CN1136009C - Film Coating agent insoluble colour material addition method - Google Patents
Film Coating agent insoluble colour material addition method Download PDFInfo
- Publication number
- CN1136009C CN1136009C CNB001358227A CN00135822A CN1136009C CN 1136009 C CN1136009 C CN 1136009C CN B001358227 A CNB001358227 A CN B001358227A CN 00135822 A CN00135822 A CN 00135822A CN 1136009 C CN1136009 C CN 1136009C
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- film coating
- coating agent
- color
- colour material
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Abstract
The present invention relates to a method for adding an insoluble coloring material into a film coating agent, which belongs to the technical field of processing techniques of auxiliary materials of medicines. The present invention is characterized in that a wet process is adopted to disperse the insoluble coloring material; the coloring material is dispersed over macromolecular polymer solution to obtain uniform suspension; an adjuvant is added; after color is fixed, the suspension is dried by spraying so as to obtain color concentrates; the color concentrates are ground into micropowder color concentrates. The micropowder color concentrates can be directly added into a formula of the film coating agent, and thus, the film coating agent has bright color and good product quality.
Description
Technical field
Film coating agent insoluble colour material addition method relates to medicine adjuvant technology field.
Background technology
The purpose of solid dosage forms coating is used to improve the biopharmaceutics character of medicine and remedies the physical chemistry defective that medicine itself exists except that reaching pleasing, good to eat and improve the medicine stability, the more important thing is at present.The applied film coating materials is formed variation with the coating demand prescription that adapts to different preparations, and prescription is formed with high molecular polymer, plasticizer, insoluble colour material, auxiliary agent four parts usually.Preparation process generally is the mechanical mixture of a complete formula composition, adopts ball mill equipment more.Adopt this processing method to produce film coating agent, can exert an influence to clothing film character and structure owing to the solid colorant is difficult for being uniformly dispersed, as cause the embrittlement of clothing film, edge explosion and decortication, also can influence clothing permeability of the membrane and rate of releasing drug etc.Therefore the adding method of insoluble colour material is one of key factor of film coating agent quality good or not.
Summary of the invention
In order to solve insoluble colour material problem that influences to product quality in common mechanical hybrid process method, we have designed a kind of new technology-film coating agent insoluble colour material processing method.
Feature of the present invention is with xanthan gum solution concentration 4%～15%wt, stir thinning back with 800 rev/mins and throw in insoluble colour material, add in the colorant process with 3000 rev/mins, continue to stir more than 30 minutes, add polyphosphoric acids na concn 0.1%～0.4%wt again, add in the process with 300 rev/mins stir suspension, obtain 400 μ m Masterbatch through atomization drying.Grind Masterbatch and obtain straight powdered Masterbatch through 10 μ m.The colorant that this raw material can be directly used in film coating agent adds process.Mix with other composition of film coating agent prescription, the film coating agent that forms with this processes has greatly improved the degree of scatter of the colorant of film coating agent again, and the firmness of color, vividness are good, the film coating dissolving rapidly, coating evenly, stable.
Description of drawings
Figure of description is the process chart of film coating agent insoluble colour material addition method.
The specific embodiment
For further understanding content of the present invention, characteristics and work efficiency, exemplify following examples now, shown in Figure of description:
(1) preparation xanthan gum solution concentration 4%～15% (wt) adopts the THE ADIABATIC SHEAR IN formula to stir 800 rev/mins, treats that xanthan gum solution can throw in colorant after thinning.
(2) add in the colorant process and must generally be not less than 3000 rev/mins with high-speed stirred, lasting stirring is no less than 30 minutes, otherwise colorant can not fully disperse, and colorant refers to insoluble solid powder such as pharmaceutically useful titanium dioxide, color lake, ferrum oxide.
(3) adding sodium polyphosphate (0.1%～0.4% (wt)) is the chelating agent of colorant, add and keep low speed (below 300 rev/mins) stirring in the process, finely dispersed colorant is built bridge, form stable colorant suspension, colorant and high molecular polymer strong bonded, color is beautiful bright-coloured.
(4) atomization drying: with the suspension that obtains behind the said process through atomization drying get final product the Masterbatch through about 400 μ m directly.
(5) colorant that the powdered Masterbatch about Masterbatch lapping diameter 10 μ m, this raw material can be directly used in film coating agent adds process.
This invention is adopted direct mechanical to mix quite usually and is added with obvious superiority, has greatly improved the product quality of film coating agent.
Claims (1)
1. film coating agent insoluble colour material processing method, it is characterized in that: with xanthan gum solution concentration 4%～15%wt, stir thinning back with 800 rev/mins and throw in insoluble colour material, throw in the colorant process with 3000 rev/mins, continue to stir more than 30 minutes, add the sodium polyphosphate that solution concentration is 0.1%～0.4%wt again, add in the process with 300 rev/mins of following speed stir suspension, obtain Masterbatch through atomization drying, grind Masterbatch and obtain micropowder shape Masterbatch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001358227A CN1136009C (en) | 2000-12-22 | 2000-12-22 | Film Coating agent insoluble colour material addition method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001358227A CN1136009C (en) | 2000-12-22 | 2000-12-22 | Film Coating agent insoluble colour material addition method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1341450A CN1341450A (en) | 2002-03-27 |
| CN1136009C true CN1136009C (en) | 2004-01-28 |
Family
ID=4596894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB001358227A Expired - Fee Related CN1136009C (en) | 2000-12-22 | 2000-12-22 | Film Coating agent insoluble colour material addition method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1136009C (en) |
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2000
- 2000-12-22 CN CNB001358227A patent/CN1136009C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1341450A (en) | 2002-03-27 |
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| C10 | Entry into substantive examination | ||
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| C14 | Grant of patent or utility model | ||
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| CF01 | Termination of patent right due to non-payment of annual fee |