CN105378029B - 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯 - Google Patents

具有改进的稳定性和快速发光的亲水高量子产率吖啶酯 Download PDF

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Publication number
CN105378029B
CN105378029B CN201480039328.2A CN201480039328A CN105378029B CN 105378029 B CN105378029 B CN 105378029B CN 201480039328 A CN201480039328 A CN 201480039328A CN 105378029 B CN105378029 B CN 105378029B
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China
Prior art keywords
analyte
conjugate
acridinium
luminescence
product
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English (en)
Chinese (zh)
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CN105378029A (zh
Inventor
A.纳特拉简
D.夏普
姜庆平
温大伟
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Siemens Healthcare Diagnostics Inc
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Siemens Healthcare Diagnostics Inc
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Priority to CN202011347156.9A priority Critical patent/CN112521335A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • C09K11/07—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials having chemically-interreactive components, e.g. reactive chemiluminescent compositions
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F21—LIGHTING
    • F21K—NON-ELECTRIC LIGHT SOURCES USING LUMINESCENCE; LIGHT SOURCES USING ELECTROCHEMILUMINESCENCE; LIGHT SOURCES USING CHARGES OF COMBUSTIBLE MATERIAL; LIGHT SOURCES USING SEMICONDUCTOR DEVICES AS LIGHT-GENERATING ELEMENTS; LIGHT SOURCES NOT OTHERWISE PROVIDED FOR
    • F21K2/00—Non-electric light sources using luminescence; Light sources using electrochemiluminescence
    • F21K2/06—Non-electric light sources using luminescence; Light sources using electrochemiluminescence using chemiluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Electromagnetism (AREA)
  • General Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
CN201480039328.2A 2013-07-08 2014-07-04 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯 Active CN105378029B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202011347156.9A CN112521335A (zh) 2013-07-08 2014-07-04 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361843528P 2013-07-08 2013-07-08
US61/843528 2013-07-08
PCT/US2014/045505 WO2015006174A1 (en) 2013-07-08 2014-07-04 Hydrophilic high quantum yield acridinium esters with improved stability and fast light emission

Related Child Applications (1)

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CN202011347156.9A Division CN112521335A (zh) 2013-07-08 2014-07-04 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯

Publications (2)

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CN105378029A CN105378029A (zh) 2016-03-02
CN105378029B true CN105378029B (zh) 2020-12-18

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CN201480039328.2A Active CN105378029B (zh) 2013-07-08 2014-07-04 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯
CN202011347156.9A Pending CN112521335A (zh) 2013-07-08 2014-07-04 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯

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CN202011347156.9A Pending CN112521335A (zh) 2013-07-08 2014-07-04 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯

Country Status (6)

Country Link
US (5) US20170320830A1 (https=)
EP (1) EP3019575B1 (https=)
JP (1) JP6735665B2 (https=)
CN (2) CN105378029B (https=)
ES (1) ES2716395T3 (https=)
WO (1) WO2015006174A1 (https=)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006130736A2 (en) * 2005-06-02 2006-12-07 Siemens Medical Solutions Diagnostics High quantum yield acridinium compounds and their uses in improving assay sensitivity
CN101918367A (zh) * 2007-11-20 2010-12-15 西门子医疗保健诊断公司 吖啶化合物在离子液体中的简便n-烷基化方法
CN102762539A (zh) * 2009-11-16 2012-10-31 西门子医疗保健诊断公司 含两性离子的吖啶*化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4918192A (en) 1986-10-06 1990-04-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US5110932A (en) 1986-10-06 1992-05-05 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
ATE111083T1 (de) 1986-10-22 1994-09-15 Abbott Lab Chemilumineszierende acridinium- und phenantridiniumsalze.
US5656426A (en) 1988-08-01 1997-08-12 Chiron Diagnostics Corporation Functionaized hydrophilic acridinium esters
US6664043B2 (en) 2001-07-03 2003-12-16 Bayer Corporation Acridinium ester labels having hydrophilic modifiers
JP5503969B2 (ja) * 2006-10-13 2014-05-28 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド 迅速に発光する安定なアクリジニウムエステル

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006130736A2 (en) * 2005-06-02 2006-12-07 Siemens Medical Solutions Diagnostics High quantum yield acridinium compounds and their uses in improving assay sensitivity
CN101918367A (zh) * 2007-11-20 2010-12-15 西门子医疗保健诊断公司 吖啶化合物在离子液体中的简便n-烷基化方法
CN102762539A (zh) * 2009-11-16 2012-10-31 西门子医疗保健诊断公司 含两性离子的吖啶*化合物

Also Published As

Publication number Publication date
JP6735665B2 (ja) 2020-08-05
US11932603B2 (en) 2024-03-19
CN112521335A (zh) 2021-03-19
EP3019575A1 (en) 2016-05-18
WO2015006174A1 (en) 2015-01-15
US12275708B2 (en) 2025-04-15
US20220227711A1 (en) 2022-07-21
US20250243167A1 (en) 2025-07-31
CN105378029A (zh) 2016-03-02
US20200190037A1 (en) 2020-06-18
US11332445B2 (en) 2022-05-17
EP3019575B1 (en) 2018-12-19
ES2716395T3 (es) 2019-06-12
EP3019575A4 (en) 2016-12-28
US20240254088A1 (en) 2024-08-01
US20170320830A1 (en) 2017-11-09
JP2016531099A (ja) 2016-10-06

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