CN1053379C - Linghuang Oral Liquid - Google Patents
Linghuang Oral Liquid Download PDFInfo
- Publication number
- CN1053379C CN1053379C CN 96117834 CN96117834A CN1053379C CN 1053379 C CN1053379 C CN 1053379C CN 96117834 CN96117834 CN 96117834 CN 96117834 A CN96117834 A CN 96117834A CN 1053379 C CN1053379 C CN 1053379C
- Authority
- CN
- China
- Prior art keywords
- radix
- oral liquid
- linghuang
- magnesium
- zinc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
The invention relates to a Chinese patent medicine oral liquid preparation prepared by taking Chinese herbal medicines as raw materials and a preparation method of the preparation. The health-care food is prepared by adopting fungus lucid ganoderma, astragalus, ginseng, polygonum multiflorum and black-bone chicken according to the formula of the theory of traditional Chinese medicine, and through the steps of material selection, cleaning, drying, soaking, decocting, filtering and extracting, and adding trace elements of zinc and magnesium. The medicament of the invention contains rich ganoderan, various amino acids, vitamins, trace elements and the like, and has various medicinal values of improving immunity, enhancing antibody, resisting aging, resisting tumor, resisting inflammation, resisting virus and the like.
Description
The present invention relates to medicinal preparation, particularly a kind of is the Chinese medicine liquor preparation of feedstock production with the Chinese herbal medicine, the invention still further relates to this medicaments preparation method.
Variation along with age composition, wearing out of world population age, the sickness rate of cardiovascular and cerebrovascular vessel rises year by year, simultaneously, the raising of living standards of the people, dietary structure is improved and the increase and the intake of picked-up finishing food reduce, and causes the trace element deficiency disease outstanding, becomes one of major issue that influences human health, middle-aged and elderly people replenishes some trace element at any time in right amount, seem very necessary,, improve middle-aged and elderly people body constitution for reducing the sickness rate of cardiovascular and cerebrovascular disease, improve the population average life span, press for and seek to be applicable to the middle-aged and elderly people treatment, health care, slow down aging is an one, and taking convenience, the medicine of nontoxic pair of effect.
Though the Chinese Traditional Medicines of many treatment cardiovascular and cerebrovascular diseases and other person in middle and old age's disease are also arranged at present,,, treatment are seen that with the angle that health care combines effect is not fairly obvious from the comprehensive function of human body of improving because curative effect is single.
The object of the present invention is to provide a kind of can the prevention and the treatment cardiovascular and cerebrovascular disease, simultaneously to the central nervous system, respiratory system, aspect diseases such as digestive system all have certain treatment and preventive effect, body-building is anti-ageing, improves immunity, promotes antibody, be applicable to that middle-aged and elderly people treatment, health care, slow down aging are the oral liquid medicine of one, and this medicaments preparation method.
Technical scheme of the present invention is based on the principle of motherland's traditional medicine to the understanding of aging and invigorating the spleen and replenishing QI, the liver and the kidney tonifying, employing cures mainly two flavor principal agents of deficiency of spleen-QI and stomach-QI: the Radix Astragali and Radix Ginseng, add medicine Radix Polygoni Multiflori with the liver and the kidney tonifying effect, spleen invigorating, calm the nerves, reinforcing the heart, the medicine Ganoderma of QI invigorating and the Gallus Domesticus of benefiting QI and nourishing blood, by the theory of Chinese medical science prescription, skim the cream off milk, its performance viscosity reduction, blood fat reducing, antithrombotic are formed, improve circulation, strengthen myocardial contraction, increase the regional myocardial blood flow; Adjusting, calm central nervous system; The liver protecting, elimination jaundice, transaminase lowering promotes appetite; Body-building is anti-ageing, exhales the old and inhale the new; Improve immunity, promote antibody; Effects such as antiinflammatory, antiviral, antiallergic also have certain treatment and prophylactic function to various cancers.
Medicament of the present invention is made (weight proportion that consumption props up by 10mL/) by following component:
The Ganoderma 0.5-0.8g Radix Astragali 0 5-0.8g Radix Ginseng 0.3-0.6g
Radix Polygoni Multiflori 0.8-1.0g Gallus Domesticus 1.0-1.5g zinc 8mg
Magnesium 15mg simple syrup 2-3mL
The formula optimization weight proportion of preparation medicament of the present invention is (propping up by 10mL/):
Ganoderma 0.8g Radix Astragali 0.5g Radix Ginseng 0.5g Radix Polygoni Multiflori 1.0g
Gallus Domesticus 1.0g zinc 8mg magnesium 15mg simple syrup 2mL
The production method of above-mentioned each component being made medicament of the present invention is:
1. Ganoderma, Radix Ginseng, the Radix Astragali, Radix Polygoni Multiflori screening clean dry are pulverized, added 6-8 60% alcohol solution dipping doubly more than 24 hours, the leaching soak is deposited;
2. Gallus Domesticus kills the back and removes unhairing, internal organs, rinsing blood and slime (gauze wrapping), preceding operation residue medicinal residues are put into the ethanol liquid (flood and be as the criterion) of 40-50% with Gallus Domesticus, regulating PH is 7.4 (regulating with 40%NaoH liquid), twice of reflux, extract,, 2 hours for the first time, 1.5 hours for the second time, merge leach cooking liquid and filter;
3. aforementioned soak and filtrate are merged, reclaim ethanol, being concentrated into relative density is 1: 1.2-1.25, put and be cooled to room temperature in the settling box and add ethanol and transfer to 30-40% concentration, add dissolved zinc, magnesium solution again, fully stir, leave standstill 24 hours precipitation (or cold preservation precipitation) after, get its supernatant;
4. filtrate recycling ethanol adds simple syrup, pure water to 10mL (Sugarless type removes simple syrup), and the adjusting pH value is 6.0-7.2, filter, and packing, sterilization is promptly.
Contain abundant nutrition in the Linghuang oral liquid made from Gaboderma lucidum and scutellaria root medicament of the present invention, comprise protein, vitamin C, B1, B2 etc., and containing 18 seed amino acids of needed by human body, (amino acid analysis uses the test of the 835-50 of Hitachi type automatic amino acid analyzer in test by analysis; Trace element analysis adopts the AAS method to measure zinc, copper, ferrum, magnesium, strontium and elemental lithium; Adopt polarography to analyze germanium and selenium element; Adopt colorimetrically analysing chromium element; The nutrition analysis adopts Kjeldahl to measure protein; Measure fat with acid-hydrolysis method; Use the colorimetric method for determining vitamin; With fluorescence spectrometry vitamin B1 and B2), each amino acid composition content such as following table:
| Title | Unit (mg/100mL) | Title | Unit (mg/100mL) |
| Aspartic Acid threonine serine | 49.40 2.81 4.77 | Isoleucine leucine tyrosine | 2.99 4.64 trace |
| The misty propylhomoserin methionine (first sulfur) of glutamic acid glycine alanine cystine | 35.60 3.08 16.40 3.63 7.22 5.67 | Phenylalanine lysine ammonia histidine arginine fat propylhomoserin | 5.93 1.56 14.50 trace 6.62 36.5 |
Also contain various trace elements such as zinc, magnesium, ferrum, germanium, selenium in Linghuang oral liquid made from Gaboderma lucidum and scutellaria root medicament of the present invention, these trace element all have important effect for raising antibody, enhance immunity, defying age.Each micronutrient levels such as following table in the medicament of the present invention:
| Title | Content (mg/L) | Title | Content (mg/L) | Title | Content (mg/L) |
| Zinc-copper ferrum | 22.55 0.19 4.70 | Magnesium strontium chromium | 14.28 0.44 0.04 | Selenium germanium | 0.0014 0.039 |
Advantage of the present invention is that to select the natural edible-plant medicine for use be raw material, through modern science and technology technology refining the forming that combine with Chinese medicine compound preparation, contain abundant ganoderan, each seed amino acid, vitamin, trace element etc., have the immunity of raising, promote multiple medical values such as antibody, defying age, antitumor, antiinflammatory, antiviral, its function and effect are:
1. viscosity reduction, blood fat reducing, antithrombotic form, and improve circulation, strengthen myocardial contraction, increase the regional myocardial blood flow, thus prevention and treatment cardiovascular and cerebrovascular disease, uneven as the rhythm of the heart, angina pectoris, myocardial infarction, coronary heart disease, cerebral thrombosis, from blood pressure, arteriosclerosis, hyperlipidemia, high blood viscosity etc.
2. the central nervous system there are adjustment, sedation; To the neurasthenia, insomnia and dreamful sleep, dizziness and tinnitus, deafness, effect such as nervus vasculairs headache is obviously.
3. the liver protecting is eliminated jaundice, and transaminase lowering promotes appetite, to the prophylactic treatment liver cirrhosis, and hepatitis A, hepatitis B, the hepatitis C effect is also good.
4. anti-ageing, the effect of exhaling the old and inhale the new of body-building.Rich in amino acid, vitamin, trace element are good nutrient excellent products; Ganoderan, zinc, chromium, selenium, organic germanium; has intensive deoxidizing capacity; it is extremely strong antioxidant; improve the sudismase vigor, the protection body cell is not subjected to the damage of free radical, increases the cell oxygen content; reduce the erosion of toxic substance to body; make human body viscera or organ be tending towards normally regulating inharmonious part comprehensively, thereby reach the anti-ageing purpose of body-building.
5. improve immunity, promote antibody.Ganoderan, organic germanium, selenium, zinc and each seed amino acid, vitamin all can be regulated immunologic function, promote normal immunity, germanium, selenium can make TC and bone-marrow-derived lymphocyte increased functionality, natural killer cell hypertrophy and activation, so effective to the immunologic hypofunction associated diseases, as cancer, nephritis, rheumatoid arthritis, lupus erythematosus, liver cirrhosis etc.
6. to the effect of respiratory system, because this medicine has antiinflammatory, antiviral, anti-allergic effects, so also effective to chronic bronchitis, bronchial asthma.
Linghuang oral liquid made from Gaboderma lucidum and scutellaria root medicament of the present invention has passed through toxicology and has cured mainly relevant Pharmacodynamic test of active extract with function.By life span of drosophila melanogaster and defying age series of experiment research being shown energy enhancing body vigor, enhancing body cold tolerance, enhancement sexual function; Show by series of experimental research the BALB/C mice Immune Function, to specific cellular immunity (hemolytic plaque test), specific humoral immunity (drenching changes test) and non-specific monokaryon one macrophage phagocytic function etc. all have stronger adjusting potentiation; By chmice acute per os toxicity test, rabbit skin irritation test, family exempts from eye irritation test, proves that this oral liquid acute oral toxicity belongs to non-toxic type, its maximum tolerated dose greater than 20g/kg (be equivalent to clinical application amount 33.33 times) to the equal nonirritant of skin and eye; Show that by 90 days subchronic toxicity tests of rat 11 kinds of major organs such as rat Liver and kidney are not had the form structural damage, do not cause whole body physiology, biochemical function state and tissue morphology structural change, show that this oral liquid takes no toxicity for a long time.
For showing the therapeutic effect of Linghuang oral liquid made from Gaboderma lucidum and scutellaria root medicament of the present invention, select the patient of medical history, age, sex, severity extent, complication treatment time basically identical, divide treatment group " A " 48 examples, matched group " B " 30 examples, carried out the clinical case treatment and observed, treatment group conventional therapy adds Linghuang oral liquid made from Gaboderma lucidum and scutellaria root 10mL, every day 2-3 time, matched group is treated routinely, and the result is as follows:
| Disease name | Group | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Obvious effective rate % |
| Brain A sclerosis | A B | 34 17 | 22 7 | 12 9 | 1 | 65 41 |
| Coronary heart disease | A B | 18 6 | 16 2 | 2 4 | 89 33.3 | ||
| Cerebral thrombosis | A B | 10 8 | 5 3 | 3 2 | 2 3 | 80 62.5 | |
| Sudden deafness | A B | 3 2 | 3 | 1 | 1 | 100 0 | |
| Hepatitis B | A B | 3 4 | 3 | 4 | 100 0 | ||
| Hypertension | A B | 6 8 | 5 3 | 1 2 | 1 | 83 37.5 |
The result shows that Linghuang oral liquid made from Gaboderma lucidum and scutellaria root of the present invention is obvious to cardiovascular and cerebrovascular vessel ischemic diseases effect, and effect is better than matched group, as can be seen hepatitis b surface antigen positive is had the gratifying effect of turning out cloudy simultaneously.The clinical symptoms curative effect of carrying out in treatment clinical course simultaneously comparison shows that: oral liquid of the present invention has very obvious effects to improving clinical symptoms such as dizziness, tinnitus, numb limbs and tense tendons, insomnia and dreamful sleep, cardiopalmus tachypnea; The prompting of hemorheology index comparing result: the whole blood viscosity height is cut and erythrocyte sedimentation rate binomial index P＜0.01, and significant differences is arranged, and illustrates that to blood viscosity lowering the depolymerization erythrocyte aggregation increases erythrocyte and takes O
2, improving blood circulation has important effect and clinical meaning; Contrast shows before and after the lipid therapy: to improving high-density lipoprotein, reducing low-density lipoprotein has the important clinical meaning.
Fig. 1 is a medicaments preparation process chart of the present invention.
Embodiments of the invention are:
Take by weighing raw material by following proportioning:
Ganoderma 0.8g Radix Astragali 0.5g Radix Ginseng 0.5g Radix Polygoni Multiflori 1.0g
Gallus Domesticus 1.0g zinc 8mg magnesium 15mg simple syrup 2mL
Production method is as follows:
1. Ganoderma, Radix Ginseng, the Radix Astragali, Radix Polygoni Multiflori screening clean dry are pulverized, added 6-8 60% alcohol solution dipping doubly more than 24 hours, the leaching soak is deposited;
2. Gallus Domesticus kills the back and removes unhairing, internal organs, rinsing blood and slime (gauze wrapping), preceding operation residue medicinal residues are put into the ethanol liquid (flood and be as the criterion) of 40-50% with Gallus Domesticus, regulating PH is 7.4 (regulating with 40%NaoH liquid), twice of reflux, extract,, 2 hours for the first time, 1.5 hours for the second time, merge leach cooking liquid and filter;
3. aforementioned soak and filtrate are merged, reclaim ethanol, being concentrated into relative density is 1: 1.2-1.25, put and be cooled to room temperature in the settling box and add ethanol and transfer to 30-40% concentration, add dissolved zinc, magnesium solution again, fully stir, leave standstill post precipitation more than 24 hours, get its supernatant;
4. recovery ethanol, filtrate add simple syrup (Sugarless type does not add simple syrup), pure water to 10mL, and adjustings pH value is 6.0-7.2, filter, and packing is sterilized promptly.
Product specification is by every 10mL, 10 dresses of every box.
Claims (3)
1. Linghuang oral liquid made from Gaboderma lucidum and scutellaria root medicine is characterized in that it is the medicament of being made by the following weight proportion raw material, props up by 10mL/:
Ganoderma 0.5-0.8g Radix Astragali 0.5-0.8g Radix Ginseng 0.3-0.6g
Radix Polygoni Multiflori 0.8-1.0g Gallus Domesticus 1.0-1.5g zinc 8mg
Magnesium 15mg simple syrup 2mL-3mL.
2. Linghuang oral liquid made from Gaboderma lucidum and scutellaria root medicine according to claim 1, wherein the weight proportion of each raw material props up by 10mL/ and is:
Ganoderma 0.8g Radix Astragali 0.5g Radix Ginseng 0.5g Radix Polygoni Multiflori 1.0g
Gallus Domesticus 1.0g zinc 8mg magnesium 15mg simple syrup 2mL.
3. claim 1, the preparation method of 2 described Linghuang oral liquid made from Gaboderma lucidum and scutellaria root medicines, it is characterized in that: with Ganoderma, Radix Ginseng, the Radix Astragali, the Radix Polygoni Multiflori drying and crushing, add 6-8 60% alcohol solution dipping doubly more than 24 hours, the leaching soak is deposited, the residue medicinal residues are put into the ethanol liquid of 40-50% with the gauze wrapping with Gallus Domesticus, flood and be as the criterion, regulating pH value is 7.4, twice of reflux, extract,, merging twice leach cooking liquid filters, reclaim ethanol and be concentrated into relative density 1: 1.2-1.25, soak and filtrate merging are concentrated in the rearmounted settling box, be cooled to room temperature adding ethanol and transfer to 30-40% concentration, add dissolved zinc again, magnesium solution, fully stir, leave standstill post precipitation more than 24 hours, get its supernatant and reclaim ethanol, add simple syrup, pure water is to 10mL, the adjusting pH value is 6.0-7.2, filters packing, sterilization makes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96117834 CN1053379C (en) | 1996-12-12 | 1996-12-12 | Linghuang Oral Liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96117834 CN1053379C (en) | 1996-12-12 | 1996-12-12 | Linghuang Oral Liquid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1170593A CN1170593A (en) | 1998-01-21 |
| CN1053379C true CN1053379C (en) | 2000-06-14 |
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ID=5124651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 96117834 Expired - Fee Related CN1053379C (en) | 1996-12-12 | 1996-12-12 | Linghuang Oral Liquid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1053379C (en) |
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1996
- 1996-12-12 CN CN 96117834 patent/CN1053379C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1170593A (en) | 1998-01-21 |
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