CN105381150A - Traditional Chinese medicine composition for treating cervical spondylosis and lubar intervertebral disc protrusion - Google Patents

Traditional Chinese medicine composition for treating cervical spondylosis and lubar intervertebral disc protrusion Download PDF

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CN105381150A
CN105381150A CN201510854565.0A CN201510854565A CN105381150A CN 105381150 A CN105381150 A CN 105381150A CN 201510854565 A CN201510854565 A CN 201510854565A CN 105381150 A CN105381150 A CN 105381150A
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chinese medicine
medicine composition
intervertebral disc
cervical spondylosis
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杨春风
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Abstract

The invention relates to a traditional Chinese medicine composition for treating cervical spondylosis and lubar intervertebral disc protrusion. The traditional Chinese medicine composition is prepared from the following substances including herba lycopi, angelica, earthworms, dipsacus roots, medicinal cyathula roots, moutan bark, ossa draconis, rhizoma corydalis, cortex acanthopanacis, cassia twig, almond, kaladana, prepared native copper, ligusticum wallichii, pawpaw, fructus forsythiae, peach seeds, phryma leptostachya, lignum dalbergiae odoriferae, pericarpium zanthoxyli, dried eupolyphaga, rhizoma drynariae, semen momordicae, safflower, sapanwood, pyrolusite, borneol, borax, lamber, cinnabar, catechu, fructus psoraleae, frankincense, myrrh, clove, ningpo yam rhizome and saussurea involucrate. The traditional Chinese medicine composition mainly treats cervical spondylosis, lubar intervertebral disc protrusion, scapulohumeral periarthritis, rheumatism, bone fracture recovery and ankylosing spondylitis.

Description

A kind of Chinese medicine composition for the treatment of cervical spondylosis and prolapse of lumbar intervertebral disc
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of Chinese medicine composition for the treatment of cervical spondylosis and prolapse of lumbar intervertebral disc.
Background technology
Prolapse of lumbar intervertebral disc is also known as " Annulus Fibrosus of Lumbar Intervertebral Discs breaks ", it is one of disease of clinical common lumbago and skelalgia, the regression due to lumbar intervertebral disc and damage, cause mechanical balance imbalance inside and outside spinal column, the vertebral pulp of intervertebral disc is given prominence to, compressing spinal nerves root and a kind of disease of lumbago and skelalgia of causing from rent.Primary disease is mainly in 30 ~ 50 years old, and male is more than women.Clinical in outstanding in the majority between waist 4-5 and waist 5-sacrum 1.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of cervical spondylosis and prolapse of lumbar intervertebral disc.
In order to realize object of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of cervical spondylosis and prolapse of lumbar intervertebral disc, it comprises the material of following weight portion: Herba Lycopi 20-30 part, Radix Angelicae Sinensis 15-20 part, Pheretima 15-20 part, Radix Dipsaci 20-30 part, Radix Cyathulae 20-30 part, Cortex Moutan 20-30 part, Os Draconis 30-40 part, Rhizoma Corydalis 20-30 part, Cortex Acanthopancis 20-25 part, Ramulus Cinnamomi 20-30 part, Semen Armeniacae Amarum 5-10 part, Semen Pharbitidis 5-8 part, Pyritum (processed) 5-10 part, Rhizoma Chuanxiong 25-30 part, Fructus Chaenomelis 20-30 part, Fructus Forsythiae 15-20 part, Semen Persicae 20-30 part, Herba speranskiae tuberculatae 20-25 part, Lignum Dalbergiae Odoriferae 20-30 part, Fructus Zanthoxyli 20-30 part, eupolyphage sece steleophaga 15-20 part, Rhizoma Drynariae 15-20 part, Semen Momordicae 20-25 part, Flos Carthami 20-30 part, Lignum Sappan 20-30 part, pyrolusitum 20-30 part, Borneolum Syntheticum 5-10 part, Borax 15-20 part, succinum 15-20 part, Cinnabaris 5-8 part, catechu 20-25 part, Fructus Psoraleae 15-25 part, Olibanum 20-25 part, Myrrha 20-25 part, Flos Caryophylli 20-25 part, Rhizoma Dioscoreae Nipponicae 15-20 part and Herba Saussureae Involueratae 5-10 part.
Preferably, the Chinese medicine composition for the treatment of cervical spondylosis of the present invention and prolapse of lumbar intervertebral disc comprises the material of following weight portion: Herba Lycopi 25 parts, Radix Angelicae Sinensis 18 parts, Pheretima 18 parts, Radix Dipsaci 25 parts, Radix Cyathulae 25 parts, Cortex Moutan 25 parts, Os Draconis 35 parts, Rhizoma Corydalis 25 parts, Cortex Acanthopancis 22 parts, Ramulus Cinnamomi 25 parts, 8 parts, Semen Armeniacae Amarum, Semen Pharbitidis 7 parts, Pyritum (processed) 8 parts, Rhizoma Chuanxiong 28 parts, Fructus Chaenomelis 25 parts, Fructus Forsythiae 18 parts, 25 parts, Semen Persicae, Herba speranskiae tuberculatae 22 parts, Lignum Dalbergiae Odoriferae 25 parts, Fructus Zanthoxyli 25 parts, eupolyphage sece steleophaga 18 parts, Rhizoma Drynariae 18 parts, Semen Momordicae 22 parts, 25 parts, Flos Carthami, Lignum Sappan 25 parts, pyrolusitum 25 parts, Borneolum Syntheticum 7 parts, Borax 18 parts, succinum 18 parts, 7 parts, Cinnabaris, 22 parts, catechu, Fructus Psoraleae 18 parts, Olibanum 22 parts, Myrrha 22 parts, Flos Caryophylli 22 parts, Rhizoma Dioscoreae Nipponicae 18 parts and Herba Saussureae Involueratae 6 parts.
More preferably, the Chinese medicine composition for the treatment of cervical spondylosis of the present invention and prolapse of lumbar intervertebral disc also comprises the material of following weight portion: 2-(3-trifluoromethyl the phenylimino)-4-phenyl thiazole of 0.02 part.
Most preferably, described Chinese medicine composition can be tablet, dispersible tablet, capsule, pill or decoction.
The present invention also provide 2-(3-trifluoromethyl phenylimino)-4-phenyl thiazole preparation treatment cervical spondylosis and prolapse of lumbar intervertebral disc, osteoarthritis medicine in purposes.
Chinese medicine composition of the present invention cures mainly: cervical spondylosis, prolapse of lumbar intervertebral disc, scapulohumeral periarthritis, rheumatism, fracture are recovered, ankylosing spondylitis.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment
Take Herba Lycopi 25 grams, Radix Angelicae Sinensis 18 grams, Pheretima 18 grams, Radix Dipsaci 25 grams, Radix Cyathulae 25 grams, Cortex Moutan 25 grams, Os Draconis 35 grams, Rhizoma Corydalis 25 grams, Cortex Acanthopancis 22 grams, Ramulus Cinnamomi 25 grams, 8 grams, Semen Armeniacae Amarum, Semen Pharbitidis 7 grams, Pyritum (processed) 8 grams, Rhizoma Chuanxiong 28 grams, Fructus Chaenomelis 25 grams, Fructus Forsythiae 18 grams, 25 grams, Semen Persicae, Herba speranskiae tuberculatae 22 grams, Lignum Dalbergiae Odoriferae 25 grams, Fructus Zanthoxyli 25 grams, eupolyphage sece steleophaga 18 grams, Rhizoma Drynariae 18 grams, Semen Momordicae 22 grams, 25 grams, Flos Carthami, Lignum Sappan 25 grams, pyrolusitum 25 grams, Borneolum Syntheticum 7 grams, Borax 18 grams, succinum 18 grams, 7 grams, Cinnabaris, 22 grams, catechu, Fructus Psoraleae 18 grams, Olibanum 22 grams, Myrrha 22 grams, Flos Caryophylli 22 grams, Rhizoma Dioscoreae Nipponicae 18 grams and Herba Saussureae Involueratae 6 grams, pulverize, cross 100 mesh sieves, mix homogeneously obtains powder.
Experimental example
Osteoarthritis is the coefficient result of mechanics and biological factor, thinks that IL-4 level is relevant with the order of severity of the course of disease and disease at present, and after osteoarthritis, IL-4 level declines obviously.
Knee osteoarthritis model and administration
By cleaning grade (SPF) male Wistar rat (Mus 5-6 in the age month, weight 170.0 ± 20.5) be divided into 6 groups: Normal group (Normalcontrolgroup, NC), model control group (Modelcontrolgroup, MC), glucosamine matched group (Glucosaminecontrolgroup, GS), administration group 1, administration group 2, administration group 3.Often organize 10.Except Normal group, respectively organize the Cys aqueous solution of right knee joint injection 4 % by weight Papain enzyme aqueous solution 10 μ L and 0.03mol/L of rat to all the other, and strengthened respectively at the 3rd, 7 day, cause osteoarthritis.After modeling the 14th day starts administration, and each group dosage is as follows: normal group and model group, give normal saline gavage 1mL/100g body weight; Glucosamine group, glucosamine 1g adds 100mL normal saline and becomes suspension, gives gavage 1mL/100g body weight; Administration group 1, the powder 10g of embodiment adds 1000mL normal saline and becomes suspension, gives gavage 1mL/100g body weight; 2-(3-trifluoromethyl the phenylimino)-4-phenyl thiazole of administration group 2,0.02g adds 1000mL normal saline and becomes suspension, gives gavage 1mL/100g body weight; Administration group 3,2-(3-trifluoromethyl the phenylimino)-4-phenyl thiazole of powder 5g with 0.01g of embodiment adds 1000mL normal saline and becomes suspension, gives gavage 1mL/100g body weight.1 times/day, successive administration 30d, draws materials for after modeling the 49th day.
ELISA method detects IL-4
The 49th day by sacrifice of animal after, row ventral aorta take a blood sample, by the centrifugal 5min of institute blood sampling 3000r/min, get serum, put-80 DEG C of Refrigerator stores to be measured.Concrete operation step is undertaken by test kit (IL-4ELISA test kit is purchased from Mei Lian bio tech ltd, Shanghai) description.The results are shown in following table.
Group IL-4(pg·mL -1)
Normal group 163.17±7.29
Model group 35.29±5.71
Glucosamine group 60.09±6.28
Administration group 1 109.26±6.96
Administration group 2 148.29±7.01
Administration group 3 128.34±6.62

Claims (5)

1. treat the Chinese medicine composition of cervical spondylosis and prolapse of lumbar intervertebral disc for one kind, it is characterized in that, it comprises the material of following weight portion: Herba Lycopi 20-30 part, Radix Angelicae Sinensis 15-20 part, Pheretima 15-20 part, Radix Dipsaci 20-30 part, Radix Cyathulae 20-30 part, Cortex Moutan 20-30 part, Os Draconis 30-40 part, Rhizoma Corydalis 20-30 part, Cortex Acanthopancis 20-25 part, Ramulus Cinnamomi 20-30 part, Semen Armeniacae Amarum 5-10 part, Semen Pharbitidis 5-8 part, Pyritum (processed) 5-10 part, Rhizoma Chuanxiong 25-30 part, Fructus Chaenomelis 20-30 part, Fructus Forsythiae 15-20 part, Semen Persicae 20-30 part, Herba speranskiae tuberculatae 20-25 part, Lignum Dalbergiae Odoriferae 20-30 part, Fructus Zanthoxyli 20-30 part, eupolyphage sece steleophaga 15-20 part, Rhizoma Drynariae 15-20 part, Semen Momordicae 20-25 part, Flos Carthami 20-30 part, Lignum Sappan 20-30 part, pyrolusitum 20-30 part, Borneolum Syntheticum 5-10 part, Borax 15-20 part, succinum 15-20 part, Cinnabaris 5-8 part, catechu 20-25 part, Fructus Psoraleae 15-25 part, Olibanum 20-25 part, Myrrha 20-25 part, Flos Caryophylli 20-25 part, Rhizoma Dioscoreae Nipponicae 15-20 part and Herba Saussureae Involueratae 5-10 part.
2. the Chinese medicine composition for the treatment of cervical spondylosis according to claim 1 and prolapse of lumbar intervertebral disc, it is characterized in that, it comprises the material of following weight portion: Herba Lycopi 25 parts, Radix Angelicae Sinensis 18 parts, Pheretima 18 parts, Radix Dipsaci 25 parts, Radix Cyathulae 25 parts, Cortex Moutan 25 parts, Os Draconis 35 parts, Rhizoma Corydalis 25 parts, Cortex Acanthopancis 22 parts, Ramulus Cinnamomi 25 parts, 8 parts, Semen Armeniacae Amarum, Semen Pharbitidis 7 parts, Pyritum (processed) 8 parts, Rhizoma Chuanxiong 28 parts, Fructus Chaenomelis 25 parts, Fructus Forsythiae 18 parts, 25 parts, Semen Persicae, Herba speranskiae tuberculatae 22 parts, Lignum Dalbergiae Odoriferae 25 parts, Fructus Zanthoxyli 25 parts, eupolyphage sece steleophaga 18 parts, Rhizoma Drynariae 18 parts, Semen Momordicae 22 parts, 25 parts, Flos Carthami, Lignum Sappan 25 parts, pyrolusitum 25 parts, Borneolum Syntheticum 7 parts, Borax 18 parts, succinum 18 parts, 7 parts, Cinnabaris, 22 parts, catechu, Fructus Psoraleae 18 parts, Olibanum 22 parts, Myrrha 22 parts, Flos Caryophylli 22 parts, Rhizoma Dioscoreae Nipponicae 18 parts and Herba Saussureae Involueratae 6 parts.
3. the Chinese medicine composition for the treatment of cervical spondylosis according to claim 1 and 2 and prolapse of lumbar intervertebral disc, is characterized in that, it also comprises the material of following weight portion: 2-(3-trifluoromethyl the phenylimino)-4-phenyl thiazole of 0.02 part.
4. the Chinese medicine composition for the treatment of cervical spondylosis according to claim 3 and prolapse of lumbar intervertebral disc, is characterized in that, described Chinese medicine composition can be tablet, dispersible tablet, capsule, pill or decoction.
The purposes of 5.2-(3-trifluoromethyl phenylimino)-4-phenyl thiazole in the medicine preparing treatment cervical spondylosis and prolapse of lumbar intervertebral disc.
CN201510854565.0A 2015-11-29 2015-11-29 Traditional Chinese medicine composition for treating cervical spondylosis and lubar intervertebral disc protrusion Pending CN105381150A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106692569A (en) * 2017-01-13 2017-05-24 商南县融汇城商贸有限公司 Traditional Chinese medicine for treating cervical vertebra, lumbar vertebra and various kinds of arthritis

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Publication number Priority date Publication date Assignee Title
CN1270833A (en) * 1999-04-15 2000-10-25 那春朝 Bone fracture setting medicine powder

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Publication number Priority date Publication date Assignee Title
CN1270833A (en) * 1999-04-15 2000-10-25 那春朝 Bone fracture setting medicine powder

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PEI-YING LIN等: "Efficient Synthesis of 2-Aminothiazoles and Fanetizole in Liquid PEG-400 at Ambient Conditions", 《JOURNAL OF THE CHINESE CHEMICAL SOCIETY》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106692569A (en) * 2017-01-13 2017-05-24 商南县融汇城商贸有限公司 Traditional Chinese medicine for treating cervical vertebra, lumbar vertebra and various kinds of arthritis

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Application publication date: 20160309