CN105362956A - Traditional Chinese medicine compound capable of removing chloasma and beautifying faces - Google Patents

Traditional Chinese medicine compound capable of removing chloasma and beautifying faces Download PDF

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CN105362956A
CN105362956A CN201510949061.7A CN201510949061A CN105362956A CN 105362956 A CN105362956 A CN 105362956A CN 201510949061 A CN201510949061 A CN 201510949061A CN 105362956 A CN105362956 A CN 105362956A
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parts
radix
semen
chinese medicine
fructus
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杜小卫
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    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/55Liquid-liquid separation; Phase separation

Abstract

The invention provides a traditional Chinese medicine compound capable of removing chloasma and beautifying faces. The compound is obtained in the mode that corallina officinalis, orange peel, salviae miltiorrhizae, bamboo juice, radix curcumae, tribulus terrestris, dried persimmon frost and fried soybean powder are used in raw materials and have the effects of expelling toxicant and beautifying faces, clearing away the heart fire and reducing the liver fire, and oranges, muskmelon seeds, hawthorn fruits, ginkgoes, prepared rehmannia roots, radix angelica sinensis and dictamnus dasycarpus turcz can smooth liver qi, promote blood circulation and remove blood stasis. The medicine materials take effects together to condition the viscera, balance yin and yang, completely eliminate stain causes and beautify faces.

Description

A kind of Chinese medicine composition of eliminating chloasma looks improving and the skin nourishing
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine composition of eliminating chloasma looks improving and the skin nourishing.
Background technology
Chloasma: chloasma betides the filbert or brown macules of face, is a kind of common chromatopathy.Primary disease is equivalent to " chloasma hepaticum " of the traditional Chinese medical science, also known as " chloasma ", is mainly in middle-aged women, is a kind of posteriority limitation hyperpigmentation disease, and to claim butterfly spot, cyasma etc., these are several is that same is sick, names according to the difference such as form, age bracket feature.
The traditional Chinese medical science is thought, chloasma many because of feelings will unsuccessful, depression of liver-QI, strongly fragrant heat-transformation of a specified duration, cloudy blood of burning makes face qi-blood disharmony and cause; Or stagnated QI transforming into fire, the moon of consumption impairing the liver kidney, and cause general on water colour and this speckle occurs, single with regard to primary disease without much suffering of illness, but form the reason polyphyly spirit emotional factors of primary disease, dysthymia then can affect ortho sleep unavoidably; And after forming primary disease, the gorgeous of appearance is held back, its inward world certainly will get up with regard to complexity, thus also can affect normal sleep.Spirit emotional factors is form the major reason of primary disease, is again increase the weight of state of an illness condition, is easy to be formed because dysthymia causes the generation of chloasma, generates the vicious cycle that bad spiritual emotion after this speckle can increase the weight of again the state of an illness conversely.For the patient with chloasma that a little mental state is bad, there is insomnia just not at all surprising.Practical observation is learnt, about has the chloasma patient of nearly 2/3rds to there is sleep disorder, and it is just further serious that it asks the heart of U.S. more not cut person's phenomenon of having a sleepless night.
All the time the skin protecting us has all been needed throughout the year thus; not so there is facial intensely dark pool after one period of age; the freckle etc. of various form; the cosmetics of prior art can only ensure the effect of short time; some cosmetic effect are fine; but there is larger side effect, in a word, all can not reach the desirable effect of user.
Summary of the invention
Technical assignment of the present invention is to provide a kind of Chinese medicine composition of eliminating chloasma looks improving and the skin nourishing.
Technical assignment of the present invention realizes in the following manner, use Flos Spatholirionis longifolii, Citrus pericarp, Radix Salviae Miltiorrhizae in raw material, Succus Bambusae, Radix Curcumae, Fructus Atriplicis Sibiricae, Mannosum Kaki, parching to brown Semen Glycines powder have eliminating toxin and beautifying the skin, clearing away heart-fire, fall effect of liver-fire, Fructus Citri junoris, Semen Melo, Fructus Crataegi, Semen Ginkgo, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Cortex Dictamni soothing liver-QI gas, promoting blood circulation, change blood stasis, all medicines share conditioning viscera, Yin Yang balancing, thorough elimination mottle forms root, increase-volume face.
A Chinese medicine composition for eliminating chloasma looks improving and the skin nourishing is made up of the herbal raw material of following weight proportion:
Flos Spatholirionis longifolii 20-30 part, Citrus pericarp 20-30 part, Radix Salviae Miltiorrhizae 20-30 part, Succus Bambusae 20-30 part, Radix Curcumae 20-30 part, Fructus Atriplicis Sibiricae 20-30 part, Mannosum Kaki 20-30 part, parching to brown Semen Glycines powder 20-30 part, Fructus Citri junoris 20-30 part, Semen Melo 20-30 part, Fructus Crataegi 20-30 part, Semen Ginkgo 20-30 part, Radix Rehmanniae Preparata 20-30 part, Radix Angelicae Sinensis 20-30 part, Cortex Dictamni 20-30 part.
Preparation method:
A, raw medicinal material is put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, 2 extracting solution are merged filtering and standing; In described step b, the medicinal residues refined can be put into 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, 3 extracting solution be merged, filtering and standing.
B, again by medicinal residues water heating and refluxing extraction;
C, above-mentioned two kinds of filtrates to be merged, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder and incapsulate.
A Chinese medicine composition for eliminating chloasma looks improving and the skin nourishing is made up of the herbal raw material of following weight proportion:
Flos Spatholirionis longifolii 22-28 part, Citrus pericarp 22-28 part, Radix Salviae Miltiorrhizae 22-28 part, Succus Bambusae 22-28 part, Radix Curcumae 22-28 part, Fructus Atriplicis Sibiricae 22-28 part, Mannosum Kaki 22-28 part, parching to brown Semen Glycines powder 22-28 part, Fructus Citri junoris 22-28 part, Semen Melo 22-28 part, Fructus Crataegi 22-28 part, Semen Ginkgo 22-28 part, Radix Rehmanniae Preparata 22-28 part, Radix Angelicae Sinensis 22-28 part, Cortex Dictamni 22-28 part.
A Chinese medicine composition for eliminating chloasma looks improving and the skin nourishing is made up of the herbal raw material of following weight proportion:
Flos Spatholirionis longifolii 25 parts, Citrus pericarp 25 parts, Radix Salviae Miltiorrhizae 25 parts, Succus Bambusae 25 parts, Radix Curcumae 25 parts, Fructus Atriplicis Sibiricae 25 parts, Mannosum Kaki 25 parts, parching to brown Semen Glycines powder 25 parts, Fructus Citri junoris 25 parts, Semen Melo 25 parts, Fructus Crataegi 25 parts, Semen Ginkgo 25 parts, Radix Rehmanniae Preparata 25 parts, Radix Angelicae Sinensis 25 parts, Cortex Dictamni 25 parts.
Selected by the present invention, the function of medicine cures mainly and is respectively:
Flos Spatholirionis longifolii:
[nature and flavor] are puckery, cool.
Effect of [function cures mainly] Flos Spatholirionis longifolii is QI and blood regulating, pain relieving, and treatment menoxenia, nervous headache and constipation, have toxin expelling effect.
Citrus pericarp:
Pericarpium Citri Reticulatae, gives out golden yellow clear bright peel, except fragrant sour-sweet taste, also has one simple and elegant flowery odour, can promote appetite, skin maintenance, minimizing feeling of fatigue.Sweet strongly fragrant fruital, is applicable to drinking together with other flowers and plants very much.
Mandarin orange is nutritious and one of maximum fruit of consumption figure.Pulp flavor is splendid, and juice sweet taste is beautiful, also often makes popular drink.Can be made into confection and fruit jelly etc. after Pericarpium Citri Reticulatae processing, is the traditional Chinese medical science conventional " Pericarpium Citri Reticulatae " after drying; Blade, flower and fruit can refine quintessence oil, perfume.Marc and peel also can obtain through refining pectin and aromatic oil Pericarpium Citri Reticulatae brews up, and can utilize that Pericarpium Citri Reticulatae alleviating distention in middle-JIAO is regulated the flow of vital energy, effect of stopping coughing and removing phlegm, and Pericarpium Citri Reticulatae bubble green tea, can reduce phlegm and internal heat and separate expectorant, anti-inflammation, therefore cough ant phlegm person drink is useful.
Radix Salviae Miltiorrhizae:
[meridian distribution of property and flavor] cold nature, bitter in the mouth.
[effect] has the function of calming the nerves, living blood stasis and tissue regeneration promoting blood.
Succus Bambusae:
[meridian distribution of property and flavor] sweetness and bitterness is trembled with fear, Gui Jing: enter the heart, stomach warp, 1. " medicineization justice ": " enter lung, stomach two warp." 2. " book on Chinese herbal medicine is new again ": " enters the heart, liver, lung three warp."
The sliding expectorant of [function cures mainly] heat clearing away, relieving convulsion sharp key.Control middle wind-phlegm fan, lung-heat expectorant is stopped up, infantile convulsion, epilepsy, high fever excessive thirst, restlessness during pregnancy, tetanus.1. " not Lu ": " treat sudden and violent apoplexy migratory arthralgia, in the heart large heat, only unhappy (have under " detailed outline " last sentence ' recurrence caused by overexertion of quenching one's thirst ')." 2. " property of medicine opinion ": " controls apoplexy aphonia in silence." 3. supplement to the Herbal: " is yearningly vexed for a long time." 4. " detailed outline ": " controls eclampsia gravidarum puerperal tetanus, separates Extract Aconiti Radicis sucus poison." 5. essentials of Matea Medica: " pathogenic wind expelling pathogenic fire reducing, moisturize row expectorant, nourish blood tonifying YIN, sharp key tomorrow.Control apoplexy locked mouth, the large heat of expectorant fan, puerperal tetanus is demented, and unhappiness is quenched one's thirst, spontaneous sweating due to deficientcy of blood." 6. " book on Chinese herbal medicine is new again ": " clearing away heart-fire, fall liver-fire, reduce phlegm and quench the thirst, antipyretic relieving restlessness, controls toothache, bright eyes."
Radix Curcumae:
[meridian distribution of property and flavor] is pungent, bitter, cold; GUIXIN, lung, Liver Channel.
[effect] promoting blood circulation and stopping pain, dispersing the stagnated live-QI to relieve the stagnation of QI, removing heat from blood clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice.
Fructus Atriplicis Sibiricae:
[meridian distribution of property and flavor] is bitter, pungent; Enter Liver Channel.
[function] suppressing the hyperactive liver resolving depression, dispelling pathogenic wind for improving eyesight, for dizziness due to hyperactivity of liver-YANG headache, hypochondriac pain due to stagnation of liverQI, headache due to pathogenic wind-heat, conjunctival congestion and swelling pain, the diseases such as skin pruritus.
Mannosum Kaki:
[meridian distribution of property and flavor] is sweet, cool.
[function cures mainly] secretion replenishing and throat moistening, nourishing the lung to arrest cough.For aphtha, throat pain, dry pharynx is coughed.Energy removing heat-phlegm, moisturizes and promotes the production of body fluid.For lung-heat type cough, expectorant is thick, and dry pharynx is had sore throat, xerostomia of quenching one's thirst, and spits blood, spitting of blood.
Parching to brown Semen Glycines powder:
I.e. dry parching to brown bean, the traditional Chinese medical science think Semen Glycines alleviating distention in middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, sharp large intestine, consumer edema poison, having effect of invigorating the spleen and replenishing QI, heat reliving and toxin-eliminating, is dietetic therapy good merchantable brand.Containing the abundant disorderly A that supports one's family in Semen Glycines, vitamin B group, vitamin D, vitamin E and multiple human body can not synthesize but required nitrilo is sour.Normal food Semen Glycines, can make skin delicacy, Bai Zhe, moisten, effectively prevent the appearance of freckle and wrinkle.High content of protein matter in Semen Glycines, can nutrition skin hair, and make human body plentiful solid, hair is pitch-black glossy, agerasia.
Fructus Citri junoris:
[nature and flavor] acid, cool.1. " Kaibao Bencao ": sour in the mouth.2. principle of Correct Diet: sweet in the mouth acid is nontoxic.3. " beautiful Chinese catalpa medicine solution ": bitter in the mouth acid, micro-cool.[return through] " beautiful Chinese catalpa medicine solution ": enter lung meridian.[function cures mainly] preventing or arresting vomiting is disliked, the chest stuffiness relieving diaphragm, and disappear wart, relieves the effect of alcohol, and separates fish, Eriocheir sinensis poison.1. " feeding habits book on Chinese herbal medicine ": sector-style gas, treat goiter, send out scrofula, kill worm for fishing (' worm ' one do ' Eriocheir sinensis ') poison.2. " Kaibao Bencao ": flesh, go to feel sick, wash away sour juice, fritter and decoct into salt honey, eat it, remove floating wind in stomach.3. " beautiful Chinese catalpa medicine solution ": the chest stuffiness relieving promoting the circulation of QI, relieve the effect of alcohol.4. " detailed outline is picked up any lost article from the road ": orange cake: disappear pertinacious phlegm, sending down the abnormal ascending QI, and in, appetizing; Wide diaphragm, spleen invigorating, separates fish, Eriocheir sinensis poison, relieving alcoholic intoxication.
Semen Melo:
[meridian distribution of property and flavor] is sweet, cold.Nontoxic.
[function cures mainly] reduces phlegm, evacuation of pus, eliminating stagnation repercussive, lung heat clearing intestine moistening., chronic bronchitis poly-for knot in lung abscess, abdomen, stool is smooth, cough due to lung-heat, appendicitis etc.
Fructus Crataegi:
[nature and flavor] sour in the mouth, sweet, slightly warm in nature.
[function cures mainly] appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, circulation of qi promoting of reducing phlegm.For meat stagnant long-pending, lump in the abdomen, abdominal distention feeling of fullness, stasis blocking stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc.
Semen Ginkgo:
[nature and flavor] are sweet; Bitter; Puckery; Property is put down; Mild toxicity.
[return through] lung meridian; Kidney channel.
[function] astringing lung QI for relieving asthma; Leukorrhagia stopping reducing urination.
[curing mainly] asthma phlegmatic cough; Leucorrhea; Nebulousurine; Seminal emission; Frequent micturition; Innominate toxic swelling; Zha nose; Tinea skin ulcer.
Radix Rehmanniae Preparata:
[meridian distribution of property and flavor] property is sweet, tepor, enters liver, kidney channel.
[effect] nourishing the blood and yin, vital essence replenishing and marrow benifiting.
Radix Angelicae Sinensis:
[nature and flavor] are warm in nature, hide sweet, pungent.
[function cures mainly] is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Cortex Dictamni:
[meridian distribution of property and flavor] bitter cold, enters spleen, stomach warp.
[function] heat-clearing and toxic substances removing, expelling wind and removing dampness.Scratch for damp and hot sore, rubella, scabies, skin, the disease such as arthralgia chiefly caused by damp pathogen, jaundice.
Detailed description of the invention
embodiment 1, formula:
Flos Spatholirionis longifolii 20g, Citrus pericarp 20g, Radix Salviae Miltiorrhizae 20g, Succus Bambusae 20g, Radix Curcumae 20g, Fructus Atriplicis Sibiricae 20g, Mannosum Kaki 20g, parching to brown Semen Glycines powder 20g, Fructus Citri junoris 20g, Semen Melo 20g, Fructus Crataegi 20g, Semen Ginkgo 20g, Radix Rehmanniae Preparata 20g, Radix Angelicae Sinensis 20g, Cortex Dictamni 20g.
Preparation method:
A, raw medicinal material is put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, 2 extracting solution are merged filtering and standing; In described step b, the medicinal residues refined can be put into 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, 3 extracting solution be merged, filtering and standing.
B, again by medicinal residues water heating and refluxing extraction;
C, above-mentioned two kinds of filtrates to be merged, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder and incapsulate.
Using method:
Once a day oral, one time four, within 20/ day, be a course for the treatment of.
case 1:
Neat certain, female 19 years old, Hangzhou Designer, after getting sun, the burnt pain of buccal, skin is dark red at every turn, and after four courses for the treatment of of oral Chinese medicine of the present invention in 2014, the face colour of skin is normal, can normal outdoor activities non-rebound phenomenon so far.
embodiment 2, formula:
Flos Spatholirionis longifolii 22g, Citrus pericarp 22g, Radix Salviae Miltiorrhizae 22g, Succus Bambusae 22g, Radix Curcumae 22g, Fructus Atriplicis Sibiricae 22g, Mannosum Kaki 22g, parching to brown Semen Glycines powder 22g, Fructus Citri junoris 22g, Semen Melo 22g, Fructus Crataegi 22g, Semen Ginkgo 22g, Radix Rehmanniae Preparata 22g, Radix Angelicae Sinensis 22g, Cortex Dictamni 22g.
Preparation method is identical with embodiment 1.
case 2:
Zhao, female, 55 one full year of life, retirement, mottle 20 years, oral Chinese medicine of the present invention in 2014 after 30 days mottle desalination obviously, disappear completely after 40 days, without decortication, non-pigment is calm, and it is normal to cure the colour of skin.
embodiment 3, formula:
Flos Spatholirionis longifolii 25g, Citrus pericarp 25g, Radix Salviae Miltiorrhizae 25g, Succus Bambusae 25g, Radix Curcumae 25g, Fructus Atriplicis Sibiricae 25g, Mannosum Kaki 25g, parching to brown Semen Glycines powder 25g, Fructus Citri junoris 25g, Semen Melo 25g, Fructus Crataegi 25g, Semen Ginkgo 25g, Radix Rehmanniae Preparata 25g, Radix Angelicae Sinensis 25g, Cortex Dictamni 25g.
Preparation method is identical with embodiment 1.
case 3:
Huang, female 26 years old, white collar, freckle of looking unfamiliar more than 10 year, oral Chinese medicine of the present invention in 2010, treatment cycle is 3 courses for the treatment of, follow-up investigation: mottle desalination in 20 days, disappears for 40 days, and treatments period is without decortication, and non-pigment is calm, and the healing colour of skin is normal.So far do not recur.
embodiment 4, formula:
Flos Spatholirionis longifolii 28g, Citrus pericarp 28g, Radix Salviae Miltiorrhizae 28g, Succus Bambusae 28g, Radix Curcumae 28g, Fructus Atriplicis Sibiricae 28g, Mannosum Kaki 28g, parching to brown Semen Glycines powder 28g, Fructus Citri junoris 28g, Semen Melo 28g, Fructus Crataegi 28g, Semen Ginkgo 28g, Radix Rehmanniae Preparata 28g, Radix Angelicae Sinensis 28g, Cortex Dictamni 28g.
Preparation method is identical with embodiment 1.
case 4:
Zhang, female 32 years old, chloasma faciei, oral Chinese medicine of the present invention in 2014, treatment cycle is 2 courses for the treatment of, and the cycle of consolidation is 1 course for the treatment of, follow-up investigation: mottle desalination in 20 days, disappears for 40 days, and treatments period is without decortication, and non-pigment is calm, and the healing colour of skin is normal.So far do not recur.
embodiment 5, formula:
Flos Spatholirionis longifolii 30g, Citrus pericarp 30g, Radix Salviae Miltiorrhizae 30g, Succus Bambusae 30g, Radix Curcumae 30g, Fructus Atriplicis Sibiricae 30g, Mannosum Kaki 30g, parching to brown Semen Glycines powder 30g, Fructus Citri junoris 30g, Semen Melo 30g, Fructus Crataegi 30g, Semen Ginkgo 30g, Radix Rehmanniae Preparata 30g, Radix Angelicae Sinensis 30g, Cortex Dictamni 30g.
Preparation method is with embodiment 1.
case 5:
Hu, man, 28 years old.Patient is facial over 3 years engenders pigmented spots, and summer is particularly serious, oral Chinese medicine of the present invention in 2014, and treatment cycle is 2 courses for the treatment of, the cycle of consolidation is 1 course for the treatment of, follow-up investigation: mottle desalination in 20 days, disappears for 40 days, treatments period is without decortication, and non-pigment is calm, and the healing colour of skin is normal.So far do not recur.
Pharmacological toxicity is tested
1, acute toxicity test
Application mice carries out acute toxicity testing and shows: the Traditional Chinese medicine preparation capsule agent of the present invention of Mouse oral gavage, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Traditional Chinese medicine preparation capsule agent of the present invention is 488.8g crude drug/kg/d (LD50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.
2, long term toxicity test
Select SD rat, give the Chinese medicine preparation of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: invention formulation is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
ureteral Calculus:
In order to clear and definite the present invention is to the therapeutic effect of mottle, the present invention is by having carried out the clinical observation of system to the treatment of 100 routine mottle patients, and concrete outcome is as follows:
Object and method: patient is totally 100 examples, treatment group 100 example, man 2 example, female 98 example, one full year of life mean age 33, sick time 1 month-18 years;
1, Therapeutic Method: once a day oral, one time four, within 20/ day, be a course for the treatment of, Continuous Observation carries out efficacy evaluation after treating 3 courses for the treatment of.
2, efficacy assessment standard: cure: facial skin is normal skin tone; Take a turn for the better: skin lesion disappears more than 30%; Invalid: skin lesion is without significant change or disappear less than more than 30%.
3, untoward reaction: skin is without any stimulation and pigmentation.
4, therapeutic effect:
Recovery from illness >=76%; Take a turn for the better >=22%; Invalid >=2%; Total effective rate >=98%.

Claims (3)

1. a Chinese medicine composition for eliminating chloasma looks improving and the skin nourishing, is characterized in that: be made up of the herbal raw material of following weight proportion:
Flos Spatholirionis longifolii 20-30 part, Citrus pericarp 20-30 part, Radix Salviae Miltiorrhizae 20-30 part, Succus Bambusae 20-30 part, Radix Curcumae 20-30 part, Fructus Atriplicis Sibiricae 20-30 part, Mannosum Kaki 20-30 part, parching to brown Semen Glycines powder 20-30 part, Fructus Citri junoris 20-30 part, Semen Melo 20-30 part, Fructus Crataegi 20-30 part, Semen Ginkgo 20-30 part, Radix Rehmanniae Preparata 20-30 part, Radix Angelicae Sinensis 20-30 part, Cortex Dictamni 20-30 part;
Preparation method:
A, raw medicinal material is put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, 2 extracting solution are merged filtering and standing; In described step b, the medicinal residues refined can be put into 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, 3 extracting solution be merged, filtering and standing;
B, again by medicinal residues water heating and refluxing extraction;
C, above-mentioned two kinds of filtrates to be merged, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder and incapsulate.
2. the Chinese medicine composition of a kind of eliminating chloasma looks improving and the skin nourishing according to claim 1, is characterized in that: be made up of the herbal raw material of following weight proportion:
Flos Spatholirionis longifolii 22-28 part, Citrus pericarp 22-28 part, Radix Salviae Miltiorrhizae 22-28 part, Succus Bambusae 22-28 part, Radix Curcumae 22-28 part, Fructus Atriplicis Sibiricae 22-28 part, Mannosum Kaki 22-28 part, parching to brown Semen Glycines powder 22-28 part, Fructus Citri junoris 22-28 part, Semen Melo 22-28 part, Fructus Crataegi 22-28 part, Semen Ginkgo 22-28 part, Radix Rehmanniae Preparata 22-28 part, Radix Angelicae Sinensis 22-28 part, Cortex Dictamni 22-28 part.
3. the Chinese medicine composition of a kind of eliminating chloasma looks improving and the skin nourishing according to claim 1, is characterized in that: be made up of the herbal raw material of following weight proportion:
Flos Spatholirionis longifolii 25 parts, Citrus pericarp 25 parts, Radix Salviae Miltiorrhizae 25 parts, Succus Bambusae 25 parts, Radix Curcumae 25 parts, Fructus Atriplicis Sibiricae 25 parts, Mannosum Kaki 25 parts, parching to brown Semen Glycines powder 25 parts, Fructus Citri junoris 25 parts, Semen Melo 25 parts, Fructus Crataegi 25 parts, Semen Ginkgo 25 parts, Radix Rehmanniae Preparata 25 parts, Radix Angelicae Sinensis 25 parts, Cortex Dictamni 25 parts.
CN201510949061.7A 2015-12-18 2015-12-18 Traditional Chinese medicine compound capable of removing chloasma and beautifying faces Pending CN105362956A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05124922A (en) * 1991-04-09 1993-05-21 Sansho Seiyaku Co Ltd External preparation with melanin production-inhibitory activity
CN101112599A (en) * 2007-08-29 2008-01-30 北京艺信堂医药研究所 Chinese patent drug for treating chloasma
CN102579908A (en) * 2012-03-19 2012-07-18 常熟华港制药有限公司 Traditional Chinese medicine preparation for toxin expelling, refreshment and beautifying
CN104840648A (en) * 2015-06-15 2015-08-19 王艳娣 Traditional Chinese medicine preparation for treating facial freckles

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05124922A (en) * 1991-04-09 1993-05-21 Sansho Seiyaku Co Ltd External preparation with melanin production-inhibitory activity
CN101112599A (en) * 2007-08-29 2008-01-30 北京艺信堂医药研究所 Chinese patent drug for treating chloasma
CN102579908A (en) * 2012-03-19 2012-07-18 常熟华港制药有限公司 Traditional Chinese medicine preparation for toxin expelling, refreshment and beautifying
CN104840648A (en) * 2015-06-15 2015-08-19 王艳娣 Traditional Chinese medicine preparation for treating facial freckles

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Title
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Application publication date: 20160302