CN105362724A - 一种治疗瘀血阻络型偏头痛的中药、其剂型及其制备方法 - Google Patents
一种治疗瘀血阻络型偏头痛的中药、其剂型及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种治疗瘀血阻络型偏头痛的中药,含有以下重量分数的组分:桃仁6-12份,川芎3-9份,九里香5-15份,尖药花5-15份,鬼毛针5-15份,八角枫3-9份,徐长卿3-9份,天麻5-15份,滚山虫:1-3份,何首乌:10-20份,白芍:5-15份,党参:10-20份,刺五加:5-15份,甘草3-9份。本发明的有益效果是:本发明中药以纯中药为原料,毒副作用小,针对瘀血阻络型偏头痛,活血化瘀、通络止痛、益气养血,治疗效果显著,药物经过超微粉碎,更大程度释放药效,中药膏剂,使用方便。
Description
技术领域
本发明涉及中药制剂技术领域,特别涉及一种治疗瘀血阻络型偏头痛的中药、其剂型及其制备方法。
背景技术
偏头痛是以反复发作性的单侧或双侧性头痛为主的一种疾病,全世界有2.4亿偏头痛患者每年要经受14亿次偏头痛的折磨。世界卫生组织(WHO)认为,重度偏头痛居最常见的使人丧失工作能力的内科疾病的前20位,而且每年呈上升趋势。
本病在中医古代文献中多被称为“偏头风”、“偏头痛”、“偏正头痛”、“头偏痛”、“偏头风痛”、“头半寒痛”、“脑风”等。《素问·奇病论》云:“帝曰:‘人有病头痛……名曰何病?’歧伯曰:‘当有所犯大寒……病名曰厥逆。’”《素问·风论》说:“风气随风府而上,则为脑风。”“新沐中风,则为首风。”《东垣十书》中有“偏头痛”、“厥逆头痛”之名;《丹溪心法·头痛》中有“偏头风”之名;且《证治准绳·头痛》中对头风病的概念亦有明确论述:“医书多分头痛、头风为二门,然一病也。
本病的病因病机主要是外感与内伤。外感头痛多以风邪为主导,常挟以寒、湿、热邪上犯清窍,引起头部经脉绌急而发生头痛。内伤头痛以实证多见,常为肝胆郁热、痰湿上扰、湿热中阻和瘀血阻络,虚证较少见,常为肝血不足或肝肾阴虚。张道厚等认为该病病位主要在肝胆,其基本的病机是肝失疏泄,挟邪上扰,头侧肝胆经络不利,不通而痛,本病应从肝辨证论治。晏招兰等认为该病病程长,多为痰瘀互结阻络,气血失和而致病且日久难愈。刘锁超认为,患者脑窍脉络素有痰瘀宿疾潜伏,羁留不去,为病之根,肝、脾、胃等脏腑功能失调,气血阴阳失衡为本;外感风寒、内伤七情、饮食失节、劳逸失度为因。综上医家所论,本病的病因主要包括风、痰、湿、火、热、血虚、气虚、气血两虚等,其中风火痰瘀为病之标,多见于急性发作阶段;肝脾肾功能失调为病之本,是发病的基础。即以内伤为主,且中医学认为“不通则痛”,风邪入脑、瘀血阻络、肝经风火、肝阳上亢、痰浊蒙窍、精血不足等病变均可导致气血不能正常运行而引起头痛。
因为引起偏头痛的原因众多,单纯服用止痛药只会暂时缓解疼痛,对疾病的治疗起不到根本的作用,有些中成药虽然能够起到很好的治疗效果,但是因为针对性不强,并不是适用于各种原因引起的偏头痛。
发明内容
本发明针对现有技术中存在的不足,提供一种治疗瘀血阻络型偏头痛的中药、其剂型及其制备方法。
本发明的技术方案是:
一种治疗瘀血阻络型偏头痛的中药,含有以下组分:
桃仁,川芎,九里香,尖药花,鬼毛针,八角枫,徐长卿,天麻,滚山虫,何首乌,白芍,党参,刺五加,甘草。
在上述方案的基础上,所述的治疗瘀血阻络型偏头痛的中药,含有以下重量分数的组分:
桃仁6-12份,川芎3-9份,九里香5-15份,尖药花5-15份,鬼毛针5-15份,八角枫3-9份,徐长卿3-9份,天麻5-15份,滚山虫:1-3份,何首乌:10-20份,白芍:5-15份,党参:10-20份,刺五加:5-15份,甘草3-9份。
在上述方案的基础上,所述的治疗瘀血阻络型偏头痛的中药,含有以下重量分数的组分:
桃仁9份,川芎6份,九里香10份,尖药花10份,鬼毛针10份,八角枫6份,徐长卿6份,天麻10份,滚山虫:2份;何首乌:15份,白芍:10份,党参:15份,刺五加:10份,甘草6份。
一种如上所述的治疗瘀血阻络型偏头痛的中药的剂型为膏剂。
一种如上所述的治疗瘀血阻络型偏头痛的中药膏剂的制备方法,具体步骤如下:
(1)称取组合物中各组分,超微粉碎至800目;
(2)将粉碎后的组合物加入到10-12倍量的清水中,搅匀;
(3)浸泡24小时后武火煮沸,之后改文火持续煎煮3小时;
(4)浓缩至含水量15-20%的稠膏。
本发明以中医传统理论为基础,针对瘀血阻络偏头痛,本发明中药以活血化瘀、通络止痛、益气养血为主要治则,按照中医君臣佐使关系组方,中药中:桃仁:活血祛瘀;川芎:活血行气、祛风止痛;九里香:活血散瘀,行气止痛;尖药花:活血消肿,益气补虚;鬼毛针:活血定痛;五药共为君药;滚山虫:祛风通络、散瘀止痛;八角枫:祛风除湿、舒筋活络、散瘀止痛;徐长卿:活血通络,祛风止痛;天麻:祛风通络、平肝潜阳、息风止痉;四药共为臣药;何首乌:养血滋阴、祛风、解毒;白芍:养血调经、敛阴止汗、柔肝止痛、平抑肝阳;党参:补中益气、生津养血;刺五加:益气健脾、补肾安神;四药共为佐药;甘草:补中益气、缓急止痛、调和诸药;为使药。
本发明的有益效果是:本发明中药以纯中药为原料,毒副作用小,针对瘀血阻络型偏头痛,活血化瘀、通络止痛、益气养血,治疗效果显著,药物经过超微粉碎,更大程度释放药效,中药膏剂,使用方便。
具体实施方式
本发明的具体实施方式如下:
实施例1:
一种治疗瘀血阻络型偏头痛的中药膏,由以下组分按照重量制备而成:
桃仁6g,川芎3g,九里香5g,尖药花5g,鬼毛针5g,八角枫3g,徐长卿3g,天麻5g,滚山虫:1g,何首乌:10g,白芍:5g,党参:10g,刺五加:5g,甘草3g。
制备方法具体步骤如下:
(1)称取组合物中各组分,超微粉碎至800目;
(2)将粉碎后的组合物加入到10-12倍量的清水中,搅匀;
(3)浸泡24小时后武火煮沸,之后改文火持续煎煮3小时;
(4)浓缩至含水量15-20%的稠膏。
实施例2:
一种治疗瘀血阻络型偏头痛的中药膏,由以下组分按照重量制备而成:
桃仁9g,川芎6g,九里香10g,尖药花10g,鬼毛针10g,八角枫6g,徐长卿6g,天麻10g,滚山虫:2g;何首乌:15g,白芍:10g,党参:15g,刺五加:10g,甘草6g。
制备方法具体步骤如下:
(1)称取组合物中各组分,超微粉碎至800目;
(2)将粉碎后的组合物加入到10-12倍量的清水中,搅匀;
(3)浸泡24小时后武火煮沸,之后改文火持续煎煮3小时;
(4)浓缩至含水量15-20%的稠膏。
实施例3:
一种治疗瘀血阻络型偏头痛的中药膏,由以下组分按照重量制备而成:
桃仁12g,川芎9g,九里香15g,尖药花15g,鬼毛针15g,八角枫9g,徐长卿9g,天麻15g,滚山虫3g,何首乌20g,白芍15g,党参20g,刺五加15g,甘草9g。
制备方法具体步骤如下:
(1)称取组合物中各组分,超微粉碎至800目;
(2)将粉碎后的组合物加入到10-12倍量的清水中,搅匀;
(3)浸泡24小时后武火煮沸,之后改文火持续煎煮3小时;
(4)浓缩至含水量15-20%的稠膏。
本发明药物的临床观察资料
1、一般资料
瘀血阻络型偏头痛门诊患者28例,其中男16例,女12例。
2、诊断标准
2.1头痛部位多在头部一侧额颞、前额、颠顶,或左或右辗转发作。头痛的性质多为跳痛、刺痛、胀痛、昏痛、隐痛,或头痛如裂等。头痛每次发作可持续数分钟、数小时、数天,也有持续数周者。瘀血阻络型偏头痛症候:偏头痛经久不愈,痛处固定不移,如锥如刺,或有头部外伤史,舌质紫暗,或有瘀斑、瘀点,脉细涩。
2.2隐袭起病,逐渐加重或反复发作。
2.3应查血常规,测血压,必要时做腰穿、骨穿,脑电图。有条件时做经颅多普勒、CT、磁共振等检查,以明确头痛的病因,排除器质性疾病。
2.4排除标准:
2.4.1排除雷头风雷头风起病急骤,头痛如雷鸣,头面部起核块,红肿热痛,常伴恶寒发热、大便燥结,多为湿热或痰火上冲所致。
2.4.2排除类中风类中风病多见于45岁以上,眩晕反复发作,头痛突然加重时,常兼半身肢体活动不灵,或舌蹇语涩,多为风痰壅盛所致。
3、治疗方法
将本发明制备的膏剂涂抹于太阳穴处,每处10g,每日1次,10天为1疗程,连续使用2个疗程。
4、疗效标准
(1)治愈:症状消失无复发,相关实验室检查正常;
(2)显效:症状消失,颈颅多普勒超声检查正常,半年以内无复发;
(3)有效:症状减轻,实验室检查有所改善;
(4)无效:症状及实验室检查均无改善。
5、治疗结果
使用本发明实施例2制备的药物涂抹于患者的两个太阳穴处,每处10g,每日1次,10天为1疗程,连续使用2个疗程。经过2个疗程的治疗,28例患者的治疗结果如下:
治愈:16例;显效:8例;有效:4例;无效:0例。
治疗期间无不良反应。
上述实施例是说明性的而不是限定性的,在本发明的治疗原则下,可按照所限定范围列举出若干个实施例,因此在不脱离本发明总体构思下的变化和修改,均属本发明的保护范围之内。
Claims (5)
1.一种治疗瘀血阻络型偏头痛的中药,其特征在于,含有以下组分:
桃仁,川芎,九里香,尖药花,鬼毛针,八角枫,徐长卿,天麻,滚山虫,何首乌,白芍,党参,刺五加,甘草。
2.根据权利要求1所述的治疗瘀血阻络型偏头痛的中药,其特征在于,含有以下重量分数的组分:
桃仁6-12份,川芎3-9份,九里香5-15份,尖药花5-15份,鬼毛针5-15份,
八角枫3-9份,徐长卿3-9份,天麻5-15份,滚山虫:1-3份,
何首乌:10-20份,白芍:5-15份,党参:10-20份,刺五加:5-15份,
甘草3-9份。
3.根据权利要求2所述的治疗瘀血阻络型偏头痛的中药,其特征在于,含有以下重量分数的组分:
桃仁9份,川芎6份,九里香10份,尖药花10份,鬼毛针10份,
八角枫6份,徐长卿6份,天麻10份,滚山虫:2份
何首乌:15份,白芍:10份,党参:15份,刺五加:10份,
甘草6份。
4.一种根据权利要求1-3所述的治疗瘀血阻络型偏头痛的中药的剂型,其特征在于,剂型为膏剂。
5.一种根据权利要求4所述的治疗瘀血阻络型偏头痛的中药膏剂的制备方法,其特征在于,具体步骤如下:
(1)称取组合物中各组分,超微粉碎至800目;
(2)将粉碎后的组合物加入到10-12倍量的清水中,搅匀;
(3)浸泡24小时后武火煮沸,之后改文火持续煎煮3小时;
(4)浓缩至含水量15-20%的稠膏。
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