CN105412977A - 一种壳聚糖伤口敷料 - Google Patents
一种壳聚糖伤口敷料 Download PDFInfo
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- CN105412977A CN105412977A CN201511010766.9A CN201511010766A CN105412977A CN 105412977 A CN105412977 A CN 105412977A CN 201511010766 A CN201511010766 A CN 201511010766A CN 105412977 A CN105412977 A CN 105412977A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
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Abstract
一种壳聚糖伤口敷料,按照重量百分比由1-5%海藻酸钠,1-5%壳聚糖,5-10%透明质酸,1-5%有机硅季铵盐,5-10%甘油以及65%-87%纯化水所组成。其制备方法是按重量百分比称取海藻酸钠、壳聚糖及纯化水,在搅拌速度为10转/分钟的条件下加热至75℃,保持10分钟,得混合物;按重量百分比称取透明质酸、有机硅季铵盐及甘油放入容器中,在搅拌速度20转/分钟的条件下加热至80℃,保持15分钟后,得另一混合溶液;将两混合溶液趁热混合,以10转/分钟,搅拌10分钟,降温至35-45℃,即得。
Description
技术领域
本发明涉及生物医药领域,具体的涉及一种含有壳聚糖的敷料。
背景技术
伤口愈合学会对慢性伤口的定义为一个无法通过正常有序而及时的修复过程达到解剖和功能上的完整状态的伤口。一般将慢性伤口划分为静脉性溃疡、动脉性溃疡、糖尿病性溃疡、创伤性溃疡、压力性溃疡5类常见类型,其他还有由肿瘤和结缔组织疾病麻风等引起的创面。
目前,慢性伤口的高发病率、高患病率、高费用已成为医疗保健的一大难题。1%-2%人口比例会罹患腿部溃疡,且随着人口老龄化,这个数字也将有所增加。其治疗费用非常昂贵,全球用于伤口护理的费用每年高达130-150亿美金。
壳聚糖又称脱乙酰甲壳素,是由自然界广泛存在的几丁质经过脱乙酰作用得到的,化学名称为聚葡萄糖胺(1-4)-2-氨基-B-D葡萄糖。自1859年,法国人Rouget首先得到壳聚糖后,这种天然高分子的生物官能性和相容性、血液相容性、安全性、微生物降解性等优良性能被各行各业广泛关注。在医药方面,壳聚糖主要用于药物的缓释基质——壳聚糖能被生物体内的溶菌酶降解生成天然的代谢物,具有无毒、能被生物体完全吸收的特点,因此用它作药物缓释剂具有较大的优越性。日本已有以壳聚糖作为基质的缓释药物出售。
发明内容
本发明的目的是提出一种方便患者使用,且价格低廉,制作简单的一种用于慢性难愈合伤口的敷料,及其制备方法。
本发明的技术方案概述如下:
一种壳聚糖伤口敷料,按照重量百分比由1-5%海藻酸钠,1-5%壳聚糖,5-10%透明质酸,1-5%有机硅季铵盐,5-10%甘油以及65%-87%纯化水所组成。
优选的是一种壳聚糖伤口敷料,所述用于慢性伤口的敷料按照重量百分比由3%海藻酸钠,2%壳聚糖,7%透明质酸,2%有机硅季铵盐,6%甘油以及80%纯化水所组成。
一种壳聚糖伤口敷料其制备方法是按重量百分比称取海藻酸钠、壳聚糖及纯化水,在搅拌速度为10转/分钟的条件下加热至75℃,保持10分钟,得混合物;按重量百分比称取透明质酸、有机硅季铵盐及甘油放入容器中,在搅拌速度20转/分钟的条件下加热至80℃,保持15分钟后,得另一混合溶液;将两混合溶液趁热混合,以10转/分钟,搅拌10分钟,降温至35-45℃,即得。
本发明的使用方法是,对伤口用生理盐水进行简单清洁,后将本发明的敷料涂抹于伤口上约0.5mm厚度。该发明原理为湿性伤口愈合理论,为伤口愈合提供一个积极的湿润环境,并保持创面不积液,无侵蚀,隔绝细菌感染,起到快速止血、阵痛,促进伤口愈合减少疤痕的作用。
具体实施方式
下面结合具体实施例对本发明作进一步的说明。
实施例1
一种壳聚糖伤口敷料,按照重量百分比由3%海藻酸钠,2%壳聚糖,7%透明质酸,2%有机硅季铵盐,6%甘油以及80%纯化水所组成。
实施例2
一种壳聚糖伤口敷料,按照重量百分比由1%海藻酸钠,1%壳聚糖,5%透明质酸,1%有机硅季铵盐,5%甘油以及87%纯化水所组成。
实施例3
一种壳聚糖伤口敷料,按照重量百分比由5%海藻酸钠,5%壳聚糖,10%透明质酸,5%有机硅季铵盐,10%甘油以及65%纯化水所组成。
实施例4
一种壳聚糖伤口敷料其制备方法是按重量百分比称取海藻酸钠、壳聚糖及纯化水,在搅拌速度为10转/分钟的条件下加热至75℃,保持10分钟,得混合物;按重量百分比称取透明质酸、有机硅季铵盐及甘油放入容器中,在搅拌速度20转/分钟的条件下加热至80℃,保持15分钟后,得另一混合溶液;将两混合溶液趁热混合,以10转/分钟,搅拌10分钟,降温至35-45℃,即得。
Claims (4)
1.一种壳聚糖伤口敷料,其特征是按照重量百分比由1-5%海藻酸钠,1-5%壳聚糖,5-10%透明质酸,1-5%有机硅季铵盐,5-10%甘油以及65%-87%纯化水所组成。
2.根据权利要求1所述的一种壳聚糖伤口敷料,其特征是所述用于慢性伤口的敷料按照重量百分比由3%海藻酸钠,2%壳聚糖,7%透明质酸,2%有机硅季铵盐,6%甘油以及80%纯化水所组成。
3.根据权利要求1和2所述的一种壳聚糖伤口敷料,其特征是所述壳聚糖为壳聚糖季铵盐、壳聚糖盐酸盐、羧甲基壳聚糖。
4.根据权利要求1和2所述的一种壳聚糖伤口敷料,其特征是用于慢性伤口的敷料。
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106215220A (zh) * | 2016-09-18 | 2016-12-14 | 天津北洋百川生物技术有限公司 | 一种新型复合交联普鲁兰多糖的伤口敷料 |
WO2020228736A1 (zh) * | 2019-05-14 | 2020-11-19 | 暨南大学 | 一种高载药量的缓释微凝胶药膏及其制备方法与应用 |
WO2023233299A1 (en) * | 2022-05-31 | 2023-12-07 | Instituto Politécnico Da Guarda | Wound dressing comprising a ph sensor composition and method of producing the same |
-
2015
- 2015-12-30 CN CN201511010766.9A patent/CN105412977A/zh active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106215220A (zh) * | 2016-09-18 | 2016-12-14 | 天津北洋百川生物技术有限公司 | 一种新型复合交联普鲁兰多糖的伤口敷料 |
WO2020228736A1 (zh) * | 2019-05-14 | 2020-11-19 | 暨南大学 | 一种高载药量的缓释微凝胶药膏及其制备方法与应用 |
WO2023233299A1 (en) * | 2022-05-31 | 2023-12-07 | Instituto Politécnico Da Guarda | Wound dressing comprising a ph sensor composition and method of producing the same |
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Application publication date: 20160323 |