CN105362786A - 一种治疗胆结石的中药胶囊及其制备方法 - Google Patents
一种治疗胆结石的中药胶囊及其制备方法 Download PDFInfo
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- CN105362786A CN105362786A CN201510970741.7A CN201510970741A CN105362786A CN 105362786 A CN105362786 A CN 105362786A CN 201510970741 A CN201510970741 A CN 201510970741A CN 105362786 A CN105362786 A CN 105362786A
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Abstract
本发明涉及一种治疗胆结石的中药胶囊；本发明还涉及一种治疗胆结石的中药胶囊的制备方法，本发明的治疗胆结石的中药胶囊，制成胶囊的原料药有效成分质量份数包括：大金钱草26～35份、竻苋菜11～20份、猫须草12～23份、水飞蓟9～18份、水杨柳10～20份、玉米须7～18份、鸡肫草13～25份、茵陈11～21份、忍冬10～19份、多茎野豌豆12～21份、蒲黄10～19份、牛胆8～17份、虎耳草12～21份、曲花紫堇10～19份、十姊妹9～18份、栀子根10～21份、小口小金发藓9～17份、甘草10～21份，对胆结石具有良好的治疗效果。
Description
技术领域
本发明涉及治疗胆结石技术领域，具体是一种治疗胆结石的中药胶囊及其制备方法。
背景技术
胆结石是指结石在胆囊内形成后，可刺激胆囊粘膜，不仅可引起胆囊的慢性炎症，而且当结石嵌顿在胆囊颈部或胆囊管后，还可以引起继发感染，导致胆囊的急性炎症。
中医学认为胆结石其形成与胆肝相关，胆依附于肝，胆与肝气的运行和脾胃吸收食物精华，有排泄浊物功能。由于饮食不节，或暴饮暴食，损伤脾胃、脾失健运，水湿不化，积湿成痰，痰混内生，阻碍气机，气机郁滞胆汁疏泄失常，郁久化热化火，痰湿生热，湿热与痰互结，痰热互结湿热蕴结石久成胆结石。
目前西医主要临床上常用脱氧胆酸和熊脱氧胆酸等药物治疗胆结石，使用这些药物治疗会产生一定的副作用，因而更增加了治疗难度，在使用上存在一定的弊端，并且西药只能对胆囊内的炎症进行治疗，但是不能对患者机体进行理气疏肝，清热化湿等，使胆结石复发几率高，给胆结石的治疗带来一定局限性。
发明内容
本发明的目的是为了解决以上问题，而提供对在对胆结石进行治疗见效快、复发率低的一种治疗胆结石的中药胶囊及其制备方法。
本发明采用的技术方案为：一种治疗胆结石的中药胶囊，制成胶囊的原料药有效成分质量份数包括：大金钱草26～35份、竻苋菜11～20份、猫须草12～23份、水飞蓟9～18份、水杨柳10～20份、玉米须7～18份、鸡肫草13～25份、茵陈11～21份、忍冬10～19份、多茎野豌豆12～21份、蒲黄10～19份、牛胆8～17份、虎耳草12～21份、曲花紫堇10～19份、十姊妹9～18份、栀子根10～21份、小口小金发藓9～17份、甘草10～21份。
进一步，一种治疗胆结石的中药胶囊，制成胶囊的原料药有效成分质量份数包括：大金钱草28～32份、竻苋菜15～17份、猫须草15～19份、水飞蓟13～16份、水杨柳13～17份、玉米须11～15份、鸡肫草16～21份、茵陈13～16份、忍冬13～17份、多茎野豌豆15～18份、蒲黄13～16份、牛胆12～15份、虎耳草14～17份、曲花紫堇12～16份、十姊妹12～16份、栀子根12～16份、小口小金发藓12～15份、甘草13～17份。
进一步，一种治疗胆结石的中药胶囊，制成胶囊的原料药有效成分质量份数包括：大金钱草29份、竻苋菜16份、猫须草17份、水飞蓟15份、水杨柳16份、玉米须12份、鸡肫草17份、茵陈14份、忍冬14份、多茎野豌豆16份、蒲黄15份、牛胆13份、虎耳草16份、曲花紫堇15份、十姊妹13份、栀子根14份、小口小金发藓13份、甘草14份。
进一步，一种治疗胆结石的中药胶囊的制备方法，制备方法如下：
(1)大金钱草、竻苋菜、猫须草、水飞蓟、水杨柳、玉米须、鸡肫草、茵陈、忍冬按照原料药与蛤粉重量比为2:1加入蛤粉进行在120～160℃行进炒制，炒制完成后，去除蛤粉；
(2)原料药多茎野豌豆、蒲黄、牛胆、虎耳草、曲花紫堇、十姊妹、栀子根、小口小金发藓、甘草按照原料药与盐水重量比为50:1加入盐水进行盐炒，盐水浓度为20％，温度为100～120℃；
(3)将经步骤(1)(2)得到装入球磨机研磨2h，过80目筛，得研磨粉；
(4)将步骤(3)得到的研磨粉加热至沸腾后煮沸2h，分离取出煎出液，继续向药材内加入4份的纯化水，加热至沸腾后继续煮沸1.5h，合并两次煎出液即为提取液；
(5)步骤(4)得到的提取液放置于超临界萃取仪中的萃取釜中，利用二氧化碳作为介质进行萃取，萃取釜压力为40Mpa，萃取温度为45℃，分离器压力12Mpa，分离器温度为70℃，萃取2小时，得到萃取液；萃取液在外循环浓缩器浓缩，浓缩条件为：压力0.03Mpa，温度70℃，浓缩至相对密度为1.13～1.14的浸膏；
(6)向步骤(5)得到的浸膏于50℃干燥，过16目筛，得干燥粉，干燥粉中加入占胶囊总质量70％的糊精，混匀，胶囊机制成胶囊。
服用方法：成人每日2次，早晚各1粒，10天为一个疗程。
本发明的药材功效解析如下：
大金钱草味甘淡，性平，具有清热，利湿，消肿，解毒的功效，治黄疸，水肿，胆结石、肾结石、膀胱结石，反胃噎膈，跌打损伤，疔疮肿毒。竻苋菜味甘，性寒，具有利湿，解毒，消肿的功效，治痢疾，便血，浮肿，白带，胆结石，瘰疬，痔疮，疔疮，喉痛，蛇咬伤。猫须草味甘、微苦，性凉，具有清热祛湿，排石利尿的功效，用于急慢性肾炎，膀胱炎，尿路结石，胆结石。水飞蓟味苦，性凉，具有清热解毒，保肝、利胆的功效。水杨柳味苦，性寒，具有清热，利胆，消炎，解毒的功效，治跌打，溃疡，痔疮，淋病，梅毒，膀胱结石，胆囊结石。玉米须味甘、淡，性平，具有利尿消肿，平肝利胆的功效，用于急、慢性肾炎，水肿，急、慢性肝炎，高血压，糖尿病，慢性鼻窦炎，尿路结石，胆道结石，小便不利、湿热黄胆等症。鸡肫草味淡、性平，具有清肺止咳，利水祛湿的功效，用于久咳咯血，疟疾，肾结石，胆石症，白带，跌打损伤；外用治湿热疮毒。茵陈味苦、辛，性微寒，具有清热利湿、退黄的功效，主治：黄疸、小便不利、湿疮瘙痒、传染性黄疸型肝炎，等，药理学研究有利胆，保护肝功能，解热，抗炎，降血脂，降压，扩冠等作用。忍冬性寒，味甘，具有清热解毒、抗炎、补虚疗风的功效，主治胀满下疾、温病发热，热毒痈疡和肿瘤等症。蒲黄味甘，性平，具有止血，化瘀，通淋的功效，用于吐血，衄血，咯血，崩漏，外伤出血，经闭通经，胸腹刺痛，跌扑肿痛，血淋涩痛。多茎野豌豆味辛，性平，发汗除湿，活血止痛。治风湿疼痛，筋骨拘挛，黄疸肝炎，白带，鼻血，热疟，阴囊湿疹。牛胆味苦，性寒，清肝明目，利胆通肠，解毒消肿，治风热目疾，黄疸，便秘，消渴，小儿惊风，痈肿痔疮。虎耳草味性：苦，寒，具有清肝胆热；健胃的功效，主肝炎；胆结石；流感发烧；消化不良。曲花紫堇味苦，性寒，清热毒，利肝胆，凉血止血，主热病高热，湿热黄疸，衄血，月经过多。十姊妹味苦，性平，清热化湿，疏肝利胆，主黄疸，痞积，妇女白带。栀子根味甘，性苦；寒，清热利湿；凉血止血，主黄疸型肝炎，痢疾，胆结石，感冒高热，吐血，衄血，尿路感染，肾炎水肿，乳腺炎，风火牙痛，疮痈肿毒，跌打损伤。小口小金发藓味辛，性凉，具有舒肝利胆，排石止痛的功效，主治胆囊积石等。甘草味甘、性平，其含有多种化学成分，功效为益气健脾、祛痰止咳。
本发明具有以下有益效果：
(1)大金钱草有清热，利湿，消肿，解毒的功效，为君药，对胆结石具有良好的疗效。竻苋菜利湿，解毒，消肿，猫须草清热祛湿，排石利尿，水飞蓟清热解毒，保肝、利胆，水杨柳清热，利胆，消炎，解毒，玉米须利尿消肿，平肝利胆，竻苋菜、猫须草、水飞蓟、水杨柳、玉米须为臣药，能辅助君药对胆石症具有良好治疗疗效，可使肝脏病患者自觉症状和某些生化指数如血清胆红素、白皖及球皖系数、凝血酶元、谷丙转氨酶等迅速改善。鸡肫草清肺止咳，利水祛湿，茵陈清热利湿、退黄，忍冬清热解毒、抗炎、补虚疗风，蒲黄止血，化瘀，通淋，多茎野豌豆发汗除湿，活血止痛，牛胆清肝明目，利胆通肠，解毒消肿，玉米须、鸡肫草、茵陈、忍冬、多茎野豌豆、蒲黄、牛胆为佐使，能有效的缓解胆结石的症状；虎耳草清肝胆热，健胃，曲花紫堇清热毒，利肝胆，凉血止血，十姊妹清热化湿，疏肝利胆，栀子根清热利湿，凉血止血，小口小金发藓舒肝利胆，排石止痛，虎耳草、曲花紫堇、十姊妹、栀子根、小口小金发藓、甘草能从患者的身体内部调理清热化湿，疏肝利胆，促进胆结石患者的康复。
(2)蛤粉进行炒制，使药物便于制剂和调剂，降低药物的滋腻之性，矫正不良气味，可增强药物疏肝利胆的作用，加入盐水进行盐炒，盐水浓度为20％，盐水炒后与药物起到协同作用，能增强消肿解毒的功效，有效治疗胆结石症状；研磨使药材中的淀粉、蛋白质在后续步骤更充分的析出；煎煮可以改变药物的刺激性作用，较温和的作用于人体，促进药物的吸收；超临界萃取、浓缩步骤最大限度的保留本发明中药中的有效成分，从而使胶囊达到精制的目的。
具体实施方式
下面结合实施例对本发明作进一步阐述。
实施例1：
一种治疗胆结石的中药胶囊，制成胶囊的原料药有效成分质量份数包括：大金钱草26份、竻苋菜11份、猫须草12份、水飞蓟9份、水杨柳10份、玉米须7份、鸡肫草13份、茵陈11份、忍冬10份、多茎野豌豆12份、蒲黄10份、牛胆8份、虎耳草12份、曲花紫堇10份、十姊妹9份、栀子根10份、小口小金发藓9份、甘草10份。
一种治疗胆结石的中药胶囊的制备方法：
(1)大金钱草、竻苋菜、猫须草、水飞蓟、水杨柳、玉米须、鸡肫草、茵陈、忍冬按照原料药与蛤粉重量比为2:1加入蛤粉进行在120～160℃行进炒制，炒制完成后，去除蛤粉；
(2)原料药多茎野豌豆、蒲黄、牛胆、虎耳草、曲花紫堇、十姊妹、栀子根、小口小金发藓、甘草按照原料药与盐水重量比为50:1加入盐水进行盐炒，盐水浓度为20％，温度为100～120℃；
(3)将经步骤(1)(2)得到装入球磨机研磨2h，过80目筛，得研磨粉；
(4)将步骤(3)得到的研磨粉加热至沸腾后煮沸2h，分离取出煎出液，继续向药材内加入4份的纯化水，加热至沸腾后继续煮沸1.5h，合并两次煎出液即为提取液；
(5)步骤(4)得到的提取液放置于超临界萃取仪中的萃取釜中，利用二氧化碳作为介质进行萃取，萃取釜压力为40Mpa，萃取温度为45℃，分离器压力12Mpa，分离器温度为70℃，萃取2小时，得到萃取液；萃取液在外循环浓缩器浓缩，浓缩条件为：压力0.03Mpa，温度70℃，浓缩至相对密度为1.13～1.14的浸膏；
(6)向步骤(5)得到的浸膏于50℃干燥，过16目筛，得干燥粉，干燥粉中加入占胶囊总质量70％的糊精，混匀，胶囊机制成胶囊。
实施例2：
一种治疗胆结石的中药胶囊，制成胶囊的原料药有效成分质量份数包括：大金钱草35份、竻苋菜20份、猫须草23份、水飞蓟18份、水杨柳20份、玉米须18份、鸡肫草25份、茵陈21份、忍冬19份、多茎野豌豆21份、蒲黄19份、牛胆17份、虎耳草21份、曲花紫堇19份、十姊妹18份、栀子根21份、小口小金发藓17份、甘草21份。
一种治疗胆结石的中药胶囊的制备方法：
(1)大金钱草、竻苋菜、猫须草、水飞蓟、水杨柳、玉米须、鸡肫草、茵陈、忍冬按照原料药与蛤粉重量比为2:1加入蛤粉进行在120～160℃行进炒制，炒制完成后，去除蛤粉；
(2)原料药多茎野豌豆、蒲黄、牛胆、虎耳草、曲花紫堇、十姊妹、栀子根、小口小金发藓、甘草按照原料药与盐水重量比为50:1加入盐水进行盐炒，盐水浓度为20％，温度为100～120℃；
(3)将经步骤(1)(2)得到装入球磨机研磨2h，过80目筛，得研磨粉；
(4)将步骤(3)得到的研磨粉加热至沸腾后煮沸2h，分离取出煎出液，继续向药材内加入4份的纯化水，加热至沸腾后继续煮沸1.5h，合并两次煎出液即为提取液；
(5)步骤(4)得到的提取液放置于超临界萃取仪中的萃取釜中，利用二氧化碳作为介质进行萃取，萃取釜压力为40Mpa，萃取温度为45℃，分离器压力12Mpa，分离器温度为70℃，萃取2小时，得到萃取液；萃取液在外循环浓缩器浓缩，浓缩条件为：压力0.03Mpa，温度70℃，浓缩至相对密度为1.13～1.14的浸膏；
(6)向步骤(5)得到的浸膏于50℃干燥，过16目筛，得干燥粉，干燥粉中加入占胶囊总质量70％的糊精，混匀，胶囊机制成胶囊。
实施例3：
一种治疗胆结石的中药胶囊，制成胶囊的原料药有效成分质量份数包括：大金钱草28份、竻苋菜15份、猫须草15份、水飞蓟13份、水杨柳13份、玉米须11份、鸡肫草16份、茵陈13份、忍冬13份、多茎野豌豆15份、蒲黄13份、牛胆12份、虎耳草14份、曲花紫堇12份、十姊妹12份、栀子根12份、小口小金发藓12份、甘草13份。
一种治疗胆结石的中药胶囊的制备方法：
(1)大金钱草、竻苋菜、猫须草、水飞蓟、水杨柳、玉米须、鸡肫草、茵陈、忍冬按照原料药与蛤粉重量比为2:1加入蛤粉进行在120～160℃行进炒制，炒制完成后，去除蛤粉；
(2)原料药多茎野豌豆、蒲黄、牛胆、虎耳草、曲花紫堇、十姊妹、栀子根、小口小金发藓、甘草按照原料药与盐水重量比为50:1加入盐水进行盐炒，盐水浓度为20％，温度为100～120℃；
(3)将经步骤(1)(2)得到装入球磨机研磨2h，过80目筛，得研磨粉；
(4)将步骤(3)得到的研磨粉加热至沸腾后煮沸2h，分离取出煎出液，继续向药材内加入4份的纯化水，加热至沸腾后继续煮沸1.5h，合并两次煎出液即为提取液；
(5)步骤(4)得到的提取液放置于超临界萃取仪中的萃取釜中，利用二氧化碳作为介质进行萃取，萃取釜压力为40Mpa，萃取温度为45℃，分离器压力12Mpa，分离器温度为70℃，萃取2小时，得到萃取液；萃取液在外循环浓缩器浓缩，浓缩条件为：压力0.03Mpa，温度70℃，浓缩至相对密度为1.13～1.14的浸膏；
(6)向步骤(5)得到的浸膏于50℃干燥，过16目筛，得干燥粉，干燥粉中加入占胶囊总质量70％的糊精，混匀，胶囊机制成胶囊。
实施例4：
一种治疗胆结石的中药胶囊，制成胶囊的原料药有效成分质量份数包括：大金钱草32份、竻苋菜17份、猫须草19份、水飞蓟16份、水杨柳17份、玉米须15份、鸡肫草21份、茵陈16份、忍冬17份、多茎野豌豆18份、蒲黄16份、牛胆15份、虎耳草17份、曲花紫堇16份、十姊妹16份、栀子根16份、小口小金发藓15份、甘草17份。
一种治疗胆结石的中药胶囊的制备方法：
(1)大金钱草、竻苋菜、猫须草、水飞蓟、水杨柳、玉米须、鸡肫草、茵陈、忍冬按照原料药与蛤粉重量比为2:1加入蛤粉进行在120～160℃行进炒制，炒制完成后，去除蛤粉；
(2)原料药多茎野豌豆、蒲黄、牛胆、虎耳草、曲花紫堇、十姊妹、栀子根、小口小金发藓、甘草按照原料药与盐水重量比为50:1加入盐水进行盐炒，盐水浓度为20％，温度为100～120℃；
(3)将经步骤(1)(2)得到装入球磨机研磨2h，过80目筛，得研磨粉；
(4)将步骤(3)得到的研磨粉加热至沸腾后煮沸2h，分离取出煎出液，继续向药材内加入4份的纯化水，加热至沸腾后继续煮沸1.5h，合并两次煎出液即为提取液；
(5)步骤(4)得到的提取液放置于超临界萃取仪中的萃取釜中，利用二氧化碳作为介质进行萃取，萃取釜压力为40Mpa，萃取温度为45℃，分离器压力12Mpa，分离器温度为70℃，萃取2小时，得到萃取液；萃取液在外循环浓缩器浓缩，浓缩条件为：压力0.03Mpa，温度70℃，浓缩至相对密度为1.13～1.14的浸膏；
(6)向步骤(5)得到的浸膏于50℃干燥，过16目筛，得干燥粉，干燥粉中加入占胶囊总质量70％的糊精，混匀，胶囊机制成胶囊。
实施例5：
一种治疗胆结石的中药胶囊，制成胶囊的原料药有效成分质量份数包括：大金钱草29份、竻苋菜16份、猫须草17份、水飞蓟15份、水杨柳16份、玉米须12份、鸡肫草17份、茵陈14份、忍冬14份、多茎野豌豆16份、蒲黄15份、牛胆13份、虎耳草16份、曲花紫堇15份、十姊妹13份、栀子根14份、小口小金发藓13份、甘草14份。
一种治疗胆结石的中药胶囊的制备方法：
(1)大金钱草、竻苋菜、猫须草、水飞蓟、水杨柳、玉米须、鸡肫草、茵陈、忍冬按照原料药与蛤粉重量比为2:1加入蛤粉进行在120～160℃行进炒制，炒制完成后，去除蛤粉；
(2)原料药多茎野豌豆、蒲黄、牛胆、虎耳草、曲花紫堇、十姊妹、栀子根、小口小金发藓、甘草按照原料药与盐水重量比为50:1加入盐水进行盐炒，盐水浓度为20％，温度为100～120℃；
(3)将经步骤(1)(2)得到装入球磨机研磨2h，过80目筛，得研磨粉；
(4)将步骤(3)得到的研磨粉加热至沸腾后煮沸2h，分离取出煎出液，继续向药材内加入4份的纯化水，加热至沸腾后继续煮沸1.5h，合并两次煎出液即为提取液；
(5)步骤(4)得到的提取液放置于超临界萃取仪中的萃取釜中，利用二氧化碳作为介质进行萃取，萃取釜压力为40Mpa，萃取温度为45℃，分离器压力12Mpa，分离器温度为70℃，萃取2小时，得到萃取液；萃取液在外循环浓缩器浓缩，浓缩条件为：压力0.03Mpa，温度70℃，浓缩至相对密度为1.13～1.14的浸膏；
(6)向步骤(5)得到的浸膏于50℃干燥，过16目筛，得干燥粉，干燥粉中加入占胶囊总质量70％的糊精，混匀，胶囊机制成胶囊。
1、动物实验
动物急性毒性实验：将上述制备的中药胶囊对小鼠进行LD50测试，使用剂量为：按体重计的用量为5000mg/kg，相当于人用量的1000倍。实验结果为：小鼠在72小时内无死亡。
亚急性毒性试验验证：将上述制备的中药胶囊对大鼠和犬连续给予相当于人的用药量，100天，进行血液学检查，肝肾功能、心电图记忆力均无明显变化。
2、临床资料及病例：
为了表明本发明的治疗效果，对100例胆结石患者进行系统临床观察治疗，在上述临床观察的过程中对上述患者的病史、病情及疗效进行记录。
临床治疗效果判断标准为：
好转：常见症状疼痛位于右上腹或上腹部，呈阵发性，或者持续疼痛阵发性加剧，可向右肩胛部和背部放射，可伴恶心、呕吐等基本消失。
无效：症状无明显改善。
治疗效果：本发明经过对100例胆结石患者进行治疗，98例好转，2例无效，总有效率达到98％，且无人出现副作用。
典型病例：
病例1：患者蒋某某，男，50岁，患者疼痛位于右上腹呈阵发性疼痛，可向右肩胛部和背部放射，可伴恶心、呕吐，使用本发明中药胶囊4个疗程后，症状明显减轻，继续使用1个疗程，症状好转。
病例2：患者李某，男，34岁，患者工作紧张或休息不好时感到上腹部或右上腹隐痛，或者有饱胀不适、嗳气、呃逆，使用本发明中药胶囊2个疗程后，症状明显改善，继续使用2个疗程，症状好转。
病例3：患者张某某，女，27岁，患者常在饱餐、进食油腻食物后上腹部持续疼痛，使用本发明中药胶囊3个疗程后，症状明显好转，继续使用本发明中药胶囊2个疗程后，症状好转。
以上所述是本发明的优选实施方式，其目的在于让熟悉此项技术的人了解本发明内容并加以实施，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也视为本发明的保护范围。
Claims (4)
1.一种治疗胆结石的中药胶囊，其特征在于，制成胶囊的有效成分质量份数包括：大金钱草26～35份、竻苋菜11～20份、猫须草12～23份、水飞蓟9～18份、水杨柳10～20份、玉米须7～18份、鸡肫草13～25份、茵陈11～21份、忍冬10～19份、多茎野豌豆12～21份、蒲黄10～19份、牛胆8～17份、虎耳草12～21份、曲花紫堇10～19份、十姊妹9～18份、栀子根10～21份、小口小金发藓9～17份、甘草10～21份。
2.根据权利要求1所述的一种治疗胆结石的中药胶囊，其特征在于，制成胶囊的有效成分质量份数包括：大金钱草28～32份、竻苋菜15～17份、猫须草15～19份、水飞蓟13～16份、水杨柳13～17份、玉米须11～15份、鸡肫草16～21份、茵陈13～16份、忍冬13～17份、多茎野豌豆15～18份、蒲黄13～16份、牛胆12～15份、虎耳草14～17份、曲花紫堇12～16份、十姊妹12～16份、栀子根12～16份、小口小金发藓12～15份、甘草13～17份。
3.根据权利要求1所述的一种治疗胆结石的中药胶囊，其特征在于，制成胶囊的有效成分质量份数包括：大金钱草29份、竻苋菜16份、猫须草17份、水飞蓟15份、水杨柳16份、玉米须12份、鸡肫草17份、茵陈14份、忍冬14份、多茎野豌豆16份、蒲黄15份、牛胆13份、虎耳草16份、曲花紫堇15份、十姊妹13份、栀子根14份、小口小金发藓13份、甘草14份。
4.一种治疗胆结石的中药胶囊的制备方法，其特征在于，所述制备方法具体步骤如下：
(1)大金钱草、竻苋菜、猫须草、水飞蓟、水杨柳、玉米须、鸡肫草、茵陈、忍冬按照原料药与蛤粉重量比为2:1加入蛤粉进行在120～160℃行进炒制，炒制完成后，去除蛤粉；
(2)原料药多茎野豌豆、蒲黄、牛胆、虎耳草、曲花紫堇、十姊妹、栀子根、小口小金发藓、甘草按照原料药与盐水重量比为50:1加入盐水进行盐炒，盐水浓度为20％，温度为100～120℃；
(3)将经步骤(1)(2)得到装入球磨机研磨2h，过80目筛，得研磨粉；
(4)将步骤(3)得到的研磨粉加热至沸腾后煮沸2h，分离取出煎出液，继续向药材内加入4份的纯化水，加热至沸腾后继续煮沸1.5h，合并两次煎出液即为提取液；
(5)步骤(4)得到的提取液放置于超临界萃取仪中的萃取釜中，利用二氧化碳作为介质进行萃取，萃取釜压力为40Mpa，萃取温度为45℃，分离器压力12Mpa，分离器温度为70℃，萃取2小时，得到萃取液；萃取液在外循环浓缩器浓缩，浓缩条件为：压力0.03Mpa，温度70℃，浓缩至相对密度为1.13～1.14的浸膏；
(6)向步骤(5)得到的浸膏于50℃干燥，过16目筛，得干燥粉，干燥粉中加入占胶囊总质量70％的糊精，混匀，胶囊机制成胶囊。
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