CN105341919B - A kind of pharmaceutical composition for improving memory and preparation method thereof - Google Patents
A kind of pharmaceutical composition for improving memory and preparation method thereof Download PDFInfo
- Publication number
- CN105341919B CN105341919B CN201510815525.5A CN201510815525A CN105341919B CN 105341919 B CN105341919 B CN 105341919B CN 201510815525 A CN201510815525 A CN 201510815525A CN 105341919 B CN105341919 B CN 105341919B
- Authority
- CN
- China
- Prior art keywords
- gelatin
- beeswax
- taurine
- dha
- lecithin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000002360 preparation method Methods 0.000 title abstract description 12
- 239000008194 pharmaceutical composition Substances 0.000 title abstract description 5
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 42
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 30
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims abstract description 30
- 239000000203 mixture Substances 0.000 claims abstract description 22
- 229960003080 taurine Drugs 0.000 claims abstract description 21
- 108010010803 Gelatin Proteins 0.000 claims abstract description 20
- 235000013871 bee wax Nutrition 0.000 claims abstract description 20
- 239000012166 beeswax Substances 0.000 claims abstract description 20
- 229920000159 gelatin Polymers 0.000 claims abstract description 20
- 239000008273 gelatin Substances 0.000 claims abstract description 20
- 235000019322 gelatine Nutrition 0.000 claims abstract description 20
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 20
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims abstract description 16
- 229940114079 arachidonic acid Drugs 0.000 claims abstract description 16
- 235000000193 zinc lactate Nutrition 0.000 claims abstract description 16
- 229940050168 zinc lactate Drugs 0.000 claims abstract description 16
- 239000011576 zinc lactate Substances 0.000 claims abstract description 16
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 15
- 235000021342 arachidonic acid Nutrition 0.000 claims abstract description 15
- 235000011187 glycerol Nutrition 0.000 claims abstract description 15
- 235000010445 lecithin Nutrition 0.000 claims abstract description 15
- 229940067606 lecithin Drugs 0.000 claims abstract description 15
- 239000000787 lecithin Substances 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000007901 soft capsule Substances 0.000 claims abstract description 13
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims abstract description 11
- 235000020778 linoleic acid Nutrition 0.000 claims abstract description 11
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims abstract description 11
- 239000004480 active ingredient Substances 0.000 claims abstract description 10
- 239000002775 capsule Substances 0.000 claims abstract description 8
- 238000000746 purification Methods 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims description 8
- 239000008213 purified water Substances 0.000 claims description 7
- 239000001993 wax Substances 0.000 claims 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 7
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 abstract description 6
- SBJKKFFYIZUCET-JLAZNSOCSA-N Dehydro-L-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-JLAZNSOCSA-N 0.000 abstract description 6
- MBMBGCFOFBJSGT-KUBAVDMBSA-N docosahexaenoic acid Natural products CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 15
- 238000012360 testing method Methods 0.000 description 8
- 230000005611 electricity Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000008279 sol Substances 0.000 description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 229940092738 beeswax Drugs 0.000 description 4
- 229910052802 copper Inorganic materials 0.000 description 4
- 239000010949 copper Substances 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 238000000227 grinding Methods 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- -1 pelleting Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 210000001525 retina Anatomy 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 235000020256 human milk Nutrition 0.000 description 2
- 210000004251 human milk Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 230000002028 premature Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 description 1
- ADVPTQAUNPRNPO-REOHCLBHSA-N 3-sulfino-L-alanine Chemical compound OC(=O)[C@@H](N)C[S@@](O)=O ADVPTQAUNPRNPO-REOHCLBHSA-N 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 241001553178 Arachis glabrata Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 235000021294 Docosapentaenoic acid Nutrition 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 208000036626 Mental retardation Diseases 0.000 description 1
- 101100246038 Mus musculus Ptpn5 gene Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- ADVPTQAUNPRNPO-UHFFFAOYSA-N alpha-amino-beta-sulfino-propionic acid Natural products OC(=O)C(N)CS(O)=O ADVPTQAUNPRNPO-UHFFFAOYSA-N 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000003022 colostrum Anatomy 0.000 description 1
- 235000021277 colostrum Nutrition 0.000 description 1
- 210000003792 cranial nerve Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
- 230000009189 diving Effects 0.000 description 1
- 229940090949 docosahexaenoic acid Drugs 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 150000002066 eicosanoids Chemical class 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 150000002617 leukotrienes Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000005709 nerve cell growth Effects 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 230000036417 physical growth Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000010118 platelet activation Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000015170 shellfish Nutrition 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention provides a kind of pharmaceutical composition for improving memory and preparation method thereof, its active ingredient of the composition is made of the component of following parts by weight：DHA 5 15, arachidonic acid 10 30, zinc lactate 0.3 0.9, taurine 37, linoleic acid 15 30, lecithin 0.2 0.4.Gelatin, glycerin purification water can be mixed and made into colloidal sol, pelleting, obtains soft capsule using the active ingredient and beeswax ground and mixed as the capsule heart.The present invention is combined by DHA, arachidonic acid, zinc lactate, taurine, linoleic acid, lecithin, finds to be acted synergistically between them, effectively increases health-care effect, improves memory.
Description
Technical field
The present invention relates to a kind of health products, specifically relate to a kind of pharmaceutical composition for improving memory, the invention further relates to this
The preparation method of pharmaceutical composition.
Background technology
DHA, docosahexaenoic acid, is commonly called as docosapentaenoic acid, is a kind of to the very important unrighted acid of human body, belongs to
Important member in omega-3 unsaturated fatty acid family.DHA is nervous system cell growth and a kind of main component maintained, is
The important composition component of brain and retina, content is up to 20% in human brain cortex, institute's accounting in eye retina
Example is maximum, accounts for 50%, therefore, most important to tire infant intelligence and visual acuity.
Arachidonic acid, is all-cis formula-Arachidonic Acid, and chemical formula is as follows：4 (CH=of CH3 (CH2)
CH-CH2) 4 (CH2) 2COOH, belongs to unrighted acid, wherein containing four carbon-to-carbon double bonds, a carbon-oxygen double bond, for height
Level unrighted acid.It is distributed widely in the animal kingdom, is present on a small quantity in the glyceride of some kind, also can be in glycerophosphatide class
Find.Arachidonic acid, is the bioactive substance of many circulation eicosanoid derivatives, such as prostaglandin E2 (PGE2), preceding
Row gland ring element (PGI2), thromboxane element A2 (TXA2) and the direct precursor of leukotrienes and C4 (LTC4).These bioactivity
Metabolism, hemorheology, blood vessel elasticity, leukocyte function and the platelet activation of material to lipid protein etc. has important tune
Section acts on.
Zinc is one of the essential trace elements of the human body, important in growth in humans's development, reproduction heredity, immune, endocrine etc.
Play an important role in physiology course.Zinc lactate is a kind of food zinc enhancer well, to baby and teen-age
Intelligence and body development play the role of important, and assimilation effect is better than inorganic zinc.
Taurine increases in the rich content, widely distributed of intracerebral, the growth and development and cell that can be obviously promoted nervous system
Grow, break up, and be in dose dependent, play an important role in cranial nerve cell growth course.Research shows：In premature's brain
Content of taurine is significantly lower than term infant, this is because the cysteine sulfinic acid dehydrogenase (CSAD) in premature's body is not yet sent out
It is bred as ripe, synthesizing taurine is insufficient for the needs of body, need to be supplemented by breast milk.Content of taurine in breast milk is higher, especially
Content higher in its colostrum.If supplement deficiency, it will make physical growth of children develop slow, mental retardation.Taurine and children
The development of youngster, the nervous centralis of fetus and retina etc. has close relationship, and long-term simple milk is fed, and easily causes taurine
Shortage.
Mentioned component is widely used as active material in health products, but different activities component needs to be closed
Reason collocation could effectively play respective effect.Up to the present, field of health care products has had many products for improving memory,
But effect is still not fully up to expectations, need to be further improved.
The content of the invention
The present invention provides a kind of composition for improving memory for above-mentioned deficiency, and the present invention also provides prepare the combination
The method of thing.
To achieve the above object, technical scheme is as follows：
A kind of composition for improving memory, its active ingredient are made of the component of following parts by weight：DHA 5-15, peanut four
Olefin(e) acid 10-30, zinc lactate 0.3-0.9, taurine 3-7, linoleic acid 15-30, lecithin 0.2-0.4.
Preferably, its active ingredient is made of the component of following parts by weight：DHA 10, arachidonic acid 20, zinc lactate
0.6, taurine 5, linoleic acid 20, lecithin 0.33.
Above-mentioned composition can be prepared into pharmaceutically acceptable various formulations, include but not limited to soft capsule, pill, piece
Agent, pulvis.
It is preferred that the formulation is soft capsule, the soft capsule is by beeswax, gelatin, G ＆ W and the active ingredient system
Into.
Preferably, the beeswax, gelatin, the parts by weight of G ＆ W are：Beeswax 1-3, gelatin 10-15, glycerine 3-7 are pure
Change water 10-15.In one embodiment of the invention, the beeswax, gelatin, the parts by weight of G ＆ W are：Beeswax 1.58, it is bright
Glue 12, glycerine 4.8, purified water 12.
A kind of method for preparing above-mentioned composition, it is using the active ingredient and beeswax ground and mixed as the capsule heart, is incited somebody to action
Gelatin, glycerin purification water are mixed and made into colloidal sol, and pelleting, obtains soft capsule.
The present invention is combined by DHA, arachidonic acid, zinc lactate, taurine, linoleic acid, lecithin, finds between them
Acted synergistically, effectively increase health-care effect, improve memory.
Embodiment
Following embodiments further illustrate present disclosure, but should not be construed as limiting the invention.Without departing substantially from
In the case of of the invention spirit and essence, the modifications or substitutions made to the method for the present invention, step or condition belong to the present invention
Scope.
Unless otherwise specified, the conventional means that technological means used in embodiment is well known to those skilled in the art.
A kind of composition for improving memory of embodiment 1 and preparation method thereof
Formula：DHA 10kg, arachidonic acid 20kg, zinc lactate 0.6kg, taurine 5kg, linoleic acid 20kg, lecithin
0.33kg, beeswax 1.58kg, gelatin 12kg, glycerine 4.8kg, purified water 12kg.
Its preparation method is as follows：By DHA, arachidonic acid, zinc lactate, taurine, linoleic acid, lecithin, beeswax grinding
Mixing is used as the capsule heart, gelatin, glycerin purification water is mixed and made into colloidal sol, pelleting, soft capsule is obtained according to common process.
A kind of composition for improving memory of embodiment 2 and preparation method thereof
Formula：DHA 15kg, arachidonic acid 30kg, zinc lactate 0.3kg, taurine 7kg, linoleic acid 30kg, lecithin
0.4kg, beeswax 3kg, gelatin 15kg, glycerine 7kg, purified water 15kg.
Its preparation method is as follows：By DHA, arachidonic acid, zinc lactate, taurine, linoleic acid, lecithin, beeswax grinding
Mixing is used as the capsule heart, gelatin, glycerin purification water is mixed and made into colloidal sol, pelleting, soft capsule is obtained according to common process.
A kind of composition for improving memory of embodiment 3 and preparation method thereof
Formula：DHA 5kg, arachidonic acid 10kg, zinc lactate 0.9kg, taurine 3kg, linoleic acid 10kg, lecithin
0.2kg, beeswax 1kg, gelatin 10kg, glycerine 3kg, purified water 10kg.
Its preparation method is as follows：By DHA, arachidonic acid, zinc lactate, taurine, linoleic acid, lecithin, beeswax grinding
Mixing is used as the capsule heart, gelatin, glycerin purification water is mixed and made into colloidal sol, pelleting, soft capsule is obtained according to common process.
A kind of composition for improving memory of embodiment 4 and preparation method thereof
Formula：DHA 10kg, arachidonic acid 18kg, zinc lactate 0.45kg, taurine 2kg, linoleic acid 12kg, lecithin
0.3kg, beeswax 2kg, gelatin 12.5kg, glycerine 5kg, purified water 12.5kg.
Its preparation method is as follows：By DHA, arachidonic acid, zinc lactate, taurine, linoleic acid, lecithin, beeswax grinding
Mixing is used as the capsule heart, gelatin, glycerin purification water is mixed and made into colloidal sol, pelleting, soft capsule is obtained according to common process.
5 health products effect detection of embodiment
1st, mouse step down test
The experimental provision of step dow n test is a rectangle reflective box, its major diameter is divided into some sections, bottom by black plastic plate
The copper grid using spacing as 5mm are spread, appropriate electric current (32V alternating currents) can be led to.Each small section has a height and the diameter to be
The chain-wales of 4.5cm.During experiment, mouse is placed on copper grid first, when copper grid are powered, the mouse jumped on copper grid is subject to electricity
Hit, its normal reaction is to hide electric shock to jump onto platform, and most mouse, which is possible to jump off platform again or repeatedly, is shocked by electricity, and is subject to electricity
Platform can be snapped back when hitting again.So training 5min, and the number (errors number) that every mouse is shocked by electricity is recorded, as
School grade.Test after 24h, when this time testting, mouse is placed on diving tower first again, the time that record jumps off for the first time is (latent
The volt phase), the errors number in the number of animals and 5min that are shocked by electricity, memory holding situation is reflected with this.
Experiment and packet：The composition being prepared according to embodiment 1-4 is experimental group 1-4, prepared according to embodiment 1 but
The composition obtained without linoleic acid is test group 5, and linoleic acid is experimental group 6, and commercially available also shellfish soothing soft capsule is experimental group 7, real
The blank capsule casing material for applying example 1 is experimental group 8.Every group of 10 mouse.Every mouse is measured according to 25mg/kg after mouse adapts to environment
Gavage, control group give 0.1ml physiological saline gavages.Step down test is carried out respectively after before administration and when administration 24 is small.
As a result it is as shown in the table
2nd, clinical test
The composition of embodiment 1 is each according to 1200mg, 30-40 Sui adult is provided 3 times a day, continuous 7 days, is divided into
Two groups of every group of 10 people, control group give blank control, carry out Blind Test.Memory state before and after testing is recorded, as a result experimental group self-induction
Memory is obviously improved, and control group does not have significant change.
Claims (7)
1. a kind of composition for improving memory, its active ingredient are made of the component of following parts by weight：DHA 5-15, arachidonic
Sour 10-30, zinc lactate 0.3-0.9, taurine 3-7, linoleic acid 15-30, lecithin 0.2-0.4.
2. composition according to claim 1, it is characterised in that its active ingredient is made of the component of following parts by weight：
DHA 10, arachidonic acid 20, zinc lactate 0.6, taurine 5, linoleic acid 20, lecithin 0.33.
3. composition according to claim 1 or 2, it is soft capsule.
4. composition according to claim 3, it is characterised in that its described soft capsule by beeswax, gelatin, G ＆ W with
The active ingredient is made.
5. composition according to claim 4, it is characterised in that the beeswax, gelatin, the parts by weight of G ＆ W are：
Beeswax 1-3, gelatin 10-15, glycerine 3-7, purified water 10-15.
6. composition according to claim 5, it is characterised in that the beeswax, gelatin, the parts by weight of G ＆ W are：
Beeswax 1.58, gelatin 12, glycerine 4.8, purified water 12.
A kind of 7. method for preparing any one of the claim 1-6 compositions, it is characterised in that by the active ingredient and bee
Gelatin, glycerin purification water are mixed and made into colloidal sol, pelleting, obtains soft capsule by wax ground and mixed as the capsule heart.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510815525.5A CN105341919B (en) | 2015-11-23 | 2015-11-23 | A kind of pharmaceutical composition for improving memory and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510815525.5A CN105341919B (en) | 2015-11-23 | 2015-11-23 | A kind of pharmaceutical composition for improving memory and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105341919A CN105341919A (en) | 2016-02-24 |
| CN105341919B true CN105341919B (en) | 2018-05-01 |
Family
ID=55318197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510815525.5A Active CN105341919B (en) | 2015-11-23 | 2015-11-23 | A kind of pharmaceutical composition for improving memory and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105341919B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108783294A (en) * | 2018-05-24 | 2018-11-13 | 哈福科技（武汉）集团有限公司 | A kind of functional food and preparation method thereof improving memory |
| CN113519848A (en) * | 2021-07-28 | 2021-10-22 | 宁波天皓生物科技有限公司 | Processing method of DHA algae oil and ARA composition product |
| CN115192628A (en) * | 2022-08-24 | 2022-10-18 | 辽宁华康星辰医药科技有限公司 | Composition and preparation with memory enhancing effect and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007128801A1 (en) * | 2006-05-08 | 2007-11-15 | Novartis Ag | Combination of organic compounds |
| CN101965875A (en) * | 2010-10-12 | 2011-02-09 | 李国勇 | Milk powder for improving children intelligence |
| CN103211022A (en) * | 2013-04-24 | 2013-07-24 | 江西雄鹰乳业有限公司 | Intelligence reinforcing milk powder for children |
| CN103989184A (en) * | 2014-06-08 | 2014-08-20 | 宁波市成大机械研究所 | Algal oil soft capsule containing arachidonic acid |
-
2015
- 2015-11-23 CN CN201510815525.5A patent/CN105341919B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007128801A1 (en) * | 2006-05-08 | 2007-11-15 | Novartis Ag | Combination of organic compounds |
| CN101965875A (en) * | 2010-10-12 | 2011-02-09 | 李国勇 | Milk powder for improving children intelligence |
| CN103211022A (en) * | 2013-04-24 | 2013-07-24 | 江西雄鹰乳业有限公司 | Intelligence reinforcing milk powder for children |
| CN103989184A (en) * | 2014-06-08 | 2014-08-20 | 宁波市成大机械研究所 | Algal oil soft capsule containing arachidonic acid |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105341919A (en) | 2016-02-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6375296B2 (en) | Internal composition for improving brain function, internal composition for suppressing amyloid β accumulation in brain, food composition for improving brain function and food composition for suppressing amyloid β accumulation in brain | |
| ES2828479T3 (en) | Methods and compositions to treat, reduce or prevent the deterioration of the visual system of animals | |
| EP1635810A2 (en) | Inflammatory disease treatment | |
| TWI407963B (en) | Contains the composition of riboflavin and sesamin | |
| CN102422907A (en) | Brain tonifying and intelligence developing blend oil | |
| CN105341919B (en) | A kind of pharmaceutical composition for improving memory and preparation method thereof | |
| RU2012114057A (en) | COMPOSITIONS AND METHODS FOR STRENGTHENING THE COGNITIVE FUNCTION AND FUNCTIONS ASSOCIATED WITH IT IN ANIMALS | |
| AU2008301694B2 (en) | Compositions Containing Sesamin-Class Compound(s) and Arachidonic Acid Class Compound(s) | |
| CN107427485B (en) | Medium chain fatty acids and triglycerides thereof for the treatment of anxiety disorders | |
| CN104543274B (en) | A kind of soft sweets containing DHA | |
| CN109419800B (en) | Pharmaceutical composition and application thereof | |
| CN103989179A (en) | Deep sea fish oil soft capsule containing ginkgo leaf extract | |
| CN103989184A (en) | Algal oil soft capsule containing arachidonic acid | |
| WO2015069974A1 (en) | Capsules containing nutritional supplement formulations with enhanced absorption of lipophilic nutrients | |
| JP6368368B2 (en) | Compositions and methods using p-anisaldehyde | |
| CA2914796C (en) | Compositions and methods using tiglic aldehyde | |
| CN102499364A (en) | Soft capsule health-care food capable of delaying senility and resisting radiation | |
| WO2009017343A2 (en) | Functional feed additive | |
| JP2017002015A (en) | Supplement and production method thereof | |
| CN103989176A (en) | Deep sea fish oil soft capsule containing radix puerariae extract | |
| WO2014102643A1 (en) | Novel use of canthaxanthin and 25-hydroxy vitamin d3 | |
| JP2019038770A (en) | Sleep improving composition | |
| JPH0870786A (en) | Improving agent for olfactory function of animal and intellectual training for animal | |
| JP2006282644A (en) | Fatigue recovery agent | |
| CN108064971A (en) | A kind of fish oil health food of brain tonic |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |