CN105396530A - Biochemical reaction apparatus for preparing biological preparations - Google Patents
Biochemical reaction apparatus for preparing biological preparations Download PDFInfo
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- CN105396530A CN105396530A CN201410464449.3A CN201410464449A CN105396530A CN 105396530 A CN105396530 A CN 105396530A CN 201410464449 A CN201410464449 A CN 201410464449A CN 105396530 A CN105396530 A CN 105396530A
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Abstract
The invention relates to a biochemical reaction apparatus for preparing biological preparations. The biochemical reaction apparatus comprises a reaction container, an alternating magnetic field generator, a magnetic stirring system, a condenser, temperature sensing devices, a fluidized bed, a control box and other components, and is characterized in that the reaction container is connected to a flange through threads, a cylinder cover and the flange are connected through bolts, the spherical surface on the cylinder cover and the cone surface on the container form a line contact sealing, and the sealing structure between the magnetic stirring system and the fluidized bed is enhanced by the magnetic fluid known in mechanical sealing. According to the present invention, the apparatus uses the fully-sealed static closed structure, such that the temperature inside the reaction apparatus can be ensured, no leakage and no noise in the apparatus can be achieved, the reaction quality can be ensured, the opportunity of the cross infection between the outside and the biological preparation in the pipe is eliminated, the biochemical reaction safety is substantially improved, and the biological reaction requirements of a variety of substances, particular the biochemical preparations, can be met.
Description
Technical field
The present invention relates to a kind of biochemical reaction device that can be used for medication chemistry, biochemical industry etc. and prepare biologic product, particularly a kind of biochemical reaction device preparing antigen-antibody biologic product product.
Background technology
At present, conventional in medication chemistry, biochemical industry and Fine Chemical, for guaranteeing the cleanliness factor and anticorrosion etc. of sintetics, the conventional fluoroplastics of general employing are as the cylindrical shell (retort) of reaction unit, seal cover and carrier pipe and pipe joint etc., although this type of reaction unit has the advantages such as structure is simple, corrosion-resistant, but owing to adopting popular response still, be difficult to accomplish to monitor parameters in reactor constantly, be difficult to control course of reaction, such as be burned owing to heating the uneven part that causes, partial reaction is not thorough; Or because agitating device exists dead angle, reactant can not fully mix; Or be difficult to mix during the large material reaction of specific gravity difference.In a word, above-mentioned reaction unit also exists defects such as entering material in reaction tube is too concentrated, dispersed and poor yields.
Summary of the invention
The object of the invention is to design a kind of medicine and biochemical industry with preparing biologic product biochemical reaction device, the deficiencies in the prior art can be solved, by this tight system, development temperature control system, achieve response parameter to monitor in real time, decrease the manual intervention of whole process, improve the accuracy of chemical reaction.
For solving the problems of the technologies described above, the technical solution used in the present invention is as follows:
The invention provides a kind of biochemical reaction device for the preparation of biologic product, be made up of parts such as reaction vessel, alternating magnetic field generator, magnetic agitation system, condenser, temperature sensing device, fluid bed, control cabinets, it is characterized in that, described reaction unit container is threaded with flange, with bolts between cover and flange, the sphere on described cover and the conical surface on container form line contact sealing.
Further, the hermetically-sealed construction between described magnetic agitation system and fluid bed is strengthened by magnetic fluid known in mechanical seal.
Further, described condenser is positioned at apart from retort top 1/6 place.
Further, described reaction vessel is jacketed reaction device, arranges four temperature sensing devices in interlayer by " ten " font, arranges four temperature sensing devices in reaction tube by " ten " font.
Further, described both sides, reaction vessel bottom arrange air inlet and gas vent respectively.
Further, described control cabinet is installed on outside container, and inside is provided with pressure, temperature, and temperature controller connects with temp probe in cylinder and temperature sensing device and controlled by PID.
Further, described temperature controller temperature control precision reach ± 0.1%.
Usefulness of the present invention is:
1, reaction unit tank body, reaction unit lid is by the conical surface line contact sealing on the arc surface of appliance cover and tank body, cover bolt by tightly reaction and compress and reach good sealing effectiveness, sealed by magnetic fluid between fluid bed and rotating shaft, magnet fluid sealing by magnetic field, magnetic fluid is remained in the gap between stationary element and spinner member, magnetic pole magnetic property is good, it is seal clearance between magnetic pole and rotating shaft, magnetic fluid is inhaled firmly in seal clearance, form liquid type seal ring, this gap is by magnetic fluid close encapsulation, liquid is attached to magnetic pole and axle surface when the shaft is rotated, when reaching certain rotating speed, ring is cut off by hoop, and remain on original position formation movable sealing.
This device adopts above-mentioned totally-enclosed static seal structure, both temperature in reaction unit can be ensured, can make again to realize No leakage, noiselessness in reaction unit, ensure reaction mass, stop the chance of biologic product generation cross-infection in extraneous and body, drastically increase the security of biochemical reaction, many kinds of substance can be met and carry out the requirement of biologically at particularly biochemical preparation.
2, temprature control unit is intelligent, input design temperature, with temperature in reaction unit in temperature inductor detection chuck, temperature sense induced signal changes with two place's temperature, and pass to temperature controller, by the switch of the PID control circui solid-state voltage regulator in temperature controller, thus adjust the time into vapours, reach Automatic-heating and be warming up to design temperature, prevent the object of high temperature overshoot and maintenance constant temperature.
3, this reaction unit adopts Steam Heating, and improve the rate of heat addition, reduce power consumption, condenser is arranged at body top, can effective control valve temperature.
4, this reaction unit temperature controller connects with temperature sensing device in cylinder and is controlled by PID, and control accuracy can reach ± and 0.1%.In a word, be originally exclusively used in the biochemical reaction device design science preparing biologic product reasonable, be easy to operation, there is good promotion prospect.
Accompanying drawing illustrates:
Fig. 1 is structural representation of the present invention
Fig. 2 is circuit front panel schematic diagram of the present invention
Fig. 3 is circuit rear board schematic diagram of the present invention
In Fig. 1,1 is reaction vessel lid, and 2 is control cabinet, 3 is milling cutter, and 4 is fluid bed, and 5 is rotating shaft, 6 is fluidisation bed bracket, and 7 is magnet rotor, and 8 is waste liquid outlet, 9 is charging aperture, and 10 is condenser pipe, and 11 is reaction vessel body heating jacket, 12 is temperature inductor, and 13 is overflow pipe, and 14 is discharging opening, 15 is air admission hole, and 16 is alternating magnetic field generator, and 17 is gas vent
In Fig. 2 and Fig. 3,1 is temperature controller, and 2 is energising work stopwatch, 3 is motor working current table, 4 is rotor speed table, and 5 is electric machine speed regulation potentiometer, and 6 is power switch, 7 is electric power incoming line socket, 8 is motor lines socket, and 9 is detecting element socket, and 10 is thermometric inductor leading-in socket, 11 is main fuse seat, and 12 is motor fuse holder.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with accompanying drawing, the present invention is further elaborated.
As shown in Figure 1, a kind of biochemical reaction device for the preparation of biologic product, be made up of parts such as reaction vessel, alternating magnetic field generator, magnetic agitation system, condenser, temperature sensing device, fluid bed, control cabinets, it is characterized in that, described reaction unit container is threaded with flange, with bolts between cover and flange, the sphere on described cover and the conical surface on container form line contact sealing.
Hermetically-sealed construction between magnetic agitation system and fluid bed is strengthened by magnetic fluid known in mechanical seal, condenser is positioned at apart from retort top 1/6 place, reaction vessel is jacketed reaction device, in interlayer, four temperature sensing devices are set by " ten " font, in reaction tube, four temperature sensing devices are set by " ten " font, both sides, reaction vessel bottom arrange air inlet and gas vent respectively, control cabinet is installed on outside container, inside is provided with temperature controller, temperature controller connects with temp probe in cylinder and temperature sensing device and is controlled by PID, temperature controller temperature control precision reaches ± and 0.1%.
This reaction unit tank body, reaction unit lid is by the conical surface line contact sealing on the arc surface of appliance cover and tank body, cover bolt by tightly reaction and compress and reach good sealing effectiveness, sealed by magnetic fluid between fluid bed and rotating shaft, magnet fluid sealing by magnetic field, magnetic fluid is remained in the gap between stationary element and spinner member, magnetic pole magnetic property is good, it is seal clearance between magnetic pole and rotating shaft, magnetic fluid is inhaled firmly in seal clearance, form liquid type seal ring, this gap is by magnetic fluid close encapsulation, liquid is attached to magnetic pole and axle surface when the shaft is rotated, when reaching certain rotating speed, ring is cut off by hoop, and remain on original position formation movable sealing.
This reaction unit adopts above-mentioned totally-enclosed static seal structure, both temperature in reaction unit can be ensured, can make again to realize No leakage, noiselessness in reaction unit, ensure reaction mass, stop the chance of biologic product generation cross-infection in extraneous and body, drastically increase the security of biochemical reaction, many kinds of substance can be met and carry out the requirement of biologically at particularly biochemical preparation.
This reaction unit temperature controller connects with temperature sensing device in cylinder and is controlled by PID, and control accuracy can reach ± and 0.1%.
In a word, be originally exclusively used in the biochemical reaction device design science preparing biologic product reasonable, be easy to operation, there is good promotion prospect.
Certainly; the present invention also can have other various embodiments; when not departing from spirit of the present invention and essence thereof; those of ordinary skill in the art are when making various corresponding change and distortion according to the present invention, but these change accordingly and are out of shape the protection domain that all should belong to the claim appended by the present invention.
Claims (4)
1. a biochemical reaction device, be made up of parts such as reaction vessel, alternating magnetic field generator, magnetic agitation system, condenser, temperature sensing device, fluid bed, control cabinets, it is characterized in that, described reaction unit container is threaded with flange, with bolts between cover and flange, the sphere on described cover and the conical surface on container form line contact sealing.
2. a kind of biochemical reaction device according to claim 1, is characterized in that, the hermetically-sealed construction between described magnetic agitation system and fluid bed is strengthened by magnetic fluid known in mechanical seal.
3. a kind of biochemical reaction device according to claim 1, is characterized in that, described condenser is positioned at apart from retort top 1/6 place.
4. a kind of biochemical reaction device according to claim 1, is characterized in that, described reaction vessel is jacketed reaction device, arranges four temperature sensing devices in interlayer by " ten " font, arranges four temperature sensing devices in reaction tube by " ten " font.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410464449.3A CN105396530A (en) | 2014-09-12 | 2014-09-12 | Biochemical reaction apparatus for preparing biological preparations |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410464449.3A CN105396530A (en) | 2014-09-12 | 2014-09-12 | Biochemical reaction apparatus for preparing biological preparations |
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| Publication Number | Publication Date |
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| CN105396530A true CN105396530A (en) | 2016-03-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410464449.3A Pending CN105396530A (en) | 2014-09-12 | 2014-09-12 | Biochemical reaction apparatus for preparing biological preparations |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01304004A (en) * | 1988-05-31 | 1989-12-07 | Tokuden Co Ltd | Heating/cooling container |
| JPH0656909A (en) * | 1992-08-10 | 1994-03-01 | Sekisui Chem Co Ltd | Temperature control device of reactor |
| CN2423949Y (en) * | 1999-10-18 | 2001-03-21 | 曹树林 | Mechanical sealing device for agitated reactor |
| CN201346457Y (en) * | 2008-12-08 | 2009-11-18 | 核工业理化工程研究院华核新技术开发公司 | Integrated gas-liquid reactor |
| CN202778472U (en) * | 2012-07-16 | 2013-03-13 | 东北石油大学 | Chemical synthesis device |
| CN203170324U (en) * | 2013-04-01 | 2013-09-04 | 重庆中科过滤设备制造有限公司 | Industrial oil reaction kettle type decoloring device |
| WO2014035211A1 (en) * | 2012-09-03 | 2014-03-06 | (주)라미나 | Refining device including continuous reactor and refining method using continuous reactor |
| CN204134632U (en) * | 2014-09-12 | 2015-02-04 | 天津法莫西医药科技有限公司 | A kind of biochemical reaction device |
-
2014
- 2014-09-12 CN CN201410464449.3A patent/CN105396530A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01304004A (en) * | 1988-05-31 | 1989-12-07 | Tokuden Co Ltd | Heating/cooling container |
| JPH0656909A (en) * | 1992-08-10 | 1994-03-01 | Sekisui Chem Co Ltd | Temperature control device of reactor |
| CN2423949Y (en) * | 1999-10-18 | 2001-03-21 | 曹树林 | Mechanical sealing device for agitated reactor |
| CN201346457Y (en) * | 2008-12-08 | 2009-11-18 | 核工业理化工程研究院华核新技术开发公司 | Integrated gas-liquid reactor |
| CN202778472U (en) * | 2012-07-16 | 2013-03-13 | 东北石油大学 | Chemical synthesis device |
| WO2014035211A1 (en) * | 2012-09-03 | 2014-03-06 | (주)라미나 | Refining device including continuous reactor and refining method using continuous reactor |
| CN203170324U (en) * | 2013-04-01 | 2013-09-04 | 重庆中科过滤设备制造有限公司 | Industrial oil reaction kettle type decoloring device |
| CN204134632U (en) * | 2014-09-12 | 2015-02-04 | 天津法莫西医药科技有限公司 | A kind of biochemical reaction device |
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Application publication date: 20160316 |
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| RJ01 | Rejection of invention patent application after publication |