CN105310797A - Bionics artificial blood vessel with valvula - Google Patents
Bionics artificial blood vessel with valvula Download PDFInfo
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- CN105310797A CN105310797A CN201410301301.8A CN201410301301A CN105310797A CN 105310797 A CN105310797 A CN 105310797A CN 201410301301 A CN201410301301 A CN 201410301301A CN 105310797 A CN105310797 A CN 105310797A
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- blood vessel
- artificial blood
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Abstract
The invention discloses a bionics artificial blood vessel with a valvula. The artificial blood vessel with the valvula comprises an artificial blood vessel body, a cavity sinus and the three-leaf valvula. The three-leaf valvula is made of PRECLUDE pericardium materials, and the artificial blood vessel body and the cavity sinus are made of Gore-Tex artificial blood vessel materials. In the preparation process, the artificial blood vessel does not need to be unfolded, an air compressor is adopted to compress the blood vessel, and the sinus is formed directly, so that the integrity of the vessel is preserved, an ePTFE membrane is artificially sewed to the peculiarly made artificial blood vessel with the valvula, a three-leaf right ventricular valved conduit is synthesized, and the sunken structure of a valvula sinus enhances the opening/closing effect of the valvula. According to the bionics artificial blood vessel, the air compressor is adopted for compressing the blood vessel, do that sinus forming is more stable, deformation cannot occur easily, and the effect is relatively obvious.
Description
Technical field:
The present invention relates to a kind of bionics band lobe artificial blood vessel, artificial blood vessel is adopted to make bionics band lobe artificial blood vessel, manually make ePTFE film as functional valve of pulmonary trunk, the Pulmonic synthetic right ventricular valved conduit of simulation Human Physiology, be applied to outflow tract of right ventricle reconstruction operations, treatment was difficult to the complicated congenital heart disease patient given treatment in the past.
Background technology:
The congenital heart disease of many complexity and acquired disease, the surgical intervention merging the CMH etc. of stenosis of pulmonary artery, double outlet of right ventricle, persistent truncus arteriosus and other rare complexity as serious tetralogy of Fallot, pulmonary atresia, transposition of conducting arteries all needs artificial lung tremulous pulse Valved allograft, to rebuild right ventricle-pulmonary artery-length of tape lobe trunk heavy connection of pipe.In view of the application of tremulous pulse Valved allograft in right ventricular outflow tract reconstruction operation, the complicated congenital heart disease patient being difficult in the past give treatment to is made to see dawn.It is narrow that the reported first application such as nineteen fifty-five Lillehei widen treatment right ventricular outflow across lobe ring sticking patch, Klinner in 1963 and colleague's application thereof are without valve pipeline construction right ventricular outflow treatment tetralogy of Fallot, and within 1964, Rasteli adopts the Vein graft pipe without valve to treat pulmonary atresia as right ventricle pulmonary artery pipeline.
At present, pulmonary artery of the same race is transplanted because duct wall is thinner, right ventricle-pulmonary artery pressure reduction is little, there is the natural right side and feel concerned about system cmot, and operation technique is convenient, simple, fewer than aortic homografts calcification, even if the advantage such as also can to perform the operation in the complicated pulmonary artery of child is dissected safely, become optimal selection material in right ventricular outflow tract reconstruction operation.But this pipeline source difficulty, model are limited, are difficult to meet wilderness demand clinically.PTFE making SANYE lobe and artificial vessel is adopted to rebuild right ventricular outflow in view of Ando statistics has 139 routine patients from 1997 to 2009, medium-long term excellent effect, therefore we adopt artificial blood vessel to make bionics band lobe artificial blood vessel, bonding sews up ePTFE film as functional valve of pulmonary trunk, and simulation Human Physiology Pulmonic bionics band lobe artificial blood vessel has good development prospect.
Summary of the invention:
For overcoming pulmonary artery graft pipeline of the same race source difficulty, model is limited, xenogenesis pulmonary artery pipeline immunogenicity is higher, artificial blood vessel hemodynamics difference is large waits difficulty, the invention provides a kind of bionics band lobe artificial blood vessel, the right belt lobe bionics Valved allograft that it is take pericardium as valve material, artificial blood vessel is shaped for vascular grafts making chamber hole, the important function of lobe hole in valve opening-closing process, the umbilicate type structure of valve-open phase lobe hole makes the stop of lobe leaf to blood flow be down to minimum, contributes to reducing pressure gradient; And at valve closed-down period, the eddy current that draining blood is formed in lobe hole impels lobe leaf fully to open, promote that valve is closed, reduce blood flow for the shearing force of lobe limb edge simultaneously, avoid the long-term strain of valve structure.
Technical scheme of the present invention is:
A kind of bionics band lobe artificial blood vessel, comprise artificial blood vessel, chamber hole and SANYE valve, wherein: described SANYE valve is PRECLUDE pericardium material (ePTFE film), described artificial blood vessel and chamber hole are made by Gore-Tex artificial blood vessel material.The degree of depth of described chamber hole and the ratio of artificial blood vessel pipe diameter are 1:4.
Described band lobe artificial blood vessel preparation process is as follows:
(1) select the mould pipeline of required specification, mould pipeline has corresponding hole for the preparation of the position of chamber hole;
(2) chamber hole makes: be enclosed within by artificial blood vessel on a mould pipeline, then be set with by outside artificial blood vessel with another mould pipeline and compress, and then makes it be connected with air compressor by silica gel tube and keep sealing; Then keep 30 minutes under pressure 100KPa, temperature 180 DEG C of conditions, the obtained artificial blood vessel with chamber hole; In this step, by air compressor persistent pressure, high-temperature test chamber is adopted to heat artificial blood vessel.
(3) SANYE valve makes: be cut into valve up to specification according to artificial blood vessel internal diameter of the pipeline and chamber hole size, bond line is combined on the hole of chamber, forms the right heart Valved allograft of three lobe leaves.
The invention has the beneficial effects as follows:
1, the present invention is without the need to launching artificial blood vessel, adopts air compressor pressurization blood vessel directly to become hole, saves the integrity of pipeline like this, without the need to reworking artificial blood vessel.
2, preparation temperature of the present invention is far below its 330 DEG C, only needs 180 DEG C, little to the change of artificial blood vessel nature like this, more easily keeps the nature and function of pipeline.
3, ePTFE film is manually sewn on the artificial blood vessel of special band lobe hole by the present invention, synthesizes three lobe leaf right ventricular valved conduit, and the umbilicate type structure of lobe hole enhances valve opening and closing effect.
4, the present invention adopts air compressor pressurization blood vessel, and make into hole more stable, not yielding, effect is also relatively obvious.
5, the present invention is with artificial blood vessel and pericardium for material makes bionics band lobe artificial blood vessel, and its simple process, flow process is clear and definite.Functionally become the right ventricular outflow of artificial blood vessel closer to human body of hole.
Accompanying drawing illustrates:
Fig. 1 is chamber hole shaping blood vessel mould of the present invention; Wherein: (a) pipe mould I; (b) pipe mould II.
Fig. 2 is the blood vessel after the present invention becomes hole.
Fig. 3 is the present invention three lobe leaf right ventricular valved conduit.
In figure: 1-artificial blood vessel; 2-chamber hole; 3-valve.
Detailed description of the invention:
Below in conjunction with drawings and Examples in detail the present invention is described in detail.
Mould pipeline has different models by the size (mm) point of internal diameter of the pipeline, from 12mm ~ 22mm, there is 1 model every 2mm, if needed, mould and the bionics band lobe artificial blood vessel of other models can be made, to be applicable to various types of patient according to patient's concrete condition.Fig. 1 (a)-(b) is depicted as the pipe mould I of diameter 20mm and the pipe mould II of diameter 30mm.
The bionics band lobe artificial blood vessel that the present invention makes is with artificial blood vessel 1 for pipeline, and the artificial high-temperature pressurizing method that adopts makes chamber hole 2, the pulmonary artery of simulation human body band hole.By on the pipe mould I shown in artificial blood pipe box to Fig. 1 (a), utilize the pipe mould II fastening artificial blood vessel shown in Fig. 1 (b), be connected with air compressor by silica gel tube again, all fixed by clip, air compressor persistent pressure, pressure maintains 100kpa, simultaneously with high-temperature test chamber heating blood vessel to 180 DEG C, continue 30 minutes, Fig. 2 is into the blood vessel after hole, and Dou Shen is about 1:4 with artificial blood vessel pipe diameter ratio.
Using pericardium material as valve 3, be cut into according to internal diameter of the pipeline and lobe hole size the valve meeting duct size, bond line is combined on lobe hole, synthesizes the right heart Valved allograft of three lobe leaves, and Fig. 3 is the right heart Valved allograft of three lobe leaves made.The umbilicate type structure of lobe hole makes the stop of lobe leaf valve-open phase to blood flow be down to minimum, contribute to reducing pressure gradient, valve closed-down period, the eddy current that draining blood is formed in lobe hole impels lobe leaf fully to open, promote that valve is closed, reduce blood flow for the shearing force of lobe limb edge simultaneously, avoid the long-term strain of valve structure.
Claims (4)
1. a bionics band lobe artificial blood vessel, it is characterized in that: described band lobe artificial blood vessel comprises artificial blood vessel, chamber hole and SANYE valve, wherein: described SANYE valve is PRECLUDE pericardium material, described artificial blood vessel and chamber hole are made by Gore-Tex artificial blood vessel material.
2. bionics band lobe artificial blood vessel according to claim 1, is characterized in that: the degree of depth of described chamber hole and the ratio of artificial blood vessel pipe diameter are 1:4.
3. bionics band lobe artificial blood vessel according to claim 1, is characterized in that: described band lobe artificial blood vessel preparation process is as follows:
(1) select the mould pipeline of required specification, mould pipeline has corresponding hole for the preparation of the position of chamber hole;
(2) chamber hole makes: be enclosed within by artificial blood vessel on a mould pipeline, then be set with by outside artificial blood vessel with another mould pipeline and compress, and then makes it be connected with air compressor by silica gel tube and keep sealing; Then keep 30 minutes under pressure 100KPa, temperature 180 DEG C of conditions, the obtained artificial blood vessel with chamber hole;
(3) SANYE valve makes: be cut into valve up to specification according to artificial blood vessel internal diameter of the pipeline and chamber hole size, bond line is combined on the hole of chamber, forms the right heart Valved allograft of three lobe leaves.
4. bionics band lobe artificial blood vessel according to claim 3, is characterized in that: in step (2), by air compressor persistent pressure, adopts high-temperature test chamber to heat artificial blood vessel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410301301.8A CN105310797A (en) | 2014-06-27 | 2014-06-27 | Bionics artificial blood vessel with valvula |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410301301.8A CN105310797A (en) | 2014-06-27 | 2014-06-27 | Bionics artificial blood vessel with valvula |
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| Publication Number | Publication Date |
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| CN105310797A true CN105310797A (en) | 2016-02-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410301301.8A Pending CN105310797A (en) | 2014-06-27 | 2014-06-27 | Bionics artificial blood vessel with valvula |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107744413A (en) * | 2017-09-22 | 2018-03-02 | 南京市儿童医院 | The preparation method of new Valved allograft |
| CN109893294A (en) * | 2019-03-20 | 2019-06-18 | 武汉杨森生物技术有限公司 | A kind of artificial blood vessel's valved conduit and preparation method thereof |
| CN110236733A (en) * | 2019-07-18 | 2019-09-17 | 南京市儿童医院 | A kind of novel valved conduit and preparation method thereof |
Citations (5)
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|---|---|---|---|---|
| US6197143B1 (en) * | 1996-04-24 | 2001-03-06 | Endre Bodnar | Bioprosthetic conduits |
| US6375679B1 (en) * | 1997-07-18 | 2002-04-23 | Advanced Medical Solutions Ltd. | Prosthetic valve sinus |
| CN200987710Y (en) * | 2006-12-22 | 2007-12-12 | 袁发焕 | Artificial blood vessed sinus for hemodialysis |
| CN101610738A (en) * | 2006-12-22 | 2009-12-23 | 艾斯丘莱普股份公司 | What have head weaves the aortic sinus prosthese |
| WO2013184552A1 (en) * | 2012-06-04 | 2013-12-12 | Edwards Lifesciences Corporation | Pre-assembled bioprosthetic valve and sealed conduit |
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2014
- 2014-06-27 CN CN201410301301.8A patent/CN105310797A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197143B1 (en) * | 1996-04-24 | 2001-03-06 | Endre Bodnar | Bioprosthetic conduits |
| US6375679B1 (en) * | 1997-07-18 | 2002-04-23 | Advanced Medical Solutions Ltd. | Prosthetic valve sinus |
| CN200987710Y (en) * | 2006-12-22 | 2007-12-12 | 袁发焕 | Artificial blood vessed sinus for hemodialysis |
| CN101610738A (en) * | 2006-12-22 | 2009-12-23 | 艾斯丘莱普股份公司 | What have head weaves the aortic sinus prosthese |
| WO2013184552A1 (en) * | 2012-06-04 | 2013-12-12 | Edwards Lifesciences Corporation | Pre-assembled bioprosthetic valve and sealed conduit |
Non-Patent Citations (1)
| Title |
|---|
| TAKAKO MIYAZAKI ET AL: "Expanded polytetrafluoroethylene valved conduit and patch with bulging sinuses in right ventricular outflow tract reconstruction", 《THE JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107744413A (en) * | 2017-09-22 | 2018-03-02 | 南京市儿童医院 | The preparation method of new Valved allograft |
| CN109893294A (en) * | 2019-03-20 | 2019-06-18 | 武汉杨森生物技术有限公司 | A kind of artificial blood vessel's valved conduit and preparation method thereof |
| WO2020187293A1 (en) * | 2019-03-20 | 2020-09-24 | 武汉杨森生物技术有限公司 | Artificial blood vessel having valve and manufacturing method therefor |
| CN109893294B (en) * | 2019-03-20 | 2021-06-22 | 武汉杨森生物技术有限公司 | Artificial blood vessel valved pipeline and manufacturing method thereof |
| CN110236733A (en) * | 2019-07-18 | 2019-09-17 | 南京市儿童医院 | A kind of novel valved conduit and preparation method thereof |
| CN110236733B (en) * | 2019-07-18 | 2021-06-04 | 南京市儿童医院 | Valved pipeline and preparation method thereof |
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Application publication date: 20160210 |