mentioned nano material dispersion is added, in 60 DEG C of items
Colloidal sol under part；
（4）Prepare Capsules：After mixing, carried out dipping in glue glue capsule base with mold, capsule base is under the conditions of 70 DEG C
Dry hardening, through pulling out shell, cutting is controlled with Capsules, the moisture of Capsules after arrangement, is made 15%.
Embodiment 4
A kind of Capsules containing nano-ZnO of the present embodiment, are made of the raw material of following parts by weight：
Major ingredient：58 parts, plasticizer：6 parts, Tween-80：6 parts, titanium dioxide：22 parts, pigment：6 parts, nano-ZnO：8 parts, water
：38 parts.
Wherein, it with mass ratio is 3 that the major ingredient, which is gelatin, hydroxypropyl methyl cellulose,:1 mixture；
The content of imino acid is the 16% of gelatin gross mass in the gelatin.
Methoxyl content in the hydroxypropyl methyl cellulose is 25%, hydroxypropyl content 8%%, and at 20 DEG C
The aqueous solution medium viscosity that mass concentration is 2% is 12mPa .s.
Wherein, it with mass ratio is 2 that the plasticizer, which is glycerine, polyethylene glycol,:1 mixture.The polyethylene glycol is
PEG 400。
The grain size of the nano-ZnO is 80nm.
It with mass ratio is 1 that the pigment, which is brilliant blue, lemon yellow,:1 mixture.
A kind of preparation method of Capsules containing nano-ZnO of the present embodiment, includes the following steps：
（1）It weighs：Major ingredient, plasticizer, Tween-80, titanium dioxide, pigment, nano-ZnO, the water for weighing formula ratio are spare；
（2）Prepare nano material dispersion：By plasticizer, Tween-80, nano-ZnO and water, it is dispersed into and is received by ultrasonic wave
Rice material dispersion, the vibration frequency of ultrasonic wave is 23KHz；
（3）Colloidal sol：Major ingredient, titanium dioxide, pigment are uniformly mixed, above-mentioned nano material dispersion is added, in 65 DEG C of items
Colloidal sol under part；
（4）Prepare Capsules：After mixing, carried out dipping in glue glue capsule base with mold, capsule base is under the conditions of 80 DEG C
Dry hardening, through pulling out shell, cutting is controlled with Capsules, the moisture of Capsules after arrangement, is made 12.5%.
Embodiment 5
A kind of Capsules containing nano-ZnO of the present embodiment, are made of the raw material of following parts by weight：
Major ingredient：60 parts, plasticizer：8 parts, tween：8 parts, titanium dioxide：25 parts, pigment：8 parts, nano-ZnO：10 parts, water：
40 parts.
Wherein, the major ingredient is hydroxypropyl methyl cellulose；Methoxyl content in the hydroxypropyl methyl cellulose is
22%, hydroxypropyl content 11%, and the aqueous solution medium viscosity that mass concentration is 2% at 20 DEG C is 10mPa .s.
Wherein, it with mass ratio is 3 that the plasticizer, which is glycerine, polyethylene glycol,:1 mixture.The polyethylene glycol is PEG
400, PEG 4000 with mass ratio be 5:1 mixture.
It is 1 that the tween, which is Tween-20 with Tween-80 with mass ratio,:3 mixture.
The grain size of the nano-ZnO is 100nm.
It with mass ratio is 1 that the pigment, which is brilliant blue, lemon yellow, iron oxide,:1:2 mixture.
A kind of preparation method of Capsules containing nano-ZnO of the present embodiment, includes the following steps：
（1）It weighs：Major ingredient, plasticizer, tween, titanium dioxide, pigment, nano-ZnO, the water for weighing formula ratio are spare；
（2）Prepare nano material dispersion：By plasticizer, tween, nano-ZnO and water, nanometer is dispersed by ultrasonic wave
The vibration frequency of material dispersion, ultrasonic wave is 25KHz；
（3）Colloidal sol：Major ingredient, titanium dioxide, pigment are uniformly mixed, above-mentioned nano material dispersion is added, in 75 DEG C of items
Colloidal sol under part；
（4）Prepare Capsules：After mixing, carried out dipping in glue glue capsule base with mold, capsule base is under the conditions of 90 DEG C
Dry hardening, through pulling out shell, cutting is controlled with Capsules, the moisture of Capsules after arrangement, is made 10%.
In order to confirm that it is more more superior than being free of nano material capsule performance, now two kinds of capsule materials are packed by quasi- listing
Carry out accelerated test 6 months, room temperature natural reserved 12 months periodically samples, key project is compared, is pressed according to investigation project
According to《Pharmacopoeia of People's Republic of China》2010 editions pertinent regulations are detected.
（1）Accelerated test
Experimental condition：40 ± 1 DEG C of temperature, RH75%
Sample packaging：PVC is packed
Sample source：Research and development centre of company provides
Lot number：（Control）20130801 （Containing nano-ZnO）20130802
Investigation project：Aberration（△ E values）Micro biological Tests
Test method：
Each 1 batch of sample difference bottom set of capsule containing nano-ZnO and the capsule without nano-ZnO portion is equipped with saturated sodium-chloride
Solution（RH75%）Closed container in set and place 6 months in 40 ± 1 DEG C of insulating box in 0,1,2,3, June timing sampling, according to
Investigation project according to《Pharmacopoeia of People's Republic of China》2010 editions pertinent regulations are detected, and the results are shown in Table 1.
Table 1：Accelerated test
。
（2）Room temperature keeps sample investigation：
Experimental condition：Room temperature is placed naturally（25 DEG C ± 2 DEG C of temperature, RH60 ± 10%）
Sample packaging：PVC is packed
Sample source：Research and development centre of company provides
Lot number：（Control）20130801 （Containing nano-ZnO）20130802
Investigation project：Aberration（△ E values）Micro biological Tests
Test method：
Each 1 batch of sample of capsule containing nano-ZnO and the capsule without nano-ZnO is set respectively and is placed at room temperature for, in 0,3,6,
9, timing sampling in December, according to investigate project according to《Pharmacopoeia of People's Republic of China》2010 editions pertinent regulations are detected,
It the results are shown in Table 2.
Table 2：Room temperature experiment investigation table
。
（3）Conclusion：
As it can be seen from table 1 in accelerated test：The Capsules of the application are when storing 0 month, aberration 0, bacterium
Number is 9/g, and fungi count is 22/g, and after preserving 6 months, aberration 0.56, bacterial population is 16/g, fungi count 41
A/g, and reference examples（Without nano-ZnO）After preserving 6 months, aberration is 4.67 times of the aberration of the application, bacterial population
It is 2.18 times of the bacterial population of the application, fungi count is 2.97 times of the application.
From table 2 it can be seen that in room temperature keeps sample investigation：The Capsules of the application are when storing 0 month, aberration 0,
Bacterial population is 10/g, and fungi count is 21/g, and after preserving 6 months, aberration 0.44, bacterial population is 14/g, fungi count
For 33/g, and reference examples（Without nano-ZnO）After preserving 6 months, aberration is 4.65 times of the aberration of the application, bacterium
Number is 2.14 times of the bacterial population of the application, and fungi count is 2.69 times of the application.
Superior function experiment has been carried out through the capsule to capsule and control containing nano-ZnO, 1 table 2 of consolidated statement is analyzed, this
The Capsules items containing nano-ZnO of invention are investigated result and are basically unchanged compared with 0 month, and the capsule without nano-ZnO is each
Item investigates result and larger variation has occurred compared with 0 month.The result shows that the present invention the Capsules containing nano-ZnO have compared with
Strong superiority, uvioresistant Anti-tarnish property is good, good from antibacterial functions.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than the present invention is protected
The limitation of range is protected, although being explained in detail to the present invention with reference to preferred embodiment, those skilled in the art answer
Work as understanding, technical scheme of the present invention can be modified or replaced equivalently, without departing from the reality of technical solution of the present invention
Matter and range.
Claims (7)
1. a kind of Capsules containing nano-ZnO, it is characterised in that：It is made of the raw material of following parts by weight：
Wherein, the major ingredient is one or both of gelatin, hydroxypropyl methyl cellulose, and imino acid contains in the gelatin
Amount is the 10-20% of gelatin gross mass, and the methoxyl content in the hydroxypropyl methyl cellulose is 20-25%, and hydroxypropyl contains
Amount is 8%-12%, and the aqueous solution medium viscosity that mass concentration is 2% at 20 DEG C is 10-20mPa.s；
Wherein, the plasticizer is one or both of glycerine, polyethylene glycol；
The tween is at least one of Tween-20, Tween-40, Tween-60, Tween-80；
Wherein, the grain size of the nano-ZnO is 20-100nm.
2. a kind of Capsules containing nano-ZnO according to claim 1, it is characterised in that：By the original of following parts by weight
Material composition：
3. a kind of Capsules containing nano-ZnO according to claim 1, it is characterised in that：The pigment is brilliant blue, lemon
At least one of lemon Huang, iron oxide.
4. a kind of Capsules containing nano-ZnO according to claim 1, it is characterised in that：The polyethylene glycol is PEG
400, one or both of PEG 4000.
5. a kind of preparation method of Capsules containing nano-ZnO according to any one of claim 1-4, feature
It is：Include the following steps：
(1) it weighs：Major ingredient, plasticizer, tween, titanium dioxide, pigment, nano-ZnO, the water for weighing formula ratio are spare；
(2) nano material dispersion is prepared：By plasticizer, tween, nano-ZnO and water, nano material is dispersed by ultrasonic wave
Dispersion；
(3) colloidal sol：Major ingredient, titanium dioxide, pigment are uniformly mixed, above-mentioned nano material dispersion is added, in 50-75 DEG C of condition
Lower colloidal sol；
(4) Capsules are prepared：After mixing, carry out dipping in glue glue capsule base, capsule base is dry hard under the conditions of 50-90 DEG C
Change, through pulling out shell, cutting is controlled with Capsules, the moisture of Capsules after arrangement, is made in 10-18%.
6. a kind of preparation method of Capsules containing nano-ZnO according to claim 5, it is characterised in that：The step
Suddenly in (2), the vibration frequency of ultrasonic wave is 20-35KHz.
7. a kind of preparation method of Capsules containing nano-ZnO according to claim 5, it is characterised in that：The step
Suddenly in (3), collosol temperature is 55-65 DEG C；In the step (4), capsule base dry hardening, hollow glue under the conditions of 60-80 DEG C
The moisture of capsule is controlled in 12.5-17.5%.
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|---|---|---|---|---|
| CN1791387A (en) * | 2003-05-19 | 2006-06-21 | 沃尼尔·朗伯有限责任公司 | Hard gelatin capsule containing titanium oxide with a controlled particle size and process for producing the same |
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