CN1053546A - Preparation of tinea-curing medicine capable of forming thin film - Google Patents
Preparation of tinea-curing medicine capable of forming thin film Download PDFInfo
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- CN1053546A CN1053546A CN 90110108 CN90110108A CN1053546A CN 1053546 A CN1053546 A CN 1053546A CN 90110108 CN90110108 CN 90110108 CN 90110108 A CN90110108 A CN 90110108A CN 1053546 A CN1053546 A CN 1053546A
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- tinea
- preparation
- thin film
- clotrimazole
- forming thin
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Abstract
Preparation of tinea-curing medicine capable of forming thin film is the compound method that treatment fungal infection tinea is coated with ointment outward, preparation of tinea-curing medicine capable of forming thin film is as principal agent with clotrimazole, molten mixed solvent with dimethyl sulfoxide, ethanol, ethyl acetate, mixture mix homogeneously with sodium alginate soln, urea, glycerol forms again, technology is simple, power consumption less, easy to operate.The clean tinea liniment of making is all effective in cure to various dermatophytosis, and effective percentage reaches 98%, and release is fast, transdermal characteristic is strong, curative effect is fast, nonirritant, is membranaceous not pollution clothes, difficult drop-off after being coated with.
Description
Preparation of tinea-curing medicine capable of forming thin film is the compound method that treatment fungal infection tinea is coated with ointment outward, is that principal agent is formulated with the clotrimazole.
The clotrimazole liniment preparation technology of " pharmacy circular " the 9th phase 40 pages of records in 1980 is to get the ethanol that clotrimazole 2 gram is dissolved in 95% purity, filters 5 milliliters of phenol 1 gram, glycerol adding thermosol, adds the ethanol to 100 milliliter of 95% purity, and stirring forms.The course of processing needs to filter, and also wants Pyrogentisinic Acid, glycerol to heat, and remains on the thermosol state.The technology more complicated needs to consume more energy.Clotrimazole liniment adhesion is relatively poor, and penetration is poor.And the clotrimazole ointment preparation method of 276 pages of records of " Liaoning Province's drug standard " book that Liaoning Province Department of Public Health publishes, be get stearic acid 4%, octadecanol 5.5%, unit tristerin 3.5%, white vaseline 5%, glycerol 5%, and ethyl hydroxybenzoate 0.1% be heated to 85 ° and filter again, adding clotrimazole fine powder 3% stirring and dissolving again is first liquid; Other gets triethanolamine 0.2%, adds the suitable quantity of water dilution and is second liquid; Second liquid is being kept about 80 ° down, and impouring first liquid continues to be stirred to complete emulsifying, replenishes moisture content to 100% and makes.This preparation method, the number of raw material composition is more, need heating and be kept above under the room temperature to operate, need to consume more energy, technology more complicated, prepared clotrimazole ointment, adhesion is relatively poor, penetration is relatively poor, drug absorption is insufficient, and clotrimazole ointment is easily gone by other positions and object are sticking, and pollution clothes.
The object of the present invention is to provide that a kind of preparation needn't be heated, technological operation is fairly simple, drug penetration is strong, adhesive force is stronger, and clotrimazole is the preparation of tinea-curing medicine capable of forming thin film of principal agent.
Preparation of tinea-curing medicine capable of forming thin film of the present invention is:
A: get the ethanol 5-12% of dimethyl sulfoxide 4-15%, 95% above purity, the solvent of three kinds of clotrimazoles of ethyl acetate 12-30% is mixed into organic matchmaker, adds clotrimazole 1.5-4% again, is dissolved into a solution;
B, the sodium alginate soln 9-66% mixing of getting urea 5-20%, glycerol 6-10%, 4-6% add a solution again and mix.
Composite ointment shape is exactly clean tinea liniment.Technical process is carried out at normal temperatures, and the raw material composition umber of use is less.Operate fairly simple.Water insoluble because of clotrimazole, blended ethanol, ethyl acetate are convenient to the dissolving of clotrimazole as the solvent of clotrimazole, and dimethyl sulfoxide not only can dissolve clotrimazole, can also dissolve other adjuvant drugs, and can increase the transdermal characteristic (permeability) of medicine, make the transdermal characteristic of clean tinea liniment stronger.When clotrimazole being added the composite organic matchmaker of these three kinds of solvents, preferably be dissolved into clear and bright solution fully, a solution is dissolved into clear and bright a solution.Sodium alginate in the blended sodium alginate soln substrate can film forming as carrier, and what make clean tinea liniment is coated with the back film forming, is difficult for being bumped strong adhesion by other positions or object.And a solution is being added in urea, glycerol, the sodium alginate mixture process, constantly mix, make the abundant mix homogeneously of clean tinea liniment.Can repeatedly a solution be added and constantly mix the mix homogeneously of being more convenient for.
When the clotrimazole combined amount is less than 1.5%, mycocidal effect is not remarkable, therapeutic effect is not remarkable, when the clotrimazole combined amount greater than 4%, though fungicidal action strengthens, and needs the solvent amount also many, and reduce relatively as the amount of the sodium alginate of substrate, dosage form is destroyed, can not joined the clean tinea liniment of homogenizing.Urea is as adjuvant drug, and the solubilized horny layer increases the permeability of clotrimazole, and is also effective in cure to phosphorus shape tinea, chapped skin simultaneously.When the urea combined amount is less than 5%, permeability is reduced, drug effect is not remarkable, when the urea combined amount greater than 20%, easy dry and cracked fragmentation influences adhesive force after the film forming, the medicine film easily comes off naturally.Glycerol is wetting agent.When the glycerol combined amount was less than 6%, clean tinea liniment pondage reduced, and after the film forming, is rigid membranously, and elasticity, toughness are little, and is easily cracked and come off.When the glycerol combined amount greater than 9%, make clean tinea liniment water content excessive, be difficult for smearing film forming.When the ethanol combined amount is less than 5%, clotrimazole is all dissolved, if clotrimazole is all dissolved, must increase other solvent amounts, the pungent taste of clean tinea liniment is increased, will feel to skin irritation, and easily burning sensation be arranged.When the ethanol combined amount greater than 12% the time, though favourable to the dissolving clotrimazole, make the sodium alginate dissolving unfavorable, solidification phenomenon takes place.When the dimethyl sulfoxide combined amount is less than 4%, make to promote that transdermal characteristic significantly reduces, make curative effect not remarkable.When the dimethyl sulfoxide combined amount greater than 15%, the stimulation abnormal flavour is arranged, skin is had zest, burning sensation.When the ethyl acetate combined amount is less than 12%, clotrimazole is all dissolved, want to make clotrimazole all to dissolve, certainly will increase the content of other two kinds of molten coals.When the ethyl acetate combined amount greater than 30%, also occur to stimulate abnormal flavour, skin is had zest.Ethyl acetate is inflammable and explosive, has also increased the danger of preparation manipulation.
Generally be to mix the drug solution that contains sodium alginate 4~6%.Be lower than 4% sodium alginate soln and sneak into, make clean tinea liniment water content excessive, be coated in drying and forming-film overlong time on the skin, membranous soft excessively, influence clotrimazole and urea stability simultaneously, facile hydrolysis quickens.Be higher than 5% sodium alginate soln and sneak into, the sodium alginate soln denseness is big, is difficult to stir, and does not form mixture uniformly.
Preparation of tinea-curing medicine capable of forming thin film of the present invention is compared with existing technology has following advantage:
1. preparation process is to carry out at normal temperatures, needn't heat and be incubated.The raw material umber that adds is less.Operational process of craft is simple, convenient, less energy consumption, and safe and reliable, processing cost is low, and operating equipment is simple, easily forms the sterile working.
2. the clean tinea liniment of preparing is convenient to smear, and spreads upon easy film forming on the skin, and strong adhesion, film have certain toughness, elasticity, and difficult drop-off is had an effect medicine for a long time.Clean tinea membrane transdermal characteristic is stronger, makes principal agent clotrimazole and adjuvant drug urea infiltrate skin and plays one's part to the full good effect.
Further specify preparation of tinea-curing medicine capable of forming thin film of the present invention below in conjunction with example.Get dimethyl sulfoxide 5%(50 gram), the ethanol 6%(60 gram of purity 95%), ethyl acetate 15%(150 gram) mix homogeneously, add clotrimazole 2%(20 gram again), be dissolved into clear and bright a solution, i.e. organic a solution of clotrimazole.Get urea 10%(100 gram again), glycerol 7%(70 gram), 5% sodium alginate soln 50%(500 gram) mix homogeneously, the organic a solution with clotrimazole divides six addings then, and constantly mixes.The mixture that stirs just becomes the clean tinea liniment of paste of the present invention.The preparation device just wants some containers and agitator to get final product, and technical process need not heat and be incubated, and is simple to operate, safe and reliable.Make case treatment contrast test with the clotrimazole water preparation of clean tinea liniment of the present invention and 2%, 2% clotrimazole ointment.2% clotrimazole water preparation cure rate 81.3%, inefficiency 12.4%, average curative day 11.8 days.2% clotrimazole ointment cure rate 88%, inefficiency 8%, average curative day 11.2 days.And clean tinea liniment cure rate of the present invention reaches 98%, inefficiency 1%, average curative day 7.2 days.
Claims (4)
1, preparation of tinea-curing medicine capable of forming thin film:
After A, the ethanol 5--12%, the ethyl acetate 12--30% that get dimethyl sulfoxide 4--15%, 95% above purity mix, add clotrimazole 1.5--4%, be dissolved into a solution,
B, the sodium alginate soln 9--66% mixing of getting urea 5--20%, glycerol 6--10%, 4--6% add a solution again and mix.
2, preparation of tinea-curing medicine capable of forming thin film according to claim 1 is dissolved into clear and bright a solution.
3, preparation of tinea-curing medicine capable of forming thin film according to claim 1 and 2 adds a solution and constantly mixes.
4, preparation of tinea-curing medicine capable of forming thin film according to claim 3, gradation add a solution and constantly mix.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 90110108 CN1021798C (en) | 1990-12-19 | 1990-12-19 | Preparation of tinea-curing medicine capable of forming thin film |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 90110108 CN1021798C (en) | 1990-12-19 | 1990-12-19 | Preparation of tinea-curing medicine capable of forming thin film |
Publications (2)
Publication Number | Publication Date |
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CN1053546A true CN1053546A (en) | 1991-08-07 |
CN1021798C CN1021798C (en) | 1993-08-18 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN 90110108 Expired - Fee Related CN1021798C (en) | 1990-12-19 | 1990-12-19 | Preparation of tinea-curing medicine capable of forming thin film |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1062128C (en) * | 1995-08-18 | 2001-02-21 | 王阶平 | Ointment for eliminating tinea |
US9877983B2 (en) | 2007-11-27 | 2018-01-30 | Algipharma As | Use of alginate oligomers in combating biofilms |
-
1990
- 1990-12-19 CN CN 90110108 patent/CN1021798C/en not_active Expired - Fee Related
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1062128C (en) * | 1995-08-18 | 2001-02-21 | 王阶平 | Ointment for eliminating tinea |
US9877983B2 (en) | 2007-11-27 | 2018-01-30 | Algipharma As | Use of alginate oligomers in combating biofilms |
US10624920B2 (en) | 2007-11-27 | 2020-04-21 | Algipharma As | Use of alginate oligomers in combating biofilms |
Also Published As
Publication number | Publication date |
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CN1021798C (en) | 1993-08-18 |
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Co-applicant before: Affiliated Hospital of Medical College of Dalian University |
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