CN105343194A - Pharmaceutical composition for treating stomach cancer and preparation method thereof - Google Patents

Pharmaceutical composition for treating stomach cancer and preparation method thereof Download PDF

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CN105343194A
CN105343194A CN201510871931.3A CN201510871931A CN105343194A CN 105343194 A CN105343194 A CN 105343194A CN 201510871931 A CN201510871931 A CN 201510871931A CN 105343194 A CN105343194 A CN 105343194A
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pharmaceutical composition
gastric cancer
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庞大坤
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Jinan Xingyi Medical Technology Co Ltd
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Jinan Xingyi Medical Technology Co Ltd
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Abstract

The invention discloses a pharmaceutical composition for treating stomach cancer and a preparation method thereof. The pharmaceutical composition is prepared from crude drugs comprising mature seeds of entada phaseoloides, whole herb of corydalis hendersonii, whole herb of ajuga lupulina, sciadopitysin, taraxerol and inokosterone according to ratio, can be prepared into various dosage forms according to a conventional preparation process and has a remarkable curative effect for treating the stomach cancer.

Description

A kind of pharmaceutical composition for the treatment of gastric cancer and preparation method thereof
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of pharmaceutical composition for the treatment of gastric cancer and preparation method thereof.
Background technology
Gastric cancer is one of common malignant tumor of China, and its sickness rate, case fatality rate all come out at the top in various tumor, and serious threat is to the life and health of people.Therefore studying the active drug to curing gastric cancer and method, is a vital problem.Operative treatment is the important means for the treatment of gastric cancer at present, but its cure rate is lower than 30%.In recent years, the TCM Therapy especially combined therapy of Chinese and Western medicine plays more and more important effect in the prevention, treatment, nursing etc. of gastric cancer, can significantly improve the curative effect of curing gastric cancer, extends the life cycle of patients with gastric cancer and improve the quality of living.
The mechanism of Traditional Chinese Medicine Anti gastric cancer: propagation, the inducing apoptosis of tumour cell of (1) inhibition tumor cell.Most Chinese medicines inherently have the effect of inhibition tumor cell, inducing apoptosis of tumour cell, and its toxic and side effects is less.Current research finds Radix Salviae Miltiorrhizae, Fructus Bruceae, Rhizoma Chuanxiong, Radix Sophorae Flavescentis, Radix Puerariae, Fructus Trichosanthis, Radix Glycyrrhizae, Herba Hedyotidis Diffusae, Radix Et Rhizoma Rhei etc.Chinese medicine has the effect of reversing stomach multidrug resistance.The 26 taste Chinese herbal medicine for the treatment of gastric cancer the most frequently used in recent years have the Qi-tonifying drug such as the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae; There are the heat and toxic materials clearing away medicine such as Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Radix Actinidiae Chinensis, Herba Agrimoniae; There is the edema-alleviating diuretic such as Poria, Semen Coicis; There is the QI regulating medicine such as Pericarpium Citri Reticulatae, the Radix Aucklandiae; There are the hematonic such as Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Rehmanniae Preparata; There is Rhizoma Pinelliae isothermal chemical medicine; There is the YIN-tonifying drug such as Radix Ophiopogonis, Fructus Lycii; There are the blood-activating analgesics such as Rhizoma Chuanxiong, Rhizoma Corydalis, Oletum Trogopterori; There are the digestantss such as Massa Medicata Fermentata, paddy Fructus Hordei Germinatus, Endothelium Corneum Gigeriae Galli.Zhao Yongbin research finds that capsule with pseudo-ginseng and Chinese fanpalm seed has really and to kill with the effect of Tumor suppression and toxic and side effects is less, and treatment carcinoma of esophago cardia, patients with gastric cancer total effective rate are 78184%.Li Maokui etc.] use the flat injection of cancer that disappears to carry out vivo and vitro test, flow cytomery and morphological examination to people's gastric cancer (SGC-7901) cell, the discovery flat injection of cancer that disappears obviously can suppress the growth of people's gastric cancer (SGC-7901) cell, have and significantly block G1 phase cytosis, make tumor somatic cell mainly stop the G1 phase.(2) immunity of body is regulated.Have research prompting, Chinese medicine has and regulates the effect of immunity of organism, and can stop the growth of tumor, send out and recur.The research to the precious capsule of stilbene such as woods good friends shows that it has obvious tumor-inhibiting action, can improve body's immunity, promote leukocyte, improve patient's physical condition.Li Rujun etc. study the therapeutical effect of FUFANG TIANXIAN JIAONANG to malignant tumor and find that it can significantly improve lymhocyte transformation rate and NK cytoactive, show to have to improve body's immunity effect.
The tcm clinical progress of gastric cancer shows that Chinese medicine is suppressing to have unique advantage in the development of gastric cancer, prolongation survival periods of gastric carcinoma patients, raising patients ' life quality etc.And the experimentation of Traditional Chinese Medicine for Gastric Carcinoma is also achieving gratifying progress in recent years, not only have studied single medicinal material and the effect of Chinese patent medicine in suppression Growth of Gastric, also inquire into the drug Mechanism of the aspects such as its immunology, cytobiology, molecular biology.But some research also fails deeply to recognize contact between the too many levels for the treatment of by Chinese herbs gastric cancer, Mutiple Targets and impact.Also there is difference to the TCM Syndrome Type of gastric cancer and the understanding of diagnostic criteria thereof at present, a lot of research data is only one man's opinion, lacks ripe diagnosis and treatment specification, thus causes the difference of clinical diagnosis operation.Should make great efforts in diagnosis, medication standardization from now on and meet in clinical practice application etc. and make real work.And screening active drug or prescription, develop reasonable dosage form, give full play of the unique advantage that adverse reaction of tcm is little, sphere of action is wide, cost is low further.
Semen Entadae: this product is the mature seed of Dou section Zhi Wu Caulis Endadae phaseoloidis Entadaphaseoloides (L.) Merr..Winter collects seed sub, and peeling, boils or fry, dry.[nature and flavor] are sweet, cool; Poisonous.[function with cure mainly] removing heat from the liver, strong the kidney invigorating, emetic.For heart disease, the liver-heat syndrome, nephropathy, the heat symptom-complex of nosotoxicosis, aortic arch syndrome.[character] this product is oblate, diameter 4 ~ 15cm, thick 10 ~ 18mm.Surface sepia, tool gloss, minority two sides central authorities nick, by brown color powder, reticular texture fine and closely woven as seen after removing.Hilum oblong, seed coat is extremely hard.Break thick 1 ~ 2mm, kernel milky, cotyledon two panels, very greatly, about thick 5 ~ 7mm, often there are cavity in cotyledon central authorities, and there is tiny embryo at nearly hilum place.Feeble QI, lightly seasoned, that chews has beany flavor.Semen Entadae records in health Tibetan medicine standard promulgated by the ministries or commissions of the Central Government (first), standard number: WS3-BC-0116-95.
White luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.): this product is the dry herb of the white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) AjugalupulinaMaxim. of labiate.Florescence in summer gathers, and cleans, dries.[nature and flavor] are bitter, puckery, cold.[function with cure mainly] heat-clearing and toxic substances removing.For anthrax, furuncle, epilepsy, parasitosis.[character] this product root is carefully many, off-white color or faint yellow, frangibility, section out-of-flatness.Stem four prismatic, distortion, long 18 ~ 25cm, along on rib and joint by the long pubescence of white, Section Central has a small sircle hole.The many shrinkages of blade, broken; Intact leaf, in draping over one's shoulders needle-like Long Circle, grows 5 ~ 12cm; Bract is large-scale, faint yellow or yellow-white, shrinkage; Calyx funnel-form, tool 10 arteries and veins; The narrow funnel-form of corolla, off-white color is extremely faint yellow, tool purple speckle, the last 2 stamen.Gas delicate fragrance, bitter in the mouth.Record in health Tibetan medicine standard promulgated by the ministries or commissions of the Central Government (first), standard number: WS3-BC-0031-95.
Herba Corydalis: this product is the dry herb of bloodroot Herba Corydalis CorydalishendersoniiHemsl. (C.nepaiesiskitamura), and summer has grubbed out, cleans, dries in the shade.[nature and flavor] are bitter, cool.[function with cure mainly] heat clearing and inflammation relieving.For high mountain plethora, canker sores, vasculitis, enteritis.[character] this product is dry herb, long 10 ~ 25cm.Cylindrical or the rectangular capitate of root class, slightly bending, branch is arranged at bottom more, long 6 ~ 15cm, diameter 2 ~ 10mm; Surface brownish red, brown color or dun redness, often there is withered or broken leaf and stem residue on top, and fine and closely woven and ring grain that is slightly projection is arranged at root top, and longitudinal furrow stricture of vagina is arranged at bottom; The crisp frangibility of matter; Fracture is orange red, and center is yellow; Odorless, the micro-acid of bitter in the mouth.Stem is short, not obvious, the leaf that surrounding and cardinal extremity tool cluster.The many shrinkages of leaf are broken, dirty-green or yellow green, and the moistening expansion of complete leaf is go out the long 1 ~ 2cm of pinnation for two times or one time three, and stem's petiole is constitute sheath-like, long 1 ~ 3cm.Spend rare.The long 5cm of capsule Long Circle, the purplish red or yellowish red color in surface, has obvious longitudinal grin, feeble QI, bitter in the mouth.Record in health Tibetan medicine standard promulgated by the ministries or commissions of the Central Government (first), standard number: WS3-BC-0114-95.
7,4',4'''-Trimethylamentoflavone (Sciadopitysin): CAS 521-34-6, molecular weight 580.53766, molecular formula C 33h 24o 10, fusing point 296-298 DEG C.[ingredient origin] Semen Ginkgo Ginkgobiloba, Folium et Ramulus Cephalotaxi Cephalotaxusfortunei, Ramulus et folium taxi cuspidatae Taxuscuspidata.
Taraxerol (Taraxerol): CAS 127-22-0, molecular formula C 30h 50o, molecular weight 426.73.[pharmacological action] antiulcer, anti-gastric acid secretion.[ingredient origin] feverfew Europe Radix Taraxaci; Ebenaceae Diospyros plant, Fagaceae platymiscium, Canarium plant.
Inokosterone (Inokosterone): CAS 15130-85-5, molecular formula C 27h 44o 7, molecular weight 480.63.[pharmacological action] ecdyson, blood sugar lowering.[ingredient origin] Amaranthaceae Radix Achyranthis Bidentatae, Japanese Radix Achyranthis; The leaf of Moraceae Mulberry; Blechnaceae Rhizoma Woodwardiae Orientalis Rhizoma pteridii latiusculi stem; The rhizome of Compositae Liu Zi chrysanthemum.
The chemical constitution of 3 crude drug is as follows:
Taraxerol (Taraxerol) inokosterone (Inokosterone)
7,4',4'''-Trimethylamentoflavone (Sciadopitysin).
Summary of the invention
The object of the invention is the deficiency overcoming background technology, pharmaceutical composition of a kind of effective treatment gastric cancer and preparation method thereof is provided.
The present invention adopts following technical scheme to realize:
Composition and the weight portion of making the crude drug of the pharmaceutical composition of this treatment gastric cancer are:
The white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 140-160 weight portion 7,4',4'''-Trimethylamentoflavone 3-4 weight portion taraxerol 1-2 weight portion inokosterone 0.3-0.9 weight portion of Semen Entadae 180-200 weight portion Herba Corydalis 165-175 weight portion.
Preferably be used for the treatment of the pharmaceutical composition of gastric cancer, be made up of the crude drug of following weight portion:
White luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 150 weight portion 7,4',4'''-Trimethylamentoflavone 3.5 weight portion taraxerol 1.5 weight portion inokosterone 0.6 weight portion of Semen Entadae 190 weight portion Herba Corydalis 170 weight portion.
Treat a pharmaceutical composition for gastric cancer, it is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
Treat a pharmaceutical composition for gastric cancer, it is characterized in that the treatment gastric cancer medicament that pharmaceutical composition and chemical drugs or Chinese medicine form.
Treat a preparation method for the pharmaceutical composition of gastric cancer, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are the white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 140-160 weight portion 7,4',4'''-Trimethylamentoflavone 3-4 weight portion taraxerol 1-2 weight portion inokosterone 0.3-0.9 weight portion of: Semen Entadae 180-200 weight portion Herba Corydalis 165-175 weight portion;
Preparation method:
(1) by crude drug proportioning Qu Semen Entadae, Herba Corydalis, white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), mixing, micronizing to 50 micron, with weight percent concentration 75% ethanol as solvent, 50 DEG C of warm macerating extract, and extraction time is 3 times, each extraction time is 2 hours, each solvent load is 15 times of medical material gross weight, filters, obtains medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentrated, dry, obtain extract A;
(2) step (1) obtains medicinal residues A weight percent concentration 25% ethanol is solvent, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 16 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by LS300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) get 7,4',4'''-Trimethylamentoflavone, taraxerol, inokosterone by crude drug proportioning, mixing, adds extract A, extract B successively, and mixing, obtains pharmaceutical composition.
Preferably treat a preparation method for the pharmaceutical composition of gastric cancer, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 150 weight portion 7,4',4'''-Trimethylamentoflavone 3.5 weight portion taraxerol 1.5 weight portion inokosterone 0.6 weight portion of: Semen Entadae 190 weight portion Herba Corydalis 170 weight portion;
Preparation method:
(1) by crude drug proportioning Qu Semen Entadae, Herba Corydalis, white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), mixing, micronizing to 50 micron, with weight percent concentration 75% ethanol as solvent, 50 DEG C of warm macerating extract, and extraction time is 3 times, each extraction time is 2 hours, each solvent load is 15 times of medical material gross weight, filters, obtains medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentrated, dry, obtain extract A;
(2) step (1) obtains medicinal residues A weight percent concentration 25% ethanol is solvent, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 16 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by LS300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) get 7,4',4'''-Trimethylamentoflavone, taraxerol, inokosterone by crude drug proportioning, mixing, adds extract A, extract B successively, and mixing, obtains pharmaceutical composition.
Treat a preparation method for the pharmaceutical composition of gastric cancer, it is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
Treat a preparation method for the pharmaceutical composition of gastric cancer, it is characterized in that pharmaceutical composition and chemical drugs or Chinese medicine form and treat gastric cancer medicament.
Pharmaceutical composition is evident in efficacy in treatment gastric cancer, and total effective rate reaches 93.3%, is obviously better than for lucky capsule matched group (64.4%) difficult to understand.
Detailed description of the invention
Embodiment 1: pharmaceutical composition for the treatment of gastric cancer and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of gastric cancer are:
The white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 150g 7,4',4'''-Trimethylamentoflavone 3.5g taraxerol 1.5g inokosterone 0.6g of Semen Entadae 190g Herba Corydalis 170g;
Preparation method:
(1) by crude drug proportioning Qu Semen Entadae, Herba Corydalis, white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), mixing, micronizing to 50 micron, with weight percent concentration 75% ethanol as solvent, 50 DEG C of warm macerating extract, and extraction time is 3 times, each extraction time is 2 hours, each solvent load is 15 times of medical material gross weight, filters, obtains medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentrated, dry, obtain extract A;
(2) step (1) obtains medicinal residues A weight percent concentration 25% ethanol is solvent, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 16 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by LS300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) get 7,4',4'''-Trimethylamentoflavone, taraxerol, inokosterone by crude drug proportioning, mixing, adds extract A, extract B successively, and mixing, obtains pharmaceutical composition.
Embodiment 2: pharmaceutical composition for the treatment of gastric cancer and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of gastric cancer are:
The white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 140g 7,4',4'''-Trimethylamentoflavone 4g taraxerol 1g inokosterone 0.9g of Semen Entadae 180g Herba Corydalis 175g;
Preparation method:
(1) by crude drug proportioning Qu Semen Entadae, Herba Corydalis, white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), mixing, micronizing to 50 micron, with weight percent concentration 75% ethanol as solvent, 50 DEG C of warm macerating extract, and extraction time is 3 times, each extraction time is 2 hours, each solvent load is 15 times of medical material gross weight, filters, obtains medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentrated, dry, obtain extract A;
(2) step (1) obtains medicinal residues A weight percent concentration 25% ethanol is solvent, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 16 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by LS300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) get 7,4',4'''-Trimethylamentoflavone, taraxerol, inokosterone by crude drug proportioning, mixing, adds extract A, extract B successively, and mixing, obtains pharmaceutical composition.
Embodiment 3: pharmaceutical composition for the treatment of gastric cancer and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of gastric cancer are:
The white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 160g 7,4',4'''-Trimethylamentoflavone 3g taraxerol 2g inokosterone 0.3g of Semen Entadae 200g Herba Corydalis 165g;
Preparation method:
(1) by crude drug proportioning Qu Semen Entadae, Herba Corydalis, white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), mixing, micronizing to 50 micron, with weight percent concentration 75% ethanol as solvent, 50 DEG C of warm macerating extract, and extraction time is 3 times, each extraction time is 2 hours, each solvent load is 15 times of medical material gross weight, filters, obtains medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentrated, dry, obtain extract A;
(2) step (1) obtains medicinal residues A weight percent concentration 25% ethanol is solvent, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 16 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by LS300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) get 7,4',4'''-Trimethylamentoflavone, taraxerol, inokosterone by crude drug proportioning, mixing, adds extract A, extract B successively, and mixing, obtains pharmaceutical composition.
Embodiment 4: the preparation of tablet
Example 1 pharmaceutical composition 125g, adds starch 55g, mixing, granulates, dry, adds microcrystalline Cellulose 25g, magnesium stearate 1.0g, and mixing, is pressed into 1000, obtains medicinal composition tablets.
Embodiment 5: the preparation of capsule
Example 2 pharmaceutical composition 125g, adds starch 55g, mixing, granulates, and dry, granulate, adds appropriate magnesium stearate, and mixing, obtains medicament composition capsule by encapsulated 1000.
Embodiment 6: the preparation of drop pill
Taking polyethylene glycol 6000 200g water-bath (80 DEG C) heating boils molten, add embodiment 3 pharmaceutical composition 25g, stirring, is coolant with liquid paraffin, puts in glass tubing (4*80cm), chilling temperature is 6 DEG C, drip internal-and external diameter is 7.0/2.0 (mm/mm), and drip is 2.5cm apart from liquid level, drips speed with per minute 50 for optimum condition, blot the condensing agent on drop pill surface with cotton, obtain medicament composition dropping pills.
Embodiment 7: the pharmaceutical composition for the treatment of gastric cancer
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of gastric cancer are:
Semen Entadae 100 weight portion 7,4',4'''-Trimethylamentoflavone 1.5 weight portion taraxerol 0.4 weight portion inokosterone 1 weight portion.
Embodiment 8: the pharmaceutical composition for the treatment of gastric cancer
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of gastric cancer are:
Semen Entadae 200 weight portion 7,4',4'''-Trimethylamentoflavone 4 weight portion taraxerol 1 weight portion inokosterone 0.9 weight portion.
Embodiment 9: the pharmaceutical composition for the treatment of gastric cancer
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of gastric cancer are:
Semen Entadae 150 weight portion 7,4',4'''-Trimethylamentoflavone 3 weight portion taraxerol 1.2 weight portion inokosterone 5 weight portion.
experimental example 1: treatment gastric cancer experimental study
1. clinical data
Choose the 90 routine patients with gastric cancer that this provincial hospital accepts for medical treatment in February, 2012 ~ in February, 2014, wherein man 54 example, female 36 example, 45 ~ 82 years old age, 56 years old mean age; The course of disease 4.6 ~ 12.8 months, average course of disease 7.8 months.Pathological adenocarcinoma 68 example, mucinous adenocarcinoma 15 example, signet-ring cell carcinoma 3 example, scale cancer 4 example.Diagnosis all meets documentation standards, and confirms through pathologic finding.Inclusive criteria: 1. meet diagnosing gastric cancer standard and through the clear and definite typing of pathological examination; 2. TNM is I ~ IV phase by stages; 3. Karnofsky scoring >=60 points; 4. expectation ﹥ life cycle 3 months; 5. possess certain bone marrow reserve, liver function is normal; 6. previously chemotherapy is not accepted; 7. patient's informed consent.Exclusion standard: 1. do not meet above-mentioned inclusive criteria; 2. double or multiple cancer patient; 3. pathological diagnosis is adenosquamous carcinoma, squamous cell carcinoma, carcinoid, the gastric cancer of small cell carcinoma, malignant lymphoma of stomach, Gastric stromal tumors patient; 4. anemia of pregnant woman, mental disease patient; 5. merge other acute and chronic diseases such as myocardial infarction, cerebral infarction to wait indefinitely; 6. hepatic and kidney function obstacle person.90 routine patients are divided into matched group and observation group at random, often organize 45 examples.Two groups of physical data have comparability.
2. Therapeutic Method
Matched group: adopt oxaliplatin 130mg/m 2, the 1st day; For lucky capsule difficult to understand (Qilu Pharmaceutical Co., Ltd.) 80mg/m 2oral, every day 2 times, being used in conjunction 14 days, 21 days is 1 course for the treatment of, is used in conjunction 2 courses for the treatment of.Treatment group: on treatment of control group basis, add pharmaceutical composition (embodiment 1 pharmaceutical composition) treatment, every day 2 times, each 1g, is used in conjunction 14 days, within 21 days, is 1 course for the treatment of, is used in conjunction 2 courses for the treatment of.And March after patient treatment is followed up a case by regular visits to.Adopt SPSS18.0 software building database, adopt χ 2statistical procedures is carried out in inspection.
3. therapeutic outcome
3.1 criterions of therapeutical effect are according to WTO solid tumor short term effect standard evaluation curative effect.
3.2 liang of group patient clinical curative effects relatively in table 1.
Table 1 a liang group patient outcomes compare
Group Number of cases Effective Effectively Invalid Total effective rate (%)
Matched group 45 12 17 16 64.4
Treatment group 45 29 △ 13 3 93.3 △△
Compare with matched group △p < 0.05, △ △p < 0.01
3.3 liang of group follow-up of patients the results are shown in Table 2.
Table 2 liang is organized Patients on Recurrence, is shifted and increase the weight of situation
Group Number of cases Recurrence Transfer Aggravation
Matched group 45 11 10 9
Treatment group 45 2 △△ 2 △ 3 △
Compare with matched group △p < 0.05, △ △p < 0.01
Clinical observation result shows, pharmaceutical composition group overall clinical efficacy rate reaches 93.3%, obviously be better than for lucky capsule matched group (64.4%) difficult to understand, between two groups, statistical procedures has notable difference (P < 0.01), and the later stage follow up a case by regular visits to Preventive and increase the weight of situation medicine composite for curing group obviously comparatively matched group be light (P < 0.05, P < 0.01).Show this medicine composite for curing gastric cancer determined curative effect.

Claims (8)

1. treat a pharmaceutical composition for gastric cancer, it is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
The white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 140-160 weight portion 7,4',4'''-Trimethylamentoflavone 3-4 weight portion taraxerol 1-2 weight portion inokosterone 0.3-0.9 weight portion of Semen Entadae 180-200 weight portion Herba Corydalis 165-175 weight portion.
2. a kind of pharmaceutical composition for the treatment of gastric cancer according to claim 1, is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
White luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 150 weight portion 7,4',4'''-Trimethylamentoflavone 3.5 weight portion taraxerol 1.5 weight portion inokosterone 0.6 weight portion of Semen Entadae 190 weight portion Herba Corydalis 170 weight portion.
3. a kind of pharmaceutical composition for the treatment of gastric cancer according to claim 1, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
4. a kind of pharmaceutical composition for the treatment of gastric cancer according to claim 1, is characterized in that the treatment gastric cancer medicament that pharmaceutical composition and chemical drugs or Chinese medicine form.
5. treat a preparation method for the pharmaceutical composition of gastric cancer, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are the white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 140-160 weight portion 7,4',4'''-Trimethylamentoflavone 3-4 weight portion taraxerol 1-2 weight portion inokosterone 0.3-0.9 weight portion of: Semen Entadae 180-200 weight portion Herba Corydalis 165-175 weight portion;
Preparation method:
(1) by crude drug proportioning Qu Semen Entadae, Herba Corydalis, white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), mixing, micronizing to 50 micron, with weight percent concentration 75% ethanol as solvent, 50 DEG C of warm macerating extract, and extraction time is 3 times, each extraction time is 2 hours, each solvent load is 15 times of medical material gross weight, filters, obtains medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentrated, dry, obtain extract A;
(2) step (1) obtains medicinal residues A weight percent concentration 25% ethanol is solvent, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 16 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by LS300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) get 7,4',4'''-Trimethylamentoflavone, taraxerol, inokosterone by crude drug proportioning, mixing, adds extract A, extract B successively, and mixing, obtains pharmaceutical composition.
6. a kind of preparation method for the treatment of the pharmaceutical composition of gastric cancer according to claim 5, is characterized in that preparing as follows:
The composition of crude drug and weight portion are white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 150 weight portion 7,4',4'''-Trimethylamentoflavone 3.5 weight portion taraxerol 1.5 weight portion inokosterone 0.6 weight portion of: Semen Entadae 190 weight portion Herba Corydalis 170 weight portion;
Preparation method:
(1) by crude drug proportioning Qu Semen Entadae, Herba Corydalis, white luxuriant Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), mixing, micronizing to 50 micron, with weight percent concentration 75% ethanol as solvent, 50 DEG C of warm macerating extract, and extraction time is 3 times, each extraction time is 2 hours, each solvent load is 15 times of medical material gross weight, filters, obtains medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentrated, dry, obtain extract A;
(2) step (1) obtains medicinal residues A weight percent concentration 25% ethanol is solvent, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 16 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, be concentrated into relative density 1.12, filter, medicinal liquid is by LS300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 60% again, collect weight percent concentration 60% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) get 7,4',4'''-Trimethylamentoflavone, taraxerol, inokosterone by crude drug proportioning, mixing, adds extract A, extract B successively, and mixing, obtains pharmaceutical composition.
7. a kind of preparation method for the treatment of the pharmaceutical composition of gastric cancer according to claim 5, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
8. a kind of preparation method for the treatment of the pharmaceutical composition of gastric cancer according to claim 5, is characterized in that pharmaceutical composition and chemical drugs or Chinese medicine form and treats gastric cancer medicament.
CN201510871931.3A 2015-12-03 2015-12-03 Pharmaceutical composition for treating stomach cancer and preparation method thereof Withdrawn CN105343194A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106581139A (en) * 2016-12-10 2017-04-26 济南昊雨青田医药技术有限公司 Pharmaceutical composition for curing stomach cancer and preparation method of pharmaceutical composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106581139A (en) * 2016-12-10 2017-04-26 济南昊雨青田医药技术有限公司 Pharmaceutical composition for curing stomach cancer and preparation method of pharmaceutical composition

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