CN105350098A - Preparation device and method for nanofiber support having three-dimensional structure - Google Patents
Preparation device and method for nanofiber support having three-dimensional structure Download PDFInfo
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Abstract
The invention discloses a preparation device and method for a nanofiber support having a three-dimensional structure. The preparation device comprises an alternating-current high-voltage generator, a liquid supply device, an air supply device, a coaxial sprayer and a rotary receiver. The coaxial sprayer is provided with a liquid outlet and an air outlet. The air supply device is used for conveying a spinning solution or melts to the coaxial sprayer and enabling the spinning solution or melts to flow out of the liquid outlet. The air supply device can be used for generating air flow blowing from the liquid outlet to the rotary receiver via the air outlet. The alternating-current high-voltage generator forms an alternating electric field between the coaxial sprayer and the rotary receiver. The rotary receiver comprises a rotary shaft, a transmission device and support arms. A bowl-shaped revolution surface is formed when the support arms rotate with the rotary shaft. The spinning solution or melts flowing out of the liquid outlet form jet flow under effects of airflow and the alternating electric field.The preparation device and method for the nanofiber support having the three-dimensional structure have following beneficial effects: the method can be used for preparing a nanofiber three-dimensional support which is broad in material scope, tiny in fiber diameter, uniform in distribution of filament diameters, loose in structure, great in thickness and superior in mechanical properties; and the nanofiber three-dimensional support is stably in technology and good in universality and can be extensively applied to the field of tissue engineering.
Description
Technical field
The present invention is used for nano fiber scaffold technical field, particularly relates to a kind of nano fiber scaffold preparation facilities and the method with three-dimensional structure.
Background technology
In recent years, 3-D nano, structure is waited until showing great attention to of people in fields such as organizational projects and is furtherd investigate.The principle of organizational project is induction and promotes a series of physiological activities such as the growth of cell in vitro or in body, migration and propagation, and final formation has the organ or tissue of three-dimensional structure.The supporting structure how preparing function admirable directly decides the development of organizational project, and this also becomes domestic and international organizational project worker and is studying one of difficult problem of capturing always.
At present, nano fibrous tissue engineering support many employings method of electrostatic spinning is prepared.Electrospinning process has the advantages such as simple and efficient, with low cost, is expected to become the preparation method of desirable organizational project biomimetic scaffolds.But Traditional DC electrospinning process is used for the controlled three-dimensional structure of efficient preparation and still there is certain technical bottleneck.
Electrostatic spinning is prepared fibrous framework and is had following limitation:
1, traditional electrostatic spinning be spinning solution or melt under the orientation of direct current field force, form taylor cone, the final surface tension that breaks through forms jet.Jet is drawn into nanofiber under the effect of Coulomb force, and fiber is grounded collecting board layer by layer and attracts to pile up, and forms the support of film or approximate three-dimensional.But the fiber of support piles up by charge attraction, the space of arrangement closely, between fiber is too small, makes cell be difficult to grow into, cannot construct gratifying three-dimensional tissue.On the other hand, traditional direct current electrospinning, electric field force direction is constant, and when the viscosity of spinning solution or melt is larger, the starting resistor that jet needs is high.
2, along with film frame thickness increases, electric field between shower nozzle and collecting board will weaken gradually, film frame surface charges is caused constantly to accumulate, because of band like charges, the fiber first deposited has an impact to Electric Field Distribution, and subsequent shot is produced and repels, thus affect the formation of taylor cone and the duration of spinning, reduce spinning efficiency, finally cause electrospinning procedure ends, limit the thickness (being generally micron order thickness) that can obtain support, the electrospinning three-dimensional structure manufacturing the real meaning of heavy thickness is still comparatively difficult.
3, when adopting the collector of given shape, fiber deposits toward the place that the electric-field intensity such as most advanced and sophisticated place are larger, is difficult to form three-dimensional structure.
4, traditional sprinkler heads formula electrospinning inefficiency, single jet output only has 0.1-1g/h usually, is difficult to realize three-dimensional rack in large-scale, high-efficiency and manufactures.
High-speed air-blowing polymer solution prepares the technology (high velocity air spinning technology) of nanofiber on a large scale, the more original electrostatic spinning speed of the preparation speed of fiber can be made to improve more than 10 times, but, tradition gas spins the closed receiver of many employings or drum receiver, under action of high-speed airflow, easily produce recoil air-flow, affect the orientated deposition of fiber, how to adopt high speed gas to spin the nano fiber scaffold of three-dimensional fluff structure of getting everything ready, still lack the technique of stable versatility.Further, the fibre diameter comparatively large (micron order) of rotor spinning, diameter has a very wide distribution, and prepares nanofiber and still there is technical bottleneck.
The mainly electrostatic spinning (high direct voltage electrospinning) of current laboratory research and suitability for industrialized production application, high voltage source generally adopts direct current (DC) power supply as high voltage source; Exchanging electrospinning (ACelectrospinning) has had researcher to adopt as far back as the electrostatic spinning technique early stage of development, but is not still furtherd investigate so far and develop.Exchange electrospinning production efficiency relatively high.And exchanging electrospinning does not need ground connection or connects the collector of negative voltage, and the flexibility ratio of collection mode is higher.But, directional collecting have given shape, structure fibrous framework comparatively difficult, and production efficiency also needs to be improved further.
In sum, preparation material ranges is extensive, fibre diameter is minimum, string diameter is evenly distributed, structure is fluffy, thickness is very big, the nanofiber three-dimensional rack of excellent in mechanical performance does not still have general solution.
Summary of the invention
For solving the problem, the invention provides a kind of nano fiber scaffold preparation facilities and the method with three-dimensional structure, preparation method's technique is simple, and device is simple and easy, adaptability for materials is wide, and production efficiency is high, and obtainable three-dimensional rack thickness is large, density is low, and porosity is high, is expected to realize mass production.Use different spinning materials directly can prepare the Three Dimensional Fiber Scaffolds of different mechanical strength, biocompatibility and degradation property.
The technical solution adopted for the present invention to solve the technical problems is: a kind of nano fiber scaffold preparation facilities with three-dimensional structure, comprise ac high voltage generator, liquid feed device, feeder, Coaxial nozzle and the rotating receiver be oppositely arranged with described Coaxial nozzle, described Coaxial nozzle has the liquid feeding channel be connected with liquid feed device and the air supply channel be connected with feeder, liquid feeding channel has liquid outlet, spinning solution or melt can be sent into Coaxial nozzle and be flowed out by liquid outlet by liquid feed device, air supply channel has gas outlet, described feeder can produce the air-flow being blowed to rotating receiver by liquid outlet by gas outlet, ac high voltage generator is connected with described Coaxial nozzle and can forms alternating electric field between Coaxial nozzle and rotating receiver, described rotating receiver comprises rotating shaft, the transmission device of described axis of rotation can be driven and be located at the some support arms in described rotating shaft, support arm is with being formed just to the bowl-shape surface of revolution of described Coaxial nozzle during axis of rotation, the spinning solution flowed out in liquid outlet or melt form jet under the effect of described air-flow and alternating electric field between Coaxial nozzle and rotating receiver.
Be further used as the improvement of technical solution of the present invention, described feeder comprises the air pressure feeding mechanism be connected with air supply channel by appendix, described appendix is provided with accurate air pressure regulator, and appendix is also provided with heating element heater between accurate air pressure regulator and Coaxial nozzle.
Be further used as the improvement of technical solution of the present invention, described liquid feeding channel and air supply channel be equipped with temperature element, also comprise numerical control unit, described temperature element, liquid feed device, air pressure feeding mechanism are all connected with numerical control unit with heating element heater.
Be further used as the improvement of technical solution of the present invention, described support arm adopts bending sheet metal or Metallic rod or plastic bar, and each described support arm to be evenly distributed in described rotating shaft and to form bowl-shape pawl structure.
Be further used as the improvement of technical solution of the present invention, described air supply channel forms the air storing cavity surrounded outside liquid feeding channel in Coaxial nozzle, described air storing cavity forms the gas outlet of annular in the outside of described liquid outlet, described gas outlet and liquid outlet are positioned on same axis.
Be further used as the improvement of technical solution of the present invention, described ac high voltage generator comprises function signal generator and high-voltage amplifier.
There is a nano fiber scaffold preparation method for three-dimensional structure, comprise the following steps:
S10. liquid feed device can provide spinning solution or melt, opens liquid feed device, and spinning solution or melt enter Coaxial nozzle and flowed out by the liquid outlet of Coaxial nozzle;
S20. the rotating receiver be oppositely arranged with described Coaxial nozzle is started, rotating receiver comprises rotating shaft, can drive the transmission device of described axis of rotation and is located at the some support arms in described rotating shaft, and support arm is with being formed just to the bowl-shape surface of revolution of described Coaxial nozzle during axis of rotation;
S30. feeder is opened, numerical control unit controls feeder and provides the gas that flow velocity, temperature are suitable, gas flow is through the air supply channel of Coaxial nozzle, finally form air-flow from the ejection of Coaxial nozzle gas outlet, regulate ac high voltage generator, export the voltage of suitable waveform, frequency, amplitude, and form alternating electric field between Coaxial nozzle and rotating receiver;
S40., under the acting in conjunction of alternating electric field power and air-flow, spinning solution or melt drop are stretched formation jet, and under the continuous action of air-flow, and under the effect of alternating electric field power, jet Brazilian tension, obtains nanofiber;
S50. under airflow thrust effect, nanofiber is toward the orientated deposition of rotating receiver direction, and meanwhile, air-flow is derived from the side of rotating receiver, and aided nano fiber deposits and becomes three dimensional scaffold structure on rotating collector.
In the present invention, spinning solution or melt are under the effect of liquid feed device, flow to Coaxial nozzle and flowed out by the liquid outlet of Coaxial nozzle, under the acting in conjunction of alternating electric field and air-flow, surface tension is not enough to maintain poised state, thus the spontaneous formation multiple jets that breaks under the acting in conjunction of alternating electric field power and high velocity air, jet accelerates under alternating electric field power and air-flow thrust, electric field is change alternately, jet is alternately change electrically, continuation splitting is become more little jet, form more tiny fiber, continue to stretch under the effect of high velocity air simultaneously, fiber with different electric charge attracts each other, neutralization, form uncharged nanofiber.Under high velocity air thrust, fiber is toward the orientated deposition of rotating receiver direction, and meanwhile, air-flow is derived from the side of rotating receiver, and aided nano fiber deposits on the collector and becomes fluffy three dimensional scaffold structure.
Beneficial effect of the present invention: apparatus structure of the present invention is simple, can impel the nanofiber biological support of three-dimensional structure directly to be formed in the process exchanging pneumoelectric spinning.
Method technique of the present invention is simple, cost is lower, be suitable for solution electrospinning and melting electrospinning, be suitable for the Three Dimensional Fiber Scaffolds preparing different mechanical strength, biocompatibility and degradation property with different spinning materials, and can directly prepare a large amount of nanofiber biological support by the method;
Compared with preparing biological support with conventional electrostatic spinning, use the present invention to prepare nano fiber scaffold, because fiber becomes electroneutral, collector is without the need to ground connection or connect negative high voltage, more easily, effectively can deposit and form the large three-dimensional fibrous structure of thickness.And can not cause charge accumulated, do not make significant difference to subsequent fiber deposition, can carry out spinning for a long time, technique is more stable.
Compared with preparing biological support with conventional air spinning, invention introduces high-voltage alternating electric field, jet is under the acting in conjunction of air-flow shearing and alternating electric field, further stretching splitting, the three-dimensional rack fibre diameter obtained is thinner, and string diameter is more evenly distributed, excellent in mechanical performance, solve rotor spinning and prepare the fibre diameter of biological support greatly, the problem of string diameter skewness.
Compared with common interchange electrospinning, the present invention is under the acting in conjunction of alternating electric field and high velocity air, and production efficiency greatly improves, be the 10-20 of traditional electrospinning doubly.And under the effect of high velocity air shearing, exacerbate the disturbance to drop surface, the startup alternating voltage forming nanofiber significantly reduces, and meanwhile, solves the susceptible to plugging problem of shower nozzle, improves technology stability.And under the acting in conjunction of high velocity air and alternating electric field, jet stretching splitting, the nanofiber diameter of formation significantly reduces.
The thought in face is moved into according to line, innovatively use the rotating receiver of open type, the neutral nanofiber exchanging pneumoelectric spinning acquisition is carried out three-dimensional collect, compare classic flat-plate collector or closed collector, can high velocity air be effectively made to pass through, thus avoid producing recoil air-flow, affect fiber laydown.On the contrary, high velocity air also can play deposition guide effect, the nanofibres deposit that orientable supplementary AC pneumoelectric spinning obtains under airflow thrust effect, becomes the Three Dimensional Fiber Scaffolds with given shape, structure, solves the problem exchanging electrospinning fiber collecting difficulty.
Traditional electrostatic spinning is under the effect of electric field, is successively attracted to pile up by electrically contrary ground connection collecting board, and the fiber alignment of the support space closely, between fiber is too small, makes cell be difficult to grow into, cannot construct gratifying three-dimensional tissue.When adopting the collector of given shape, fiber deposits toward the place that the electric-field intensity such as most advanced and sophisticated place are larger, is difficult to form three-dimensional structure.And adopt the present invention, jet stretching splitting under alternating electric field and high velocity air acting in conjunction, jet is alternately change electrically, the nanofiber formed is electroneutral, and on rotation open type receiver, three-dimensional structure is deposited as under air-flow is auxiliary, can obtain thickness greatly, loose, low-density support, be more conducive to Growth of Cells.
The present invention can prepare that material ranges is extensive, fibre diameter is minimum, string diameter is evenly distributed, structure is fluffy, thickness is very big, the nanofiber three-dimensional rack of excellent in mechanical performance, and process stabilizing, versatility is good, can be widely used in field of tissue engineering technology.
Accompanying drawing explanation
Below in conjunction with accompanying drawing, the invention will be further described:
Fig. 1 is structural representation of the present invention;
Fig. 2 is Coaxial nozzle structural representation of the present invention.
Detailed description of the invention
With reference to Fig. 1, Fig. 2, that show the concrete structure of the preferred embodiment of the present invention.To the design feature of the present invention each element be described in detail below, and if be described to direction (upper and lower, left and right, before and after) time, be with the structure shown in Fig. 1 for reference to describing, but actual user of the present invention is to being not limited thereto.
The invention provides a kind of nano fiber scaffold preparation facilities with three-dimensional structure, comprise numerical control unit 1, ac high voltage generator 2, liquid feed device 3, feeder 4, Coaxial nozzle 5 and the rotating receiver 6 be oppositely arranged with described Coaxial nozzle 5, described Coaxial nozzle 5 has the liquid feeding channel 51 be connected with liquid feed device 3 and the air supply channel 52 be connected with feeder 4, liquid feeding channel 51 has liquid outlet 53, spinning solution or melt can be sent into Coaxial nozzle 5 and be flowed out by liquid outlet 53 by liquid feed device 51, air supply channel 52 has gas outlet 54, described feeder 4 can produce the air-flow being blowed to rotating receiver 6 by liquid outlet 53 by gas outlet 54, ac high voltage generator 2 is connected with described Coaxial nozzle 5 and can forms alternating electric field between Coaxial nozzle 5 and rotating receiver 6, described rotating receiver 6 comprises rotating shaft 61, the transmission device 62 that described rotating shaft 61 can be driven to rotate and the some support arms 63 be located in described rotating shaft 61, described support arm 63 adopts the sheet metal or Metallic rod or plastic bar that bend, each described support arm 63 to be evenly distributed in described rotating shaft 61 and to form bowl-shape pawl structure.Can be formed just to the bowl-shape surface of revolution of described Coaxial nozzle 5 when support arm 63 rotates with rotating shaft 61, the spinning solution flowed out in liquid outlet 53 or melt form jet under the effect of described air-flow and alternating electric field between Coaxial nozzle 5 and rotating receiver 6.
Wherein, described feeder 4 comprises the air pressure feeding mechanism 42 be connected with air supply channel 52 by appendix 41, described appendix 41 is provided with accurate air pressure regulator 43, and appendix 41 is also provided with heating element heater 44 between accurate air pressure regulator 43 and Coaxial nozzle 5.Described liquid feeding channel 51 and air supply channel 52 are equipped with temperature element 7, described temperature element 7, liquid feed device 3, air pressure feeding mechanism 42 are all connected with numerical control unit 1 with heating element heater 44, by regulating numerical control unit 1 to control air pressure feeding mechanism 42 and heating element heater 44, provide the air-flow of different air pressure, temperature, humidity, kind.Described air supply channel 52 forms the air storing cavity 55 surrounded outside liquid feeding channel 51 in Coaxial nozzle 5, described air storing cavity 55 forms the gas outlet 54 of annular in the outside of described liquid outlet 53, described gas outlet 54 and liquid outlet 53 are positioned on same axis, liquid outlet 53 aperture is 0.1mm-0.6mm, and aperture, gas outlet 54 is 0.6mm-1mm.Portion gas is had to be retained in air storing cavity 55, maintain the environment temperature of Coaxial nozzle 5 inside, melt in liquid feeding channel 51 is made to keep molten condition, when overcoming that conventional melt shower nozzle is little at flow, flow velocity is low, because of the adverse effect such as melt solidifying, shower nozzle blocking that poor thermal insulation property causes.
Described ac high voltage generator 2 comprises function signal generator and high-voltage amplifier, and described ac high voltage generator 2 can provide the voltage of random waveform, frequency, amplitude.
There is a nano fiber scaffold preparation method for three-dimensional structure, comprise the following steps:
S10. liquid feed device 51 can provide spinning solution or melt, opens liquid feed device 51, and spinning solution or melt enter Coaxial nozzle 5 and flowed out by the liquid outlet 53 of Coaxial nozzle 5;
S20. the rotating receiver 6 be oppositely arranged with described Coaxial nozzle 5 is started, the transmission device 62 that rotating receiver 6 comprises rotating shaft 61, described rotating shaft 61 can be driven to rotate and the some support arms 63 be located in described rotating shaft 61, formed just to the bowl-shape surface of revolution of described Coaxial nozzle 5 when support arm 63 rotates with rotating shaft 61;
S30. feeder 4 is opened, numerical control unit 1 controls feeder 4 and provides the gas that flow velocity, temperature are suitable, gas flow is through the air supply channel 52 of Coaxial nozzle 5, finally form air-flow from the ejection of Coaxial nozzle 5 gas outlet 54, regulate ac high voltage generator 2, export the voltage of suitable waveform, frequency, amplitude, and form alternating electric field between Coaxial nozzle 5 and rotating receiver 6;
S40., under the acting in conjunction of alternating electric field power and air-flow, spinning solution or melt drop are stretched formation jet, and under the continuous action of air-flow, and under the effect of alternating electric field power, jet Brazilian tension, obtains nanofiber;
S50. under airflow thrust effect, nanofiber is toward rotating receiver 6 direction orientated deposition, and meanwhile, air-flow is derived from the side of rotating receiver 6, and aided nano fiber deposits and becomes three dimensional scaffold structure on rotating collector 6.
Can respectively with reference to following embodiment for spinning solution and melt:
Embodiment 1:
1. spinning solution preparation, takes 1200 milligrams of PLLA(molecular weight=200,000 dalton), be dissolved in 20ml(9:1, CH
2cl
2/ DMF, v/v) in solvent, obtained 6%PLLA solution, by sealed membrane sealing, magnetic agitation 4 hours, stand-by.
2. regulate liquid feed device parameter, capacity 15 milliliters, fltting speed 5 mls/hour, run.PLLA solution is delivered to Coaxial nozzle 5, enters liquid outlet by liquid feeding channel 51, liquid outlet diameter is 0.3 millimeter;
3. the distance adjusted between Coaxial nozzle 5 to rotating collector 6 is 20cm, adjusting transmission device 62, and pawl structure is rotated under motor or other transmission devices drive, and rotary rpm is 1300rpm, forms the virtual bowl-shape surface of revolution;
4. open feeder 4, numerical control unit 1 is regulated to carry out air pressure adjustment, adjustable pressure is 0.75MPa, regulate numerical control unit 1 to regulate gas flow temperature, air-flow is heated to 30 DEG C, thermal current is through air supply channel 52, finally spray from gas outlet, regulate ac high voltage generator 2, output frequency is 100Hz, and peak-to-peak value is the sinusoidal High Level AC Voltage of 8KV;
5. under the acting in conjunction of high-voltage alternating electric field and high velocity air, the spontaneous formation multiple jets of jet break, jet accelerates under electric field force and air-flow thrust, continuation splitting is become more little jet, form more tiny fiber, continue to stretch simultaneously under the effect of high velocity air, form uncharged PLLA nanofiber;
6. under high velocity air thrust, fiber is toward rotating receiver direction deposition, and meanwhile, air-flow is derived from the side (gap of support arm) of rotating receiver 6, and assists PLLA nanofiber to deposit on the collector and become three dimensional scaffold structure;
Gained three-dimensional manometer fibrous framework, outward appearance is cotton candy shape silk group, and structure is fluffy, and pore diameter is 30 μm ~ 300 μm, and fibre diameter is 150nm ~ 1 μm.
Embodiment 2:
Present case is raw material with PLA, and detailed process is as follows:
1, take PLA as raw material, add in liquid feed device 3 by 10 grams of PLAs, after PLA is heated to molten condition in liquid feed device 3, polylactic acid melt is delivered to Coaxial nozzle 5, enters liquid outlet by liquid feeding channel, liquid outlet diameter is 0.5 millimeter;
2, the distance adjusted between Coaxial nozzle 5 to rotating collector 6 is 20cm, adjusting transmission device, and pawl structure is rotated under motor or other transmission devices drive, and rotary rpm is 1300rpm, forms virtual bowl-shape revolution receiving plane;
3, open feeder, regulate numerical control unit to carry out air pressure adjustment, adjustable pressure is 0.75MPa, and regulate numerical control unit to regulate gas flow temperature, air-flow is heated to 180-200 DEG C, and thermal current, through air supply channel, finally sprays from gas outlet; Portion gas is retained in air storing cavity, maintains the environment temperature of Coaxial nozzle inside, and make the polylactic acid melt in liquid feeding channel keep molten condition, regulate ac high voltage generator, output frequency is 90Hz, and peak-to-peak value is the sinusoidal High Level AC Voltage of 9KV;
4, under the acting in conjunction of alternating electric field and high velocity air, the spontaneous formation multiple jets of jet break, jet accelerates under electric field force and air-flow thrust, continuation splitting is become more little jet, form more tiny fiber, continue to stretch simultaneously under the effect of high velocity air, form uncharged nanofiber;
5, under high velocity air thrust, fiber is toward rotating receiver direction deposition, and meanwhile, air-flow is derived from the side of rotating receiver, and assists acid fiber by polylactic to deposit on the collector and become nanometer three dimensional scaffold structure;
Certainly, the invention is not limited to above-mentioned embodiment, those of ordinary skill in the art also can make equivalent variations or replacement under the prerequisite without prejudice to spirit of the present invention, and these equivalent modification or replacement are all included in the application's claim limited range.
Claims (7)
1. one kind has the nano fiber scaffold preparation facilities of three-dimensional structure, it is characterized in that: comprise ac high voltage generator, liquid feed device, feeder, Coaxial nozzle and the rotating receiver be oppositely arranged with described Coaxial nozzle, described Coaxial nozzle has the liquid feeding channel be connected with liquid feed device and the air supply channel be connected with feeder, liquid feeding channel has liquid outlet, spinning solution or melt can be sent into Coaxial nozzle and be flowed out by liquid outlet by liquid feed device, air supply channel has gas outlet, described feeder can produce the air-flow being blowed to rotating receiver by liquid outlet by gas outlet, ac high voltage generator is connected with described Coaxial nozzle and can forms alternating electric field between Coaxial nozzle and rotating receiver, described rotating receiver comprises rotating shaft, the transmission device of described axis of rotation can be driven and be located at the some support arms in described rotating shaft, support arm is with being formed just to the bowl-shape surface of revolution of described Coaxial nozzle during axis of rotation, the spinning solution flowed out in liquid outlet or melt form jet under the effect of described air-flow and alternating electric field between Coaxial nozzle and rotating receiver.
2. the nano fiber scaffold preparation facilities with three-dimensional structure according to claim 1, it is characterized in that: described feeder comprises the air pressure feeding mechanism be connected with air supply channel by appendix, described appendix is provided with accurate air pressure regulator, and appendix is also provided with heating element heater between accurate air pressure regulator and Coaxial nozzle.
3. the nano fiber scaffold preparation facilities with three-dimensional structure according to claim 2, it is characterized in that: described liquid feeding channel and air supply channel are equipped with temperature element, also comprise numerical control unit, described temperature element, liquid feed device, air pressure feeding mechanism are all connected with numerical control unit with heating element heater.
4. the nano fiber scaffold preparation facilities with three-dimensional structure according to claim 1,2 or 3, it is characterized in that: described support arm adopts bending sheet metal or Metallic rod or plastic bar, each described support arm to be evenly distributed in described rotating shaft and to form bowl-shape pawl structure.
5. the nano fiber scaffold preparation facilities with three-dimensional structure according to claim 1,2 or 3, it is characterized in that: described air supply channel forms the air storing cavity surrounded outside liquid feeding channel in Coaxial nozzle, described air storing cavity forms the gas outlet of annular in the outside of described liquid outlet, described gas outlet and liquid outlet are positioned on same axis.
6. the nano fiber scaffold preparation facilities with three-dimensional structure according to claim 1,2 or 3, is characterized in that: described ac high voltage generator comprises function signal generator and high-voltage amplifier.
7. there is a nano fiber scaffold preparation method for three-dimensional structure, it is characterized in that, comprise the following steps:
S10. liquid feed device can provide spinning solution or melt, opens liquid feed device, and spinning solution or melt enter Coaxial nozzle and flowed out by the liquid outlet of Coaxial nozzle;
S20. the rotating receiver be oppositely arranged with described Coaxial nozzle is started, rotating receiver comprises rotating shaft, can drive the transmission device of described axis of rotation and is located at the some support arms in described rotating shaft, and support arm is with being formed just to the bowl-shape surface of revolution of described Coaxial nozzle during axis of rotation;
S30. feeder is opened, numerical control unit controls feeder and provides the gas that flow velocity, temperature are suitable, gas flow is through the air supply channel of Coaxial nozzle, finally form air-flow from the ejection of Coaxial nozzle gas outlet, regulate ac high voltage generator, export the voltage of suitable waveform, frequency, amplitude, and form alternating electric field between Coaxial nozzle and rotating receiver;
S40., under the acting in conjunction of alternating electric field power and air-flow, spinning solution or melt drop are stretched formation jet, and under the continuous action of air-flow, and under the effect of alternating electric field power, jet Brazilian tension, obtains nanofiber;
S50. under airflow thrust effect, nanofiber is toward the orientated deposition of rotating receiver direction, and meanwhile, air-flow is derived from the side of rotating receiver, and aided nano fiber deposits and becomes three dimensional scaffold structure on rotating collector.
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| CN110205685A (en) * | 2019-05-23 | 2019-09-06 | 东华大学 | Spinning self-regulation electrostatic spinning apparatus and its application method |
| CN111118742A (en) * | 2020-02-13 | 2020-05-08 | 潘定雨 | Multi-layer non-woven fabric fiber spinning device and spinning method, non-woven fabric and filter material |
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| CN111118742B (en) * | 2020-02-13 | 2020-11-17 | 安徽昊华环保科技有限公司 | Multi-layer non-woven fabric fiber spinning device and spinning method, non-woven fabric and filter material |
| WO2024051014A1 (en) * | 2022-09-06 | 2024-03-14 | 深圳先进技术研究院 | Continuous fiber diameter-variable extrusion-type 3d printing method, and printing system and application |
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