CN105388276B - A kind of Blood Kit analysis system and analysis method - Google Patents
A kind of Blood Kit analysis system and analysis method Download PDFInfo
- Publication number
- CN105388276B CN105388276B CN201610000339.0A CN201610000339A CN105388276B CN 105388276 B CN105388276 B CN 105388276B CN 201610000339 A CN201610000339 A CN 201610000339A CN 105388276 B CN105388276 B CN 105388276B
- Authority
- CN
- China
- Prior art keywords
- data signal
- measured value
- unit
- analysis
- deviation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
A kind of Blood Kit analysis system and analysis method, are measured for such as blood-sugar content, cholesterol level of the parameter to blood sample.Analyzed by the error result for redundant measurement passage, provide wherein reliable measured value.
Description
Technical field
The present invention relates to a kind of bodily fluid analysis system, more particularly, to a kind of blood analysis system and analysis method.
Background technology
Body fluid refers to all types of liquids for including containing in human body or animal body, generally include whole blood, lymph,
Urine, saliva, sweat etc., in clinicing aspect, relate generally to the blood and urine of human body.
In chemistry or clinicing aspect, it is extremely important to carry out quantitative or qualitative analysis to analyte contained in blood sample
's.Blood liquid is tested can early and reliably find out pathological state and targetedly and base in clinical diagnosis
It is that the hiding disease in each human body is done sth. in advance to do an inspection that condition passes are monitored in fact of case in the screening of blood
Survey, can be carried out for various compositions about the detection in function index, when any detection indicates abnormal, that is, represent personal body
Body has gone out certain some defect, it is necessary to which prophylactic morbidity and early stage do a treatment ahead of time.
In blood analysis detection, the accuracy on measurement result is the major issue for needing to consider.Particularly with true
The detection of the glucose content in blood is determined, because it is the basis that diabetic uses insulin dose, its measurement result
Need to ensure as far as possible the accuracy of measurement result.
In order to realize the reliability of measurement result, 200810215254.X patent of invention passes through in blood analysis system
The assessment passage of redundancy is set, when being more than predetermined value by the measurement result deviation of the analysis system, the analysis system is provided
The information of measurement result mistake, so as to ensure that the accurate of measured value.But, due to adding redundancy in wherein analysis system,
As long as a Measurement channel in analysis system occurs in that mistake, even if another Measurement channel is accurate, then measurement result
Deviation occurs, the analysis system will provide the information of measurement result mistake, at this moment need to re-start test.That is the redundancy
The setting of passage adds system and provides the probability of measurement result mistake, so as to need to retest, increases the burden of patient.
The content of the invention
The present invention can solve the problem that the above mentioned problem of prior art as the improvement of 200810215254.X patent of invention,
Quoted in full in this.
As one aspect of the present invention there is provided a kind of Blood Kit analysis method, comprise the following steps：（1）Blood sample
Product react with reagent in the first analysis area and the second analysis area；（2）Pass through the first analog signal measuring unit and
Two analog signal measuring units generate the analog signal of the first analysis area and the second analysis area；（3）Pass through the first analog-to-digital conversion
Device and the second analog-digital converter generate the first data signal and the second data signal respectively based on above-mentioned analog signal；（4）
Pass through the data signal of memory storage first and the second data signal；（5）Assess single by the first assessment unit and second
Member produces the first measured value and the second measured value of blood sample based on above-mentioned first data signal and the second data signal；
（6）Comparator unit is compared to the first measured value and the second measured value, judges whether its deviation is more than specific threshold；
（6.1）If the deviation is less than specific first threshold, analysis result generation unit uses the first measured value and the second measured value
In any one as measurement result value, terminate this measurement；（6.2）If the deviation is more than specific first threshold, carry out
Step (7)；（7）Comparator unit compares the first data signal and the second data signal in memory, judges the first numeral
Whether the deviation of signal and the second data signal is less than specific Second Threshold；（7.1）If the deviation is more than specific second threshold
Value, then analysis result generation unit provides the information of this measurement result mistake；(7.2) if the deviation is less than specific second threshold
Value, carries out step（8）；（8）First data signal is inputted by the second assessment unit, the input of the second data signal by control unit
First assessment unit；Second assessment unit is based on the first data signal and generates the 3rd measured value, first assessment unit
4th measured value is generated based on the second data signal；（9）Comparator unit is respectively compared first measured value and described
The deviation S2 between deviation S1, second measured value and the 4th measured value between four measured values：If only S1
Less than specific first threshold, then analysis result generation unit provides first measured value as the measurement of this blood sample
Value；If only S2 is less than specific first threshold, analysis result generation unit provides second measured value as this blood
The measured value of liquid sample；Otherwise, analysis result generation unit provides the information of this measurement result mistake.
As another aspect of the present invention there is provided the analysis system for above-mentioned Blood Kit analysis method, including：
Reagent system, the first analysis area, the second analysis area, the first analog signal measuring unit, the second analog signal measuring unit, first
Analog-digital converter, the second analog-digital converter, the first assessment unit, the second assessment unit, memory, analysis result generation unit with
And control unit.
It is preferred that, first analysis area and the second analysis area are respectively used to blood sample and occurred wherein with reagent
Reaction；The first analog signal measuring unit and the second analog signal measuring unit, be based respectively on the first analysis area and
The reaction of second analysis area produces analogue measurement signal；First analog-digital converter and the second analog-digital converter, respectively will
First analog signal and the second analog signal are digitized, the first data signal of generation and the second data signal；It is described
First assessment unit and the second assessment unit, its be based respectively on the first analog-digital converter and the second analog-digital converter generation
Data signal produces the first measured value and the second measured value of blood sample；Comparator unit, it can be assessed for first
The first measured value and the second measurement of unit and the generation of the second assessment unit are compared：Analysis result generation unit, its
Generate the analysis result of single measurement；Memory, it can store the first data signal and the second data signal；Control is single
Member, it can control the input signal of the first assessment unit and the second assessment unit；When the comparator unit first is measured
Deviation between value and the second measured value is more than specific first threshold, and the comparator unit can compare in the memory
The first data signal and the second data signal, whether the deviation based on the multilevel iudge measurement result from assessment unit
Deviation；If the deviation of first data signal and the second data signal is more than specific Second Threshold, measurement knot is judged
The deviation of fruit is not from assessment unit, and the analysis result generation unit provides the information of this measurement result mistake；If
The deviation of first data signal and the second data signal is less than Second Threshold, then judges that the deviation of measurement result carrys out self-appraisal
Unit is estimated, according to first data signal, the second data signal, the first measured value and the second measured value, the analysis knot
Fruit generation unit provides measurement result in first measured value and the second measured value and is correctly worth as this blood sample
Measured value.
Brief description of the drawings
Fig. 1 is the schematic diagram of the Blood Kit analysis system of the embodiment of the present invention.
Fig. 2 is the flow chart of the blood analysis method of the embodiment of the present invention.
Embodiment
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
There is the accompanying drawing used required in technology description to be briefly described, it should be apparent that, drawings in the following description are only this
Some embodiments of invention, for those of ordinary skill in the art, without having to pay creative labor, may be used also
To obtain other accompanying drawings according to these accompanying drawings.
The Blood Kit analysis system of the embodiment of the present invention, as shown in figure 1, including reagent system（It is not shown）, first point
Analyse area 1a and the second analysis area 1b, the first analog signal measuring unit 2a and the second analog signal measuring unit 2b, first
Analog-digital converter 3a and the second analog-digital converter 3b, the first assessment unit 4a and the second assessment unit 4b, comparator unit
5, memory 6, control unit 7, analysis result generation unit 8.
Reagent system is used to input to Blood Kit analysis system to be used for and reaction of blood, forms the thing of reaction blood parameters
Reason amount, after the measured value of the physical quantity is determined, can pass through the survey of the physical quantity by the measured value and the model of blood parameters
Value, determines blood parameters.Measured blood parameters can be such as blood-sugar content or cholesterol level.
First analysis area 1a and the second analysis area 1b are of similar shape and conversion zone, receive input it respectively
In identical type dosage blood sample and reagent so that blood sample and reagent in each analysis area with reagent send out
Raw reaction.The reaction of generation is can to provide the course of reaction of blood parameters value, for example, can provide the anti-of optical change signal
Answer or electrochemical reaction.
First analog signal measuring unit 2a and the second analog signal measuring unit 2b, is based respectively on the first analysis area 1a
And second analysis area 1b reaction produce analogue measurement signal.Wherein, measuring unit is corresponding to analysis area reaction type
When what measuring cell, such as analysis area were produced is the optical signalling of change, measuring unit can make such as optical strength measurement single
Member；When occurring electrochemical reaction in analysis area, measuring unit can be such as voltage or current sensor.
First analog-digital converter 3a and the second analog-digital converter 3b, it respectively surveys the first analog signal measuring unit 2a
First analog signal of amount and the second analog signal of the first analog signal measuring unit 2a measurements are digitized, generation the
One data signal and the second data signal.
First assessment unit 4a and the second assessment unit 4b, it is respectively by respective model, based on the first numeral letter
Number and the second data signal determine the first measured value and the second measured value of blood sample.Memory 6, it can store first
Data signal and the second data signal.Control unit 7, it can read the first data signal and second in memory 6
Data signal, and can be to the input data signal for controlling the first assessment unit 4a and the second assessment unit 4b.Analysis knot
Fruit generation unit 8, it generates the analysis result of single measurement.
The Blood Kit analysis method of the embodiment of the present invention, comprises the following steps：（1）Blood sample is with reagent at first point
Analysis area 1a and the second analysis area 1b reacts；（2）Pass through the first analog signal measuring unit 2a and the second analog signal
2b measuring units generate the first analysis area 1a and the second analysis area 1b analog signal；（3）Pass through the first analog-digital converter 3a
And second analog-digital converter 3b the first data signal and the second data signal are generated based on above-mentioned analog signal respectively；（4）
First data signal and the second data signal are stored by memory 6；（5）Assessed by the first assessment unit 4a and second
Unit 4b produces the first measured value and the second survey of blood sample based on above-mentioned first data signal and the second data signal
Value；（6）5 pair of first measured value of comparator unit and the second measured value are compared, and judge whether its deviation is more than specific
Threshold value；（6.1）If the deviation is less than specific first threshold, analysis result generation unit 8 uses the first measured value and second
Any one in measured value terminates this measurement as measurement result value；（6.2）If the deviation is more than specific first threshold
Value, carries out step (7)；（7）Comparator unit 5 compares the first data signal and the second data signal in memory 6, judges
Whether the deviation of the first data signal and the second data signal is less than specific Second Threshold；（7.1）If the deviation is more than spy
Determine Second Threshold, then analysis result generation unit 8 provides the information of this measurement result mistake；(7.2) if the deviation is less than
Specific Second Threshold, represents that the deviation comes from assessment unit, carries out step（8）；（8）First numeral is believed by control unit 7
Number input the second assessment unit 4b, the second data signal input the first assessment unit 4a；Second assessment unit 4b is based on the first number
The measured value of word signal generation the 3rd, the first assessment unit 4a is based on the second data signal and generates the 4th measured value；（9）Comparator list
Member 5 is respectively compared deviation S1, second measured value and institute between first measured value and the 4th measured value
State the deviation S2 between the 4th measured value：（9.1）If only S1 is less than specific first threshold, represent that the first assessment unit 1a gives
The measured value gone out is credible, then analysis result generation unit 8 provides first measured value as the measured value of this blood sample；
(9.2) if only S2 is less than specific first threshold, represent that the measurement result that the second assessment unit 1b is provided is credible, then analysis knot
Fruit generation unit 8 provides second measured value as the measured value of this blood sample；(9.3) otherwise, expression can not be determined
Whether the result that the first assessment unit 1a and the second assessment unit 1b are provided is credible, and analysis result generation unit 8 provides this
The information of measurement result mistake.
It the above is only the preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-described embodiment,
All technical schemes belonged under thinking of the present invention belong to protection scope of the present invention.For the ordinary skill people of the art
For member, some improvements and modifications without departing from the principles of the present invention should be regarded as falling into protection scope of the present invention.
Claims (2)
1. a kind of Blood Kit analysis method, comprises the following steps：（1）Blood sample is with reagent in the first analysis area and second
Analysis area reacts；First analysis area and the second analysis area are of similar shape and conversion zone, receive defeated respectively
Enter the blood sample and reagent of identical type dosage therein；（2）Pass through the first analog signal measuring unit and the second mould
Intend the analog signal that signal measurement unit generates the first analysis area and the second analysis area；Wherein, occurs electrochemistry in analysis area
Reaction, measuring unit is voltage or current sensor；（3）It is based on by the first analog-digital converter and the second analog-digital converter
Above-mentioned analog signal generates the first data signal and the second data signal respectively；（4）Pass through the numeral letter of memory storage first
Number and the second data signal；（5）By the first assessment unit and the second assessment unit be based on above-mentioned first data signal with
And second data signal produce blood sample the first measured value and the second measured value；（6）Comparator unit is measured first
Value and the second measured value are compared, and judge whether its deviation is more than specific threshold；（6.1）If the deviation is less than specific the
One threshold value, analysis result generation unit uses any one in the first measured value and the second measured value as measurement result
Value, terminates this measurement；（6.2）If the deviation is more than specific first threshold, step (7) is carried out；（7）Comparator unit compares
The first data signal and the second data signal in memory, judge the deviation of the first data signal and the second data signal
Whether specific Second Threshold is less than；（7.1）If the deviation is more than specific Second Threshold, analysis result generation unit provides this
The information of secondary measurement result mistake；(7.2) if the deviation is less than specific Second Threshold, step is carried out（8）；（8）Pass through control
First data signal is inputted the second assessment unit by unit, and the second data signal inputs the first assessment unit；Described second assesses
Unit is based on the first data signal and generates the 3rd measured value, and first assessment unit is based on the second data signal generation the 4th and surveyed
Value；（9）Comparator unit is respectively compared deviation S1 between first measured value and the 4th measured value, described
Deviation S2 between two measured values and the 4th measured value：（9.1）If only S1 is less than specific first threshold, analyze
As a result generation unit provides first measured value as the measured value of this blood sample；(9.2) if only S2 is less than spy
Determine first threshold, then analysis result generation unit provides second measured value as the measured value of this blood sample；(9.3)
Otherwise, analysis result generation unit provides the information of this measurement result mistake.
2. a kind of Blood Kit analysis system, it is used for the Blood Kit analysis method described in claim 1.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710300287.3A CN106990232B (en) | 2016-01-01 | 2016-01-01 | Blood Kit analysis system and analysis method |
| CN201610000339.0A CN105388276B (en) | 2016-01-01 | 2016-01-01 | A kind of Blood Kit analysis system and analysis method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610000339.0A CN105388276B (en) | 2016-01-01 | 2016-01-01 | A kind of Blood Kit analysis system and analysis method |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710300287.3A Division CN106990232B (en) | 2016-01-01 | 2016-01-01 | Blood Kit analysis system and analysis method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105388276A CN105388276A (en) | 2016-03-09 |
| CN105388276B true CN105388276B (en) | 2017-08-04 |
Family
ID=55420791
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610000339.0A Expired - Fee Related CN105388276B (en) | 2016-01-01 | 2016-01-01 | A kind of Blood Kit analysis system and analysis method |
| CN201710300287.3A Active CN106990232B (en) | 2016-01-01 | 2016-01-01 | Blood Kit analysis system and analysis method |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710300287.3A Active CN106990232B (en) | 2016-01-01 | 2016-01-01 | Blood Kit analysis system and analysis method |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN105388276B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108107195B (en) * | 2017-12-16 | 2019-09-24 | 山东卫康医学检验有限公司 | Blood sample analysis test method |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1012257B (en) * | 1986-09-09 | 1991-04-03 | 顾涵森 | Bioelectric signal measuring apparatus |
| US4775237A (en) * | 1987-03-16 | 1988-10-04 | Innovative Medical Systems Corp. | Electro-optical detection system |
| AU702209B2 (en) * | 1996-07-16 | 1999-02-18 | Roche Diagnostics Gmbh | Analytical system with means for detecting too small sample volumes |
| DK1077636T3 (en) * | 1998-05-13 | 2004-05-24 | Cygnus Therapeutic Systems | Signal processing for measurement of physiological analytes |
| EP1133878A1 (en) * | 1998-09-15 | 2001-09-19 | In Touch Technologies Limited | Communication services |
| GB0005564D0 (en) * | 2000-03-08 | 2000-05-03 | Inverness Medical Ltd | Measurjement of substances in liquid |
| US6560471B1 (en) * | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
| ATE482649T1 (en) * | 2002-03-22 | 2010-10-15 | Animas Technologies Llc | PERFORMANCE IMPROVEMENT OF AN ANALYTE MONITORING DEVICE |
| US7468125B2 (en) * | 2005-10-17 | 2008-12-23 | Lifescan, Inc. | System and method of processing a current sample for calculating a glucose concentration |
| ES2400966T3 (en) * | 2007-09-22 | 2013-04-15 | F. Hoffmann-La Roche Ag | Analysis system to determine the concentration of an analyte in a body fluid |
| CN104122191B (en) * | 2007-10-29 | 2020-02-18 | 希森美康株式会社 | Cell analyzer and cell analysis method |
| CN102046076A (en) * | 2008-04-03 | 2011-05-04 | Kai医药公司 | Non-contact physiologic motion sensors and methods for use |
| US8653826B2 (en) * | 2010-04-19 | 2014-02-18 | General Electric Company | Connector monitoring assembly and a detector assembly including the same |
| CN103492875B (en) * | 2011-04-28 | 2016-03-09 | 希森美康株式会社 | Blood analysis device and blood analysis method |
| US9913642B2 (en) * | 2014-03-26 | 2018-03-13 | Ethicon Llc | Surgical instrument comprising a sensor system |
| CN104569097B (en) * | 2014-12-17 | 2018-01-12 | 浙江理工大学 | The preparation method and applications of copper nano-wire graphene complex modified electrode |
-
2016
- 2016-01-01 CN CN201610000339.0A patent/CN105388276B/en not_active Expired - Fee Related
- 2016-01-01 CN CN201710300287.3A patent/CN106990232B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN105388276A (en) | 2016-03-09 |
| CN106990232B (en) | 2019-05-28 |
| CN106990232A (en) | 2017-07-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107703132B (en) | Reaction curve abnormity processing method and device, biochemical analyzer and storage medium | |
| Njoroge et al. | Risk management in the clinical laboratory | |
| US6564153B2 (en) | Method and apparatus for predicting the presence of an abnormal level of one or more proteins in the clotting cascade | |
| US11579155B2 (en) | Using patient risk in analysis of quality control strategy for lab results | |
| US20150025808A1 (en) | Methods and Systems for Processing Test Results Based on Patient-Specific Data and Reference Data | |
| EP1147423B1 (en) | A method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample | |
| Neves et al. | Method comparison and validation of a prototype device for measurement of ionized calcium concentrations cow-side against a point-of-care instrument and a benchtop blood-gas analyzer reference method | |
| CN108431599A (en) | Method for detecting the presence of a clot in a liquid sample analyzer | |
| CN108572250A (en) | The method for determining analyte concentration | |
| CN105403691B (en) | A kind of Blood Kit analysis system | |
| CN105388276B (en) | A kind of Blood Kit analysis system and analysis method | |
| CN1529816B (en) | Clinical examination analysing device | |
| CN101828188A (en) | The estimation of diagnosis marker | |
| Solnica et al. | Quality control of self-monitoring of blood glucose: why and how? | |
| Ceriotti et al. | A risk-analysis approach to the evaluation of analytical quality | |
| EP1188060A1 (en) | Method and apparatus for presenting thrombosis and hemostasis assay data | |
| US10605759B2 (en) | Verifying operation of a meter | |
| CN104545910A (en) | Method and system for chronic disease early period electrophysiological detection | |
| Givens et al. | Classification of factor deficiencies from coagulation assays using neural networks | |
| EP4407319A1 (en) | System for determining a functional fibrinogen concentration | |
| US20240280392A1 (en) | Bubble detection | |
| AU2004201011B2 (en) | Method and apparatus for presenting thrombosis and hemostasis assay data | |
| Nascimben et al. | Visually enhanced python functions for clinical equality of measurement assessment | |
| WO2024054890A1 (en) | Systems and methods for determining test result accuracies in diagnostic laborabory systems | |
| CN115453104A (en) | Internet in-vitro diagnosis product double-line quality control method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Qin Ling Inventor after: Xu Deying Inventor after: Sun Zhenzhen Inventor after: Wei Wei Inventor after: Zhang Yiting Inventor before: Huang Youfeng |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20170704 Address after: 471003 Henan Province, Luoyang city Jianxi District King Road No. 24 Applicant after: The First Affiliated Hospital of Henan University of Science and Technology Address before: 350000 Fuzhou, Gulou District, Fujian City, the new right road, No. 29 Applicant before: Huang Youfeng |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170804 Termination date: 20210101 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |