CN105395929A - Externally-applied agent for removing scars - Google Patents
Externally-applied agent for removing scars Download PDFInfo
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- CN105395929A CN105395929A CN201510851333.XA CN201510851333A CN105395929A CN 105395929 A CN105395929 A CN 105395929A CN 201510851333 A CN201510851333 A CN 201510851333A CN 105395929 A CN105395929 A CN 105395929A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention provides an externally-applied agent for removing scars. The externally-applied agent is prepared from aloes, folium artemisiae argyi, mongolian dandelion herbs, nutmeg, lavender, scarlet kadsura stems and leaves, abrus herbs, poria cocos, lygodium japonicum, rhizoma imperatae, flos rosae rugosae, hairyvein agrimony, rose mallow roots or herbs, bock greenbrier rhizome, coptis chinensis, pearl, radix sophorae flavescentis, nuces vomicae, hydnocarpus and long-noded pit viper. The preparation method of the externally-applied agent includes the steps that after being soaked by water for 5-10 days first, the raw materials are placed in a hot pan to be stir-fried, and coconut oil is added for stir-frying during the period; the raw materials are taken out to be cooled and then are added into rice wine to be soaked for 10-30 days, and accordingly the externally-applied agent can be prepared. The externally-applied agent for removing scars is small in toxic and side effect, fast to take effect and good in curative effect.
Description
Technical field
The present invention relates to a kind of medicine for external use of dispeling scar, belong to technical field of Chinese medicines.
Background technology
Cicatrix is that the detrimental effect of the factors such as physics, biology, chemistry is in human body skin soft tissue, cause the major injury of skin soft tissue and can not normally repair completely voluntarily, turn stayed by fibrous tissue replacement reparation not only affect outward appearance but also affect the local symptom of function.In order to dispeling scar, existing commercially there is various Skin whitening care cosmetics, although these Skin whitening care cosmeticses can play the effect covered up, can not fundamentally dispeling scar; And use Skin whitening care cosmetics for a long time, be also easy to the skin injuring user, cause various side effect.
Summary of the invention
The technical problem to be solved in the present invention is: the medicine for external use providing a kind of dispeling scar, has that toxic and side effects is little, the advantage such as instant effect and good effect.
For solving the problems of the technologies described above, the present invention by the following technical solutions:
The medicine for external use of dispeling scar, is obtained by the raw material of following weight parts:
Aloe 20 ~ 30 parts, Folium Artemisiae Argyi 20 ~ 30 parts, Herba Taraxaci 20 ~ 30 parts, Semen Myristicae 20 ~ 30 parts, lavandula angustifolia 20 ~ 30 parts, Caulis Kadsurae Coccineae 10 ~ 20 parts, Herba Abri 10 ~ 20 parts, 10 ~ 20 parts, Poria, Herba lygodii 10 ~ 20 parts, Rhizoma Imperatae 10 ~ 20 parts, Flos Rosae Rugosae 1 ~ 10 part, Herba Agrimoniae 1 ~ 10 part, Radix Urenae Lobatae 1 ~ 10 part, Rhizoma Smilacis Bockii 1 ~ 10 part, Rhizoma Coptidis 1 ~ 10 part, Margarita 1 ~ 10 part, Radix Sophorae Flavescentis 1 ~ 10 part, Semen Strychni 0.1 ~ 1 part, Semen Hydnocarpi 0.1 ~ 1 part, Agkistrodon 0.1 ~ 1 part.
As preferably, provide a concrete formula here, the weight portion of described raw material is:
Aloe 25 parts, Folium Artemisiae Argyi 30 parts, Herba Taraxaci 20 parts, Semen Myristicae 25 parts, lavandula angustifolia 30 parts, Caulis Kadsurae Coccineae 10 parts, Herba Abri 15 parts, 20 parts, Poria, Herba lygodii 10 parts, Rhizoma Imperatae 15 parts, Flos Rosae Rugosae 10 parts, Herba Agrimoniae 1 part, Radix Urenae Lobatae 5 parts, Rhizoma Smilacis Bockii 10 parts, Rhizoma Coptidis 1 part, Margarita 5 parts, Radix Sophorae Flavescentis 10 parts, Semen Strychni 0.1 part, Semen Hydnocarpi 0.5 part, Agkistrodon 1 part.
As preferably, provide second concrete formula here, the weight portion of described raw material is:
Aloe 20 parts, Folium Artemisiae Argyi 25 parts, Herba Taraxaci 30 parts, Semen Myristicae 20 parts, lavandula angustifolia 25 parts, Caulis Kadsurae Coccineae 20 parts, Herba Abri 10 parts, 15 parts, Poria, Herba lygodii 20 parts, Rhizoma Imperatae 10 parts, Flos Rosae Rugosae 5 parts, Herba Agrimoniae 10 parts, Radix Urenae Lobatae 1 part, Rhizoma Smilacis Bockii 5 parts, Rhizoma Coptidis 10 parts, Margarita 1 part, Radix Sophorae Flavescentis 5 parts, Semen Strychni 1 part, Semen Hydnocarpi 0.1 part, Agkistrodon 0.5 part.
As preferably, provide the 3rd concrete formula here, the weight portion of described raw material is:
Aloe 30 parts, Folium Artemisiae Argyi 20 parts, Herba Taraxaci 25 parts, Semen Myristicae 30 parts, lavandula angustifolia 20 parts, Caulis Kadsurae Coccineae 15 parts, Herba Abri 20 parts, 10 parts, Poria, Herba lygodii 15 parts, Rhizoma Imperatae 20 parts, Flos Rosae Rugosae 1 part, Herba Agrimoniae 5 parts, Radix Urenae Lobatae 10 parts, Rhizoma Smilacis Bockii 1 part, Rhizoma Coptidis 5 parts, Margarita 10 parts, Radix Sophorae Flavescentis 1 part, Semen Strychni 0.5 part, Semen Hydnocarpi 1 part, Agkistrodon 0.1 part.
The present invention also provides the preparation method of above-mentioned medicine for external use, its step the following is: by raw material with the water soak at room temperature of its weight 5 ~ 10 times after 5 ~ 10 days, taking-up drains, then be placed in 270 ~ 280 DEG C of hot pots to stir-fry 10 ~ 20 minutes, then after adding the Oleum Cocois of its weight 0.1% ~ 1%, continue to stir-fry 10 ~ 20 minutes, after taking out cooling, add in the yellow wine of its weight 3 ~ 8 times, soak after 10 ~ 30 days and namely obtain this medicine for external use.
The using method of this medicine for external use is: will soak the medicated wine uniform application that obtains in affected part, dosage for be no more than 20mL at every turn, every day 3 times.
The invention has the beneficial effects as follows: raw material of the present invention is conventional Chinese herbal medicine, wide material sources, low price; Preparation method of the present invention is simple, the scientific formulation of medicine is reasonable, synergism between each component, obtained medicine has flat chapped wrinkle, protects blood vessel, increases blood flow, evacuation of pus granulation promoting, promoting blood circulation and stopping pain, antibacterial, antiviral and antiinflammatory effect, to Acne treatment cicatrix, operative scar, burn and scald cicatrix, cigarette scar cicatrix and other cicatrix various, there is advantage that is effective, instant effect.
Detailed description of the invention
Further illustrate the present invention by the following examples, but the invention is not restricted to these embodiments.
Embodiment 1
The medicine for external use of dispeling scar, is obtained by the raw material of following weight parts: Aloe 25 parts, Folium Artemisiae Argyi 30 parts, Herba Taraxaci 20 parts, Semen Myristicae 25 parts, lavandula angustifolia 30 parts, Caulis Kadsurae Coccineae 10 parts, Herba Abri 15 parts, 20 parts, Poria, Herba lygodii 10 parts, Rhizoma Imperatae 15 parts, Flos Rosae Rugosae 10 parts, Herba Agrimoniae 1 part, Radix Urenae Lobatae 5 parts, Rhizoma Smilacis Bockii 10 parts, Rhizoma Coptidis 1 part, Margarita 5 parts, Radix Sophorae Flavescentis 10 parts, Semen Strychni 0.1 part, Semen Hydnocarpi 0.5 part, Agkistrodon 1 part.
The preparation method of medicine for external use is: by raw material with the water soak at room temperature of its weight 5 times after 8 days, taking-up drains, then be placed in 270 ~ 280 DEG C of hot pots to stir-fry 20 minutes, then after adding the Oleum Cocois of its weight 0.1%, continue to stir-fry 20 minutes, after taking out cooling, add in the yellow wine of its weight 5 times, soak after 10 days and namely obtain this medicine for external use.
Embodiment 2
The medicine for external use of dispeling scar, is obtained by the raw material of following weight parts: Aloe 20 parts, Folium Artemisiae Argyi 25 parts, Herba Taraxaci 30 parts, Semen Myristicae 20 parts, lavandula angustifolia 25 parts, Caulis Kadsurae Coccineae 20 parts, Herba Abri 10 parts, 15 parts, Poria, Herba lygodii 20 parts, Rhizoma Imperatae 10 parts, Flos Rosae Rugosae 5 parts, Herba Agrimoniae 10 parts, Radix Urenae Lobatae 1 part, Rhizoma Smilacis Bockii 5 parts, Rhizoma Coptidis 10 parts, Margarita 1 part, Radix Sophorae Flavescentis 5 parts, Semen Strychni 1 part, Semen Hydnocarpi 0.1 part, Agkistrodon 0.5 part.
The preparation method of medicine for external use is: by raw material with the water soak at room temperature of its weight 8 times after 10 days, taking-up drains, then be placed in 270 ~ 280 DEG C of hot pots to stir-fry 10 minutes, then after adding the Oleum Cocois of its weight 0.5%, continue to stir-fry 10 minutes, after taking out cooling, add in the yellow wine of its weight 8 times, soak after 20 days and namely obtain this medicine for external use.
Embodiment 3
The medicine for external use of dispeling scar, is obtained by the raw material of following weight parts: Aloe 30 parts, Folium Artemisiae Argyi 20 parts, Herba Taraxaci 25 parts, Semen Myristicae 30 parts, lavandula angustifolia 20 parts, Caulis Kadsurae Coccineae 15 parts, Herba Abri 20 parts, 10 parts, Poria, Herba lygodii 15 parts, Rhizoma Imperatae 20 parts, Flos Rosae Rugosae 1 part, Herba Agrimoniae 5 parts, Radix Urenae Lobatae 10 parts, Rhizoma Smilacis Bockii 1 part, Rhizoma Coptidis 5 parts, Margarita 10 parts, Radix Sophorae Flavescentis 1 part, Semen Strychni 0.5 part, Semen Hydnocarpi 1 part, Agkistrodon 0.1 part.
The preparation method of medicine for external use is: by raw material with the water soak at room temperature of its weight 10 times after 5 days, taking-up drains, then be placed in 270 ~ 280 DEG C of hot pots to stir-fry 15 minutes, then after adding the Oleum Cocois of its weight 1%, continue to stir-fry 10 minutes, after taking out cooling, add in the yellow wine solution of its weight 3 times, soak after 30 days and namely obtain this medicine for external use.
Toxicity test
Get ICR mice, before experiment, water 15h is can't help in fasting, is divided into 19 groups (the test medicine for external use group 6 groups of each embodiment, matched groups 1 group).Each group of mouse tail vein administration, test 1 group and be all according to dosage respectively 500mg/kg, 1000mg/kg, 2000mg/kg, 5000mg/kg, 10000mg/kg, 20000mg/kg to test 6 groups of dosages, control group mice gives same volume distilled water.Examine and record administration at once to toxic reaction and the death condition of mice appearance in 7d; Bliss ' s method is adopted to calculate LD50.The following form of experimental result:
Group | mg/kg |
Embodiment 1 medicine for external use | 4858.74 |
Embodiment 2 medicine for external use | 4754.63 |
Embodiment 3 medicine for external use | 4971.11 |
The LD50 of this medicine for external use is at more than 4754mg/kg as seen from the above table, and obviously the toxicity of this medicine for external use is very low, and this medicine for external use is based on external, in the rational scope of application, can ignore to the toxic and side effects of human body.
Therapeutic effect
Use the obtained medicine for external use of embodiment 1 to have the patient of cicatrix to carry out proof test to 150 body surfaces, average effectiveness level reaches 84.7%.Wherein: be less than 12 people's cicatrixes in 30 people of 20 years old and disappear, 15 people's cicatrixes shoal; In 30 people of 20 ~ 30 years old, 10 people's cicatrixes disappear, and 16 people's cicatrixes shoal; In 30 people of 30 ~ 40 years old, 9 people's cicatrixes disappear, and 17 people's cicatrixes shoal; In 30 people of 40 ~ 50 years old, 15 people's cicatrixes disappear, and 9 people's cicatrixes shoal; In 30 people of more than 50 years old, 9 people's cicatrixes disappear, and 15 people's cicatrixes shoal.
Claims (5)
1. the medicine for external use of dispeling scar, is characterized in that, is obtained by the raw material of following weight parts:
Aloe 20 ~ 30 parts, Folium Artemisiae Argyi 20 ~ 30 parts, Herba Taraxaci 20 ~ 30 parts, Semen Myristicae 20 ~ 30 parts, lavandula angustifolia 20 ~ 30 parts, Caulis Kadsurae Coccineae 10 ~ 20 parts, Herba Abri 10 ~ 20 parts, 10 ~ 20 parts, Poria, Herba lygodii 10 ~ 20 parts, Rhizoma Imperatae 10 ~ 20 parts, Flos Rosae Rugosae 1 ~ 10 part, Herba Agrimoniae 1 ~ 10 part, Radix Urenae Lobatae 1 ~ 10 part, Rhizoma Smilacis Bockii 1 ~ 10 part, Rhizoma Coptidis 1 ~ 10 part, Margarita 1 ~ 10 part, Radix Sophorae Flavescentis 1 ~ 10 part, Semen Strychni 0.1 ~ 1 part, Semen Hydnocarpi 0.1 ~ 1 part, Agkistrodon 0.1 ~ 1 part.
2. medicine for external use according to claim 1, is characterized in that, the weight portion of described raw material is:
Aloe 25 parts, Folium Artemisiae Argyi 30 parts, Herba Taraxaci 20 parts, Semen Myristicae 25 parts, lavandula angustifolia 30 parts, Caulis Kadsurae Coccineae 10 parts, Herba Abri 15 parts, 20 parts, Poria, Herba lygodii 10 parts, Rhizoma Imperatae 15 parts, Flos Rosae Rugosae 10 parts, Herba Agrimoniae 1 part, Radix Urenae Lobatae 5 parts, Rhizoma Smilacis Bockii 10 parts, Rhizoma Coptidis 1 part, Margarita 5 parts, Radix Sophorae Flavescentis 10 parts, Semen Strychni 0.1 part, Semen Hydnocarpi 0.5 part, Agkistrodon 1 part.
3. medicine for external use according to claim 1, is characterized in that, the weight portion of described raw material is:
Aloe 20 parts, Folium Artemisiae Argyi 25 parts, Herba Taraxaci 30 parts, Semen Myristicae 20 parts, lavandula angustifolia 25 parts, Caulis Kadsurae Coccineae 20 parts, Herba Abri 10 parts, 15 parts, Poria, Herba lygodii 20 parts, Rhizoma Imperatae 10 parts, Flos Rosae Rugosae 5 parts, Herba Agrimoniae 10 parts, Radix Urenae Lobatae 1 part, Rhizoma Smilacis Bockii 5 parts, Rhizoma Coptidis 10 parts, Margarita 1 part, Radix Sophorae Flavescentis 5 parts, Semen Strychni 1 part, Semen Hydnocarpi 0.1 part, Agkistrodon 0.5 part.
4. medicine for external use according to claim 1, is characterized in that, the weight portion of described raw material is:
Aloe 30 parts, Folium Artemisiae Argyi 20 parts, Herba Taraxaci 25 parts, Semen Myristicae 30 parts, lavandula angustifolia 20 parts, Caulis Kadsurae Coccineae 15 parts, Herba Abri 20 parts, 10 parts, Poria, Herba lygodii 15 parts, Rhizoma Imperatae 20 parts, Flos Rosae Rugosae 1 part, Herba Agrimoniae 5 parts, Radix Urenae Lobatae 10 parts, Rhizoma Smilacis Bockii 1 part, Rhizoma Coptidis 5 parts, Margarita 10 parts, Radix Sophorae Flavescentis 1 part, Semen Strychni 0.5 part, Semen Hydnocarpi 1 part, Agkistrodon 0.1 part.
5. the medicine for external use according to any one of Claims 1 to 4, is characterized in that, the preparation method of this medicine for external use is:
By raw material with the water soak at room temperature of its weight 5 ~ 10 times after 5 ~ 10 days, taking-up drains, then be placed in 270 ~ 280 DEG C of hot pots to stir-fry 10 ~ 20 minutes, then after adding the Oleum Cocois of its weight 0.1% ~ 1%, continue to stir-fry 10 ~ 20 minutes, after taking out cooling, the volumetric concentration adding its weight 3 ~ 8 times is in the alcoholic solution of 40% ~ 70%, soaks after 10 ~ 30 days and namely obtains this medicine for external use.
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