CN105327083A - Traditional Chinese medicine composition for treating blood stasis and internal blockage type vascular dementia after cerebral arterial thrombosis. - Google Patents
Traditional Chinese medicine composition for treating blood stasis and internal blockage type vascular dementia after cerebral arterial thrombosis. Download PDFInfo
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- CN105327083A CN105327083A CN201510856791.2A CN201510856791A CN105327083A CN 105327083 A CN105327083 A CN 105327083A CN 201510856791 A CN201510856791 A CN 201510856791A CN 105327083 A CN105327083 A CN 105327083A
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Abstract
The invention relates to a traditional Chinese medicine composition for treating blood stasis and internal blockage type vascular dementia after cerebral arterial thrombosis, which belongs to the technical field of medicine. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 5 to 13 parts of latouchea fokiensis, 4 to 8 parts of aralia undulata, 4 to 8 parts of benzoin, 4 to 8 parts of calamus, 4 to 8 parts of irkutsk anemone rhizome, 4 to 8 parts of ramin, 4 to 8 parts of pericarp of sterculia nobilis, 4 to 8 parts of Lanjiang lily bulb and 4 to 8 parts of liquorice. All of the medicines are combined, so as to achieve the effects of promoting blood circulation, dispersing blood stasis, activating the brain and regaining consciousness, and clinical symptoms and signs of patients with the blood stasis and internal blockage type vascular dementia after the cerebral arterial thrombosis can be obviously improved.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine composition for the treatment of vascular dementia after type of blood-stasis obstructing in the interior cerebral infarction.
Background technology
Vascular dementia (VasculardementiaVD) is a kind of serious cognitive dysfunction syndrome caused by cerebrovascular disease.Cerebral infarction (IschemicstrokeIS) is one of main cerebrovascular disease causing VD, and after bibliographical information IS, VD incidence rate is 18.2% ~ 34.2%.Doctor trained in Western medicine mainly relies at present improves cerebral circulation, and the methods such as nutrition cranial nerve are treated vascular dementia, but its clinical therapeutic efficacy is unanimously not ideal.
Summary of the invention
Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of Chinese medicine composition for the treatment of vascular dementia after type of blood-stasis obstructing in the interior cerebral infarction.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for vascular dementia after type of blood-stasis obstructing in the interior cerebral infarction, be made up of the Chinese medicine of following weight portion:
Radix limonii sinensis 5-13 part, Radix Araliae undulatae 4-8 part, Benzoinum 4-8 part, Rhizoma Acori Calami 4-8 part, Rhizoma Anemones Altaicae 4-8 part, Rhizoma Atractylodis macrocephalae 4-8 part, Pericarpium Sterculiae nobilis 4-8 part, Bulbus lilii lankongensis 4-8 part, Radix Glycyrrhizae 4-8 part.
Preferably, the Chinese medicine composition of vascular dementia after above-mentioned treatment type of blood-stasis obstructing in the interior cerebral infarction, is made up of the Chinese medicine of following weight portion:
Radix limonii sinensis 7-11 part, Radix Araliae undulatae 5-7 part, Benzoinum 5-7 part, Rhizoma Acori Calami 5-7 part, Rhizoma Anemones Altaicae 5-7 part, Rhizoma Atractylodis macrocephalae 5-7 part, Pericarpium Sterculiae nobilis 5-7 part, Bulbus lilii lankongensis 5-7 part, Radix Glycyrrhizae 5-7 part.
Preferred, the Chinese medicine composition of vascular dementia after above-mentioned treatment type of blood-stasis obstructing in the interior cerebral infarction, is made up of the Chinese medicine of following weight portion:
Radix limonii sinensis 9 parts, Radix Araliae undulatae 6 parts, Benzoinum 6 parts, Rhizoma Acori Calami 6 parts, Rhizoma Anemones Altaicae 6 parts, Rhizoma Atractylodis macrocephalae 6 parts, Pericarpium Sterculiae nobilis 6 parts, Bulbus lilii lankongensis 6 parts, 6 parts, Radix Glycyrrhizae.
The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.
The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.
The indication of Chinese medicine of the present invention: be used for the treatment of vascular dementia after type of blood-stasis obstructing in the interior cerebral infarction.
The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.
In Chinese medicine composition of the present invention,
Radix limonii sinensis another name mother honker leaf, red shrimp toad leaf are the herb of gentianaceae plant Radix limonii sinensis LatoucheafokiensisFranch..Bitter in the mouth; Pungent; Cold in nature.Return lung; Liver; Large intestine channel.Function blood circulation promoting and blood stasis dispelling; Clearing and antitussive.Blood stasis mass in the abdomen in main abdomen; Epersalgia cough.
Rhizoma Acori Calami another name mud is prosperous, Shui Chang, Shui Su, stem Pu, Rhizoma Acori Calami (" not Lu "), small stream sweet-smelling grass, blue sweet-smelling grass (TAO Hong-Jing), the earth's core (" stone medicine is elegant "), mud Rhizoma Acori Graminei (" detailed outline "), the swordlike leaf of calamus (" vegetation is side just "), Rhizoma begoniae pedatifidae grass, family calamus (" Guangxi Chinese veterinarian's medicine is planted "), smelly Pu (" medicine will is planted in Jiangsu "), great Ye Rhizoma Acori Graminei, native Artemisia Pu (" Traditional Chinese Medicine in Sichuan will ").For the rhizome of aroid calamus.Bitter in the mouth is pungent, warm in nature.Toil, temperature.Function is reduced phlegm, and has one's ideas straightened out, spleen invigorating, dampness removing.Control epilepsy, palpitate with fear forgetful, mind is not asked, and humidity hysteresis painful abdominal mass is swollen, dysentery, rheumatalgia, carbuncle scabies.
The two bottle prunus mume (sieb.) sieb.et zucc. of Rhizoma Anemones Altaicae another name chrysanthemum shape, Taiyuan Chang, capital Rhizoma Acori Graminei, Shaanxi Chang, Rhizoma Anemones Altaicae, little Rhizoma Acori Graminei.Derive from Ranunculaceae thimbleweed anemone altaica AnemonealtaicaMey., be used as medicine with root stock.Pungent, temperature.Function causing resuscitation with aromatic drugs, reduces phlegm, and calms the nerves.Calentura is gone into a coma, and the turbid illiteracy key of expectorant, epilepsy, neurosis, Hiccough and deaf, breast abdominal distention is vexed.External application carbuncle skin ulcer tinea.
Rhizoma Atractylodis macrocephalae calls Folium seu Radix Clausenae dentatae, Ovum Gallus domesticus Flavus, little Citrus chachiensis Hort., Radix araliae armatae, puts loose, wild Fructus Capsici on the skin.For rutaceae bassoon Micromelumfalcatum(Lour.) root of Tanaka [AulasiafalcatumLour.] or leaf.Acrid in the mouth; Bitter; Warm in nature.Return liver; Kidney channel.Function blood-activating and qi-promoting; Eliminating stasis to stop pain.The main thoracic obstruction; Treating swelling and pain by traumatic injury; Fracture; Sprain; Rheumatic arthralgia; Wait pain; Venom.
Pericarpium Sterculiae nobilis another name Semen Sterculiae Nobilis pod, sterculia nobilis's shell.For the shell of Sterculiaceae plant sterculia nobilis SterculianobilisSmith.Sweet in the mouth; Property is put down.Return small intestine meridian.Function blood-activating and qi-promoting.Main dysentery; Inguinal hernia; Hemorrhoid; Otitis media.
Bulbus lilii lankongensis another name Cha Qu large silk U.S. many (Tibetan name) is the bulb of liliaceous plant Bulbus lilii lankongensis.Cold in nature, bitter but sweet flavor.Function nourishing the lung to arrest cough, heat clearing and tranquillizing.Control pulmonary tuberculosis, chronic cough is spitted blood, chronic bronchitis, the disease such as to be dimly insomnia.
Radix Glycyrrhizae is sweet, flat.GUIXIN, lung, spleen, stomach warp.Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Motherland's traditional medicine, by vascular dementia ownership and the category of " dementia ", thinks that due to internal injury caused by excess of seven emotions, prolonged illness is multiple, and body deficiency due to old age etc. cause insufficiency of vital energy and blood, deficiency of kidney-essence, expectorant stasis blocking numbness, and gradually make brains hollow, brains lose foster because main within its cause of disease.Its basic pathogenesis is that marrow subtracts brain and disappears, refreshing machine apraxia.Its sick position is at brain, closely related with conscience spleen renal dysfunction.The present inventor sums up long-term work experience in the past, thinks that the pathogenesis of post-stroke vascular dementia is relevant with " blood-stasis internal-depression ".The traditional Chinese medical science thinks damaged by excess of seven emotions, stagnation of QI due to depression of the liver, and functional activity of QI being not smooth then blood is puckery not all right, and qi depression to blood stasis hoodwinks key clearly, or blood-stasis internal-depression, and brain arteries and veins is obstructed, and brain gas must not connect with visceral-qi, or with the passing of time heat-dissipating fire-transformation, and gods are disturbed, then disposition is confusing, suddenly cry and suddenly laugh at, changeable.Therefore, post-stroke vascular dementia (type of blood-stasis obstructing in the interior) should be treated with the ruling by law of " blood circulation promoting and blood stasis dispelling, inducing resuscitation ".
Chinese medicine composition of the present invention, its prescription mechanism is as follows:
Monarch drug: Radix limonii sinensis, Radix Araliae undulatae merit are with blood circulation promoting and blood stasis dispelling.
Ministerial drug: Benzoinum, Rhizoma Acori Calami, Rhizoma Anemones Altaicae merit are with refreshment of having one's ideas straightened out
Adjuvant drug: Rhizoma Atractylodis macrocephalae, Pericarpium Sterculiae nobilis merit are with blood-activating and qi-promoting, and Bulbus lilii lankongensis merit is with heat clearing and tranquillizing.
Make medicine: Radix Glycyrrhizae merit is with coordinating the actions of various ingredients in a prescription.
We's compatibility is reasonable, and all medicines share, and play blood circulation promoting and blood stasis dispelling altogether, the effect of inducing resuscitation, and obviously can improve the Clinical symptom and sign of cerebral infarction vascular dementia (type of blood-stasis obstructing in the interior) patient, TCM syndrome is evident in efficacy, is worthy to be popularized.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Treat a Chinese medicine composition for vascular dementia after type of blood-stasis obstructing in the interior cerebral infarction, each crude drug weight proportion is as follows:
Radix limonii sinensis 9g, Radix Araliae undulatae 6g, Benzoinum 6g, Rhizoma Acori Calami 6g, Rhizoma Anemones Altaicae 6g, Rhizoma Atractylodis macrocephalae 6g, Pericarpium Sterculiae nobilis 6g, Bulbus lilii lankongensis 6g, Radix Glycyrrhizae 6g.
Embodiment 2
Treat a Chinese medicine composition for vascular dementia after type of blood-stasis obstructing in the interior cerebral infarction, each crude drug weight proportion is as follows:
Radix limonii sinensis 7g, Radix Araliae undulatae 5g, Benzoinum 5g, Rhizoma Acori Calami 5g, Rhizoma Anemones Altaicae 5g, Rhizoma Atractylodis macrocephalae 5g, Pericarpium Sterculiae nobilis 5g, Bulbus lilii lankongensis 5g, Radix Glycyrrhizae 5g.
Embodiment 3
Treat a Chinese medicine composition for vascular dementia after type of blood-stasis obstructing in the interior cerebral infarction, each crude drug weight proportion is as follows:
Radix limonii sinensis 11g, Radix Araliae undulatae 7g, Benzoinum 7g, Rhizoma Acori Calami 7g, Rhizoma Anemones Altaicae 7g, Rhizoma Atractylodis macrocephalae 7g, Pericarpium Sterculiae nobilis 7g, Bulbus lilii lankongensis 7g, Radix Glycyrrhizae 7g.
Embodiment 4
Treat a Chinese medicine composition for vascular dementia after type of blood-stasis obstructing in the interior cerebral infarction, each crude drug weight proportion is as follows:
Radix limonii sinensis 13g, Radix Araliae undulatae 8g, Benzoinum 8g, Rhizoma Acori Calami 8g, Rhizoma Anemones Altaicae 8g, Rhizoma Atractylodis macrocephalae 8g, Pericarpium Sterculiae nobilis 8g, Bulbus lilii lankongensis 8g, Radix Glycyrrhizae 8g.
Embodiment 5
Treat a Chinese medicine composition for vascular dementia after type of blood-stasis obstructing in the interior cerebral infarction, each crude drug weight proportion is as follows:
Radix limonii sinensis 5g, Radix Araliae undulatae 4g, Benzoinum 4g, Rhizoma Acori Calami 4g, Rhizoma Anemones Altaicae 4g, Rhizoma Atractylodis macrocephalae 4g, Pericarpium Sterculiae nobilis 4g, Bulbus lilii lankongensis 4g, Radix Glycyrrhizae 4g.
Carried out clinical pharrnacokinetics test to Chinese medicine composition of the present invention, Details as Follows:
1. data and method
1.1 object of study
Choose Patients with Vascular Dementia 160 example (type of blood-stasis obstructing in the interior) after cerebral infarction.Inclusive criteria: (1) cerebral infarction (IS) diagnosis meets the diagnostic criteria that the 4th national cerebrovascular Symposium Held is formulated, and confirm through cerebral CT or MRI; (2) vascular dementia (VD) diagnosis meets the diagnostic criteria that US National neuropathy and apoplexy institute are formulated, VD generation and have regular hour relation; (3) Hachinskiischemicscore(HIS) >=7 points; (3) age >=60 years old.(4) differential diagnosis in tcm belongs to " type of blood-stasis obstructing in the interior "; (5) energy partner treatment and observer; Exclusion standard: (1) has dement and the indefinite person of VD and IS time relationship before getting rid of IS; (2) dementia that the reasons such as the dull-witted and endocrine metabolism disease of Mixed dementia, psychosis, Parkinsonism, poisoning, infection cause is got rid of; (3) can not partner treatment and observer.
1.2 differential diagnosis in tcm diagnostic criterias
With reference to " dementia " " type of blood-stasis obstructing in the interior " diagnostic criteria in " Chinese Internal Medicine ": express one's feelings blunt, aphasia, forgetful, easily in terror, or thinking is abnormal, oddity of behavior, companion's squamous and dry skin, xerostomia is not for drink, binocular clouding, dark tongue quality or have petechia ecchymosis, thready and hesitant pulse.
1.3 Therapeutic Method
Give the embodiment of the present invention 1 Chinese medicine composition oral medication, prescription is as follows: Radix limonii sinensis 9g, Radix Araliae undulatae 6g, Benzoinum 6g, Rhizoma Acori Calami 6g, Rhizoma Anemones Altaicae 6g, Rhizoma Atractylodis macrocephalae 6g, Pericarpium Sterculiae nobilis 6g, Bulbus lilii lankongensis 6g, Radix Glycyrrhizae 6g, be decocted in water for oral dose, sub-service sooner or later, day potion was a course for the treatment of with 2 weeks.
1.4 observation index
All carry out vascular dementia HIS scoring before and after treatment, observe the change of HIS scoring before and after treatment.Observe the change of TCM syndrome integration, TCM syndrome integral estimation is with reference to relevant criterion in " new Chinese medicine guideline of clinical investigations ", and according to nothing 0 point, slight 1 point, moderate 2 points, severe 3 points is scored simultaneously.
1.5 evaluation of clinical curative effect standards
" new Chinese medicine clinical research medication guide principle " that evaluation criteria was promulgated with reference to 2002.
1. fully recover: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%
2. effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%
3. effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%
4. invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces <30%.
Computing formula: nimodipine method: integration x100% before (before treatment the rear integration of integration-treatment)/treatment.
1.6 statistical method
SPSS14.0 version statistical software is used to carry out analytic statistics analysis.Measurement data adopts mean plus-minus standard deviation to represent, compares and adopts t inspection, represent that difference has statistical significance with P<0.05 before and after treatment.
2. result
HIS scoring change before and after 2.1 treatments
Before 160 example treatments, average HIS scoring is (17.45 ± 2.54) point, and drop to after treatment (3.32 ± 0.64) point, difference has statistical significance (t=4.874, P<0.05).
TCM syndrome integration change before and after 2.2 treatments
Before treatment, TCM syndrome integration is (25.23 ± 5.94) point, and be reduced to after treatment (4.58 ± 1.36) point, difference has statistical significance (t=3.384, P<0.05).
2.3 clinical efficacy
160 routine patients cure 144 examples, effective 10 examples, effective 5 examples, invalid 1 example, cure rate 90.0%, total obvious effective rate 96.3%, total effective rate 99.4%.
Claims (3)
1. treat a Chinese medicine composition for vascular dementia after type of blood-stasis obstructing in the interior cerebral infarction, be made up of the Chinese medicine of following weight portion:
Radix limonii sinensis 5-13 part, Radix Araliae undulatae 4-8 part, Benzoinum 4-8 part, Rhizoma Acori Calami 4-8 part, Rhizoma Anemones Altaicae 4-8 part, Rhizoma Atractylodis macrocephalae 4-8 part, Pericarpium Sterculiae nobilis 4-8 part, Bulbus lilii lankongensis 4-8 part, Radix Glycyrrhizae 4-8 part.
2. the Chinese medicine composition of vascular dementia after treatment type of blood-stasis obstructing in the interior cerebral infarction according to claim 1, is characterized in that, be made up of the Chinese medicine of following weight portion:
Radix limonii sinensis 7-11 part, Radix Araliae undulatae 5-7 part, Benzoinum 5-7 part, Rhizoma Acori Calami 5-7 part, Rhizoma Anemones Altaicae 5-7 part, Rhizoma Atractylodis macrocephalae 5-7 part, Pericarpium Sterculiae nobilis 5-7 part, Bulbus lilii lankongensis 5-7 part, Radix Glycyrrhizae 5-7 part.
3. the Chinese medicine composition of vascular dementia after treatment type of blood-stasis obstructing in the interior cerebral infarction according to claim 3, is characterized in that, be made up of the Chinese medicine of following weight portion:
Radix limonii sinensis 9 parts, Radix Araliae undulatae 6 parts, Benzoinum 6 parts, Rhizoma Acori Calami 6 parts, Rhizoma Anemones Altaicae 6 parts, Rhizoma Atractylodis macrocephalae 6 parts, Pericarpium Sterculiae nobilis 6 parts, Bulbus lilii lankongensis 6 parts, 6 parts, Radix Glycyrrhizae.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090011836A (en) * | 2007-07-27 | 2009-02-02 | 주식회사 엘지생활건강 | Copmosition comprising extract of fermented soybean |
| CN104587191A (en) * | 2015-02-02 | 2015-05-06 | 张成杰 | Traditional Chinese medicine for treating vascular dementia |
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- 2015-11-30 CN CN201510856791.2A patent/CN105327083A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090011836A (en) * | 2007-07-27 | 2009-02-02 | 주식회사 엘지생활건강 | Copmosition comprising extract of fermented soybean |
| CN104587191A (en) * | 2015-02-02 | 2015-05-06 | 张成杰 | Traditional Chinese medicine for treating vascular dementia |
Non-Patent Citations (1)
| Title |
|---|
| 高尚社: "《常见疑难病中西医诊治精要》", 31 October 2000, 民族出版社 * |
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Application publication date: 20160217 |