CN106419970A - Strut type bicuspid valve airbag closing plate obstruction body implanted through cardiac apex, and implantation method thereof - Google Patents
Strut type bicuspid valve airbag closing plate obstruction body implanted through cardiac apex, and implantation method thereof Download PDFInfo
- Publication number
- CN106419970A CN106419970A CN201610631620.4A CN201610631620A CN106419970A CN 106419970 A CN106419970 A CN 106419970A CN 201610631620 A CN201610631620 A CN 201610631620A CN 106419970 A CN106419970 A CN 106419970A
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- heart
- apex
- air bag
- closure plate
- snap ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00579—Barbed implements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00592—Elastic or resilient implements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00623—Introducing or retrieving devices therefor
Abstract
The invention belongs to the human body heart repairing technology and medical instrument field, and discloses a strut type bicuspid valve airbag closing plate obstruction body implanted through the cardiac apex, and an implantation method thereof; an airbag is arranged in the airbag closing plate; before implantation, a strut, a support framework and the airbag are compressed in a puncture conduit, and implanted along with the puncture conduit; after implantation, the airbag closing plate is inflated by air or fluid through an infusion tube, and is expanded to take position between two leaves of the heart bicuspid valve, thus obstructing a bicuspid valve countercurrent flow channel formed by pathology, and curing the bicuspid valve countercurrent flow; the airbag closing plate obstruction body is simple in structure, strong in reliability, very low in residual countercurrent flow incidence rate, and the implantation method has less wound on human body; the airbag closing plate obstruction body can treat functional bicuspid valve incomplete closure diseases, and the functional bicuspid valve countercurrent flow restoration success rate can be above 90%.
Description
Technical field
The invention belongs to human heart recovery technique and medical instruments field, especially to repair heart bicuspid valve anti-for one
The apparatus of stream, specially a kind of supporting rod type bicuspid valve air bag closure plate occluder through apex of the heart implantation and method for implantation.
Background technology
Human heart and valve are as it is shown in figure 1, left ventricle 3 is positioned at the apex of the heart 5 upper left side, and bicuspid valve 2 is positioned at atrium sinistrum 1 and a left side
Between ventricle 3, bicuspid valve 2 control blood from atrium sinistrum 1 unidirectional inflow left ventricle 3.The bicuspid valve 2 of functional disturbance can cause two points
Two leaflet incompetences of lobe 2, make blood go back to atrium sinistrum 1 at paradoxical expansion from left ventricle 3 reflux.Mitral regurgitation will cause
Stethemia and left ventricle 3 are loose, ultimately result in heart failure and the death of patient.
The structure of bicuspid valve 2 is as in figure 2 it is shown, bicuspid valve 2 is a complicated one-way valve structures bearing blood pressure, by annulus
2.1st, the cardiac muscle composition on front leaflet the 2.2nd, posterior valve leaflet the 2.3rd, chordae tendineae the 2.4th, papillary muscle 2.5 and left ventricular wall.Papillary muscle 2.5 adheres to
On left ventricular wall, front leaflet the 2.2nd, posterior valve leaflet 2.3 is attached in annulus 2.1.Annulus 2.1 be one connect before leaflet the 2.2nd, after
Leaflet 2.3 and the internal organizational structure of left ventricular wall.According to the institutional framework of annulus 2.1, it is divided into the fiber of front medial segment
Layer and the muscle layer of rear segmentum laterale.Chordae tendineae 2.4 originates in papillary muscle 2.5, is attached in leaflet, when being prevented from heart contraction before
Leaflet the 2.2nd, posterior valve leaflet 2.3 collapses into atrium sinistrum 1.
Normally functioning bicuspid valve Guan Bi when state as shown in Figure 3, Figure 4, front leaflet the 2.2nd, back lobe after MC
Between leaf 2.3 very close to each other, of completely closed between leaflet junction 2.6 front and back, reflux phenomenon will not be produced.When bicuspid valve 2 closes
State during conjunction as shown in Figure 5, Figure 6 when, have gap to occur between leaflet junction 2.6 before and after bicuspid valve 2, front and back leaflet knot
At conjunction, the gap between 2.6 makes blood be back to atrium sinistrum 1 (as illustrated by arrows 5 anti-when heart contraction from left ventricle 3
Flow path direction), this backflow is referred to as mitral regurgitation, and mitral regurgitation can reduce cardiac efficiency and cause heart failure.
Currently for the treatment method of mitral regurgitation, mainly there are annulus orthopedic, Mitral Mechanical or biological bicuspid valve
Transplanting etc., these need out chest, happy mostly, and big to human body wound, reliability is not high, cause treating in latter 5 years 50%
Mitral regurgitation again recur.Existing more advanced Minimal invasive procedures is by bicuspid valve clamp, by leaflet front and back
The midpoint at edge is clipped together, and forms two independent channel of blood flow, reduces the reflux of blood, but this method has remaining anti-
Stream occurs.
Content of the invention
Present invention aim to address problem present in existing mitral regurgitation treatment method, provide one to plant through the apex of the heart
The supporting rod type bicuspid valve air bag closure plate occluder of the reparation mitral regurgitation entering, blocks mitral reflux passage, effectively
Prevent mitral reflux；The present invention also provides the method for implantation of this strut-type air bag bicuspid valve closure plate occluder simultaneously, logical
Cross Minimally Invasive Surgery and be implanted to the reflux hole site at leaflet Guan Bi before and after bicuspid valve, it is not necessary to open chest, happy, to human body wound
Little, occur without remaining reflux, reliability is high.
In order to reach object above, a kind of supporting rod type bicuspid valve air bag closure plate occluder implanted through the apex of the heart of the present invention
Employed technical scheme comprise that：Described supporting rod type air bag bicuspid valve closure plate occluder is by air bag closure plate, apex of the heart snap ring, positioning
Axle sleeve, fixing plug and plug composition.Described air bag closure plate is by support frame, air bag, support bar, check valve and woven hose group
Become；
There is an air bag inside described air bag closure plate, compress to be placed into before implanting together with support bar, support frame and wear
With puncturing conduit implantation in thorn conduit, implant rear gasbag closure plate and inflated by woven hose or launch after topping up, be positioned at heart two
Between cusp two leaflet, block and due to illness sell of one's property raw mitral reflux passage, treat mitral regurgitation；Described support bar is sky
The hollow pipe with certain angle of bend (15-30 °) of the heart, its one end is connected with air bag closure plate, and embedded air bag Guan Bi
Plate, embedded part has through hole to be connected with inside air bag, it is simple to the topping up of woven hose or inflation, the other end and positioning shaft sleeve phase
Even；Described support frame is positioned at air bag closure plate left and right sides edge, for the sizing of air bag closure plate；Described check valve
It is positioned inside support bar, is connected with woven hose, prevent from inputting the liquid reflux of air bag closure plate；Described woven hose one end and list
Being connected to valve, the other end leads in vitro by support bar, for air bag closure plate topping up or inflation；Described apex of the heart snap ring can
It is fixed on apex of the heart position, prevent from departing from from the apex of the heart；The lower end of described positioning shaft sleeve and support bar is connected through the hinge, for determining
Position air bag closure plate so that it is low-angle can swing and rotate；Described fixing plug is positioned at outside the apex of the heart, and positioning shaft sleeve is solid
Being scheduled on apex of the heart snap ring, described plug is connected with fixing plug, and for the sealing of left ventricle, anti-Hemostatic Oral Liquid flows out.
It is preferred that support bar and positioning shaft sleeve connect the good thin-film material of outer one layer of blood compatibility of bread.
It is preferred that air bag closure plate launch after be shaped as the radian plate that radial position has 5-10 degree, closure plate intermediate thin,
The right and left is thick, and the thickness of the right and left is different.
The described technical side using through the method for implantation of the supporting rod type bicuspid valve air bag closure plate occluder of apex of the heart implantation
Case is：Implanted by the little otch in apex of the heart position on the left of chest, enter left ventricle through the apex of the heart, air bag closure plate is placed on before and after's leaflet
Junction, air bag closure plate is fixed on apex of the heart position by support bar, comprises the following steps that：
A, do a little otch in chest left heart apex of the heart position, the straight-through apex of the heart, does a pocket operation in apex of the heart position；
B, in vitro, first by air bag closure plate, support frame, support bar, positioning shaft sleeve, closure plate action bars and inside
Check valve and after woven hose assembles, compression is placed in puncture conduit, then, is puncturing apex of the heart card in conduit external mounting
Ring, snap ring action bars；
C, by the puncture conduit of assembling apex of the heart snap ring and snap ring action bars through left side thoracic wall small incision, reach apex of the heart position,
By puncturing conduit puncture entrance left ventricle from the pocket that apex of the heart position is sewed up, then by snap ring action bars, apex of the heart snap ring is pushed away
In the cardiac muscle of the apex of the heart, pocket of tying tight, apex of the heart snap ring is fixed on apex of the heart position；
D, withdrawing from snap ring action bars, regulation closure plate action bars and puncture conduit, by air bag closure plate from puncturing conduit
Release, after regulation positioning shaft sleeve is positioned at apex of the heart card ring position, withdraws from puncture conduit, and fixing plug is arranged on apex of the heart snap ring lower end
Screw thread on；
E, by woven hose toward inflation in air bag closure plate so that it is shaping, then woven hose is withdrawn from or from positioning shaft sleeve
Lower end is cut off；
F, being arranged on the screw thread of positioning shaft sleeve by plug, thoracic wall small incision on the left of stitching, operation finishes.
The present invention this have the advantage that after using technique scheme：
(1) bicuspid valve air bag closure plate of the present invention is made up of the good material of blood compatibility, before inflation, and can
It is very little that compression makes that diameter becomes, is placed in puncture conduit, is implanted by thoracic wall small incision on the left of human body, through the left heart of apex of the heart entrance
Room, is positioned and secured to the reflux hole site at leaflet Guan Bi before and after bicuspid valve, and when diastole, bicuspid valve is opened, blood
By the two passes between forward and backward leaflet and air bag closure plate from atrium sinistrum inflow left ventricle；When the heart contracts, forward and backward
Leaflet is closed, and together with leaflet edge closely adheres to air bag closure plate, blocks mitral reflux passage, is effectively prevented
Mitral reflux.
(2) simple in construction of air bag closure plate occluder, highly reliable, and its method for implantation is little to the wound of human body, remaining
Reflux incidence is very low, can carry out the treatment of the diseases such as feature mitral valve insufficiency, repair function type mitral regurgitation
Success rate reaches more than 90%.
Brief description
Below in conjunction with the accompanying drawings and detailed description of the invention the present invention is further illustrated, but protection scope of the present invention
It is not limited to this.
Fig. 1 is structure and the mitral valve position figure of heart；
Fig. 2 is mitral institutional framework enlarged drawing in Fig. 1；
Right side view when Fig. 3 is MC in Fig. 2；
Atrial side partial enlarged drawing when Fig. 4 is MC in Fig. 2；
The right side view of mitral regurgitation when Fig. 5 is Fig. 2 cardiac contraction mitral valve insufficiency；
Fig. 6 is the atrial side partial enlarged drawing of mitral regurgitation during Fig. 2 cardiac contraction mitral valve insufficiency；
Fig. 7 is after a kind of bicuspid valve air bag closure plate occluder through the supporting rod type of apex of the heart implantation of the present invention is implanted
Schematic diagram (front)；
Fig. 8 is the 3-D view after air bag closure plate launches；
Fig. 9 is the structural representation of air bag closure plate implant part；
Figure 10 is apparatus installation diagram before air bag closure plate Wicresoft implants；
Figure 11 is the position view (side) after air bag closure plate is implanted.
In figure：1-atrium sinistrum, 2-bicuspid valve, 2.1-annulus of mitral valve, leaflet before 2.2-, 2.3-posterior valve leaflet, 2.4-chordae tendineae,
2.5-papillary muscle, leaflet junction before and after 2.6-, 3-left ventricle, 4-aorta petal, the 5-apex of the heart, 6-air bag closure plate, 6.1-props up
Support bone frame, 6.2-air bag, 6.3-support bar, 6.4-check valve, 6.5-woven hose, the fixing plug of 7-, 8-positioning shaft sleeve, 9-apex of the heart card
Ring, 10-plug, 11-snap ring action bars, 12-closure plate action bars, 13-punctures conduit.
Detailed description of the invention
Seeing Fig. 7 and Fig. 9, a kind of structure through the supporting rod type bicuspid valve air bag closure plate of apex of the heart implantation of the present invention includes
Air bag closure plate the 6th, fixing plug the 7th, positioning shaft sleeve the 8th, apex of the heart snap ring the 9th, plug 10.Described air bag closure plate 6 is by support frame
6.1st, air bag the 6.2nd, support bar the 6.3rd, check valve the 6.4th, woven hose 6.5 forms.Before air bag closure plate is placed on bicuspid valve after implanting
Between posterior valve leaflet (the 2.2nd, 2.3), shaped by support frame 6.1, poured in air bag 6.2 by check valve 6.4 and woven hose 6.5
Gas or liquid molding.Air bag closure plate 6 is linked together by following support bar 6.3 and positioning shaft sleeve 8, is used for closure plate
Positioning.
The support bar of positioning shaft sleeve 8 and air bag closure plate 6 links together, and for the positioning of closure plate, can make Guan Bi
Plate has swing and the rotation (5-10 degree) of certain angle.Positioning shaft sleeve 8 is fixed on fixing plug 7 by plug 10.
Fixing plug 7 is connected with apex of the heart snap ring 9, for the positioning of apex of the heart snap ring 9, prevents apex of the heart snap ring toward ventricle one sidesway
Dynamic, and be connected with positioning shaft sleeve 8, it is fixed on positioning shaft sleeve 8 on apex of the heart snap ring 9.
Barb structure is arranged at apex of the heart snap ring 9 outer ring top, prevents the apex of the heart snap ring 9 from outwards deviating from from the apex of the heart 5, by fixing plug 7
It is firmly fixed to apex of the heart snap ring 9 on the apex of the heart 5.
Positioning shaft sleeve 8 is fixed on fixing plug 7 by plug 10, is used for the positioning at the apex of the heart for the air bag closure plate 6, and airtight
Envelope effect, prevents the blood in left ventricle 3 from being leaked by apex of the heart snap ring 9.
See Figure 10 and Figure 11, by the method that described supporting rod type bicuspid valve air bag closure plate Wicresoft implants left ventricle be：
Step 1, first on the left of chest, a little otch is done in apex of the heart position, the straight-through apex of the heart 5, and does in the apex of the heart 5 position
One pocket operation, for the positioning of apex of the heart snap ring 9.
Air bag closure plate 6 and positioning shaft sleeve the 8th, closure plate action bars 12 are assemblied in by step 2, as shown in Figure 10 in vitro
Together, compressing gasbag closure plate 6 so that it is be placed into together with positioning shaft sleeve the 8th, closure plate action bars 12 in puncture conduit 13, wear
It is assembled together with apex of the heart snap ring 9 and snap ring action bars 11 outside thorn conduit 13.
Step 3, the puncture conduit 13 (Figure 10) that will assemble, reach the apex of the heart by the little otch of left side chest over titie heart apex
Position in vitro, punctures in the middle of the pocket sewed up and enters left ventricle, regulate snap ring action bars 11, make apex of the heart snap ring 9 fill in the heart
In the cardiac muscle of point 5, pocket of tying tight, apex of the heart snap ring 9 is fixed.
Step 4, withdraw from snap ring operation 11, by closure plate action bars 12, air bag closure plate 6 is pushed away from puncturing conduit 13
Go out, and regulated by closure plate action bars, after making positioning shaft sleeve 8 be positioned at apex of the heart snap ring 9 position, withdraw from puncture conduit 13, and will
Fixing plug 7 is arranged on the screw thread of apex of the heart snap ring 9 lower end.
Step 5, by woven hose 6.5 toward inflation in the air bag 6.2 of air bag closure plate so that it is shaping, then by woven hose
6.5 withdraw from or cut off from positioning shaft sleeve 8 lower end.
Step 6, positioning shaft sleeve 8 lower end is thread through circular hole below fixing plug 7, plug 10 is arranged on positioning shaft sleeve 8
Screw thread on so that it is be fixed on fixing plug 7.
Thoracic wall small incision on the left of step 7, stitching, operation finishes.
Claims (4)
1. the supporting rod type bicuspid valve air bag closure plate occluder implanted through the apex of the heart, it is characterised in that include that air bag closes
Plate (6), fixing plug (7), positioning shaft sleeve (8), apex of the heart snap ring (9) and plug (10),
Described air bag closure plate (6) is by support frame (6.1), air bag (6.2), support bar (6.3), check valve (6.4) and transfusion
Pipe (6.5) composition；
Described air bag closure plate (6) is internal an air bag (6.2), with support bar (6.3), support frame (6.1) before implanting
Rise compression be placed into puncture conduit in puncture conduit implant, implant rear gasbag closure plate (6) by woven hose (6.5) inflation or
Launch after topping up, be positioned between heart bicuspid valve two leaflet；
Described support bar (6.3) is the hollow hollow pipe with certain angle of bend (15-30 °), and its one end and air bag close
Plywood (6) is connected, and embedded air bag closure plate (6), and embedded part has through hole to be connected with inside air bag, it is simple to woven hose
(6.5) topping up or inflation, the other end and positioning shaft sleeve (8) are connected；
Described support frame (6.1) is positioned at air bag closure plate (6) left and right sides edge；Described check valve (6.4) is positioned at and props up
Strut (6.3) is internal, and is connected with woven hose (6.5)；Described woven hose (6.5) one end is connected with check valve (6.4), another
End leads in vitro by support bar (6.3), for air bag closure plate topping up or inflation；Described apex of the heart snap ring (9) is fixed on the heart
Point position；The lower end of described positioning shaft sleeve (8) and support bar (6.3) is connected through the hinge, positioning gasbag closure plate (6)；Institute
The fixing plug (7) stated is positioned at outside the apex of the heart, is fixed on positioning shaft sleeve (8) on apex of the heart snap ring (9), described plug (10) and solid
Fixed plug (7) is connected, for the sealing of left ventricle.
2. a kind of supporting rod type bicuspid valve air bag closure plate occluder implanted through the apex of the heart according to claim 1, it is special
Levy and be, the thin-film material that outside described support bar (6.3) and positioning shaft sleeve (8) junction, one layer of blood compatibility of bread is good.
3. a kind of supporting rod type bicuspid valve air bag closure plate occluder implanted through the apex of the heart according to claim 1, it is special
Levying and being, being shaped as after described air bag closure plate (6) expansion radially has the radian plate of 5-10 degree, closure plate intermediate thin, a left side
Right both sides are thick, and the thickness of the right and left is different.
4. the implantation side of the supporting rod type bicuspid valve air bag closure plate occluder implanted through the apex of the heart as claimed in claim 1
Method, it is characterised in that comprise the steps：
A, do a little otch in chest left heart apex of the heart position, the straight-through apex of the heart, does a pocket operation in apex of the heart position；
B, in vitro, first by air bag closure plate (6), support frame (6.1), support bar (6.3), positioning shaft sleeve (8), closure plate
After the check valve (6.4) of action bars (12) and inside and woven hose (6.5) assemble, compression is placed in puncture conduit (13),
Then, apex of the heart snap ring (9) in conduit (13) external mounting, snap ring action bars (11) are being punctured；
The puncture conduit (13) of C, general's assembling apex of the heart snap ring (9) and snap ring action bars (11), through left side thoracic wall small incision, reaches the heart
Point position, by puncturing conduit (13) puncture entrance left ventricle from the pocket that apex of the heart position is sewed up, then passes through snap ring action bars
(11) apex of the heart snap ring (9) is shifted onto in the cardiac muscle of the apex of the heart, pocket of tying tight, apex of the heart snap ring (9) is fixed on apex of the heart position；
D, withdraw from snap ring action bars (11), regulation closure plate action bars (12) and puncture conduit (13), by air bag closure plate (6) from
Puncture in conduit (13) and release, after regulation positioning shaft sleeve (8) is positioned at apex of the heart snap ring (9) position, withdraw from puncture conduit (13), and will
Fixing plug (7) is arranged on the screw thread of apex of the heart snap ring (9) lower end；
E, by woven hose (6.5) toward inflation in air bag closure plate (6) so that it is shaping, then woven hose (6.5) is withdrawn from or from
Positioning shaft sleeve (8) lower end is cut off；
F, being arranged on plug (10) on the screw thread of positioning shaft sleeve (8), thoracic wall small incision on the left of stitching, operation finishes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610631620.4A CN106419970B (en) | 2016-08-03 | 2016-08-03 | A kind of supporting rod type bicuspid valve air bag closure plate occluder and method for implantation being implanted into through the apex of the heart |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610631620.4A CN106419970B (en) | 2016-08-03 | 2016-08-03 | A kind of supporting rod type bicuspid valve air bag closure plate occluder and method for implantation being implanted into through the apex of the heart |
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| Publication Number | Publication Date |
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| CN106419970A true CN106419970A (en) | 2017-02-22 |
| CN106419970B CN106419970B (en) | 2018-12-25 |
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Cited By (4)
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| CN107260365A (en) * | 2017-06-22 | 2017-10-20 | 上海形状记忆合金材料有限公司 | Repair the interventional systems of mitral valve |
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| CN111200995A (en) * | 2017-09-07 | 2020-05-26 | 爱德华兹生命科学公司 | Prosthetic spacer device for heart valves |
| WO2021162564A1 (en) * | 2020-02-14 | 2021-08-19 | Medarch Sp. Z O.O. | Implantable left ventricular assist device and system for ventricular-assist for use in patients with end-stage heart failure |
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| CN107260365A (en) * | 2017-06-22 | 2017-10-20 | 上海形状记忆合金材料有限公司 | Repair the interventional systems of mitral valve |
| CN107260365B (en) * | 2017-06-22 | 2024-01-09 | 上海形状记忆合金材料有限公司 | Interventional system for repairing mitral valve |
| CN111200995A (en) * | 2017-09-07 | 2020-05-26 | 爱德华兹生命科学公司 | Prosthetic spacer device for heart valves |
| CN107595347A (en) * | 2017-09-25 | 2018-01-19 | 潘湘斌 | The left atrial appendage occlusion device assembly and its interventional method of a kind of repeatable folding and unfolding |
| CN107595347B (en) * | 2017-09-25 | 2019-11-26 | 潘湘斌 | A kind of the left atrial appendage occlusion device assembly and its interventional method of repeatable folding and unfolding |
| WO2021162564A1 (en) * | 2020-02-14 | 2021-08-19 | Medarch Sp. Z O.O. | Implantable left ventricular assist device and system for ventricular-assist for use in patients with end-stage heart failure |
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| Publication number | Publication date |
|---|---|
| CN106419970B (en) | 2018-12-25 |
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