CN105343597A - Traditional Chinese medicine composition mainly for treating lymphoma and preparation method thereof - Google Patents
Traditional Chinese medicine composition mainly for treating lymphoma and preparation method thereof Download PDFInfo
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- CN105343597A CN105343597A CN201510782256.7A CN201510782256A CN105343597A CN 105343597 A CN105343597 A CN 105343597A CN 201510782256 A CN201510782256 A CN 201510782256A CN 105343597 A CN105343597 A CN 105343597A
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Abstract
The invention discloses a traditional Chinese medicine composition mainly for treating lymphoma. The traditional Chinese medicine composition is prepared from 8-13 parts by mass of duckweed, 9-14 parts by mass of Leucas zeylanica, 7-12 parts by mass of cow pea root, 6-13 parts by mass of flower of Japanese banana, 9-15 parts by mass of Osmanthus fragrans syrup, 3-8 parts by mass of muskroot-like semiaquilegia root, 9-13 parts by mass of blighted wheat, 7-14 parts by mass of root of Chinese wingleaf prickyash, 6-12 parts by mass of Betaphycus gelatinae, 4-10 parts by mass of Hypericum patulum, 7-11 parts by mass of Atalantia buxifolia, 6-11 parts by mass of fructus sophorae, 9-12 parts by mass of hairyvein agrimony, 7-13 parts by mass of herb of black medick, 6-15 parts by mass of lamium amplexicaule and 8-14 parts by mass of root of ricepaperplant. Years of clinical practice proves that the traditional Chinese medicine composition has substantial effects of reducing swelling and resolving mass, clearing away heat and toxic materials, and promoting qi to activate blood.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the Chinese medicine composition and preparation method that cure mainly lymphatic cancer.
Background technology
Lymphatic cancer is during this disease is more common in, young, male patient is more than women, and the age occurred frequently is 45-60 years old.This disease can be divided into Hokdkin disease and the large class of non_hodgkin lymphoma two by the difference of its cell component.Its grade malignancy differs, and caused by lymph one histiocyte system neoplasm, mostly occurs in lymph node.Being primary in lymph node or other adenoid malignant tumor, is one of common ten large malignant tumor of China.The topical manifestations of lymphatic cancer is 1. lymphadenectasis: comprise shallow table and deep lymph node, is characterized in that the lymph node of enlargement is Progressive symmetric erythrokeratodermia, Silent Neuritis, and matter is hard, how can promote, in early days adhesion each other, and late period then can merge, and antiinflammatory, antituberculosis therapy are invalid.Superficial lymph knot is common with cervical region, is secondly oxter and abdomen victory ditch.Deep is common with mediastinum, ventral aorta side.2. lymphadenectasis causes local compression symptom: mainly refer to deep lymph node, and as the mediastinal lymph nodes of enlargement, compressing esophagus can cause dysphagia; Compressing superior vena cava causes superior vena cava syndrome; Tracheas suppressed causes cough, uncomfortable in chest, dyspnea and cyanosis etc.General Symptoms is heating, pole night sweat of becoming thin.
Publication No. CN104043057A(application number 201410302127.9) Chinese patent literature openly to know clearly a kind of Chinese medicine composition for the treatment of lymphatic cancer, belong to technical field of Chinese medicines, the crude drug making medicament effective component by following weight parts is: Radix Curcumae, Eupolyphaga Seu Steleophaga, Radix Paeoniae Rubra, Spica Prunellae, Pericarpium Citri Reticulatae Viride, Radix Bupleuri, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Oletum Trogopterori, Rhizoma Chuanxiong, the Radix Rehmanniae, Radix Scrophulariae, the Rhizoma Anemarrhenae, Rhizoma Curcumae Longae, the Rhizoma Pinelliae, Fructus Psoraleae, Radix Angelicae Pubescentis, Rhizoma Acori Graminei, Fructus Lycii, Rhizoma Sparganii, Rhizoma Curcumae, Rhizoma Cyperi, Radix Notoginseng, Concha Ostreae, Radix Glycyrrhizae.Publication No. CN104173920A(application number 201410375839.3) Chinese patent literature disclose a kind of medicine for the treatment of lymphatic cancer, be made up of following raw material: Myrrha, Radix Sophorae Flavescentis, the Radix Astragali, Radix Glycyrrhizae, the Rhizoma Pinelliae, Bufo siccus, Scolopendra, Calculus Bovis, Herba Sarcandrae, Rhizoma Curcumae, Herba Taraxaci, Sargassum, Pericarpium Citri Reticulatae Viride, Radix Bupleuri, Radix Angelicae Sinensis, Flos Carthami.Publication No. CN103386109A(application number 201310328287.6) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of lymphatic cancer, its formula form: Radix Semiaquilegiae, Rhizoma Paridis, Pseudobulbus Cremastrae seu Pleiones, Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Herba Taraxaci, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Zingiberis, Lu Tong, Radix Glycyrrhizae, Flos Lonicerae, Arisaema Cum Bile, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Gekko Swinhonis, Scolopendra, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae 23 taste Chinese medicine composition.
The method being used for the treatment of lymphatic cancer is at present that primary and secondary effect is comparatively large mainly with chemicotherapy, and clinical effectiveness is each variant, causes larger misery to patient, and the Chinese medicine formula that a kind of curative effect is reliable in order to provide, side effect is little, need strengthen research in this respect.
Summary of the invention
For the problem of prior art, the object of this invention is to provide a kind of Be very effective, take the wide Chinese medicine composition curing mainly lymphatic cancer of safe and applicable and preparation method.
Technical scheme of the present invention is:
Cure mainly the Chinese medicine composition of lymphatic cancer, be prepared from primarily of following bulk drugs, be mass parts: Herba Spirodelae 8-13; Herba leucadis zeylanicae 9-14; Radix vignae sinensis 7-12; Flos Musae 6-13; Liquor Flos osmanthi Distillata 9-15; Radix Semiaquilegiae 3-8; Fructus Tritici Levis 9-13; Radix Zanthoxyli Planispini 7-14; Eucheuma gelatinosum 6-12; Herba Hyperici Patuli 4-10; East wind Fructus Citri tangerinae 7-11; Fructus Sophorae 6-11; Herba Agrimoniae 9-12; Herba Medicaginis Lupulinae 7-13; Herba Lamii Amplexicaulis 6-15; Radix tetrapanacis Koch 8-14.
Preferred version is, Herba Spirodelae 9-12; Herba leucadis zeylanicae 10-13; Radix vignae sinensis 9-10; Flos Musae 8-11; Liquor Flos osmanthi Distillata 11-13; Radix Semiaquilegiae 4-7; Fructus Tritici Levis 10-12; Radix Zanthoxyli Planispini 9-12; Eucheuma gelatinosum 8-10; Herba Hyperici Patuli 6-8; East wind Fructus Citri tangerinae 8-10; Fructus Sophorae 7-10; Herba Agrimoniae 10-11; Herba Medicaginis Lupulinae 9-11; Herba Lamii Amplexicaulis 8-13; Radix tetrapanacis Koch 10-12.
More preferably, Herba Spirodelae 10.5; Herba leucadis zeylanicae 11.5; Radix vignae sinensis 9.5; Flos Musae 9.5; Liquor Flos osmanthi Distillata 12; Radix Semiaquilegiae 5.5; Fructus Tritici Levis 11; Radix Zanthoxyli Planispini 10.5; Eucheuma gelatinosum 9; Herba Hyperici Patuli 7; East wind Fructus Citri tangerinae 9; The Fructus Sophorae 8.5; Herba Agrimoniae 10.5; Herba Medicaginis Lupulinae 10; Herba Lamii Amplexicaulis 10.5; Radix tetrapanacis Koch 11.
The preparation method of the decoction of described Chinese medicine composition, step is as follows:
(1) Herba Spirodelae, Herba leucadis zeylanicae, Herba Medicaginis Lupulinae and Herba Lamii Amplexicaulis wash quickly is got clean, under 80 DEG C of environment, constant temperature drying to surface is yellow, take out and mix thoroughly with crystal sugar water while hot, be together placed in frying pan with Rhizoma Zingiberis, slow fire stir-fry 12-24 minute (preferred: slow fire stir-fries 16-20 minute; Be more preferably: slow fire stir-fries 18 minutes), take out, removing Rhizoma Zingiberis;
(2) by Fructus Tritici Levis and Fructus Sophorae removing impurity, add two kinds of crude drug quality 1-2 yellow wine doubly (preferred: the yellow wine adding two kinds of crude drug quality 1.5 times) and soak 10 minutes, big fire is heated to wine and is sucked, and takes out and is placed in frying pan, slow fire stir-fries to being charred taste effusion, and taking-up is pulverized;
(3) get Radix vignae sinensis, Radix Semiaquilegiae, Radix Zanthoxyli Planispini, east wind Fructus Citri tangerinae and Radix tetrapanacis Koch removing impurity, soak 10-18 minute (preferably: soak 12-16 minute with washing water of rice; Be more preferably: soak 14 minutes), take out, be cut into sheet, add Sal and mix thoroughly, slow fire stir-fries to surperficial zoom, and taking-up cools;
(4) Flos Musae, Eucheuma gelatinosum, Herba Hyperici Patuli and Herba Agrimoniae are cleaned remove impurity, be placed in marmite, add total raw material medicine quality 5-8 water doubly (preferably: add total raw material medicine quality 6-7 water doubly; Be more preferably: the water adding total raw material medicine quality 6.5 times), big fire is boiled to boiling, then adds step (1) (2) (3) made crude drug, turns little fire and continues to decoct, filter, collect filtrate after closing fire;
(5) Liquor Flos osmanthi Distillata is added in step (4) gained filtrate, stirs, obtain decoction.
The preparation method of described Chinese medicine composition decoction, the little fire of step (4) continues to decoct 23-35 minute (preferably: little fire continues to decoct 27-31 minute; Be more preferably: little fire continues decoction 29 minutes).
The preparation method of the unguentum of described Chinese medicine composition, step is as follows:
(1) Herba Spirodelae, Herba leucadis zeylanicae, Herba Medicaginis Lupulinae and Herba Lamii Amplexicaulis wash quickly is got clean, under 80 DEG C of environment, constant temperature drying to surface is yellow, take out and mix thoroughly with crystal sugar water while hot, be together placed in frying pan with Rhizoma Zingiberis, slow fire stir-fry 12-24 minute (preferred: slow fire stir-fries 16-20 minute; Be more preferably: slow fire stir-fries 18 minutes), take out, removing Rhizoma Zingiberis;
(2) by Fructus Tritici Levis and Fructus Sophorae removing impurity, add two kinds of crude drug quality 1-2 yellow wine doubly (preferred: the yellow wine adding two kinds of crude drug quality 1.5 times) and soak 10 minutes, big fire is heated to wine and is sucked, and takes out and is placed in frying pan, slow fire stir-fries to being charred taste effusion, and taking-up is pulverized;
(3) get Radix vignae sinensis, Radix Semiaquilegiae, Radix Zanthoxyli Planispini, east wind Fructus Citri tangerinae and Radix tetrapanacis Koch removing impurity, soak 10-18 minute (preferably: soak 12-16 minute with washing water of rice; Be more preferably: soak 14 minutes), take out, be cut into sheet, add Sal and mix thoroughly, slow fire stir-fries to surperficial zoom, and taking-up cools;
(4) Flos Musae, Eucheuma gelatinosum, Herba Hyperici Patuli and Herba Agrimoniae are cleaned remove impurity, be placed in marmite, add total raw material medicine quality 5-8 water doubly (preferably: add total raw material medicine quality 6-7 water doubly; Be more preferably: the water adding total raw material medicine quality 6.5 times), big fire is boiled to boiling, then adds step (1) (2) (3) made crude drug, turns little fire and continues decoction 20 minutes, filter, collect filtrate after closing fire;
(5) be added to by Liquor Flos osmanthi Distillata in step (4) gained filtrate, stir, heating is concentrated into thick paste, adds refined honey mixing, obtains unguentum.
The preparation method of described Traditional Chinese medicine composition paste, it is the 0.3-0.5 of thick paste quality doubly (preferred: to add 0.4 times that refined honey amount is thick paste quality) that step (5) adds refined honey amount.
The preparation method of the tablet of described Chinese medicine composition, step is as follows:
(1) Herba Spirodelae, Herba leucadis zeylanicae, Herba Medicaginis Lupulinae and Herba Lamii Amplexicaulis wash quickly is got clean, under 80 DEG C of environment, constant temperature drying to surface is yellow, take out and mix thoroughly with crystal sugar water while hot, be together placed in frying pan with Rhizoma Zingiberis, slow fire stir-fry 12-24 minute (preferred: slow fire stir-fries 16-20 minute; Be more preferably: slow fire stir-fries 18 minutes), take out, removing Rhizoma Zingiberis;
(2) by Fructus Tritici Levis and Fructus Sophorae removing impurity, add two kinds of crude drug quality 1-2 yellow wine doubly (preferred: the yellow wine adding two kinds of crude drug quality 1.5 times) and soak 10 minutes, big fire is heated to wine and is sucked, and takes out and is placed in frying pan, slow fire stir-fries to being charred taste effusion, and taking-up is pulverized;
(3) get Radix vignae sinensis, Radix Semiaquilegiae, Radix Zanthoxyli Planispini, east wind Fructus Citri tangerinae and Radix tetrapanacis Koch removing impurity, soak 10-18 minute (preferably: soak 12-16 minute with washing water of rice; Be more preferably: soak 14 minutes), take out, be cut into sheet, add Sal and mix thoroughly, slow fire stir-fries to surperficial zoom, and taking-up cools;
(4) Flos Musae, Eucheuma gelatinosum, Herba Hyperici Patuli and Herba Agrimoniae are cleaned remove impurity, be placed in marmite, add total raw material medicine quality 5-8 water doubly (preferably: add total raw material medicine quality 6-7 water doubly; Be more preferably: the water adding total raw material medicine quality 6.5 times), big fire is boiled to boiling, then adds step (1) (2) (3) made crude drug, turns little fire and continues decoction 20 minutes, filter, collect filtrate after closing fire;
(5) be added to by Liquor Flos osmanthi Distillata in step (4) gained filtrate, stir, heating is concentrated, and oven dry pulverizes and sieves, and makes medicated powder, is crushed to round sheet dosage form, obtains tablet according to the preparation method of tablet.
The preparation method of described Chinese medicine composition tablet, it is (preferred: to pulverize 80-100 mesh sieve that step (5) pulverized 60-120 mesh sieve; Be more preferably: pulverized 90 mesh sieves).
The preparation method of the granule of described Chinese medicine composition, step is as follows:
(1) Herba Spirodelae, Herba leucadis zeylanicae, Herba Medicaginis Lupulinae and Herba Lamii Amplexicaulis wash quickly is got clean, under 80 DEG C of environment, constant temperature drying to surface is yellow, take out and mix thoroughly with crystal sugar water while hot, be together placed in frying pan with Rhizoma Zingiberis, slow fire stir-fry 12-24 minute (preferred: slow fire stir-fries 16-20 minute; Be more preferably: slow fire stir-fries 18 minutes), take out, removing Rhizoma Zingiberis;
(2) by Fructus Tritici Levis and Fructus Sophorae removing impurity, add two kinds of crude drug quality 1-2 yellow wine doubly (preferred: the yellow wine adding two kinds of crude drug quality 1.5 times) and soak 10 minutes, big fire is heated to wine and is sucked, and takes out and is placed in frying pan, slow fire stir-fries to being charred taste effusion, and taking-up is pulverized;
(3) get Radix vignae sinensis, Radix Semiaquilegiae, Radix Zanthoxyli Planispini, east wind Fructus Citri tangerinae and Radix tetrapanacis Koch removing impurity, soak 10-18 minute (preferably: soak 12-16 minute with washing water of rice; Be more preferably: soak 14 minutes), take out, be cut into sheet, add Sal and mix thoroughly, slow fire stir-fries to surperficial zoom, and taking-up cools;
(4) Flos Musae, Eucheuma gelatinosum, Herba Hyperici Patuli and Herba Agrimoniae are cleaned remove impurity, be placed in marmite, decoct with water to boiling, then add step (1) (2) (3) made crude drug, turn little fire and continue to decoct 23-35 minute (preferably: little fire continues to decoct 27-31 minute; Be more preferably: little fire continues decoction 29 minutes), filter after closing fire, collect filtrate;
(5) mixed homogeneously with step (4) gained filtrate by Liquor Flos osmanthi Distillata, spraying dry, makes medicated powder, and add adjuvant mixing, obtain mixed powder, mixed powder is made granule, dry granulate at 60 DEG C, namely sterilization packaging obtains granule.
The preparation method of described Chinese medicinal composition granules, step (4) amount of water is the 6-8 of total raw material medicine quality doubly (preferred: amount of water is 7 times of total raw material medicine quality).
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Herba Spirodelae: base is former: be the herb of plant and of its applications duckweed or Herba Spirodelae.Nature and flavor: acrid in the mouth; Cold in nature.Gui Jing: lung; Urinary bladder channel.Function cures mainly: relieving the exterior syndrome by diaphoresis; Rash is antipruritic; Inducing diuresis to remove edema; Heat-clearing and toxic substances removing.Main air hotlist is demonstrate,proved; Measles without adequate eruption; Urticaria pruritus; Edema; The difficulty in urination; Skin ulcer tinea; Erysipelas; Scald.
Herba leucadis zeylanicae: base is former: for labiate crape face is careless and the herb of honeybee fruit grass.Nature and flavor: acrid in the mouth; Bitter; Property is put down.Function cures mainly: removing toxic substances; Cough-relieving; Improving eyesight; Stimulate the menstrual flow.Main flu; Headache; Asthma; Pertussis; Laryngopharynx swelling and pain; Toothache; Dyspepsia; Menoxenia; Amenorrhea; Extort under false pretense blind; Cellular furuncle.
Radix vignae sinensis: base is former: be the root of leguminous plant Semen vignae sinensis.Nature and flavor: sweet; Flat.Gui Jing: spleen; Stomach warp.Function cures mainly: invigorating the spleen and benefiting QI; Removing food stagnancy; Removing toxic substances.Main weakness of the spleen and stomach; Food stagnation; Leucorrhea; Stranguria with turbid discharge; Hemorrhoidal bleeding; Furuncle.
Flos Musae: base is former: be the flower of Musaceae plant Musa basjoo Sieb. Et Zucc..Nature and flavor: sweet in the mouth; Micro-pungent; Cool in nature.Gui Jing: the heart; Liver; Stomach; Large intestine channel.Function cures mainly: the painful abdominal mass that disappears of reducing phlegm; Dissipating blood stasis; Pain relieving.Main chest and diaphragm is glutted; Gastral cavity abdomen painful abdominal mass is ached; Acid regurgitation regurgitation; Vomiting sputum; The head is giddy; Pained; Palpitation with a distress feeling; Rheumatalgia.
Liquor Flos osmanthi Distillata: base is former: for the flower of Oleaceae plants sweet-scented osmanthus is through distillable liquid.Nature and flavor: micro-pungent; Micro-hardship; Warm in nature.Function cures mainly: depressed liver-energy dispersing and QI regulating; Being amusing, it is dirty to ward off; Improving eyesight; Wet one's whistle.Main depression of liver-QI; The breast side of body does not relax; Swelling of the gum; Toothache; Dry pharynx; Dry mouth; Halitosis.
Radix Semiaquilegiae: base is former: be the tuber of ranunculaceae plant Radix Semiaquilegiae.Nature and flavor: bitter in the mouth; Micro-hardship; Micro-pungent; Cold in nature; Mild toxicity.Gui Jing: liver; Spleen; Urinary bladder channel.Function cures mainly: heat-clearing and toxic substances removing; Dispersing swelling and dissipating binds; Relieving stranguria by diuresis.Main children's's heat is frightened; Epilepsy; Carbuncle; Furuncle; Acute mastitis; Scrofula; Skin itching sore; Conjunctival congestion and swelling pain; Pharyngalgia; Snake bite and insect sting; Pyretic stranguria; Sand Stranguria.
Fructus Tritici Levis: base is former: the fruit of the frivolous lack of filling power of drying of grass family Triticum plant Semen Tritici aestivi.Gather during fruit maturation, get the wheat grain of the frivolous and non-peeling of lack of filling power, decontamination, sieve dedust bits, with water rinse, dry.Nature and flavor: sweet are cool.Function cures mainly: only sweating due to debility, tranquilizing by nourishing the heart.For the empty hyperhidrosis of body, hysteria.
Radix Zanthoxyli Planispini: base is former: be root bark or the root of rutaceae Fructus Zanthoxyli Plansipini.Nature and flavor: pungent; Bitter; Temperature; Mild toxicity.Gui Jing: lung meridian.Function cures mainly: expelling wind and cold; Warming middle-JIAO is regulated the flow of vital energy; Promoting blood circulation and stopping pain.Main air pain of dampness syndrome; Stomachache with cool feeling; Have loose bowels; Dysentery; Headache due to common cold; Toothache; Traumatic injury; Dysmenorrhea; Knife injury is hemorrhage; Stubborn dermatitis; Venom.
Eucheuma gelatinosum: base is former: be the frond of Hong Ling dish section plant Eucheuma gelatinosum.Chemical analysis: containing carrageenin, by β-, κ-, ε-, γ-, μ-, υ-carrageenin formed, its main component is partial desulfurization acid esters kappa carrageenan, and submember is partial desulfurization acid esters μ-carrageenin, and may also mix in the polysaccharide chain of submember has methylgalactose base and acetone acid acetal radical.Nature and flavor: sweet; Salty; Cold; Nontoxic.Gui Jing: lung; Liver; Large intestine channel.Function cures mainly: removing heat from the lung and dissipating phlegm; Hard masses softening and resolving; Removing toxic substances.Main phlegm-heat cough; Gall subcutaneous nodule; Swelling and pain of hemorrhoid or hematochezia; Enteritis.
Herba Hyperici Patuli: base is former: be the Herb of Garcinia maingayii Herba Hyperici Patuli.Nature and flavor: bitter; Cold.Gui Jing: liver; Kidney; Urinary bladder channel.Function cures mainly: clearing away heat-damp and promoting diuresis detoxifies; Dispersing the stagnated liver-QI and dredging collateral; Stasis-dispelling and pain-killing.Main damp and hot gonorrhea; Hepatitis; Flu; Tonsillitis; The hernia swelling and hanging down of either of the testes; Bones and muscles pain; Traumatic injury.
East wind Fructus Citri tangerinae: base is former: be root and the leaf of Rutaceae wine cake Jin platymiscium wine cake Jin.Nature and flavor: " Guangxi book on Chinese herbal medicine a collection of selected materials ": " mildly bitter flavor, pungent, gas is fragrant, warm in nature." function cures mainly: preventing phlegm from forming and stopping coughing, promoting the circulation of QI to relieve pain.Cure mainly cough, stomachache, hernia, rheumatic arthralgia, treating swelling and pain by traumatic injury.
The Fructus Sophorae: base is former: be the fruit of leguminous plant Chinese scholartree.Nature and flavor: bitter in the mouth; Cold in nature.Function cures mainly: cooling blood for hemostasis; Liver heat removing and eyesight improving.Main bleeding hemorrhoids; Discharging fresh blood stool; Dysentery; Metrorrhagia; Stranguria with blood; Heat in blood tells nosebleed; Liver-heat conjunctival congestion; Have a dizzy spell.
Herba Agrimoniae: base is former: be the dry aerial parts of rosaceous plant Agrimony.Nature and flavor with return through: bitter, puckery, flat.GUIXIN, Liver Channel.Function with cure mainly: astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances, tonify deficiency.For spitting of blood, spit blood, metrostaxis, malaria, dysentery, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia, de-power impairment caused by overstrain.
Herba Medicaginis Lupulinae: base is former: be the herb of leguminous plant shamrock.Nature and flavor: sweet; Bitter; Micro-puckery; Cool in nature; Mild toxicity.Gui Jing: lung; Liver; Gallbladder; Kidney channel.Function cures mainly: clearing away heat-damp and promoting diuresis; Relaxing muscles and tendons and activating QI and blood in the collateral; Relieving cough and asthma; Removing pathogenic heat from blood and toxic substance from the body.Main jaundice due to damp-heat; Pyretic stranguria; Stone jaundice due to damp-heat; Pyretic stranguria; Stranguria caused by urinary stone; Rheumatic arthralgia; Cough with asthma; Hemorrhoidal bleeding; Finger furuncle; Venom.
Herba Lamii Amplexicaulis: base is former: be the herb of labiate Herba Lamii Amplexicaulis.Nature and flavor: acrid in the mouth; Bitter; Slightly warm in nature.Function cures mainly: promoting blood circulation to remove obstruction in the collateral; Removing toxic substances and promoting subsidence of swelling.Main traumatic injury; Bones and muscles pain; Numb limbs and tense tendons; Hemiplegia; Face is completed; Jaundice; Nasal sinusitis; Scrofula; Toxic swelling; Impetigo.
Radix tetrapanacis Koch: base is former: be the root of Araliaceae rice-paper plant.Nature and flavor: taste is scorching; Micro-hardship; Cold nature.Function cures mainly: clearing away heat and promoting diuresis; Promote qi circulation digestion promoting; To invigorate blood circulation stimulating milk secretion.Main edema; Stranguria; Food stagnation drink is swollen; Mass in the abdomen; Rheumatic arthralgia; Menoxenia; Agalactia.
The Traditional Chinese medicine composition formula science curing mainly lymphatic cancer provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention, therapeutic effect is good, and remission rate is high, effectively can prevent recurrence;
2, this formula is summed up through clinical practice for many years and is formed, and has effect of dispersing swelling and dissipating binds, promoting flow of QI and blood;
3, Chinese crude drug selected by the present invention, safe and non-stimulating, and toxic and side effects is little, applied widely.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1cure mainly the Chinese medicine composition of lymphatic cancer, be prepared from (every part of 10g) primarily of following bulk drugs: 8 parts, Herba Spirodelae, Herba leucadis zeylanicae 9 parts, Radix vignae sinensis 7 parts, Flos Musae 6 parts, Liquor Flos osmanthi Distillata 9 parts, Radix Semiaquilegiae 3 parts, Fructus Tritici Levis 9 parts, Radix Zanthoxyli Planispini 7 parts, Eucheuma gelatinosum 6 parts, Herba Hyperici Patuli 4 parts, east wind Fructus Citri tangerinae 7 parts, the Fructus Sophorae 6 parts, Herba Agrimoniae 9 parts, Herba Medicaginis Lupulinae 7 parts, Herba Lamii Amplexicaulis 6 parts, Radix tetrapanacis Koch 8 parts.The above-mentioned preparation method curing mainly the decoction of the Chinese medicine composition of lymphatic cancer is:
(1) get Herba Spirodelae, Herba leucadis zeylanicae, Herba Medicaginis Lupulinae and Herba Lamii Amplexicaulis wash quickly clean, under 80 DEG C of environment, constant temperature drying is to surface in yellow, and take out and mix thoroughly with crystal sugar water while hot, be together placed in frying pan with Rhizoma Zingiberis, slow fire stir-fries 18 minutes, takes out, removing Rhizoma Zingiberis;
(2) by Fructus Tritici Levis and Fructus Sophorae removing impurity, the yellow wine adding two kinds of crude drug quality 1.5 times soaks 10 minutes, and big fire is heated to wine and is sucked, and takes out and is placed in frying pan, and slow fire stir-fries to being charred taste effusion, and taking-up is pulverized;
(3) get Radix vignae sinensis, Radix Semiaquilegiae, Radix Zanthoxyli Planispini, east wind Fructus Citri tangerinae and Radix tetrapanacis Koch removing impurity, soak 14 minutes with washing water of rice, take out, be cut into sheet, add Sal and mix thoroughly, slow fire stir-fries to surperficial zoom, and taking-up cools;
(4) Flos Musae, Eucheuma gelatinosum, Herba Hyperici Patuli and Herba Agrimoniae are cleaned remove impurity, be placed in marmite, add the water of total raw material medicine quality 6.5 times, big fire is boiled to boiling, then adds step (1) (2) (3) made crude drug, turns little fire and continues decoction 29 minutes, filter after closing fire, collect filtrate;
(5) Liquor Flos osmanthi Distillata is added in step (4) gained filtrate, stirs, obtain decoction.
embodiment 2cure mainly the Chinese medicine composition of lymphatic cancer, be prepared from (every part of 10g) primarily of following bulk drugs: 13 parts, Herba Spirodelae, Herba leucadis zeylanicae 14 parts, Radix vignae sinensis 12 parts, Flos Musae 13 parts, Liquor Flos osmanthi Distillata 15 parts, Radix Semiaquilegiae 8 parts, Fructus Tritici Levis 13 parts, Radix Zanthoxyli Planispini 14 parts, Eucheuma gelatinosum 12 parts, Herba Hyperici Patuli 10 parts, east wind Fructus Citri tangerinae 11 parts, the Fructus Sophorae 11 parts, Herba Agrimoniae 12 parts, Herba Medicaginis Lupulinae 13 parts, Herba Lamii Amplexicaulis 15 parts, Radix tetrapanacis Koch 14 parts.The above-mentioned preparation method curing mainly the unguentum of the Chinese medicine composition of lymphatic cancer is:
(1) get Herba Spirodelae, Herba leucadis zeylanicae, Herba Medicaginis Lupulinae and Herba Lamii Amplexicaulis wash quickly clean, under 80 DEG C of environment, constant temperature drying is to surface in yellow, and take out and mix thoroughly with crystal sugar water while hot, be together placed in frying pan with Rhizoma Zingiberis, slow fire stir-fries 18 minutes, takes out, removing Rhizoma Zingiberis;
(2) by Fructus Tritici Levis and Fructus Sophorae removing impurity, the yellow wine adding two kinds of crude drug quality 1.5 times soaks 10 minutes, and big fire is heated to wine and is sucked, and takes out and is placed in frying pan, and slow fire stir-fries to being charred taste effusion, and taking-up is pulverized;
(3) get Radix vignae sinensis, Radix Semiaquilegiae, Radix Zanthoxyli Planispini, east wind Fructus Citri tangerinae and Radix tetrapanacis Koch removing impurity, soak 14 minutes with washing water of rice, take out, be cut into sheet, add Sal and mix thoroughly, slow fire stir-fries to surperficial zoom, and taking-up cools;
(4) Flos Musae, Eucheuma gelatinosum, Herba Hyperici Patuli and Herba Agrimoniae are cleaned remove impurity, be placed in marmite, add the water of total raw material medicine quality 6.5 times, big fire is boiled to boiling, then adds step (1) (2) (3) made crude drug, turns little fire and continues decoction 20 minutes, filter after closing fire, collect filtrate;
(5) be added to by Liquor Flos osmanthi Distillata in step (4) gained filtrate, stir, heating is concentrated into thick paste, adds the refined honey mixing of thick paste quality 0.4 times, obtains unguentum.
Model case: xxx, male, 39 years old.Main suit: bilateral neck has lump, quality is hard; Medical history: the bimester of patient, front discovery cervical region has lump, that touches is comparatively hard, does not take notice of during beginning, after realize that lump increases gradually, and with uncomfortable diseases such as low heat coughs, then arrive examination in hospital, through pathological analysis, be diagnosed as lymphatic cancer.
The basis of chemotherapy is taken this example gained unguentum, each 6-10g, warm boiled water, one day twice 25 days is a course for the treatment of, after patient takes a course for the treatment of, lump fades away, and uncomfortable disease obviously alleviates, after adhering to taking three courses for the treatment of, clinical uncomfortable disease is eliminated substantially, lump disappears substantially, and after consolidating a course for the treatment of, patient fully recovers, follow up a case by regular visits in 1 year, the state of an illness is without recurrence.
embodiment 3cure mainly the Chinese medicine composition of lymphatic cancer, be prepared from (every part of 10g) primarily of following bulk drugs: 9 parts, Herba Spirodelae, Herba leucadis zeylanicae 10 parts, Radix vignae sinensis 9 parts, Flos Musae 8 parts, Liquor Flos osmanthi Distillata 11 parts, Radix Semiaquilegiae 4 parts, Fructus Tritici Levis 10 parts, Radix Zanthoxyli Planispini 9 parts, Eucheuma gelatinosum 8 parts, Herba Hyperici Patuli 6 parts, east wind Fructus Citri tangerinae 8 parts, the Fructus Sophorae 7 parts, Herba Agrimoniae 10 parts, Herba Medicaginis Lupulinae 9 parts, Herba Lamii Amplexicaulis 8 parts, Radix tetrapanacis Koch 10 parts.The above-mentioned preparation method curing mainly the tablet of the Chinese medicine composition of lymphatic cancer is:
(1) get Herba Spirodelae, Herba leucadis zeylanicae, Herba Medicaginis Lupulinae and Herba Lamii Amplexicaulis wash quickly clean, under 80 DEG C of environment, constant temperature drying is to surface in yellow, and take out and mix thoroughly with crystal sugar water while hot, be together placed in frying pan with Rhizoma Zingiberis, slow fire stir-fries 18 minutes, takes out, removing Rhizoma Zingiberis;
(2) by Fructus Tritici Levis and Fructus Sophorae removing impurity, the yellow wine adding two kinds of crude drug quality 1.5 times soaks 10 minutes, and big fire is heated to wine and is sucked, and takes out and is placed in frying pan, and slow fire stir-fries to being charred taste effusion, and taking-up is pulverized;
(3) get Radix vignae sinensis, Radix Semiaquilegiae, Radix Zanthoxyli Planispini, east wind Fructus Citri tangerinae and Radix tetrapanacis Koch removing impurity, soak 14 minutes with washing water of rice, take out, be cut into sheet, add Sal and mix thoroughly, slow fire stir-fries to surperficial zoom, and taking-up cools;
(4) Flos Musae, Eucheuma gelatinosum, Herba Hyperici Patuli and Herba Agrimoniae are cleaned remove impurity, be placed in marmite, add the water of total raw material medicine quality 6.5 times, big fire is boiled to boiling, then adds step (1) (2) (3) made crude drug, turns little fire and continues decoction 20 minutes, filter after closing fire, collect filtrate;
(5) be added to by Liquor Flos osmanthi Distillata in step (4) gained filtrate, stir, heating is concentrated, dries and pulverizes 90 mesh sieves, make medicated powder, be crushed to round sheet dosage form, obtain tablet according to the preparation method of tablet.
Model case: xxx, women, 47 years old.Medical history: patient was detected lymphatic cancer before half a year, accepted chemotherapy in hospital, after two courses for the treatment of, tumor regression is not obvious, because economy is comparatively difficult, just determine to stop treatment, recuperation of going home, its cardinal symptom is that body void is weak, cough heating, spirit is poor, loses confidence to life.
Recommend to take this example gained tablet, each 2-3 grain, warm boiled water through people, one day twice 25 days is a course for the treatment of, after patient takes a course for the treatment of, uncomfortable disease is taken a turn for the better gradually, and lump goes down to some extent, after continuing to take three courses for the treatment of, patient mental takes a turn for the better, and muscle power strengthens, and lump is substantially not tangible, return institute's check, lump is eliminated, and patient restarts orthobiosis, follow up a case by regular visits in two years, the state of an illness does not recur.
embodiment 4cure mainly the Chinese medicine composition of lymphatic cancer, be prepared from (every part of 10g) primarily of following bulk drugs: 12 parts, Herba Spirodelae, Herba leucadis zeylanicae 13 parts, Radix vignae sinensis 10 parts, Flos Musae 11 parts, Liquor Flos osmanthi Distillata 13 parts, Radix Semiaquilegiae 7 parts, Fructus Tritici Levis 12 parts, Radix Zanthoxyli Planispini 12 parts, Eucheuma gelatinosum 10 parts, Herba Hyperici Patuli 8 parts, east wind Fructus Citri tangerinae 10 parts, the Fructus Sophorae 10 parts, Herba Agrimoniae 11 parts, Herba Medicaginis Lupulinae 11 parts, Herba Lamii Amplexicaulis 13 parts, Radix tetrapanacis Koch 12 parts.The above-mentioned preparation method curing mainly the granule of the Chinese medicine composition of lymphatic cancer is:
(1) get Herba Spirodelae, Herba leucadis zeylanicae, Herba Medicaginis Lupulinae and Herba Lamii Amplexicaulis wash quickly clean, under 80 DEG C of environment, constant temperature drying is to surface in yellow, and take out and mix thoroughly with crystal sugar water while hot, be together placed in frying pan with Rhizoma Zingiberis, slow fire stir-fries 18 minutes, takes out, removing Rhizoma Zingiberis;
(2) by Fructus Tritici Levis and Fructus Sophorae removing impurity, the yellow wine adding two kinds of crude drug quality 1.5 times soaks 10 minutes, and big fire is heated to wine and is sucked, and takes out and is placed in frying pan, and slow fire stir-fries to being charred taste effusion, and taking-up is pulverized;
(3) get Radix vignae sinensis, Radix Semiaquilegiae, Radix Zanthoxyli Planispini, east wind Fructus Citri tangerinae and Radix tetrapanacis Koch removing impurity, soak 14 minutes with washing water of rice, take out, be cut into sheet, add Sal and mix thoroughly, slow fire stir-fries to surperficial zoom, and taking-up cools;
(4) Flos Musae, Eucheuma gelatinosum, Herba Hyperici Patuli and Herba Agrimoniae are cleaned remove impurity, be placed in marmite, add the soak by water of total raw material medicine quality 7 times to boiling, add step (1) (2) (3) made crude drug again, turn little fire and continue decoction 29 minutes, filter after closing fire, collect filtrate;
(5) mixed homogeneously with step (4) gained filtrate by Liquor Flos osmanthi Distillata, spraying dry, makes medicated powder, and add adjuvant mixing, obtain mixed powder, mixed powder is made granule, dry granulate at 60 DEG C, namely sterilization packaging obtains granule.
Model case: xxx, male, 63 years old.Main suit: repeatability is generated heat, weak with body void, inappetence; Medical history: patient occurred fever phenomenon without obvious inducement before one week, after taking medicine, effect is not remarkable, then goes to see a doctor, and finds two axillary fossa, inguinal lymphadenopathy on inspection, is diagnosed as malignant lymphoma.
The basis of chemotherapy is taken this example gained granule, each 3-4g, warm boiled water, one day twice 25 days is a course for the treatment of, after patient takes a course for the treatment of, lymph lump significantly diminishes, complexion takes a turn for the better, and appetite strengthens, after continuing to take three courses for the treatment of, lump is all eliminated, check indices is all normal, follows up a case by regular visits in two years, without recurrence.
embodiment 5cure mainly the Chinese medicine composition of lymphatic cancer, be prepared from (every part of 10g) primarily of following bulk drugs: 10.5 parts, Herba Spirodelae, Herba leucadis zeylanicae 11.5 parts, Radix vignae sinensis 9.5 parts, Flos Musae 9.5 parts, Liquor Flos osmanthi Distillata 12 parts, Radix Semiaquilegiae 5.5 parts, Fructus Tritici Levis 11 parts, Radix Zanthoxyli Planispini 10.5 parts, Eucheuma gelatinosum 9 parts, Herba Hyperici Patuli 7 parts, east wind Fructus Citri tangerinae 9 parts, the Fructus Sophorae 8.5 parts, Herba Agrimoniae 10.5 parts, Herba Medicaginis Lupulinae 10 parts, Herba Lamii Amplexicaulis 10.5 parts, Radix tetrapanacis Koch 11 parts.The above-mentioned preparation method curing mainly the decoction of the Chinese medicine composition of lymphatic cancer is:
(1) get Herba Spirodelae, Herba leucadis zeylanicae, Herba Medicaginis Lupulinae and Herba Lamii Amplexicaulis wash quickly clean, under 80 DEG C of environment, constant temperature drying is to surface in yellow, and take out and mix thoroughly with crystal sugar water while hot, be together placed in frying pan with Rhizoma Zingiberis, slow fire stir-fries 18 minutes, takes out, removing Rhizoma Zingiberis;
(2) by Fructus Tritici Levis and Fructus Sophorae removing impurity, the yellow wine adding two kinds of crude drug quality 1.5 times soaks 10 minutes, and big fire is heated to wine and is sucked, and takes out and is placed in frying pan, and slow fire stir-fries to being charred taste effusion, and taking-up is pulverized;
(3) get Radix vignae sinensis, Radix Semiaquilegiae, Radix Zanthoxyli Planispini, east wind Fructus Citri tangerinae and Radix tetrapanacis Koch removing impurity, soak 14 minutes with washing water of rice, take out, be cut into sheet, add Sal and mix thoroughly, slow fire stir-fries to surperficial zoom, and taking-up cools;
(4) Flos Musae, Eucheuma gelatinosum, Herba Hyperici Patuli and Herba Agrimoniae are cleaned remove impurity, be placed in marmite, add the water of total raw material medicine quality 6.5 times, big fire is boiled to boiling, then adds step (1) (2) (3) made crude drug, turns little fire and continues decoction 29 minutes, filter after closing fire, collect filtrate;
(5) Liquor Flos osmanthi Distillata is added in step (4) gained filtrate, stirs, obtain decoction.
test example 1gained of the present invention cures mainly the clinical practice of the Chinese medicine composition (embodiment 5) of lymphatic cancer:
Choose crowd: in April ,-2015 in June, 2014, according to medical case history, screen lymphatic cancer patient 226 example of accepting for medical treatment in four hospitals, age 30-72 year, 53.8 ± 2.4 years old mean age, the course of disease 2 months-11 months, wherein male patient 119 example, female patient 107 example.All patients all make a definite diagnosis through the imaging examinations such as CT and pathological examination, and rejecting merges serious hepatic renal dysfunction, anemia, severe infections, obviously bleeding tendency, estimates that life span is less than 3 months persons.
Before test, patient is divided into two groups at random, experimental group 140 example and matched group 86 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Matched group adopts chemotherapy; Experimental group takes products obtained therefrom of the present invention on chemotherapeutical basis, each 200-250ml, one day twice, warmly takes, and within 25 days, is a course for the treatment of.Treatments period carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) complete incidence graph CR: focus disappears completely, maintains more than 4 weeks, does not occur new focus; (2) partial rcsponse PR: focus reduces more than 50%, maintains more than 4 weeks, does not occur new focus; (3) unchanged NC: focus reduce less than 50% or increase be no more than 25%, there is not new focus; (4) PD is worsened: focus increases more than 25% or have new focus to occur.Remission rate=(CR+PR) number of cases/total number of cases × 100%, control rate=(CR+PR+NC) number of cases/total number of cases × 100%.
Clinical effectiveness: after the treatment of four courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:
The complete incidence graph patient of experimental group is 44 examples, and partial rcsponse patient is 57 examples, and remission rate is 72.1%, and control rate is 92.8%; In matched group, complete incidence graph patient is 20 examples, and partial rcsponse patient is 32 examples, and remission rate is 60.5%, and control rate is 77.9%, is starkly lower than the therapeutic effect of experimental group, and illustrate that products obtained therefrom of the present invention is evident in efficacy, remission effect is good.
Follow up a case by regular visits in two years, the patient of experimental group has 14 example recurrences, and relapse rate is 10.0%, and have 36 routine Patients on Recurrences in matched group, relapse rate is 41.9%, illustrates that products obtained therefrom of the present invention effectively can control cancerous cell diffusion, prevents recurrence.
The Chinese medicine used in the present invention, Herba Spirodelae heat-clearing and toxic substances removing, Herba leucadis zeylanicae removing toxic substances cough-relieving, Radix vignae sinensis invigorating the spleen and benefiting QI, Flos Musae eliminating stasis to stop pain, Liquor Flos osmanthi Distillata depressed liver-energy dispersing and QI regulating, Radix Semiaquilegiae dispersing swelling and dissipating binds, Fructus Tritici Levis tranquilizing by nourishing the heart, Radix Zanthoxyli Planispini promoting blood circulation and stopping pain, Eucheuma gelatinosum hard masses softening and resolving, Herba Hyperici Patuli dispersing the stagnated liver-QI and dredging collateral, east wind Fructus Citri tangerinae promoting the circulation of QI to relieve pain, Fructus Sophorae cooling blood for hemostasis, Herba Agrimoniae astringing to arrest bleeding, Herba Medicaginis Lupulinae relaxing muscles and tendons and activating QI and blood in the collateral, Herba Lamii Amplexicaulis removing toxic substances and promoting subsidence of swelling, Radix tetrapanacis Koch promote qi circulation digestion promoting, multiple medical material synergism, plays effect of dispersing swelling and dissipating binds, heat-clearing and toxic substances removing, promoting flow of QI and blood altogether.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. cure mainly the Chinese medicine composition of lymphatic cancer, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Herba Spirodelae 8-13; Herba leucadis zeylanicae 9-14; Radix vignae sinensis 7-12; Flos Musae 6-13; Liquor Flos osmanthi Distillata 9-15; Radix Semiaquilegiae 3-8; Fructus Tritici Levis 9-13; Radix Zanthoxyli Planispini 7-14; Eucheuma gelatinosum 6-12; Herba Hyperici Patuli 4-10; East wind Fructus Citri tangerinae 7-11; Fructus Sophorae 6-11; Herba Agrimoniae 9-12; Herba Medicaginis Lupulinae 7-13; Herba Lamii Amplexicaulis 6-15; Radix tetrapanacis Koch 8-14.
2. cure mainly the Chinese medicine composition of lymphatic cancer as claimed in claim 1, it is characterized in that, Herba Spirodelae 9-12; Herba leucadis zeylanicae 10-13; Radix vignae sinensis 9-10; Flos Musae 8-11; Liquor Flos osmanthi Distillata 11-13; Radix Semiaquilegiae 4-7; Fructus Tritici Levis 10-12; Radix Zanthoxyli Planispini 9-12; Eucheuma gelatinosum 8-10; Herba Hyperici Patuli 6-8; East wind Fructus Citri tangerinae 8-10; Fructus Sophorae 7-10; Herba Agrimoniae 10-11; Herba Medicaginis Lupulinae 9-11; Herba Lamii Amplexicaulis 8-13; Radix tetrapanacis Koch 10-12(is preferably: Herba Spirodelae 10.5; Herba leucadis zeylanicae 11.5; Radix vignae sinensis 9.5; Flos Musae 9.5; Liquor Flos osmanthi Distillata 12; Radix Semiaquilegiae 5.5; Fructus Tritici Levis 11; Radix Zanthoxyli Planispini 10.5; Eucheuma gelatinosum 9; Herba Hyperici Patuli 7; East wind Fructus Citri tangerinae 9; The Fructus Sophorae 8.5; Herba Agrimoniae 10.5; Herba Medicaginis Lupulinae 10; Herba Lamii Amplexicaulis 10.5; Radix tetrapanacis Koch 11).
3. the preparation method of the decoction of the Chinese medicine composition as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) Herba Spirodelae, Herba leucadis zeylanicae, Herba Medicaginis Lupulinae and Herba Lamii Amplexicaulis wash quickly is got clean, under 80 DEG C of environment, constant temperature drying to surface is yellow, take out and mix thoroughly with crystal sugar water while hot, be together placed in frying pan with Rhizoma Zingiberis, slow fire stir-fry 12-24 minute (preferred: slow fire stir-fries 16-20 minute; Be more preferably: slow fire stir-fries 18 minutes), take out, removing Rhizoma Zingiberis;
(2) by Fructus Tritici Levis and Fructus Sophorae removing impurity, add two kinds of crude drug quality 1-2 yellow wine doubly (preferred: the yellow wine adding two kinds of crude drug quality 1.5 times) and soak 10 minutes, big fire is heated to wine and is sucked, and takes out and is placed in frying pan, slow fire stir-fries to being charred taste effusion, and taking-up is pulverized;
(3) get Radix vignae sinensis, Radix Semiaquilegiae, Radix Zanthoxyli Planispini, east wind Fructus Citri tangerinae and Radix tetrapanacis Koch removing impurity, soak 10-18 minute (preferably: soak 12-16 minute with washing water of rice; Be more preferably: soak 14 minutes), take out, be cut into sheet, add Sal and mix thoroughly, slow fire stir-fries to surperficial zoom, and taking-up cools;
(4) Flos Musae, Eucheuma gelatinosum, Herba Hyperici Patuli and Herba Agrimoniae are cleaned remove impurity, be placed in marmite, add total raw material medicine quality 5-8 water doubly (preferably: add total raw material medicine quality 6-7 water doubly; Be more preferably: the water adding total raw material medicine quality 6.5 times), big fire is boiled to boiling, then adds step (1) (2) (3) made crude drug, turns little fire and continues to decoct, filter, collect filtrate after closing fire;
(5) Liquor Flos osmanthi Distillata is added in step (4) gained filtrate, stirs, obtain decoction.
4. the preparation method of Chinese medicine composition decoction as claimed in claim 3, is characterized in that, the little fire of step (4) continues to decoct 23-35 minute (preferably: little fire continues to decoct 27-31 minute; Be more preferably: little fire continues decoction 29 minutes).
5. the preparation method of the unguentum of the Chinese medicine composition as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) Herba Spirodelae, Herba leucadis zeylanicae, Herba Medicaginis Lupulinae and Herba Lamii Amplexicaulis wash quickly is got clean, under 80 DEG C of environment, constant temperature drying to surface is yellow, take out and mix thoroughly with crystal sugar water while hot, be together placed in frying pan with Rhizoma Zingiberis, slow fire stir-fry 12-24 minute (preferred: slow fire stir-fries 16-20 minute; Be more preferably: slow fire stir-fries 18 minutes), take out, removing Rhizoma Zingiberis;
(2) by Fructus Tritici Levis and Fructus Sophorae removing impurity, add two kinds of crude drug quality 1-2 yellow wine doubly (preferred: the yellow wine adding two kinds of crude drug quality 1.5 times) and soak 10 minutes, big fire is heated to wine and is sucked, and takes out and is placed in frying pan, slow fire stir-fries to being charred taste effusion, and taking-up is pulverized;
(3) get Radix vignae sinensis, Radix Semiaquilegiae, Radix Zanthoxyli Planispini, east wind Fructus Citri tangerinae and Radix tetrapanacis Koch removing impurity, soak 10-18 minute (preferably: soak 12-16 minute with washing water of rice; Be more preferably: soak 14 minutes), take out, be cut into sheet, add Sal and mix thoroughly, slow fire stir-fries to surperficial zoom, and taking-up cools;
(4) Flos Musae, Eucheuma gelatinosum, Herba Hyperici Patuli and Herba Agrimoniae are cleaned remove impurity, be placed in marmite, add total raw material medicine quality 5-8 water doubly (preferably: add total raw material medicine quality 6-7 water doubly; Be more preferably: the water adding total raw material medicine quality 6.5 times), big fire is boiled to boiling, then adds step (1) (2) (3) made crude drug, turns little fire and continues decoction 20 minutes, filter, collect filtrate after closing fire;
(5) be added to by Liquor Flos osmanthi Distillata in step (4) gained filtrate, stir, heating is concentrated into thick paste, adds refined honey mixing, obtains unguentum.
6. the preparation method of Traditional Chinese medicine composition paste as claimed in claim 5, is characterized in that, it is the 0.3-0.5 of thick paste quality doubly (preferred: to add 0.4 times that refined honey amount is thick paste quality) that step (5) adds refined honey amount.
7. the preparation method of the tablet of the Chinese medicine composition as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) Herba Spirodelae, Herba leucadis zeylanicae, Herba Medicaginis Lupulinae and Herba Lamii Amplexicaulis wash quickly is got clean, under 80 DEG C of environment, constant temperature drying to surface is yellow, take out and mix thoroughly with crystal sugar water while hot, be together placed in frying pan with Rhizoma Zingiberis, slow fire stir-fry 12-24 minute (preferred: slow fire stir-fries 16-20 minute; Be more preferably: slow fire stir-fries 18 minutes), take out, removing Rhizoma Zingiberis;
(2) by Fructus Tritici Levis and Fructus Sophorae removing impurity, add two kinds of crude drug quality 1-2 yellow wine doubly (preferred: the yellow wine adding two kinds of crude drug quality 1.5 times) and soak 10 minutes, big fire is heated to wine and is sucked, and takes out and is placed in frying pan, slow fire stir-fries to being charred taste effusion, and taking-up is pulverized;
(3) get Radix vignae sinensis, Radix Semiaquilegiae, Radix Zanthoxyli Planispini, east wind Fructus Citri tangerinae and Radix tetrapanacis Koch removing impurity, soak 10-18 minute (preferably: soak 12-16 minute with washing water of rice; Be more preferably: soak 14 minutes), take out, be cut into sheet, add Sal and mix thoroughly, slow fire stir-fries to surperficial zoom, and taking-up cools;
(4) Flos Musae, Eucheuma gelatinosum, Herba Hyperici Patuli and Herba Agrimoniae are cleaned remove impurity, be placed in marmite, add total raw material medicine quality 5-8 water doubly (preferably: add total raw material medicine quality 6-7 water doubly; Be more preferably: the water adding total raw material medicine quality 6.5 times), big fire is boiled to boiling, then adds step (1) (2) (3) made crude drug, turns little fire and continues decoction 20 minutes, filter, collect filtrate after closing fire;
(5) be added to by Liquor Flos osmanthi Distillata in step (4) gained filtrate, stir, heating is concentrated, and oven dry pulverizes and sieves, and makes medicated powder, is crushed to round sheet dosage form, obtains tablet according to the preparation method of tablet.
8. the preparation method of Chinese medicine composition tablet as claimed in claim 7, is characterized in that, it is (preferred: to pulverize 80-100 mesh sieve that step (5) pulverized 60-120 mesh sieve; Be more preferably: pulverized 90 mesh sieves).
9. the preparation method of the granule of the Chinese medicine composition as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) Herba Spirodelae, Herba leucadis zeylanicae, Herba Medicaginis Lupulinae and Herba Lamii Amplexicaulis wash quickly is got clean, under 80 DEG C of environment, constant temperature drying to surface is yellow, take out and mix thoroughly with crystal sugar water while hot, be together placed in frying pan with Rhizoma Zingiberis, slow fire stir-fry 12-24 minute (preferred: slow fire stir-fries 16-20 minute; Be more preferably: slow fire stir-fries 18 minutes), take out, removing Rhizoma Zingiberis;
(2) by Fructus Tritici Levis and Fructus Sophorae removing impurity, add two kinds of crude drug quality 1-2 yellow wine doubly (preferred: the yellow wine adding two kinds of crude drug quality 1.5 times) and soak 10 minutes, big fire is heated to wine and is sucked, and takes out and is placed in frying pan, slow fire stir-fries to being charred taste effusion, and taking-up is pulverized;
(3) get Radix vignae sinensis, Radix Semiaquilegiae, Radix Zanthoxyli Planispini, east wind Fructus Citri tangerinae and Radix tetrapanacis Koch removing impurity, soak 10-18 minute (preferably: soak 12-16 minute with washing water of rice; Be more preferably: soak 14 minutes), take out, be cut into sheet, add Sal and mix thoroughly, slow fire stir-fries to surperficial zoom, and taking-up cools;
(4) Flos Musae, Eucheuma gelatinosum, Herba Hyperici Patuli and Herba Agrimoniae are cleaned remove impurity, be placed in marmite, decoct with water to boiling, then add step (1) (2) (3) made crude drug, turn little fire and continue to decoct 23-35 minute (preferably: little fire continues to decoct 27-31 minute; Be more preferably: little fire continues decoction 29 minutes), filter after closing fire, collect filtrate;
(5) mixed homogeneously with step (4) gained filtrate by Liquor Flos osmanthi Distillata, spraying dry, makes medicated powder, and add adjuvant mixing, obtain mixed powder, mixed powder is made granule, dry granulate at 60 DEG C, namely sterilization packaging obtains granule.
10. the preparation method of Chinese medicinal composition granules as claimed in claim 9, is characterized in that, step (4) amount of water is the 6-8 of total raw material medicine quality doubly (preferred: amount of water is 7 times of total raw material medicine quality).
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972454A (en) * | 2010-11-03 | 2011-02-16 | 何玉伟 | Medicament for treating lymphoma |
| CN103386109A (en) * | 2013-07-27 | 2013-11-13 | 陈有春 | Chinese medicine composition for treating lymph cancer |
| CN104436032A (en) * | 2014-11-17 | 2015-03-25 | 丁元霞 | Traditional Chinese medicine preparation for treating lymph cancer |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972454A (en) * | 2010-11-03 | 2011-02-16 | 何玉伟 | Medicament for treating lymphoma |
| CN103386109A (en) * | 2013-07-27 | 2013-11-13 | 陈有春 | Chinese medicine composition for treating lymph cancer |
| CN104436032A (en) * | 2014-11-17 | 2015-03-25 | 丁元霞 | Traditional Chinese medicine preparation for treating lymph cancer |
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| Title |
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| 许亚梅等: "恶性淋巴瘤中医辨证治疗", 《世界中医药》 * |
| 骆洪道: "颈部肿瘤治验三则", 《四川中医》 * |
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Address after: 563000 Hongkong Road, Zunyi, Guizhou, No. 521, No. Applicant after: Zhang Xiuzhen Address before: 250000 Ji'nan Province, Lixia District,, East Shili River, No. 10 Applicant before: Zhang Xiuzhen |
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Application publication date: 20160224 |