CN105343456A - Traditional Chinese medicine composition for treating heroin dependence and nursing method - Google Patents

Traditional Chinese medicine composition for treating heroin dependence and nursing method Download PDF

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CN105343456A
CN105343456A CN201510824363.1A CN201510824363A CN105343456A CN 105343456 A CN105343456 A CN 105343456A CN 201510824363 A CN201510824363 A CN 201510824363A CN 105343456 A CN105343456 A CN 105343456A
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chinese medicine
traditional chinese
medicine composition
herba
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尤晓莉
杨培凤
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release

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Abstract

The invention discloses a traditional Chinese medicine composition for treating heroin dependence, which belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines capable of invigorating energy, nourishing blood, strengthening the body resistance to eliminate pathogenic factors, freeing the channels, stimulating the circulation of blood and expelling and eliminating toxic matters: all-grass of Khas Aletris, fruit of Thatch screwpine, rex woodbetony, root of Henry woodbetony, rust-colored crotalaria herb with root, Barleria lupulina Lindl., Japanese honeysuckle stem, all-grass of Phymatopsis hastata, Fuzhou diospyros root, Hibiscus mutabilis L., herb of Java Speedwell and cortex erythrinae. The above-mentioned traditional Chinese medicines are ground into powder and then made into a capsule. According to results of clinical test, the total effective rate of the traditional Chinese medicine composition is 96%.

Description

A kind of Chinese medicine composition and care method for the treatment of heroin dependence
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of heroin dependence.
Background technology
Heroin dependence as a kind of chronic recurrent encephalopathy, have rely on produce fast, treating narcotic addiction is difficult, relapse rate high, for patient and family members thereof bring huge psychology and economic pressures; Heroin dependence withdrawal and treatment is a kind of comprehensive systemic treatment, comprise the treatment, convalescence preventing suction again, recovery social function etc. that control acute withdrawal syndrome, protracted abstinence symptom (psa), current anti-drug institution many employings Western medicine therapy, such as methadone substitutes step-down therapy, the calm frozen sleep of Benzodiazepines and even controversial cerebral surgery operation treatment etc., but therapeutic effect is not good enough, after acute stage detoxification treatment, the relapse rate of patient remains high.Applicant, in clinical practice for many years, utilizes treatment by Chinese herbs heroin dependence, achieves good curative effect, can improve the immune system dysfunction that heroin dependence causes, and improve patient's body autoimmunity, clinic is applied.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of heroin dependence.Theory of Chinese medical science thinks that the bitter warm-dryness syndrome of the opioids such as heroin is strong, and yin-damaging and Qi consuming, cuts down the impairment of QI-blood, addiction of a specified duration, cause and sap one's vitality, Tianjin blood is dry withered, internal organs all damage, therefore clinical treatment with invigorating qi and benefiting blood, strengthening vital QI to eliminate pathogenic factors, dredge the meridian passage, dispelling toxicity, detoxicating for main principle.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment heroin dependence is made up of the Chinese medicine of following weight portion: Herba Aletridis Khasianae 15-30 part, Fructus Pandani tectorii 9-15 part, Pedicularis rex C. B. Clarke ex Maxim. 15-30 part, Radix Pedicularis Henryi 15-30 part, Herba Crotalariae Ferrugineae 15-30 part, Herba Barleriae prioniitis 6-9 part, Caulis Lonicerae 9-15 part, Phymatopsis hastata (Thunb.) Kitag. 6-15 part, Radix Diospyroris foochowensis 15-30 part, Flos Hibisci Mutabilis 6-12 part, Herba Veronicae javanicae 15-30 part, Cortex erythrinae 6-12 part.
Preferably, Herba Aletridis Khasianae 22g, Fructus Pandani tectorii 12g, Pedicularis rex C. B. Clarke ex Maxim. 22g, Radix Pedicularis Henryi 22g, Herba Crotalariae Ferrugineae 22g, Herba Barleriae prioniitis 7.5g, Caulis Lonicerae 12g, Phymatopsis hastata (Thunb.) Kitag. 10g, Radix Diospyroris foochowensis 22g, Flos Hibisci Mutabilis 9g, Herba Veronicae javanicae 23g, Cortex erythrinae 9g.
More than preparation method all medicines are pulverized, and make capsule.
Fang Zhong: Herba Aletridis Khasianae fills blood; Fructus Pandani tectorii benefiting vital QI and blood; Pedicularis rex C. B. Clarke ex Maxim. benefiting vital QI and blood; Radix Pedicularis Henryi fills blood, active; Herba Crotalariae Ferrugineae invigorating the spleen and replenishing QI; Herba Barleriae prioniitis dredge the meridian passage; Caulis Lonicerae dredging collateral, removing toxic substances; Phymatopsis hastata (Thunb.) Kitag. detoxifies; Radix Diospyroris foochowensis stimulates the menstrual flow; Flos Hibisci Mutabilis detoxifies; Herba Veronicae javanicae detoxifies; Cortex erythrinae dredging collateral.
Clinical data
1, physical data chooses my institute Heroin Addicts 110 example that in January, 2011 to 2013, year December was accepted for medical treatment, wherein, male 75 example, women 35 example, age 24-48 year, on average (25.6 ± 12.1) year, individual month of average heroin service time (56.4 ± 5.2), average day heroin consumption (1.3 ± 0.6) g; Be divided into observation group and each 55 examples of matched group at random, two groups of patients compare from sex, age, heroin service time and ordinary circumstance aspect such as day heroin use amount etc., no significant difference, has comparability (P > 0.05).
2, diagnostic criteria is with reference to meeting ICD 1 " Opioid dependence " diagnostic criteria, urine trace morphine tests positive.
3, Therapeutic Method observation group: take Herba Aletridis Khasianae 22g, Fructus Pandani tectorii 12g, Pedicularis rex C. B. Clarke ex Maxim. 22g, Radix Pedicularis Henryi 22g, Herba Crotalariae Ferrugineae 22g, Herba Barleriae prioniitis 7.5g, Caulis Lonicerae 12g, Phymatopsis hastata (Thunb.) Kitag. 10g, Radix Diospyroris foochowensis 22g, Flos Hibisci Mutabilis 9g, Herba Veronicae javanicae 23g, Cortex erythrinae 9g.All medicines are pulverized above, make capsule.1-3 days, 4-6 tablet/time of every 12h, 4-6 days, 3-5 tablet/time of every 12h, 7-10 days, 2-3 tablet/time of every 12h, 11-12 days, 1-2 tablet/time of every 12h, takes 12d continuously.Matched group: adopt acupuncture massage treatment, after routine disinfection, patient gets seat, use diameter 0.32mm, the acupuncture needle of long 25-50mm, get the acupuncture points such as wind pond, Baihui, connected valleys, Nei Guan, Tai Chong, tsu san li, sp 6, quick straight thrust people, carries slotting twistedly to bring about the desired sensation, amplitude method of reinforcement and reduction in row, let the acupuncture needle remain at a certain point about 20min, adopt rubbing and trundling to press maneuver after pulling out pin, massage therapy is carried out to acupuncture point, each acupuncture point 3-5mm, 1 times/day, treat 12d continuously.
4, criterion of therapeutical effect is given up curative effect with reference to opium abstinent syndrome scale-2 (OWS-2) to patient and is carried out judgements scoring, and before treatment and after treating, gathers detection in peripheral blood of patients underwent, detection blood samples of patients t lymphocyte subset group CD 4 +, CD 8 +content; The curative effect of clinical withdrawal and treatment: 1. clinical withdrawal and treatment success: OWS scoring < 10 points after treatment, urine trace morphine detects in resistive; 2. clinical withdrawal and treatment is effective: treat rear 10 points of < OWS scoring < 20 points, urine examination is resistive; 3. clinical withdrawal and treatment is invalid: OWS scoring > 20 points after treatment, urine examination is positive.
5, observe the curative effect after therapeutic outcome patient treatment, the routine patient of observation group 55, wherein clinical withdrawal and treatment success 25 examples (45.5%), effective 28 examples (50.9%) of clinical withdrawal and treatment, invalid 2 examples (3.6%) of clinical withdrawal and treatment, total effective rate 96.4%.The routine patient of matched group 55 is clinical withdrawal and treatment success 15 examples (27.3%) wherein, effective 29 examples (52.7%) of clinical withdrawal and treatment, invalid 11 examples (20%) of clinical withdrawal and treatment, total effective rate 80%.Two groups are compared, and treatment group cure rate, total effective rate are obviously better than matched group, have comparability (P < 0.05).In sum, treatment by Chinese herbs heroin addiction Be very effective, can effectively improve patient's immunity.
Detailed description of the invention
Embodiment one: take Herba Aletridis Khasianae 22g, Fructus Pandani tectorii 12g, Pedicularis rex C. B. Clarke ex Maxim. 22g, Radix Pedicularis Henryi 22g, Herba Crotalariae Ferrugineae 22g, Herba Barleriae prioniitis 7.5g, Caulis Lonicerae 12g, Phymatopsis hastata (Thunb.) Kitag. 10g, Radix Diospyroris foochowensis 22g, Flos Hibisci Mutabilis 9g, Herba Veronicae javanicae 23g, Cortex erythrinae 9g.All medicines are pulverized above, make capsule.
Embodiment two: take Herba Aletridis Khasianae 15g, Fructus Pandani tectorii 9g, Pedicularis rex C. B. Clarke ex Maxim. 15g, Radix Pedicularis Henryi 15g, Herba Crotalariae Ferrugineae 15g, Herba Barleriae prioniitis 6g, Caulis Lonicerae 9g, Phymatopsis hastata (Thunb.) Kitag. 6g, Radix Diospyroris foochowensis 15g, Flos Hibisci Mutabilis 6g, Herba Veronicae javanicae 15g, Cortex erythrinae 6g.Upper all medicines are pulverized, and make capsule.
Embodiment three: take Herba Aletridis Khasianae 30g, Fructus Pandani tectorii 15g, Pedicularis rex C. B. Clarke ex Maxim. 30g, Radix Pedicularis Henryi 30g, Herba Crotalariae Ferrugineae 30g, Herba Barleriae prioniitis 9g, Caulis Lonicerae 15g, Phymatopsis hastata (Thunb.) Kitag. 15g, Radix Diospyroris foochowensis 30g, Flos Hibisci Mutabilis 12g, Herba Veronicae javanicae 30g, Cortex erythrinae 12g.Upper all medicines are pulverized, and make capsule.

Claims (2)

1. treat a Chinese medicine composition for heroin dependence, it is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Herba Aletridis Khasianae 15-30 part, Fructus Pandani tectorii 9-15 part, Pedicularis rex C. B. Clarke ex Maxim. 15-30 part, Radix Pedicularis Henryi 15-30 part, Herba Crotalariae Ferrugineae 15-30 part, Herba Barleriae prioniitis 6-9 part, Caulis Lonicerae 9-15 part, Phymatopsis hastata (Thunb.) Kitag. 6-15 part, Radix Diospyroris foochowensis 15-30 part, Flos Hibisci Mutabilis 6-12 part, Herba Veronicae javanicae 15-30 part, Cortex erythrinae 6-12 part.
2. a kind of Chinese medicine composition for the treatment of heroin dependence as claimed in claim 1, it is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: preferred, Herba Aletridis Khasianae 22g, Fructus Pandani tectorii 12g, Pedicularis rex C. B. Clarke ex Maxim. 22g, Radix Pedicularis Henryi 22g, Herba Crotalariae Ferrugineae 22g, Herba Barleriae prioniitis 7.5g, Caulis Lonicerae 12g, Phymatopsis hastata (Thunb.) Kitag. 10g, Radix Diospyroris foochowensis 22g, Flos Hibisci Mutabilis 9g, Herba Veronicae javanicae 23g, Cortex erythrinae 9g.
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1260200A (en) * 1999-08-16 2000-07-19 万梦雄 Traditional Chinese medicine compound medicine for giving-up drug-taking and its compounding method
CN102824469A (en) * 2012-08-21 2012-12-19 山西省女子劳动教养管理所 Detoxification traditional Chinese medicine and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1260200A (en) * 1999-08-16 2000-07-19 万梦雄 Traditional Chinese medicine compound medicine for giving-up drug-taking and its compounding method
CN102824469A (en) * 2012-08-21 2012-12-19 山西省女子劳动教养管理所 Detoxification traditional Chinese medicine and preparation method thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
南京中医药大学编: "《中药大辞典》", 31 March 2006, 上海科学技术出版社 *
李文瑞等: "《中药别名辞典》", 30 September 1994, 中国科学技术出版社 *
杨良等: "排毒养生胶囊配合针刺疗法治疗海洛因依赖临床研究", 《中国药物滥用防治杂志》 *
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