CN105403695A - 用于致动磁性粒子的生物传感器系统 - Google Patents
用于致动磁性粒子的生物传感器系统 Download PDFInfo
- Publication number
- CN105403695A CN105403695A CN201510695553.8A CN201510695553A CN105403695A CN 105403695 A CN105403695 A CN 105403695A CN 201510695553 A CN201510695553 A CN 201510695553A CN 105403695 A CN105403695 A CN 105403695A
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- China
- Prior art keywords
- magnetic
- cartridge case
- sensor
- subelement
- magnetic field
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000006249 magnetic particle Substances 0.000 title claims abstract description 51
- 230000005291 magnetic effect Effects 0.000 claims abstract description 184
- 238000000034 method Methods 0.000 claims description 24
- 238000004458 analytical method Methods 0.000 claims description 19
- 230000008859 change Effects 0.000 claims description 12
- 238000012360 testing method Methods 0.000 abstract description 20
- 238000003018 immunoassay Methods 0.000 abstract description 2
- 239000002245 particle Substances 0.000 description 31
- 230000003287 optical effect Effects 0.000 description 19
- 239000000427 antigen Substances 0.000 description 14
- 102000036639 antigens Human genes 0.000 description 14
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- 239000011324 bead Substances 0.000 description 2
- 230000027455 binding Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
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- 102000004169 proteins and genes Human genes 0.000 description 2
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- 239000012620 biological material Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 239000003153 chemical reaction reagent Substances 0.000 description 1
- HGAZMNJKRQFZKS-UHFFFAOYSA-N chloroethene;ethenyl acetate Chemical compound ClC=C.CC(=O)OC=C HGAZMNJKRQFZKS-UHFFFAOYSA-N 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
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- 229910044991 metal oxide Inorganic materials 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
- G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
- G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Electrochemistry (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
Description
Claims (12)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08169405 | 2008-11-19 | ||
EP08169405.1 | 2008-11-19 | ||
CN2009801462984A CN102216780A (zh) | 2008-11-19 | 2009-07-22 | 用于致动磁性粒子的生物传感器系统 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009801462984A Division CN102216780A (zh) | 2008-11-19 | 2009-07-22 | 用于致动磁性粒子的生物传感器系统 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105403695A true CN105403695A (zh) | 2016-03-16 |
CN105403695B CN105403695B (zh) | 2018-08-10 |
Family
ID=41172296
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510695553.8A Active CN105403695B (zh) | 2008-11-19 | 2009-07-22 | 用于致动磁性粒子的生物传感器系统 |
CN2009801462984A Pending CN102216780A (zh) | 2008-11-19 | 2009-07-22 | 用于致动磁性粒子的生物传感器系统 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009801462984A Pending CN102216780A (zh) | 2008-11-19 | 2009-07-22 | 用于致动磁性粒子的生物传感器系统 |
Country Status (6)
Country | Link |
---|---|
US (1) | US9103824B2 (zh) |
EP (1) | EP2368116B1 (zh) |
JP (3) | JP2012509491A (zh) |
CN (2) | CN105403695B (zh) |
RU (1) | RU2519655C2 (zh) |
WO (1) | WO2010058303A1 (zh) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2720060A1 (en) | 2009-09-28 | 2014-04-16 | Koninklijke Philips N.V. | A biosensor system for single particle detection |
WO2013064990A1 (en) * | 2011-11-03 | 2013-05-10 | Koninklijke Philips Electronics N.V. | Detection of surface-bound magnetic particles |
WO2013102850A1 (en) | 2012-01-04 | 2013-07-11 | Insituto De Engenharia De Sistemas E Computadores Para Os Microsistemas E As Nanotecnologias | Monolithic device combining cmos with magnetoresistive sensors |
EP2664914A1 (en) * | 2012-05-16 | 2013-11-20 | Koninklijke Philips N.V. | Magnetically assisted processing of a medium |
JP6384965B2 (ja) | 2012-11-19 | 2018-09-05 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 呼気流を増加させるための方法及び装置 |
JP6588908B2 (ja) | 2014-06-30 | 2019-10-09 | Phcホールディングス株式会社 | 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム |
US10520521B2 (en) | 2014-06-30 | 2019-12-31 | Phc Holdings Corporation | Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system |
JP6548645B2 (ja) | 2014-06-30 | 2019-07-24 | Phcホールディングス株式会社 | 試料分析用基板および試料分析装置 |
US10539582B2 (en) | 2014-06-30 | 2020-01-21 | Phc Holdings Corporation | Substrate for sample analysis, sample analysis device, sample analysis system, and method for removing liquid from liquid that contains magnetic particles |
US9788763B1 (en) * | 2014-07-09 | 2017-10-17 | Verily Life Sciences Llc | Methods for magnetic particle capture and separation |
EP3232203B1 (en) | 2014-12-12 | 2022-02-02 | PHC Holdings Corporation | Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system |
US10145906B2 (en) | 2015-12-17 | 2018-12-04 | Analog Devices Global | Devices, systems and methods including magnetic structures |
CN107796865B (zh) | 2016-09-05 | 2021-05-25 | 财团法人工业技术研究院 | 生物分子磁传感器 |
EP3470141B1 (en) * | 2017-10-11 | 2024-04-24 | F. Hoffmann-La Roche AG | Apparatus and method for processing a biological sample with magnetic particles |
US10161856B1 (en) * | 2018-01-19 | 2018-12-25 | Ping-Chieh Wu | Magneto-optical bio-detection devices having high sensitivity |
JP7467137B2 (ja) | 2020-01-28 | 2024-04-15 | キヤノンメディカルシステムズ株式会社 | 検体分析装置 |
US11940502B2 (en) | 2021-09-24 | 2024-03-26 | Analog Devices International Unlimited Company | Magnetic field sensing based on particle position within container |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5053344A (en) | 1987-08-04 | 1991-10-01 | Cleveland Clinic Foundation | Magnetic field separation and analysis system |
JPH07111433B2 (ja) | 1988-04-26 | 1995-11-29 | 日本電信電話株式会社 | レーザ磁気免疫測定方法及び測定装置 |
US5466574A (en) | 1991-03-25 | 1995-11-14 | Immunivest Corporation | Apparatus and methods for magnetic separation featuring external magnetic means |
JPH05312786A (ja) | 1992-05-11 | 1993-11-22 | Kawasaki Steel Corp | 磁気探傷装置 |
US5394739A (en) * | 1994-06-06 | 1995-03-07 | Computational Systems, Inc. | Viscosity tester and method with orbiting object |
US5955881A (en) * | 1994-10-18 | 1999-09-21 | Cts Corporation | Linkage position sensor having a magnet with two ramped sections for providing variable magnetic field |
US6136182A (en) | 1996-06-07 | 2000-10-24 | Immunivest Corporation | Magnetic devices and sample chambers for examination and manipulation of cells |
US5779907A (en) | 1996-12-06 | 1998-07-14 | Systems Research Laboratories, Inc. | Magnetic microplate separator |
ES2313800T3 (es) | 1998-11-30 | 2009-03-01 | Veridex, Llc | Aparato y procedimiento de separacion magnetica. |
JP3266128B2 (ja) * | 1999-02-08 | 2002-03-18 | 日本鋼管株式会社 | 漏洩磁束探傷法及び漏洩磁束探傷装置 |
CN1181337C (zh) | 2000-08-08 | 2004-12-22 | 清华大学 | 微流体系统中实体分子的操纵方法及相关试剂盒 |
ATE444794T1 (de) | 2003-03-08 | 2009-10-15 | Ecole Polytech | Manipulations- und transportvorrichtung für magnetkügelchen |
CN1829916B (zh) * | 2003-07-30 | 2010-09-29 | 皇家飞利浦电子股份有限公司 | 用于确定生物活性分子之间结合的磁性粒子的使用 |
JP2009543040A (ja) * | 2006-06-29 | 2009-12-03 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 磁気マニピュレータを有するマイクロエレクトロニクス素子 |
EP3059583B1 (en) * | 2007-03-06 | 2019-05-15 | Koninklijke Philips N.V. | An electromagnetic system for biosensors |
CN101925818A (zh) | 2008-01-28 | 2010-12-22 | 皇家飞利浦电子股份有限公司 | 用于外部驱动生物传感器盒中的磁性粒子的生物传感器系统 |
CN101231287B (zh) * | 2008-02-22 | 2011-09-14 | 东南大学 | 外场诱导电极中排列纳米颗粒制备生物传感器的方法 |
-
2009
- 2009-07-22 WO PCT/IB2009/053168 patent/WO2010058303A1/en active Application Filing
- 2009-07-22 JP JP2011543845A patent/JP2012509491A/ja active Pending
- 2009-07-22 EP EP09786661.0A patent/EP2368116B1/en active Active
- 2009-07-22 US US13/129,818 patent/US9103824B2/en active Active
- 2009-07-22 RU RU2011124882/15A patent/RU2519655C2/ru active
- 2009-07-22 CN CN201510695553.8A patent/CN105403695B/zh active Active
- 2009-07-22 CN CN2009801462984A patent/CN102216780A/zh active Pending
-
2015
- 2015-02-19 JP JP2015030315A patent/JP6092910B2/ja active Active
-
2017
- 2017-02-09 JP JP2017021764A patent/JP2017106927A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
RU2011124882A (ru) | 2012-12-27 |
EP2368116A1 (en) | 2011-09-28 |
CN102216780A (zh) | 2011-10-12 |
JP2017106927A (ja) | 2017-06-15 |
WO2010058303A1 (en) | 2010-05-27 |
US9103824B2 (en) | 2015-08-11 |
US20110221427A1 (en) | 2011-09-15 |
CN105403695B (zh) | 2018-08-10 |
JP6092910B2 (ja) | 2017-03-08 |
JP2012509491A (ja) | 2012-04-19 |
EP2368116B1 (en) | 2019-07-03 |
RU2519655C2 (ru) | 2014-06-20 |
JP2015121558A (ja) | 2015-07-02 |
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Legal Events
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: Holland Ian Deho Finn Patentee after: KONINKLIJKE PHILIPS N.V. Address before: Holland Ian Deho Finn Patentee before: Koninklijke Philips Electronics N.V. |
|
TR01 | Transfer of patent right |
Effective date of registration: 20181024 Address after: Ian Deho Finn AE5656 hi tech park, Holland 29 Patentee after: Micro Care Pte. Ltd. Address before: Holland Ian Deho Finn Patentee before: KONINKLIJKE PHILIPS N.V. |
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TR01 | Transfer of patent right | ||
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: Holland Hague Patentee after: Siemens Medical Systems Holland Ltd. Address before: Holland Hague Patentee before: Siemens Medical diagnostic solutions first Holdings Ltd. |
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TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210119 Address after: Holland Hague Patentee after: Siemens Medical diagnostic solutions first Holdings Ltd. Address before: Holland Hague Patentee before: Siemens Medical Holland Ltd. Effective date of registration: 20210119 Address after: Holland Hague Patentee after: Siemens Medical Holland Ltd. Address before: Ian Deho Finn AE5656 hi tech park, Holland 29 Patentee before: Micro Care Pte. Ltd. |
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EE01 | Entry into force of recordation of patent licensing contract | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20160316 Assignee: SIEMENS HEALTHCARE DIAGNOSTICS Inc. Assignor: Siemens Medical Systems Holland Ltd. Contract record no.: X2021990000659 Denomination of invention: Biosensor system for actuating magnetic particles Granted publication date: 20180810 License type: Exclusive License Record date: 20211026 |