CN105434396A - Nano ZnO containing vacant capsules and preparation method thereof - Google Patents
Nano ZnO containing vacant capsules and preparation method thereof Download PDFInfo
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- CN105434396A CN105434396A CN201511015141.1A CN201511015141A CN105434396A CN 105434396 A CN105434396 A CN 105434396A CN 201511015141 A CN201511015141 A CN 201511015141A CN 105434396 A CN105434396 A CN 105434396A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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Abstract
The invention relates to the technical field of vacant capsules, in particular to nano ZnO containing vacant capsules and a preparation method thereof. The nano ZnO containing vacant capsules are prepared from raw materials in parts by weight as follows: 50-60 parts of main ingredients, 2-8 parts of a plasticizer, 2-8 parts of Tween, 15-25 parts of titanium dioxide, 3-8 parts of pigments, 2-10 parts of nano ZnO and 30-40 parts of water, wherein the main ingredients are one or two of gelatin and hydroxypropyl methyl cellulose; the plasticizer is one or two of glycerin and polyethylene glycol. The preparation method of the vacant capsules adopts a simple process, the water content of the vacant capsules is controlled in the range from 10% to 18%, and the prepared vacant capsules have UV-resistant and anti-discoloration performance and the self-bacterial-resistant function and can be preserved for a long time.
Description
Technical field
The present invention relates to Capsules technical field, be specifically related to a kind of Capsules containing nano-ZnO and preparation method thereof.
Background technology
In prior art, capsule has the features such as bioavailability is high, good airproof performance, medicine stability are good, content is accurate, good looking appearance compared with other dosage forms, can play the effect increasing stability, improve bioavailability and taste masking.
Existing capsule is capsule material mainly with gelatin, take glycerol as plasticizer, due to the character of gelatin self, and the high-permeability of glycerol, also there are some stability problems in capsule, as in storage period, disintegrate is defective, there is the phenomenons such as material transport in capsule, formulation development is encountered difficulties.
Research finds that strong ultraviolet or radiation of visible light can accelerate gelatin change, causes dissolution rate in vitro to reduce, and as while illumination, humidity is higher, and when gelatine capsule contains orchil, this impact is especially remarkable.Many dyestuffs can with gelatin by hydrophobic bond and hydrogen bonded, therefore existing capsule is preferably stored under lucifuge condition.In addition, traditional capsule does not have from antibacterial functions, and the storage life of capsule is considerably reduced.
Summary of the invention
The object of the invention is for above-mentioned deficiency of the prior art, provide a kind of Capsules containing nano-ZnO, it has uvioresistant Anti-tarnish property and from antibacterial functions, long shelf-life.
The object of the invention is for above-mentioned deficiency of the prior art, a kind of preparation method of the Capsules containing nano-ZnO is provided, technique is simple, Capsules moisture Control between 10-18%, can significantly improve Capsules uvioresistant Anti-tarnishing function and from antibacterial functions.
Object of the present invention is achieved through the following technical solutions.
Containing a Capsules for nano-ZnO, be made up of the raw material of following weight portion:
Major ingredient 50-60 part
Plasticizer 2-8 part
Tween 2-8 part
Titanium dioxide 15-25 part
Pigment 3-8 part
Nano-ZnO 2-10 part
Water 30-40 part
Wherein, described major ingredient is one or both in gelatin, hydroxypropyl emthylcellulose;
Wherein, described plasticizer is one or both in glycerol, Polyethylene Glycol.
Preferably, the mixture of described major ingredient to be gelatin, hydroxypropyl emthylcellulose with mass ratio be 2-3:1; Preferably, the mixture of described plasticizer to be glycerol, Polyethylene Glycol with mass ratio be 2-3:1-1.5.
Titanium dioxide of the present invention is for being Rutile type titanium dioxide, and its whiteness L-value is greater than 97, B values and is less than 0, and particle diameter is less than 4 microns.The shading of Rutile type titanium dioxide, weatherability, gloss retention, tinting strength, tinting power excellence, the good weatherability of obtained Capsules, shading performance is good.Particularly, the particle diameter of described Rutile type titanium dioxide is 3.25 microns, whiteness 99, is that the trade mark of German Kang Nuosi international corporation production is the product of K2233.
Preferably, a kind of Capsules containing nano-ZnO, is made up of the raw material of following weight portion:
Major ingredient 50-55 part
Plasticizer 3-5 part
Tween 3-5 part
Titanium dioxide 15-20 part
Pigment 3-5 part
Nano-ZnO 2-5 part
Water 30-40 part.
Wherein, the particle diameter of described nano-ZnO is 20-100nm.Preferably, particle diameter is 40-80nm.
Wherein, described pigment is at least one in light blue, lemon yellow, ferrum oxide;
Described tween is at least one in tween 20, Tween-40, Tween-60, tween 80.
Wherein, the amino acid whose content in the described gelatin Central Asia is the 10-20% of gelatin gross mass.
Gelation is the most important functional character of gelatin, it refers to that gelatin molecule reverts to orderly triple-helix structure gradually by random coil state under certain condition, this process mainly divides three phases: first, when temperature be down to freezing point about (35 DEG C) below time, in gelatin solution, the polypeptide chain of random coil revolves into left hand helix again, between adjacent left hand helix segment, effect produces hydrogen bond crosslinks, and again form the nucleus of class collagen helix body, this process is called " renaturation "; The second, the polymerization of class collagen helix body forms microgel; 3rd, aggregation forms the network gel with certain rigidity further.
Class triple-helix structure in gelatin gel mainly maintains by oxygen key in molecule and the hydration of oxygen key, and-the NH of the Pro in the imino acid ,-OH of Hyp all can form oxygen key with other amino acid side groups and hydrone, is beneficial to the stable of class triple-helix structure.Imino acid content of the present invention is up to 10-20%, and the gelling performance of gelatin is superior, and the gelation of colloidal sol is good, the stable performance of obtained Capsules.
Wherein, the molecular weight of described gelatin is 20000 ~ 250000Da, and the molecular weight of gelatin is large, and it is sterically hindered little, contributes to the stability promoting its triple-helix structure.
Wherein, methoxyl content in described hydroxypropyl emthylcellulose is 20-25%, hydroxypropyl content is 8%-12%, and at 20 DEG C, mass concentration is aqueous solution (namely hydroxypropyl emthylcellulose mass concentration is in aqueous the 2%) medium viscosity of 2% is 10-20mPa.s.
Hydroxypropyl emthylcellulose is called for short HPMC, there is hot gelling properties, hydroxypropyl emthylcellulose of the present invention, its methoxyl content is 20-25%, hydroxypropyl content is 8%-12%, and at 20 DEG C, mass concentration is the aqueous solution medium viscosity of 2% is 10-20mPa.s, its gelling temp (0.2%) is 60-90 DEG C, there is good thickening capabilities, salt discharge, PH stability, water-retaining property, dimensional stability, excellent film property and the feature such as resistance to enzymatic, dispersibility and caking property widely.
The aqueous solution of hydroxypropyl emthylcellulose has surface activity, and transparency is high, the advantage of stable performance, and itself and gelatin are used in combination, and gelling performance is more excellent, greatly improves dispersibility and the stability of nano material dispersion, the good stability of obtained Capsules.
Wherein, described Polyethylene Glycol is one or both in PEG400, PEG4000.
Polyethylene Glycol is called for short that PEG, PEG400 are liquid, it has the extensive compatibility with various solvent, is good solvent and solubilizing agent, is widely used in liquid preparation, as oral liquid, eye drop etc.The PEG4000 of high molecular is used as substrate in medicine, cosmetics industry in producing, and plays adjusting viscosity, fusing point.Preferably, the mixture of described Polyethylene Glycol to be PEG400, PEG4000 with mass ratio be 3-5:1-2.PEG400 mixes with the PEG4000 phase of high molecular, and its mixture has good dissolubility and good and drug compatibility, can prevent bonding between Capsules and bonding with between medicine bottle.
Containing a preparation method for the Capsules of nano-ZnO, comprise the following steps:
(1) weigh: take the major ingredient of formula ratio, plasticizer, tween, titanium dioxide, pigment, nano-ZnO, water are for subsequent use;
(2) prepare nano material dispersion: by plasticizer, tween, nano-ZnO and water, be dispersed into nano material dispersion by ultrasound wave;
(3) colloidal sol: by major ingredient, titanium dioxide, pigment mix homogeneously, then add above-mentioned nano material dispersion, colloidal sol under 50-75 DEG C of condition;
(4) prepare Capsules: after mix and blend, carry out dipping in glue glue capsule base with the stainless steel mould of given size, capsule base is dry sclerosis under 50-90 DEG C of condition, through pulling out shell, cut and arrange after, make Capsules, the moisture Control of Capsules is at 10-18%.
Wherein, in described step (2), hyperacoustic frequency of vibration is 20-35KHz.
Wherein, in described step (3), collosol temperature is 55-65 DEG C.
Wherein, in described step (4), capsule base is dry sclerosis under 60-80 DEG C of condition, and the moisture Control of Capsules is at 12.5-17.5%.
Beneficial effect of the present invention:
The size of nano-ZnO microgranule of the present invention and ultraviolet light wave wavelength quite or less time, small-size effect causes light absorption to strengthen, and produces light shield effect and improve the uvioresistant Anti-tarnishing function of material; Meanwhile, nano-ZnO produces electronics---hole pair by illumination, and can form active very strong free radical and superoxide ion, and microorganism killing is produced antibacterial functions.
The present invention adopts the medicinal raw material of safety non-toxic through processing and fabricating containing the Capsules system of nano-ZnO, and it not only has the characteristic of general capsule, but also has uvioresistant Anti-tarnish property and from antibacterial functions, makes that product stability is good, the storage life is long.The preparation method of Capsules, technique is simple, is conducive to applying.
Through having carried out superior function test to containing the capsule of nano-ZnO and the capsule of contrast, Capsules every investigation result containing nano-ZnO of the present invention is more constant with 0 month, and the capsule every investigation result not containing nano-ZnO compared with 0 month and there occurs larger change.Result shows that the Capsules containing nano-ZnO of the present invention has stronger superiority, and its uvioresistant Anti-tarnish property is good, good from antibacterial functions.
Detailed description of the invention
The invention will be further described with the following Examples.
Embodiment 1
A kind of Capsules containing nano-ZnO of the present embodiment, is made up of the raw material of following weight portion:
Major ingredient: 50 parts, plasticizer: 2 parts, tween 20: 2 parts, titanium dioxide: 15 parts, pigment: 3 parts, nano-ZnO: 2-part, water: 30 parts.
Wherein, described major ingredient is gelatin; The amino acid whose content in the described gelatin Central Asia is 15% of gelatin gross mass.
Wherein, described plasticizer is glycerol.
The particle diameter of described nano-ZnO is 50nm.
Described pigment is light blue.
The preparation method of a kind of Capsules containing nano-ZnO of the present embodiment, comprises the following steps:
(1) weigh: take the major ingredient of formula ratio, plasticizer, tween 20, titanium dioxide, pigment, nano-ZnO, water are for subsequent use;
(2) prepare nano material dispersion: by plasticizer, tween 20, nano-ZnO and water, be dispersed into nano material dispersion by ultrasound wave, hyperacoustic frequency of vibration is 20KHz;
(3) colloidal sol: by major ingredient, titanium dioxide, pigment mix homogeneously, then add above-mentioned nano material dispersion, colloidal sol under 50 DEG C of conditions;
(4) prepare Capsules: after mix and blend, carry out dipping in glue glue capsule base with mould, capsule base is dry sclerosis under 50 DEG C of conditions, and through pulling out shell, cut and after arranging, make Capsules, the moisture Control of Capsules is 18%.
Embodiment 2
A kind of Capsules containing nano-ZnO of the present embodiment, is made up of the raw material of following weight portion:
Major ingredient: 52 parts, plasticizer: 3 parts, Tween-40: 3 parts, titanium dioxide: 18 parts, pigment: 4 parts, nano-ZnO: 3 parts, water: 32 parts.
Wherein, described major ingredient is hydroxypropyl emthylcellulose; Methoxyl content in described hydroxypropyl emthylcellulose is 23%, and hydroxypropyl content is 10%, and at 20 DEG C, mass concentration is the aqueous solution medium viscosity of 2% is 18mPa.s.
Wherein, described plasticizer Polyethylene Glycol.The mixture of described Polyethylene Glycol to be PEG400, PEG4000 with mass ratio be 3:1.
The particle diameter of described nano-ZnO is 20nm.
Described pigment is lemon yellow.
The preparation method of a kind of Capsules containing nano-ZnO of the present embodiment, comprises the following steps:
(1) weigh: take the major ingredient of formula ratio, plasticizer, Tween-40, titanium dioxide, pigment, nano-ZnO, water are for subsequent use;
(2) prepare nano material dispersion: by plasticizer, Tween-40, nano-ZnO and water, be dispersed into nano material dispersion by ultrasound wave, hyperacoustic frequency of vibration is 35KHz;
(3) colloidal sol: by major ingredient, titanium dioxide, pigment mix homogeneously, then add above-mentioned nano material dispersion, colloidal sol under 55 DEG C of conditions;
(4) prepare Capsules: after mix and blend, carry out dipping in glue glue capsule base with mould, capsule base is dry sclerosis under 60 DEG C of conditions, and through pulling out shell, cut and after arranging, make Capsules, the moisture Control of Capsules is 17.5%.
Embodiment 3
A kind of Capsules containing nano-ZnO of the present embodiment, is made up of the raw material of following weight portion:
Major ingredient: 55 parts, plasticizer: 5 parts, tween 80: 5 parts, titanium dioxide: 20 parts, pigment: 5 parts, nano-ZnO: 5 parts, water: 35 parts.
Wherein, the mixture of described major ingredient to be gelatin, hydroxypropyl emthylcellulose with mass ratio be 2:1;
The amino acid whose content in the described gelatin Central Asia is 12% of gelatin gross mass.
Methoxyl content in described hydroxypropyl emthylcellulose is 20%, and hydroxypropyl content is 12%, and at 20 DEG C, mass concentration is the aqueous solution medium viscosity of 2% is 15mPa.s.
Wherein, described plasticizer is Polyethylene Glycol.The mixture of described Polyethylene Glycol to be PEG400, PEG4000 with mass ratio be 4:1.5.
The particle diameter of described nano-ZnO is 40nm.
Described pigment is ferrum oxide.
The preparation method of a kind of Capsules containing nano-ZnO of the present embodiment, comprises the following steps:
(1) weigh: take the major ingredient of formula ratio, plasticizer, tween 80, titanium dioxide, pigment, nano-ZnO, water are for subsequent use;
(2) prepare nano material dispersion: by plasticizer, tween 80, nano-ZnO and water, be dispersed into nano material dispersion by ultrasound wave, hyperacoustic frequency of vibration is 30KHz;
(3) colloidal sol: by major ingredient, titanium dioxide, pigment mix homogeneously, then add above-mentioned nano material dispersion, colloidal sol under 60 DEG C of conditions;
(4) prepare Capsules: after mix and blend, carry out dipping in glue glue capsule base with mould, capsule base is dry sclerosis under 70 DEG C of conditions, and through pulling out shell, cut and after arranging, make Capsules, the moisture Control of Capsules is 15%.
Embodiment 4
A kind of Capsules containing nano-ZnO of the present embodiment, is made up of the raw material of following weight portion:
Major ingredient: 58 parts, plasticizer: 6 parts, tween 80: 6 parts, titanium dioxide: 22 parts, pigment: 6 parts, nano-ZnO: 8 parts, water: 38 parts.
Wherein, the mixture of described major ingredient to be gelatin, hydroxypropyl emthylcellulose with mass ratio be 3:1;
The amino acid whose content in the described gelatin Central Asia is 16% of gelatin gross mass.
Methoxyl content in described hydroxypropyl emthylcellulose is 25%, and hydroxypropyl content is 8%%, and at 20 DEG C, mass concentration is the aqueous solution medium viscosity of 2% is 12mPa.s.
Wherein, the mixture of described plasticizer to be glycerol, Polyethylene Glycol with mass ratio be 2:1.Described Polyethylene Glycol is PEG400.
The particle diameter of described nano-ZnO is 80nm.
The mixture of described pigment to be light blue, lemon yellow with mass ratio be 1:1.
The preparation method of a kind of Capsules containing nano-ZnO of the present embodiment, comprises the following steps:
(1) weigh: take the major ingredient of formula ratio, plasticizer, tween 80, titanium dioxide, pigment, nano-ZnO, water are for subsequent use;
(2) prepare nano material dispersion: by plasticizer, tween 80, nano-ZnO and water, be dispersed into nano material dispersion by ultrasound wave, hyperacoustic frequency of vibration is 23KHz;
(3) colloidal sol: by major ingredient, titanium dioxide, pigment mix homogeneously, then add above-mentioned nano material dispersion, colloidal sol under 65 DEG C of conditions;
(4) prepare Capsules: after mix and blend, carry out dipping in glue glue capsule base with mould, capsule base is dry sclerosis under 80 DEG C of conditions, and through pulling out shell, cut and after arranging, make Capsules, the moisture Control of Capsules is 12.5%.
Embodiment 5
A kind of Capsules containing nano-ZnO of the present embodiment, is made up of the raw material of following weight portion:
Major ingredient: 60 parts, plasticizer: 8 parts, tween: 8 parts, titanium dioxide: 25 parts, pigment: 8 parts, nano-ZnO: 10 parts, water: 40 parts.
Wherein, described major ingredient is hydroxypropyl emthylcellulose; Methoxyl content in described hydroxypropyl emthylcellulose is 22%, and hydroxypropyl content is 11%, and at 20 DEG C, mass concentration is the aqueous solution medium viscosity of 2% is 10mPa.s.
Wherein, the mixture of described plasticizer to be glycerol, Polyethylene Glycol with mass ratio be 3:1.The mixture of described Polyethylene Glycol to be PEG400, PEG4000 with mass ratio be 5:1.
The mixture of described tween to be tween 20 and tween 80 with mass ratio be 1:3.
The particle diameter of described nano-ZnO is 100nm.
The mixture of described pigment to be light blue, lemon yellow, ferrum oxide with mass ratio be 1:1:2.
The preparation method of a kind of Capsules containing nano-ZnO of the present embodiment, comprises the following steps:
(1) weigh: take the major ingredient of formula ratio, plasticizer, tween, titanium dioxide, pigment, nano-ZnO, water are for subsequent use;
(2) prepare nano material dispersion: by plasticizer, tween, nano-ZnO and water, be dispersed into nano material dispersion by ultrasound wave, hyperacoustic frequency of vibration is 25KHz;
(3) colloidal sol: by major ingredient, titanium dioxide, pigment mix homogeneously, then add above-mentioned nano material dispersion, colloidal sol under 75 DEG C of conditions;
(4) prepare Capsules: after mix and blend, carry out dipping in glue glue capsule base with mould, capsule base is dry sclerosis under 90 DEG C of conditions, and through pulling out shell, cut and after arranging, make Capsules, the moisture Control of Capsules is 10%.
In order to confirm that it is not than more superior containing nano material capsule performance, now two kinds of capsule materials are carried out accelerated test 6 months by plan listing packaging, room temperature natural reserved 12 months, regular sampling, key project is compared, detects according to the pertinent regulations of investigation project according to the Pharmacopoeia of the People's Republic of China 2010 editions.
(1) accelerated test
Experimental condition: temperature 40 ± 1 DEG C, RH75%
Sample packaging: PVC is packed
Sample source: research and development centre of company provides
Lot number: (contrast) 20130801(is containing nano-ZnO) 20130802
Investigation project: aberration (△ E value) Micro biological Tests
Test method:
By containing nano-ZnO capsule and not containing nano-ZnO each 1 batch sample of capsule respectively bottom set portion mid-40 ± 1 DEG C of the hermetic container of saturated nacl aqueous solution (RH75%) is housed calorstat in placement 6 months in 0,1,2,3, June timing sampling, detect according to the pertinent regulations of investigation project according to the Pharmacopoeia of the People's Republic of China 2010 editions, the results are shown in Table 1.
Table 1: accelerated test
。
(2) room temperature keeps sample investigation:
Experimental condition: room temperature is placed naturally (temperature 25 DEG C ± 2 DEG C, RH60 ± 10%)
Sample packaging: PVC is packed
Sample source: research and development centre of company provides
Lot number: (contrast) 20130801(is containing nano-ZnO) 20130802
Investigation project: aberration (△ E value) Micro biological Tests
Test method:
To the capsule of nano-ZnO be contained and not put room temperature placement respectively containing each 1 batch sample of capsule of nano-ZnO, in 0,3,6,9, December timing sampling, detect according to the pertinent regulations of investigation project according to the Pharmacopoeia of the People's Republic of China 2010 editions, the results are shown in Table 2.
Table 2: room temperature experiment investigation table
。
(3) conclusion:
As can be seen from Table 1, in accelerated test: the Capsules of the application was when storage 0 month, and its aberration is 0, bacterial population is 9/g, fungi count is 22/g, preserves after 6 months, and its aberration is 0.56, bacterial population is 16/g, fungi count is 41/g, and reference examples (not containing nano-ZnO) is in preservation after 6 months, and its aberration is 4.67 times of the aberration of the application, its bacterial population is 2.18 times of the bacterial population of the application, and its fungi count is 2.97 times of the application.
As can be seen from Table 2, in room temperature keeps sample and investigates: the Capsules of the application was when storage 0 month, and its aberration is 0, bacterial population is 10/g, fungi count is 21/g, preserves after 6 months, and its aberration is 0.44, bacterial population is 14/g, fungi count is 33/g, and reference examples (not containing nano-ZnO) is in preservation after 6 months, and its aberration is 4.65 times of the aberration of the application, bacterial population is 2.14 times of the bacterial population of the application, and its fungi count is 2.69 times of the application.
Through having carried out superior function test to containing the capsule of nano-ZnO and the capsule of contrast, consolidated statement 1 table 2 is analyzed, Capsules every investigation result containing nano-ZnO of the present invention is more constant with 0 month, and the capsule every investigation result not containing nano-ZnO compared with 0 month and there occurs larger change.Result shows that the Capsules containing nano-ZnO of the present invention has stronger superiority, and its uvioresistant Anti-tarnish property is good, good from antibacterial functions.
Finally should be noted that; above embodiment is only in order to illustrate technical scheme of the present invention; but not limiting the scope of the invention; although done to explain to the present invention with reference to preferred embodiment; those of ordinary skill in the art is to be understood that; can modify to technical scheme of the present invention or equivalent replacement, and not depart from essence and the scope of technical solution of the present invention.
Claims (10)
1., containing a Capsules for nano-ZnO, it is characterized in that: be made up of the raw material of following weight portion:
Major ingredient 50-60 part
Plasticizer 2-8 part
Tween 2-8 part
Titanium dioxide 15-25 part
Pigment 3-8 part
Nano-ZnO 2-10 part
Water 30-40 part
Wherein, described major ingredient is one or both in gelatin, hydroxypropyl emthylcellulose;
Wherein, described plasticizer is one or both in glycerol, Polyethylene Glycol;
Described tween is at least one in tween 20, Tween-40, Tween-60, tween 80.
2. a kind of Capsules containing nano-ZnO according to claim 1, is characterized in that: be made up of the raw material of following weight portion:
Major ingredient 50-55 part
Plasticizer 3-5 part
Tween 3-5 part
Titanium dioxide 15-20 part
Pigment 3-5 part
Nano-ZnO 2-5 part
Water 30-40 part.
3. a kind of Capsules containing nano-ZnO according to claim 1, is characterized in that: the particle diameter of described nano-ZnO is 20-100nm.
4. a kind of Capsules containing nano-ZnO according to claim 1, is characterized in that: described pigment is at least one in light blue, lemon yellow, ferrum oxide.
5. a kind of Capsules containing nano-ZnO according to claim 1, is characterized in that: the amino acid whose content in the described gelatin Central Asia is the 10-20% of gelatin gross mass.
6. a kind of Capsules containing nano-ZnO according to claim 1, it is characterized in that: the methoxyl content in described hydroxypropyl emthylcellulose is 20-25%, hydroxypropyl content is 8%-12%, and at 20 DEG C, mass concentration is the aqueous solution medium viscosity of 2% is 10-20mPa.s.
7. a kind of Capsules containing nano-ZnO according to claim 1, is characterized in that: described Polyethylene Glycol is one or both in PEG400, PEG4000.
8., according to the preparation method of a kind of Capsules containing nano-ZnO in claim 1-7 described in any one, it is characterized in that: comprise the following steps:
(1) weigh: take the major ingredient of formula ratio, plasticizer, tween, titanium dioxide, pigment, nano-ZnO, water are for subsequent use;
(2) prepare nano material dispersion: by plasticizer, tween, nano-ZnO and water, be dispersed into nano material dispersion by ultrasound wave;
(3) colloidal sol: by major ingredient, titanium dioxide, pigment mix homogeneously, then add above-mentioned nano material dispersion, colloidal sol under 50-75 DEG C of condition;
(4) prepare Capsules: after mix and blend, carry out dipping in glue glue capsule base, capsule base is dry sclerosis under 50-90 DEG C of condition, and through pulling out shell, cut and after arranging, make Capsules, the moisture Control of Capsules is at 10-18%.
9. the preparation method of a kind of Capsules containing nano-ZnO according to claim 8, is characterized in that: in described step (2), hyperacoustic frequency of vibration is 20-35KHz.
10. the preparation method of a kind of Capsules containing nano-ZnO according to claim 8, it is characterized in that: in described step (3), collosol temperature is 55-65 DEG C; In described step (4), capsule base is dry sclerosis under 60-80 DEG C of condition, and the moisture Control of Capsules is at 12.5-17.5%.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114732793A (en) * | 2022-04-21 | 2022-07-12 | 湖北人福药用辅料股份有限公司 | Hollow capsule and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1791387A (en) * | 2003-05-19 | 2006-06-21 | 沃尼尔·朗伯有限责任公司 | Hard gelatin capsule containing titanium oxide with a controlled particle size and process for producing the same |
| CN104548102A (en) * | 2014-12-31 | 2015-04-29 | 广东国方医药科技有限公司 | Coating agent containing nanometer ZnO and preparation method of coating agent |
-
2015
- 2015-12-31 CN CN201511015141.1A patent/CN105434396B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1791387A (en) * | 2003-05-19 | 2006-06-21 | 沃尼尔·朗伯有限责任公司 | Hard gelatin capsule containing titanium oxide with a controlled particle size and process for producing the same |
| CN104548102A (en) * | 2014-12-31 | 2015-04-29 | 广东国方医药科技有限公司 | Coating agent containing nanometer ZnO and preparation method of coating agent |
Non-Patent Citations (2)
| Title |
|---|
| SHANKAR S.，ET AL.: ""Preparation, characterization, and antimicrobial activity of gelatin/ZnO nanocomposite films"", 《FOOD HYDROCOLLOIDS》 * |
| 姚超 等: "纳米技术与纳米材料(VI)-纳米氧化锌在防晒化妆品中的应用", 《日用化学工业》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114732793A (en) * | 2022-04-21 | 2022-07-12 | 湖北人福药用辅料股份有限公司 | Hollow capsule and preparation method thereof |
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