CN105340921A - Sterilization composition containing amisulbrom and ametoctradin - Google Patents
Sterilization composition containing amisulbrom and ametoctradin Download PDFInfo
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- CN105340921A CN105340921A CN201510812688.8A CN201510812688A CN105340921A CN 105340921 A CN105340921 A CN 105340921A CN 201510812688 A CN201510812688 A CN 201510812688A CN 105340921 A CN105340921 A CN 105340921A
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- amisulbrom
- azoles mepanipyrim
- sterilization composition
- ametoctradin
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Abstract
The invention discloses a sterilization composition containing amisulbrom and ametoctradin. According to the sterilization composition, amisulbrom and ametoctradin are taken as the active ingredients, and weight ratio of amisulbrom to ametoctradin ranges from 20:1 to 1:20; the total weight of amisulbrom and ametoctradin accounts for 5 to 80% of the weight of the sterilization composition; the sterilization composition can be prepared into one agent selected from a suspending agent, a dispersible oil suspended agent, a water dispersible granule, and a wettable powder, is used for preventing and treating crop diseases caused by fungal pathogens, and especially crop downy mildew and phytophthora disease caused by peronospora pathogens. Application amount of the sterilization composition is reduced, spraying times are reduced, application cost is reduced, and the sterilization composition is safe for crops.
Description
Technical field
What the present invention relates to is bactericidal composition, for active ingredient with amisulbrom and azoles mepanipyrim, be applicable to control by pathogen fungi and bacterial crop pest, especially the crop downy mildew, epidemic disease etc. that cause of Peronosporales (Peronosporales) pathogen.
Background technology
Amisulbrom (amisulbrom) is triazolylsulfonamide series bactericidal agent, to oomycetes and mycetozoan effective, very high to zoospore activity especially, be mainly used in the crop pest that control Oomycete fungal causes, as downy mildew of garpe, potato late blight etc., resistance of rainwater washing against, lasting effect is strong.
Azoles mepanipyrim (ametoctradin) is triazolo pyrimidine series bactericidal agent, belong to mitochondrial respiratory inhibitor, good inhibitory action is had to Oomycete pathogens such as Peronosporaceae, pythiaceae, Shuan Yimei sections, significantly can affect the formation of zoospore, release and sprouting, there is extremely strong residual activity and rain fastness.
Azoles mepanipyrim is systemic fungicide, has excellent protection, therapeutic activity, holding effect is active and resistance of rainwater washing against is active; Be applicable to downy mildew, the epidemic disease of the crops such as control is melon, solanaceous vegetables, grape.
Long-time separately easily generation resistance risk and the consumption of using of agricultural chemicals increases risk, and then increase cost and carrying capacity of environment, and the composition with excellent synergistic function is filtered out by agriculture chemical compounding, Pesticide use amount can not only be reduced, reduce use cost, reduce resistance risk, potential environmental risk can also be reduced.
Found by test, amisulbrom and azoles mepanipyrim used in combination to Peronospora (Peronospora), pythium (Pythium), Phytophthora (Phytophthora), frost Phytophthora (Peronophythora), Pseudoperonospora (Pseudoperonospora), the pathogens such as Plasmopara (Plasmopara) have synergistic function, especially in 20:1 ~ 1:20 proportion to Phytophthora (Phytophthora), Pseudoperonospora (Pseudoperonospora), Plasmopara (Plasmopara) pathogen has obvious synergistic effect.
Amisulbrom and azoles mepanipyrim mixture combine and application there is no report at present.
Summary of the invention
The present invention aims to provide the Synergistic bactericidal composition that a kind of active ingredient is amisulbrom and azoles mepanipyrim, for the prevention and control of crop fungal disease are especially for crop downy mildew, epidemic disease provide one more effective management tool.
The present inventor is by the test of a large amount of indoor bioassay and field medicine effect test, find that amisulbrom and azoles mepanipyrim are with after certain part by weight mixture, have significant synergistic effect to the crop downy mildew, epidemic disease etc. that Peronosporales (Peronosporales) pathogen causes.
On the basis of above-mentioned discovery, after further study, define technical scheme of the present invention, that is: a kind of bactericidal composition containing amisulbrom and azoles mepanipyrim, active ingredient is amisulbrom and azoles mepanipyrim, amisulbrom and azoles mepanipyrim ratio of weight and number are in the composition 20:1 ~ 1:20, and amisulbrom and azoles mepanipyrim weight summation in the composition percentage by weight are 5% ~ 80%, and all the other are the pesticidal preparations auxiliary element that agriculturally can accept and allow to use.
Bactericidal composition of the present invention can be processed into suspending agent, dispersible oil-suspending agent according to well known to a person skilled in the art method, the application forms of the applicable agricultural use such as water dispersible granules, wetting powder.
Bactericidal composition of the present invention is also containing the auxiliary element of preparation needed for pesticidal preparations, comprise one or more mixing in emulsifier, wetting agent, stabilizing agent, dispersant, thickener, defoamer, antifreezing agent, disintegrant, binding agent, filler, filler, medium etc., be known substance, various auxiliary agents conventional in pesticidal preparations, can change to some extent according to different situations, be not particularly limited.
Bactericidal composition of the present invention, for preventing and treating the crop downy mildew, epidemic disease etc. that cause Peronosporales (Peronosporales) pathogen, should before disease occurs or initial stage of origination use during dispenser.
Bactericidal composition provided by the invention, usually adopts spray method to use, also can adopt other operation techniques agriculturally applied as required.
Bactericidal composition provided by the invention has following beneficial effect:
1, bactericidal composition provided by the invention, obvious synergy or summation action is shown in certain ratio range, the control efficiency of composition to germ is significantly improved than single dose, reduce the using dosage of agricultural chemicals, decrease times for spraying, reduce drug cost, decrease the adverse effect of agricultural chemicals to ecotope.
2, bactericidal composition provided by the invention, the combination of two kinds of active ingredients, expands fungicidal spectrum, and a drug can solve multiple diseases problem, compensate for defect when single dose uses and limitation.
3, bactericidal composition provided by the invention, two kinds of active ingredient mechanism of action are not quite identical, can overcome the shortcoming that long-term single use easily produces resistance, extend the service life of medicament, to the comprehensive regulation important in inhibiting of germ resistance.
4, bactericidal composition provided by the invention, drug effect plays rapidly, and the lasting period is long, and use cost is low, easy to use, time saving and energy saving, and it applies huge economic benefit and social benefit
Embodiment
In order to make object of the present invention, technical scheme and advantage more short and sweet, the following specific embodiment of the present invention is described, but the present invention is only limitted to absolutely not these embodiments.The following stated is only the good embodiment of the present invention, only for describing the present invention, can not be interpreted as the restriction to scope of the present invention.It should be pointed out that all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Content described in embodiment is all weight percentage.
According to the abundant method of Sun Yun, the synergy of pharmacy mix is evaluated according to co-toxicity coefficient (CTC), namely CTC≤80 are joint action of antagonism, and 80 < CTC < 120 are joint action of antagonism, and CTC >=120 are synergistic function.Actual measurement toxicity index (ATI)=(EC of standard agent
50the EC of/reagent agent
50) × 100; In the toxicity index × mixture of theoretical toxicity index TTI=A medicament the percentage composition+B medicament of A medicament toxicity index × mixture in the percentage composition of B medicament; Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] × 100
Embodiment one: amisulbrom azoles mepanipyrim is tested the Toxicity Determination of phytophthora infestans (Phytophthprainfestans)
Subjects picks up from the potato late blight pathogen phytophthora infestans (Phytophthprainfestans) in field, method reference " People's Republic of China (PRC) agricultural industry criteria NY/T1156.2-2006 ", mycelial growth Plating.
Table 1, amisulbrom azoles mepanipyrim are to the Toxicity Determination result of phytophthora infestans (Phytophthprainfestans)
As shown in Table 1, amisulbrom and azoles mepanipyrim mixture are between 20:1 ~ 1:20, and have obvious synergistic effect to phytophthora infestans (Phytophthprainfestans), co-toxicity coefficient is all more than 160.
Embodiment two: amisulbrom azoles mepanipyrim is tested the Toxicity Determination of Pseudoperonospora cubensis (Pseudoperonosporacubensis).
Subjects is pick up from the cucumber downy mildew pathogen Pseudoperonospora cubensis (Pseudoperonosporacubensis) in field, method reference " People's Republic of China (PRC) agricultural industry criteria NY/T1156.3-2006 ", plate blade method.
Table 2, amisulbrom azoles mepanipyrim are to the Toxicity Determination result of Pseudoperonospora cubensis (Pseudoperonosporacubensis)
As shown in Table 2, amisulbrom and azoles mepanipyrim mixture are between 20:1 ~ 1:20, and have obvious synergistic effect to Pseudoperonospora cubensis (Pseudoperonosporacubensis), co-toxicity coefficient is all more than 170.
Embodiment three: amisulbrom azoles mepanipyrim is to the Toxicity Determination test of the raw single shaft of grape mould (Plasmoparaviticola).
Subjects is pick up from the raw single shaft of the downy mildew of garpe pathogen grape mould (Plasmoparaviticola) in field, pot experiment method.
Table 3, amisulbrom azoles mepanipyrim are to the Toxicity Determination result of the raw single shaft of grape mould (Plasmoparaviticola)
As shown in Table 3, amisulbrom and azoles mepanipyrim mixture are between 20:1 ~ 1:20, and have obvious synergistic effect to the raw single shaft of grape mould (Plasmoparaviticola), co-toxicity coefficient is all more than 150.
Below in conjunction with embodiment to further instruction of the present invention.
Embodiment four: 40% amisulbrom azoles mepanipyrim suspending agent.
Amisulbrom 10%, azoles mepanipyrim 30%, castor oil polyoxyethylene ether 10%, urea 5%, acrylic acid receives 1%, and deionized water complements to 100%, is pulverized in advance in proportion by above-mentioned formula, add in sand mill again and grind, the obtained 40% amisulbrom azoles mepanipyrim suspending agent of allotment after high shear mixing.
40% amisulbrom azoles mepanipyrim suspending agent is adopted to be used for preventing and treating potato late blight, spray by 150ga.i./ha thin up, after medicine, the preventive effect of 7 days, 14 days is 85.2%, 77.1%, 10% amisulbrom water dispersible granules presses 150ga.i./ha, 10% azoles mepanipyrim suspending agent by the spraying of 150ga.i./ha thin up, and after medicine, 7 days, 14 days preventive effects are respectively 78.2%, 72.4% and 75.0%, 79.1%.Amisulbrom and the composite rear synergistic effect of azoles mepanipyrim obvious, single dose is better than to the preventive effect successful of potato late blight, obviously reduce when in compound drug, the amount ratio of active ingredient is used alone, total active ingredient also reduces relatively, thus alleviates carrying capacity of environment, reduces use cost.
Embodiment five: 30% amisulbrom azoles mepanipyrim dispersibles oil-suspending agent.
Amisulbrom 10%, azoles mepanipyrim 20%, hydroxyethylcellulose 1.5%, polyoxyethylene polyoxypropylene base ether block copolymers 5%, methyl oleate 25%, organobentonite 8%, cocoa butter complements to 100%, pulverized in advance in proportion by above-mentioned formula, then add in sand mill and grind, after high shear mixing, the obtained 30% amisulbrom azoles mepanipyrim of allotment dispersibles oil-suspending agent.
30% amisulbrom azoles mepanipyrim is adopted to dispersible oil-suspending agent for preventing and treating downy mildew of lichee, spray by 200mg/kg thin up, after medicine, the preventive effect of 7 days, 14 days is 90.4%, 83.3%, 10% amisulbrom water dispersible granules presses 200mg./kg, 30% azoles mepanipyrim suspending agent by the spraying of 200mg/kg thin up, and after medicine, 7 days, 14 days preventive effects are respectively 80.3%, 70.3% and 81.4%, 68.3%.Amisulbrom and the composite rear synergistic effect of azoles mepanipyrim obvious, single dose is better than to the preventive effect successful of downy mildew of lichee, obviously reduce when in compound drug, the amount ratio of active ingredient is used alone, total active ingredient also reduces relatively, thus alleviates carrying capacity of environment, reduces use cost.
Embodiment six: 60% amisulbrom azoles mepanipyrim water dispersible granules.
Amisulbrom 10%, azoles mepanipyrim 50%, benzyl naphthalene sulfonic formaldehyde condensation compound 8%, polycarboxylic acids sodium 5%, sodium alginate 5%, walnut parting 4%, kaolin complements to 100%.By above-mentioned formula, 60% amisulbrom azoles mepanipyrim water dispersible granules is made and is obtained in dry pulverization process, granulation, drying, screening in proportion.
60% amisulbrom azoles mepanipyrim water dispersible granules is adopted to be used for preventing and treating downy mildew of garpe, spray by 150mg/kg thin up, after medicine, the preventive effect of 7 days, 14 days is 88.8%, 82.6%, 10% amisulbrom water dispersible granules presses 150mg/kg, 30% azoles mepanipyrim water dispersible granules by the spraying of 150mg/kg thin up, and after medicine, 7 days, 14 days preventive effects are respectively 79.6%, 68.3% and 74.4%, 70.3%.Amisulbrom and the composite rear synergistic effect of azoles mepanipyrim obvious, single dose is better than to the preventive effect successful of downy mildew of garpe, obviously reduce when in compound drug, the amount ratio of active ingredient is used alone, total active ingredient also reduces relatively, thus alleviates carrying capacity of environment, reduces use cost.
Embodiment seven: 50% amisulbrom azoles mepanipyrim wetting powder.
Amisulbrom 10%, azoles mepanipyrim 40%, wooden polyvinylpyrrolidone 7%, alkylphenol-polyethenoxy base ether 7%, white carbon 5%, potter's clay complements to 100%.Mix entering in blender after above-mentioned formula in proportion coarse crushing, more namely obtain 50% amisulbrom azoles mepanipyrim wetting powder after air-flow crushing.
Adopt 50% amisulbrom azoles mepanipyrim wetting powder for preventing and treating sight tomato late blight, spray by 160ga.i./ha thin up, after medicine, the preventive effect of 7 days, 14 days is 91.8%, 82.7%, 10% amisulbrom wetting powder presses 160ga.i./ha, 30% azoles mepanipyrim water dispersible granules by the spraying of 160ga.i./ha thin up, and after medicine, 7 days, 14 days preventive effects are respectively 89.4%, 71.6% and 81.4%, 71.3%.Amisulbrom and the composite rear synergistic effect of azoles mepanipyrim obvious, single dose is better than to the preventive effect successful seeing tomato late blight, obviously reduce when in compound drug, the amount ratio of active ingredient is used alone, total active ingredient also reduces relatively, thus alleviates carrying capacity of environment, reduces use cost.
Claims (3)
1. one kind contains the bactericidal composition of amisulbrom and azoles mepanipyrim, it is characterized in that: active ingredient is amisulbrom and azoles mepanipyrim, amisulbrom and azoles mepanipyrim ratio of weight and number are in the composition 20:1 ~ 1:20, and amisulbrom and azoles mepanipyrim weight summation in the composition percentage by weight are 5% ~ 80%.
2. a kind of bactericidal composition containing amisulbrom and azoles mepanipyrim according to claim 1, is characterized in that: described bactericidal composition is processed into suspending agent, dispersibles oil-suspending agent, water dispersible granules, wetting powder.
3. a kind of application of bactericidal composition in the crop downy mildew of preventing and treating to be caused by Peronosporales pathogen, epidemic disease containing amisulbrom and azoles mepanipyrim as claimed in claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510812688.8A CN105340921A (en) | 2015-11-19 | 2015-11-19 | Sterilization composition containing amisulbrom and ametoctradin |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510812688.8A CN105340921A (en) | 2015-11-19 | 2015-11-19 | Sterilization composition containing amisulbrom and ametoctradin |
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|---|---|---|---|
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106417313A (en) * | 2016-09-20 | 2017-02-22 | 佛山市盈辉作物科学有限公司 | Bactericidal composition containing amisulbrom and fluopicolide |
| CN106489953A (en) * | 2016-08-31 | 2017-03-15 | 广东中迅农科股份有限公司 | A kind of bactericidal composition containing ZJ0712 and amisulbrom |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101232814A (en) * | 2005-07-27 | 2008-07-30 | 巴斯福股份公司 | Fungicidal mixtures based on azolopyrimidinylamines |
-
2015
- 2015-11-19 CN CN201510812688.8A patent/CN105340921A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101232814A (en) * | 2005-07-27 | 2008-07-30 | 巴斯福股份公司 | Fungicidal mixtures based on azolopyrimidinylamines |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106489953A (en) * | 2016-08-31 | 2017-03-15 | 广东中迅农科股份有限公司 | A kind of bactericidal composition containing ZJ0712 and amisulbrom |
| CN106417313A (en) * | 2016-09-20 | 2017-02-22 | 佛山市盈辉作物科学有限公司 | Bactericidal composition containing amisulbrom and fluopicolide |
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Application publication date: 20160224 |
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