CN105343370A - 一种治疗偏头痛的中药制剂 - Google Patents

一种治疗偏头痛的中药制剂 Download PDF

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CN105343370A
CN105343370A CN201510843706.9A CN201510843706A CN105343370A CN 105343370 A CN105343370 A CN 105343370A CN 201510843706 A CN201510843706 A CN 201510843706A CN 105343370 A CN105343370 A CN 105343370A
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李军让
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Tiane Pingchang Ecological Agriculture Co Ltd
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Abstract

本发明属于中药制剂开发技术领域，具体涉及的是一种治疗偏头痛的中药制剂。一种治疗偏头痛的中药制剂，所述的中药制剂是由丁公藤、厚朴、杜仲、葛根、五灵脂、桂皮、桂枝、桑葚、牡丹皮、栀子、麻黄、川芎、泽泻、白芷、枳壳、甘草、乳香和薄荷原料所制成，此中药制剂的剂型为丸剂、散剂或汤剂。本发明治疗偏头痛的中药制剂具有疗效佳、标本兼治、见效快、无毒副作用和痊愈后不复发的优点。

Description

一种治疗偏头痛的中药制剂
技术领域
本发明属于中药制剂开发技术领域，具体涉及的是一种治疗偏头痛的中药制剂。
背景技术
偏头痛是一种原发性颅内血管运动和神经功能失常所引起的复发性疾病，具有病程长、间歇性发作、缠绵难愈等特点。
目前，对于偏头痛的大多采用西药来治疗，西药可根据发作特点的不同给予不同的药物。如麦角胺制剂主要用于中、重度偏头痛患者，本类制剂具有收缩血管的作用,因此有外周血管或冠状动脉疾病的患者禁用，妊娠、高血压、肝、肾功能衰竭和甲状腺功能亢进等也是此类药物的禁忌证；5-HT1B/1D受体激动剂是轻、中度偏头痛宜首选药，缺血性心脏病和椎-基底动脉缺血是本类药物的禁忌证；钙通道阻滞剂治疗偏头痛有效,不良反应发生率较高,如便秘、低血压、体液潴留和恶心等，禁用于抑郁、肥胖、伴椎体外系症状、充血性心力衰竭、低血压和心脏传导阻滞者；抗精神病类药适用于顽固性头痛患者，主要不良反应有口干、头痛和视物模糊，长期用药可引起心肌损害；麻醉镇痛药用于频繁头痛发作者，有成瘾和头痛反跳的危险；尽管西医治疗在控制发作、缓解症状方面虽然取得了明显疗效，但仍有反复发作，难以治愈且副作用明显的缺陷。
中医认为偏头痛的病因为风、寒、痰、瘀。治疗方法以辨证分型论治为原则，立法处方围绕在祛风散寒、通络止痛、活血化瘀等基础上，临床随症随病加减。中药治疗偏头痛毒副作用作用小，即时止痛效果也明显优于西药治疗。
公开于该背景技术部分的信息仅仅旨在增加对本发明的总体背景的理解，而不应当被视为承认或以任何形式暗示该信息构成已为本领域一般技术人员所公知的现有技术。
发明内容
本发明的目的在于提供一种疗效好，副作用少的治疗偏头痛的中药制剂。
本发明的目的通过如下技术方案实现：
一种治疗偏头痛的中药制剂，其特征在于：它由下列原料按重量份数制成：丁公藤10-20份、绞股蓝15-30份、厚朴10-20份、杜仲13-25份、葛根10-18份、五灵脂9-13份、桂皮14-20份、桂枝7-14份、桑葚7-14份、牡丹皮18-27份、栀子12-17份、麻黄9-15份、川芎5-12份、泽泻8-16份、白芷5-10份、细辛3-8份、枳壳10-16份、甘草12-17份、乳香7-11份、薄荷10-15份。
作为优选，所述的治疗偏头痛的中药制剂，由下列原料按重量份数制成：丁公藤16份、绞股蓝27份、厚朴13份、杜仲18份、葛根14份、五灵脂11份、桂皮16份、桂枝12份、桑葚12份、牡丹皮23份、栀子15份、麻黄14份、川芎10份、泽泻9份、白芷8份、细辛5份、枳壳10份、甘草16份、乳香9份、薄荷12份。
作为优选，所述的治疗偏头痛的中药制剂的剂型为汤剂、散剂或丸剂。
与现有技术相比，本发明具有如下有益效果：
1.本发明采用多味中药配制，搭配合理，治疗偏头痛疗效佳、标本兼治、见效快、无毒副作用，痊愈后不复发。
2.本发明重在补气活血疏散风寒，改善肝郁气滞、外感风寒、寒湿内停、气虚血瘀，协调人体气血及五脏平衡。
3.本发明经过多年的临床观察试验，对患者进行治疗，取得了良好的效果，有效率高达96％以上。
具体实施方式
下面结合具体实施例，对本发明作进一步详细的阐述，但本发明的实施方式并不局限于实施例表示的范围。这些实施例仅用于说明本发明，而非用于限制本发明的范围。此外，在阅读本发明的内容后，本领域的技术人员可以对本发明作各种修改，这些等价变化同样落于本发明所附权利要求书所限定的范围。
实施例1：
按照如下重量配比称取：丁公藤10g、厚朴10g、杜仲13g、葛根10g、五灵脂9g、桂皮14g、桂枝7g、桑葚7g、牡丹皮18g、栀子12g、麻黄9g、川芎5g、泽泻8g、白芷5g、枳壳10g、甘草12g、乳香7g和薄荷10g。
所述中药制剂的汤剂的制备方法为：按中药配方所需原料组分配比取中药药物于容器中，加入药物重量5倍的水，浸泡30min，使中药药物完全被水渗透，然后再进行煎煮，第1次煎煮时加热至100℃，再在95-100℃下煎煮20min，过滤；第2次煎煮15min，过滤，合并2次滤液，即得所述的中药汤剂。所述的中药汤剂的服用方法为：每日服用3次，每次服用200mL。
实施例2：
按照如下重量配比称取：丁公藤20g、厚朴20g、杜仲25g、葛根18g、五灵脂13g、桂皮20g、桂枝14g、桑葚14g、牡丹皮27g、栀子17g、麻黄15g、川芎12g、泽泻16g、白芷10g、枳壳16g、甘草17g、乳香11g和薄荷15g。
所述中药制剂的散剂的制备方法为：将所述各味在中药构成的待用原料放在一起混合均匀而获得混合原料待用，将混合原料粉碎，粉碎细度为200目，制成中药散剂。所述的中药散剂每日服用3次，每次服用6g。
实施例3：
按照如下重量配比称取：丁公藤12g、厚朴12g、杜仲15g、葛根13g、五灵脂10g、桂皮15g、桂枝9g、桑葚11g、牡丹皮22g、栀子14g、麻黄11g、川芎8g、泽泻12g、白芷7g、枳壳12g、甘草14g、乳香9g和薄荷11g。
所述的中药蜜丸的制备方法为：将所述各味中药构成的待用原料放在一起混合均匀而获得混合原料，将混合原料粉碎，粉碎细度为300目，制成中药散剂待用，加入重量为中药散剂二分之一的蜂蜜，将中药散剂与蜂蜜混合均匀获得中药蜜膏，将中药蜜膏制作成每丸重量为10克的中药蜜丸成品。所述的中药蜜丸每日服用3次，每次服用1丸。
实施例4：
按照如下重量配比称取：丁公藤18g、厚朴18g、杜仲22g、葛根16g、五灵脂12g、桂皮18g、桂枝12g、桑葚12g、牡丹皮25g、栀子15g、麻黄13g、川芎10g、泽泻14g、白芷8g、枳壳14g、甘草15g、乳香9g和薄荷13g。
所述的中药水丸的制备方法为：将所述各味中药构成的待用原料放在一起混合均匀而获得混合原料，将混合原料粉碎，粉碎细度为300目，制成中药散剂待用，加入适量的水，将中药散剂与水混合均匀制成中药水丸半成品，对中药水丸半成品进行烘干制成每丸重量为6克的中药水丸成品。所述的中药水丸每日服用3次，每次服用1丸。
实施例5：本发明中药制剂的临床试验
5.1临床人员
选自具有完整资料的门诊及住院病人共1250例，随机分为治疗组1000例(平均分为4组，每组250例)，分别服用实施例1、2、3和4中制备的中药汤剂、中药散剂、中药蜜丸、中药水丸；对照组250例；治疗组年龄为20-60岁，病程0.5-14年，对照组年龄为23-56岁，病程1.5-13年，男女之比及病程经卡方检验(P>0.05)，即无统计学差异。
5.2治疗方法
治疗组服用上述实施例1、2、3和4中制备的中药汤剂、中药散剂、中药蜜丸、中药水丸，每天分3次饭后口服，15天为1个疗程；对照组注射麦角胺咖啡因，麦角胺咖啡因每次0.25-0.5mg，24小时内不超过1mg。
5.3临床效果统计
经调查、计算得到5组的临床效果，如表1所示。
表1本发明中药制剂的临床效果
从表1可以看出，本发明的中药制剂有效率均在96％以上，对偏头痛患者具有良好的治疗效果，有良好的市场前景。
前述对本发明的具体示例性实施方案的描述是为了说明和例证的目的。这些描述并非想将本发明限定为所公开的精确形式，并且很显然，根据上述教导，可以进行很多改变和变化。对示例性实施例进行选择和描述的目的在于解释本发明的特定原理及其实际应用，从而使得本领域的技术人员能够实现并利用本发明的各种不同的示例性实施方案以及各种不同的选择和改变。本发明的范围意在由权利要求书及其等同形式所限定。

Claims (3)

1.一种治疗偏头痛的中药制剂，其特征在于，所述的中药制剂由下列原料按重量份数制成：丁公藤10-20份、厚朴10-20份、杜仲13-25份、葛根10-18份、五灵脂9-13份、桂皮14-20份、桂枝7-14份、桑葚7-14份、牡丹皮18-27份、栀子12-17份、麻黄9-15份、川芎5-12份、泽泻8-16份、白芷5-10份、枳壳10-16份、甘草12-17份、乳香7-11份和薄荷10-15份。
2.根据权利要求1所述的治疗偏头痛的中药制剂，其特征在于，所述的中药制剂由下列原料按重量份数制成：丁公藤15份、厚朴15份、杜仲18份、葛根15份、五灵脂11份、桂皮12份、桂枝10份、桑葚12份、牡丹皮20份、栀子15份、麻黄12份、川芎8份、泽泻12份、白芷8份、枳壳13份、甘草15份、乳香9份和薄荷12份。
3.根据权利要求1或2所述的治疗偏头痛的中药制剂，其特征在于：所述的中药制剂的剂型为汤剂、散剂或丸剂。
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CN105748844A (zh) * 2016-04-11 2016-07-13 周晓娟 一种治疗偏头痛的口服中药组合物及其制备方法
CN105796686A (zh) * 2016-05-30 2016-07-27 李晓维 一种治疗典型偏头痛的中药

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Publication number Priority date Publication date Assignee Title
CN105748844A (zh) * 2016-04-11 2016-07-13 周晓娟 一种治疗偏头痛的口服中药组合物及其制备方法
CN105748844B (zh) * 2016-04-11 2019-06-18 周晓娟 一种治疗偏头痛的口服中药组合物及其制备方法
CN105796686A (zh) * 2016-05-30 2016-07-27 李晓维 一种治疗典型偏头痛的中药

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