CN105311392A - 一种治疗三叉神经痛的中药 - Google Patents
一种治疗三叉神经痛的中药 Download PDFInfo
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Abstract
本发明公开了一种治疗三叉神经痛的中药，是由以下重量份的原料组成的：蔓荆子5-10份<b>，</b>山慈菇6-8份，独脚乌桕8-12份，龙葵果2-5份，透骨草3-8份，大血藤5-9份，黄花母根10-15份，八月瓜6-10份，薄荷5-15份，代赭石1-3份，白芥子6-9份，虎骨2-4份，厚朴10-14份，罗勒3-8份，蓝桉6-8份，炙甘草10-15份。本发明中药的组分辩证配伍，相辅相成，达到活血祛风、震痛安神、滋阴去燥、解痉止痛等功效，对三叉神经痛具有很好的治疗效果，具有原料充足、制法简便、价格低廉、治疗效果好、无毒副作用、有效率高、不易复发的优势，适于大规模推广应用。
Description
技术领域
本发明涉及一种中药，特别涉及一种治疗三叉神经痛的中药。
背景技术
三叉神经痛是最常见的脑神经疾病，以一侧面部三叉神经分布区内反复发作的阵发性剧烈痛为主要表现。该病发作时，在头面部三叉神经分布区域内，发病骤发骤停，如闪电样、刀割样、烧灼样、顽固性、难以忍受的剧烈性疼痛，说话、洗脸、刷牙或微风拂面，甚至走路时都会导致阵发性的剧烈疼痛，疼痛历时数秒或数分钟，疼痛呈周期性发作，发作间歇期同正常人一样，严重影响患者的正常生活和工作。因此被人称此痛为“天下第一痛”，又称痛性抽搐。
临床上，对三叉神经痛的病因及发病机制，至今尚无明确的定论，各学说均无法解释其临床症状，大多数临床医生支持三叉神经微血管压迫导致神经脱髓鞘学说，以及癫痫样神经痛学说。目前西药治疗本病主要是镇静、止痛为主，常用药如地西泮、卡马西平等，副作用大，用药成本高，易反复，效果不理想。
发明内容
本发明提供了一种治疗效果好、无毒副作用、有效率高、不易复发的治疗三叉神经痛的中药。
一种治疗三叉神经痛的中药是由以下重量份的原料组成的：蔓荆子5-10份，山慈菇6-8份，独脚乌桕8-12份，龙葵果2-5份，透骨草3-8份，大血藤5-9份，黄花母根10-15份，八月瓜6-10份，薄荷5-15份，代赭石1-3份，白芥子6-9份，虎骨2-4份，厚朴10-14份，罗勒3-8份，蓝桉6-8份，炙甘草10-15份。
优选的，一种治疗三叉神经痛的中药是由以下重量份的原料组成的：蔓荆子8份，山慈菇7份，独脚乌桕10份，龙葵果3份，透骨草5份，大血藤7份，黄花母根13份，八月瓜8份，薄荷10份，代赭石2份，白芥子8份，虎骨3份，厚朴12份，罗勒5份，蓝桉7份，炙甘草13份。
本发明的治疗三叉神经痛的中药可以是常规药剂学中的任何一种剂型，如片剂、胶囊剂、软胶囊、丸剂、颗粒剂、口服液或汤剂。可采用本领域熟知的制剂技术手段来完成本发明药剂的制备。本发明的优选剂型是胶囊剂。
本发明胶囊剂的制备方法如下：
按量称取所述药物煎煮30分钟后过滤得滤液。重复煎煮三次，合并滤液，浓缩成为60℃相对密度为1.30-1.35的浸膏，喷雾干燥得浸膏粉，加入药学可接受的适量辅料(例如糊精、淀粉等)混合制粒装胶囊300粒，每粒重0.25g。
本发明药物的用法与用量：口服，一次2粒，一日2次，饭后半小时服用。
各原料药的药理如下：
蔓荆子：味辛、苦，性微寒。归肺、膀胱、肝经。疏散风热，清利头目，除湿处关节。用于外感头痛，偏正头风，昏晕目暗，赤眼多泪，目睛内痛，齿龈肿痛，湿痹拘挛。
山慈菇：味甘、微辛，性寒。归肝、胃、脾经。清热解毒，消痈散结。用于痈宜发背、疔肿恶疮、瘰疬结核、癌瘤、喉痹、虫蛇咬伤等症。
独脚乌桕：味甘、苦，性凉。清热解毒，散结，行血。用于痈疽疮疡，淋巴结结核，跌打损伤。
龙葵果：味苦，性寒。清热消炎，凉血解毒，软坚消肿。
透骨草：味甘、辛，性温。归肺、肝经。活血化瘀、利尿解毒、通经透骨。
大血藤：味苦，性平。归大肠、肝经。清热解毒，活血，祛风止痛。用于肠痈腹痛，热毒疮疡，经闭，痛经，跌扑肿痛，风湿痹痛。
黄花母根：味辛，性凉。归肺、肝、大肠经。用于湿热痢疾，泄泻，黄疸，疮痈难溃或溃或溃后不易收口。
八月瓜：味苦，性凉。清热利湿，活血通脉，行气止痛。用于小便短赤，淋浊，水肿，风湿痹痛，跌打损伤，乳汁不通，疝气痛。
薄荷：味甘、辛，性凉。疏风，散热，辟秽，解毒。用于外感风热，头痛，目赤，咽喉肿痛，食滞气胀，口疮，牙痛，疮疥，瘾疹。
代赭石：味苦、甘，性平。归肝、胃、心胞经。平肝镇逆，凉血止血。治噫气呕逆，噎膈反胃，哮喘，惊痫，吐血，鼻衄，肠风，痔瘘，崩漏带下。
白芥子：味辛，性温。温肺豁痰利气，散结通络止痛。用于咳喘痰多，胸满肋痛，肢体麻木，关节肿痛，湿痰流注，阴疽肿毒。
虎骨：味甘、辛，性温。归肝、肾经。祛风通络，强筋健骨。用于治疗风湿痹痛，脚膝酸软。
厚朴：味苦、辛，性温。归脾、胃、大肠经。行气消积，燥湿除满，降逆平喘。用于食积气滞，腹胀便秘，湿阻中焦，脘痞吐泻，痰壅气逆，胸满喘咳。
罗勒：味辛，性温。疏风行气，化湿消食，活血，解毒。用于外感头痛，食胀气滞，脘痛，泄泻，月经不调，跌打损伤，蛇虫咬伤，皮肤湿疮，瘾疹痛痒等症。
蓝桉：味微辛、微苦，性平。疏风解热，抑菌消炎，防腐止痒。用于预防流行性感冒、流行性脑脊髓膜炎，治上呼吸道感染，咽喉炎，支气管炎，肺炎，急、慢性肾盂肾炎，肠炎，痢疾，丝虫病。
炙甘草：味甘，性平。归心、肺、脾、胃经。和中缓急，润肺，解毒，调和诸药。
本发明的有益效果：本发明中药的组分经辩证配伍，在作用上相辅相成，具有协同作用，达到活血祛风、震痛安神、滋阴去燥、解痉止痛等功效，对三叉神经痛具有很好的治疗效果，具有原料充足、制法简便、价格低廉、治疗效果好、无毒副作用、有效率高、不易复发的优势，能极大的减少患者的经济负担，适用于大规模的推广应用。
具体实施方式
下面结合具体实施例对本发明做进一步的详细说明。
实施例1
一种治疗三叉神经痛的中药是由以下重量的原料组成的：蔓荆子10g，山慈菇8g，独脚乌桕12g，龙葵果5g，透骨草8g，大血藤9g，黄花母根15g，八月瓜6g，薄荷5g，代赭石1g，白芥子6g，虎骨2g，厚朴14g，罗勒3g，蓝桉6g，炙甘草10g。
上述药物的制备方法如下：
按量称取所述药物煎煮30分钟后过滤得滤液。重复煎煮三次，合并滤液，浓缩成为60℃相对密度为1.30-1.35的浸膏，喷雾干燥得浸膏粉，加入药学可接受的适量辅料(例如糊精、淀粉等)混合制粒装胶囊300粒，每粒重0.25g。
实施例2
一种治疗三叉神经痛的中药是由以下重量的原料组成的：蔓荆子8g，山慈菇7g，独脚乌桕10g，龙葵果3g，透骨草5g，大血藤7g，黄花母根13g，八月瓜8g，薄荷10g，代赭石2g，白芥子8g，虎骨3g，厚朴12g，罗勒5g，蓝桉7g，炙甘草13g。
上述药物的制备方法同实施例1。
实施例3
一种治疗三叉神经痛的中药是由以下重量的原料组成的：蔓荆子5g，山慈菇6g，独脚乌桕8g，龙葵果2g，透骨草3g，大血藤5g，黄花母根10g，八月瓜10g，薄荷15g，代赭石3g，白芥子9g，虎骨4g，厚朴10g，罗勒8g，蓝桉8g，炙甘草15g。
上述药物的制备方法同实施例1。
临床观察
临床资料：本发明中药应用于临床多年，随机选择100例患者进行临床观察，病人均为临床医师确诊的三叉神经痛患者，其中男32例，女68例，年龄38-69岁，平均年龄47.6岁。
药物选择：所有患者使用本发明实施例2制得的中药，口服，一次2粒，一日2次，饭后半小时服用。治疗周期为30天。
诊断标准：根据《中药新药治疗三叉神经痛的临床研究指导原则》规定，疗效判定以症状消失为主，并参考体征等改变情况，分为治愈、显效、有效、无效四级。
治愈：症状及体征全部消失。
有效：症状及体征得到一定改善。
无效：症状及体征均无改善。
治疗结果：服用本发明的药物对100例三叉神经痛患者进行治疗，结果治愈71例，有效28例，无效1例，总有效率达99%。
典型病例
病例1：程某，男，64岁，患三叉神经痛1年余，服用多种中药和西药均为治愈，经朋友介绍服用本发明的中药5日，感觉各种症状减轻，继续服用20日，痊愈。随访2年无复发。
病例2：付某，女，左侧颜面三叉神经痛3年，期间疼痛逐渐加剧，次数增多，洗脸或说话时均可诱发，发作间隙则如常人一般。经多家医院诊治和多种药物治疗，均未取得明显效果，服用本发明的中药30日，自觉痊愈，停药。随访3年无复发。
Claims (2)
1.一种治疗三叉神经痛的中药，其特征在于，是由以下重量份的原料组成的：蔓荆子5-10份，山慈菇6-8份，独脚乌桕8-12份，龙葵果2-5份，透骨草3-8份，大血藤5-9份，黄花母根10-15份，八月瓜6-10份，薄荷5-15份，代赭石1-3份，白芥子6-9份，虎骨2-4份，厚朴10-14份，罗勒3-8份，蓝桉6-8份，炙甘草10-15份。
2.根据权利要求1所述的中药，其特征在于，是由以下重量份的原料组成的：蔓荆子8份，山慈菇7份，独脚乌桕10份，龙葵果3份，透骨草5份，大血藤7份，黄花母根13份，八月瓜8份，薄荷10份，代赭石2份，白芥子8份，虎骨3份，厚朴12份，罗勒5份，蓝桉7份，炙甘草13份。
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| CN106075077A (zh) * | 2016-08-19 | 2016-11-09 | 孙丰卿 | 一种治疗三叉神经痛的中药组合物及其制剂的制备方法 |
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