CN105335658A - Application system for performing urine analysis by using camera function of intelligent mobile device - Google Patents
Application system for performing urine analysis by using camera function of intelligent mobile device Download PDFInfo
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- CN105335658A CN105335658A CN201410406071.1A CN201410406071A CN105335658A CN 105335658 A CN105335658 A CN 105335658A CN 201410406071 A CN201410406071 A CN 201410406071A CN 105335658 A CN105335658 A CN 105335658A
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Abstract
The invention discloses an application system for performing urine analysis by using a camera function of an intelligent mobile device. The application system mainly comprises an application system based on an intelligent mobile terminal and a matched test paper groove. In order to realize portability and low cost required by mobile medical treatment and health management, urine analysis test paper is shot by comprehensively using a special test paper groove and a mobile application, and a relationship of urine components on color RGB values of a reagent pad on the test paper is obtained in a least square fit modeling mode, so that a detection concentration range is obtained by interpolation. In the process, in order to identify the position of the reagent pad in an image and reduce environmental noise, the position of the test paper in a photo and the position of each color block of the reagent pad are positioned in combination with the specially designed test paper groove by utilizing an image segmentation technology in image processing, and filtration, noise reduction and illumination compensation in HSV space are performed. The application system can be used for daily household urine health monitoring and doctor-seeing guidance.
Description
Technical field
The technical field of the invention is portable medical and urine detection field.
Current medical treatment and health control are key areas of internet, applications, and the rise of Mobile solution is that medical services and personal health management create huge development space.In European and American developed countries, Medical Informalization is walked far away before the world.The investigation of famous consulting firm of the U.S. finds, U.S. medical personnel apply mobile device and assist the number ratio of diagnosis and treatment work up to 70%.Before big screen intelligent mobile phone is not universal, the Mobile solution of medical personnel is all adopt palm PC (PDA) substantially.The function of present PDA is integrated in big screen intelligent mobile phone.China does not experience the stage that PDA popularizes use, but has directly been upgraded to big screen intelligent mobile phone and 3G application, and gap reduces rapidly, creates platform to sector application.Along with people are to the demand of healthy living, healthy class software will more and more come into one's own.Mobile healthy application comprises portable medical and mobile health control, mainly refers to that consumer obtains better medical treatment and Health management service by mobile terminal and mobile communication technology.
Urinalysis is the optimumitem of diagnosis of urinary diseases, observation of curative effect and prognosis, also can be used for the diagnosis of metabolic system disease, the order of severity of the reflection aspect such as kidney and the urinary tract disease and progress.Be no matter the pathology of which kind of system when causing blood constituent to occur changing, all can cause the corresponding pathology of urinary fractions to a large extent.The situations such as the inflammation of common urinary system, calculus, tumour, vascular lesion and Post kidney transplantation generation rejection, by having very important meaning to the urinalysis of human body to urinary system diagnosis and observation of curative effect.Simultaneously urinalysis can also examination with or without the disease such as kidney, liver, to have very great help for early diagnosis and prevention.
The principle of Medical urine analyser is placed in instrument cell by the reagent strip being adsorbed with urine, reagent strip produces the various reagent pads of chemical reaction by light source irradiation, its reflected light is received by surface integral instrument, the photoelectric tube of surface integral instrument is irradiated by the dual wavelength light (mensuration light and a branch of reference light by filter disc) reflected, and the selection of each wavelength is determined by test item.Instrument calculates reflectivity by reflectance formula R (%)=Tm.Cs/TsCm × 100% robotization, then compares with typical curve, finds out the accordingly result of various composition, and wherein, R (%) is reflectivity; Tm is that reagent pad is to the reflection strength measuring wavelength; Ts is the reflection strength of reagent pad to reference wavelength; Cm is that more accurate pad is to measuring the long reflection strength of defect; Cs is the reflection strength of calibration to reference wavelength.In urine, certain component content is high, and the reflected light of its corresponding reagent pad is comparatively dark, otherwise stronger.
The present invention proposes and devises a kind ofly only to utilize various intelligent mobile terminal equipment just can obtain the methods and applications system of urine Principle components analysis result by taking a picture to Urine test paper, realize low cost, the main project analysis of urinary fractions easily and monitoring.
Background technology
1. what present conventional Medical urine checkout equipment adopted is light reflectivity detection method, the principle of Urine Analyzer is placed in instrument cell by the reagent strip being adsorbed with urine, reagent strip produces the various reagent pads of chemical reaction by light source irradiation, its reflected light is received by surface integral instrument, the photoelectric tube of surface integral instrument is irradiated by the dual wavelength light (mensuration light and a branch of reference light by filter disc) reflected, and the selection of each wavelength is determined by test item.But equipment is comparatively large and need professional people to operate, generally can only use in medical institutions, low cost that modern mobile portable medical and health control embody and aim easily cannot be met.
The present invention is based on digital photographic technology, digital photographing mainly contains taking lens in image capturing part, viewing lens, flashlamp, photoreceptor and auto heterodyne pilot lamp etc.; In imaging and record, digital vedio recording, mainly by sensitive chip and memory card, is crossed inter-process and the scenery photographed is converted to the image deposited in a digital format.Therefore, the picture obtained by mobile terminal camera technique is actual is bitmap format, therefrom can extract RGB (RGB) or HSV (hue, saturation, intensity) component of each picture element point chromatic of photo.
2. present invention utilizes the chromogenic reaction of urine and Test paper.Constitutional changes tested in sample are become the chemical reaction of colored compound, be chromogenic reaction.In urine detection, the reagent in dedicated test test paper can produce the phenomenon of chromogenic reaction with urinary fractions.Test paper has specific development properties and regular feature containing the different reagent pad detecting reagent for heterogeneity in urine simultaneously, the mensuration to constituent concentration corresponding in urine can be realized according to this.Such as, the reaction principle of urine occult blood analysis test paper is the pseudo-peroxide enzymatic activity catalytic decomposition superoxide of the heme utilized in haemoglobin, produces the oxygen of nascent state, oxidation indicator, indicator is developed the color, the concentration of blood urine can be learnt from the intensity of colour developing.
3. take a picture to urine test paper with intelligent mobile terminal, the impact of test paper position and background colour when being subject to taking a picture, can None-identified reagent pad position in the picture.
For this reason, the present invention utilizes the image Segmentation Technology in image procossing, in conjunction with custom-designed test paper groove, comes the position of test paper in comparison film, the position of each reagent pad color lump positions, so that the acquisition of further process and colouring information.Iamge Segmentation is exactly image is divided into several are specific, have peculiar property region and proposes technology and the process of interesting target.It is by the committed step of image procossing to graphical analysis.Existing image partition method mainly divides following a few class: the dividing method based on threshold value, the dividing method based on region, the dividing method based on edge and the dividing method etc. based on particular theory.Here, invention is in conjunction with the indicateing arm color on test paper groove, and the method combining Threshold segmentation and edge segmentation positions test paper.
4. the Intelligent mobile equipment such as mobile phone is when taking a picture, and due to the picture noise that the environmental factor such as pixel, illumination is brought, effect diagram is as colour recognition greatly, and then cannot obtain Ingredient Concentration range more corresponding.
The present invention utilizes the filtering noise reduction technology in the HSV space in image procossing, reduces the neighbourhood noise of photo, utilizes the method for illumination compensation simultaneously, reduces the aberration brought due to different mobile phone, different light intensity.Three variablees in hsv color space represent tone, saturation degree and brightness respectively, HSV space are carried out filtering less compared to the filtering error on RGB (red, green, blue) color space.The uniform illumination of supposed premise suffered by each pixel of photo of illumination compensation, thus identical compensation can be done to every bit.
Summary of the invention
The present invention mainly comprises the Mobile solution of a intelligent mobile terminal and matching used test paper groove.Its main points are comprehensively to use test paper groove and Mobile solution to carry out taking pictures to urinalysis test paper, thus by image processing and analysis calculate important urinary fractions (comprise glucose, protein, urobilinogen, cholerythrin, occult blood, proportion, ketoboidies etc.) concentration range.
The first, the present invention obtains a kind of relation utilizing urinary fractions concentration and test paper color development to react rear color rgb value, determines the concentration range of urinary fractions to be measured.
The second, the present invention devises a special test paper groove, solves the orientation problem of reagent pad color lump on test paper and test paper in the background environment and photo of taking pictures.
3rd, this invention takes HSV space medium filtering in image processing techniques and illumination compensation to the reduce mobile phone camera environment color distortion caused, fuzzy problem, thus the color of color lump on efficiently sampling test paper.
Four, the present invention programmes according to above thinking and countermeasure, has designed and developed and can have various the application program (as smart mobile phone smart camera or panel computer) that the smart machine of camera function uses, and supporting test paper groove uses.
5th, the present invention applies the urine detection mode of this simple and fast by test paper groove and mobile phone, solves urine examination equipment and is unsuitable for using at home and the higher problem of cost.To some chronics or need the people paying close attention to urinary fractions situation, certain monitoring, analysis and prompting can be had at ordinary times or before seeking medical advice to hospital.Thus reduce the cost of the frequent time and money to hospital's urine test, also improve simultaneously and alleviate resource efficiency and the pressure of hospital.
Six, the invention solves by mobile network and intelligent terminal, urine data are carried out remote transmission, share, the problem of Collection and analysis, make the mobile interchange epoch health of masses management, doctor-patient interaction, aided remote medical control, realize being achieved as medical institutions, health control platform.
Accompanying drawing explanation
Accompanying drawing 1 is the structural representation that the present invention " utilizes the camera function of intelligent mobile terminal to carry out the system of urinary fractions analysis ".
Accompanying drawing 2 is test paper groove schematic diagram.
Embodiment
In order to make technical matters to be solved by this invention, technical scheme and beneficial effect clearly understand, below in conjunction with drawings and Examples, the present invention will be described in detail.It should be noted that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
1. obtain the concentration of urinary fractions to be measured and urine and test paper and react the relation that color afterwards changes:
And the design of algorithm of the present invention, and the reflectivity of non-used reflected light carries out urinary fractions concentration identification, but make use of the relation of urinary fractions concentration and color on standard color comparison card.The color that reagent pad is shown after reaction, can be combined by red (R), green (G), prison (B) three primary colors, each component value is all between 0 to 255.The present invention by designing about the three-component formula of RGB, and utilizes least square fitting urinary fractions about the linear equation of respective formula, makes related coefficient between the two high as much as possible.The Ingredient Concentration range that these linear equations will be used for substituting into interpolation and obtain under detection reaction color.When least square method means known Two Variables and data thereof, under plane right-angle coordinate, making each data, coordinate points is to the square distance of a certain straight line and minimum one to one, and this straight line, namely utilizes the straight line that least square fitting goes out.
2. the design of special test paper groove:
Test paper groove is fold design, and after it is folding, size is about 11cm*5cm, is similar to the size of smart mobile phone, easy to carry, and the scope that inner marker is applicable to again take a picture after deployment simultaneously limits.First user needs to infiltrate test paper with playing urine morning, when waiting question response 1 minute, starts application program, takes before window under natural lighting condition.In addition, when taking test paper, needing to open collapsible test paper groove, test paper being embedded in the special test paper groove with test paper aid identification mark, and making the border, the visual field of camera lens within test paper trough rim circle.Test paper groove, by the design of specific demarcation thing, can utilize the position of respective image partitioning algorithm determination test strips in whole pictures and the position of each reacting pad color lump central pixel point by helper.
3. the process of reacting pad patch image and calculating:
After taking pictures, application program can carry out computing automatically.
First, in conjunction with the mark on test paper groove, the method for integrated use Threshold segmentation and edge segmentation positions test paper and identifies the coordinate position of each reagent pad color lump central pixel point on test paper in photo.
After obtaining coordinate, each color lump central point is carried out to the filtering noise reduction in HSV space, three variablees in hsv color space represent tone, saturation degree and brightness respectively, HSV space are carried out filtering less compared to the filtering error on RGB (red, green, blue) color space.This process comprises medium filtering to SV variable and illumination compensation.The object of medium filtering is the error that neighbourhood noise when reducing mobile phone camera is brought.And the uniform illumination of illumination compensation supposed premise suffered by each pixel of photo, thus identical difference compensation can be done to every bit.
Finally, read the rgb value of each color lump central pixel point, and bring respective linear function interpolation calculation into and obtain Ingredient Concentration range.
4. programme:
The present invention programmes according to above thinking and countermeasure, and this program comprises login, tests, inquires about, reports, shares, wired and Wireless Data Transmission, and Quick Response Code, link port, the function such as database and long-range general news.Wherein, logged in by registration, user can log in oneself account, carries out the account setup of oneself.In test function program, program will call the camera function of intelligent mobile terminal, take pictures to playing urine infiltration test paper the morning being placed on test paper groove, after photo is confirmed by user, program will carry out above-described color lump location, image procossing and interpolation calculation step automatically, and demonstrate this report detected, scope and the order of severity of detectable concentration can be provided in report, and provide suggestion for user the need of going to hospital to carry out normal inspection further.In addition, user can also check test record in the past, and sees each index variation tendency in a period of time, according to this as Urine monitoring and the reference of seeking medical advice.
5. the convenience used and cost degradation:
Software and hardware matching design of the present invention, makes that user is easy to carry, use cost is low.One, Mobile solution can by using in common smart mobile phone, smart camera and the panel computer of any a current market, and process automation, user is easy and simple to handle.Its two, test paper groove is fold design, and after it is folding, size is about 11cm*5cm, is similar to the size of smart mobile phone, easy to carry, and inner marker is applicable to again the scope restriction of taking a picture after deployment simultaneously.Its three, whether application can record user's testing result each time, provide the need of adjustment diet and animation, go to hospital to do the suggestion of further regular detection according to user's detection case for a period of time.
6. apply the present invention to community, medical institutions, Health management service platform, database and cloud platform, mobile interchange operator, MEC etc. and download the application using and carry out urinary fractions self-monitoring as its user, also carry out promoting, developing and data management as third party service provider or authorized party.
The foregoing is only one embodiment of the present of invention, be not limited to the present invention, all do within principle of the present invention and spirit any amendment, equivalent to replace and improvement etc., be all just included within protection scope of the present invention.
Claims (9)
1. one with the use of test paper groove (1), utilize the camera function of intelligent mobile terminal to take pictures (2) to urine detection test paper, and calculate through image procossing (3) and mathematical modeling the application system (5) that (4) obtain urinary fractions analysis result.
2. test paper groove (1) according to claim 1, is characterized in that it there is cruciform density bullet.
3. test paper groove (1) according to claim 1, its in systems in which function be that auxiliary routine positions test paper in picture and reagent pad color lump.
4. according to claim 1ly take pictures (2) to urine detection test paper, it is in systems in which for realizing the necessary condition of urine detection.
5. image procossing according to claim 1 (3) method, it mainly applies medium filtering in HSV space and illumination compensation carries out noise reduction.
6. image procossing according to claim 1 (3) method, it mainly applies threshold value and edge image partitioning algorithm identification test paper and reagent pad color lump position.
7. mathematical modeling according to claim 1 calculates (4), and it is mainly through design formula and least-squares algorithm linear fitting, obtains the linear fit function of urinary fractions concentration about color lump color rgb value.
8. application system according to claim 1 (5), one of its feature is integrated use test paper groove and the mobile applications obtained of programming on said method basis, obtains urinalysis result.
9. application system according to claim 1 (5), two of its feature is by mobile network and intelligent terminal, urine data is carried out remote transmission, shares, Collection and analysis.
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| CN105761262A (en) * | 2016-02-18 | 2016-07-13 | 马春阳 | Detection apparatus and detection method |
| CN106323977A (en) * | 2016-08-23 | 2017-01-11 | 刘钢 | Mobile terminal-based color-change diagnosis test paper quantitative imaging system |
| CN106441488A (en) * | 2016-10-19 | 2017-02-22 | 杨林 | Method for measuring operative bleeding amount and measuring card |
| TWI626437B (en) * | 2017-05-15 | 2018-06-11 | 威剛科技股份有限公司 | Testing method and testing system of multi-drug test paper medical test equipment |
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| CN106323977A (en) * | 2016-08-23 | 2017-01-11 | 刘钢 | Mobile terminal-based color-change diagnosis test paper quantitative imaging system |
| CN106441488A (en) * | 2016-10-19 | 2017-02-22 | 杨林 | Method for measuring operative bleeding amount and measuring card |
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| CN109406506A (en) * | 2018-12-06 | 2019-03-01 | 北京腾康汇医科技有限公司 | A kind of shared self-rated health terminal and test method |
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| CN110196250A (en) * | 2019-05-29 | 2019-09-03 | 江汉大学 | The detection method and processing equipment of Cr VI based on color component value |
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Application publication date: 20160217 |