CN1052886C - Chinese drug powder for curing hepatitis B and its preparing method - Google Patents
Chinese drug powder for curing hepatitis B and its preparing method Download PDFInfo
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- CN1052886C CN1052886C CN94105877A CN94105877A CN1052886C CN 1052886 C CN1052886 C CN 1052886C CN 94105877 A CN94105877 A CN 94105877A CN 94105877 A CN94105877 A CN 94105877A CN 1052886 C CN1052886 C CN 1052886C
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Abstract
The present invention discloses a Chinese powder medicament for curing hepatitis B, which is prepared from various traditional Chinese medicaments including sun-dried ginseng, spring panax pseudo-ginseng, yanhusuo, raw rhubarb, etc. The medicament has a notable therapeutic effect for improving clinical symptoms and liver functions and also has a good effect on the negative conversion of hepatitis B virus replication index. Moreover, the medicament has no obvious toxic or side effect. The medicament has the advantages of extensive raw material source, low cost, good therapeutic effect, convenient use, high practical value, etc.
Description
The present invention relates to treat the medicament of hepatitis B, particularly a kind of Chinese medicine preparation.
Chronic hepatitis B is clinical common transmittable disease, frequently-occurring disease, the health that is seriously threatening people.At present, treat this disease with medicines such as advanced interferon, immunosuppressant both at home and abroad, to HB
eThe negative conversion rate of Ag and HBV-DNA is about about 50%, and the cost height, cost an arm and a leg, toxicity is many, patient is difficult to accept.Existing Chinese medicine preparation exists defectives such as weak curative effect again, can not satisfy patient's needs.
An object of the present invention is to overcome the problems referred to above, provide that a kind of good effect, cost are low, the Chinese medicine preparation of the treatment hepatitis B of no obvious toxic-side effects.1
Another object of the present invention provides a kind of preparing such formulations.
Pharmaceutical formulation of the present invention following (parts by weight):
Radix Ginseng 55-65, spring Radix Notoginseng 25-35,
Rhizoma Corydalis 55-65, Radix Et Rhizoma Rhei 55-65,
Semen Coicis 55-65, Polyporus 55-65,
Spica Prunellae 445-455, Herba Hedyotidis Diffusae 175-185,
Herba Epimedii 55-65, Fructus Forsythiae 115-125,
Fructus Schisandrae Chinensis 55-65, Rhizoma Atractylodis Macrocephalae 85-95,
Radix Clematidis 25-35, Endothelium Corneum Gigeriae Galli 25-35,
Fructus Hordei Germinatus 55-65, Rhizoma Zingiberis Recens 10-20,
Poria 55-65, Radix Paeoniae Rubra 85-95,
Radix Paeoniae Alba 235-245, Radix Bupleuri 25-35,
Herba Artemisiae Scopariae 85-95, Cortex Moutan 55-65,
Also can contain an amount of sucrose and dextrin in the medicament of the present invention.Add sucrose and be mainly seasoning, dextrin is mainly mix homogeneously.
Medicaments preparation method of the present invention is as follows:
Radix Ginseng, spring Radix Notoginseng, Rhizoma Corydalis, Semen Coicis, Cortex Moutan, Fructus Schisandrae Chinensis, Endothelium Corneum Gigeriae Galli and Poria powder are broken into powder, to decoct with water behind Radix Et Rhizoma Rhei, Polyporus, Spica Prunellae, the Rhizoma Atractylodis Macrocephalae, Herba Epimedii, Fructus Forsythiae, Radix Clematidis, Fructus Hordei Germinatus, Rhizoma Zingiberis Recens, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Bupleuri, Herba Artemisiae Scopariae and the Herba Hedyotidis Diffusae edulcoration, after the filtration filtrate reduced to and add ethanol precipitation after concentrating, the leaching supernatant, decompression recycling ethanol, be condensed into clear paste, with above-mentioned medicated powder and clear paste mix homogeneously, make granule, promptly obtain the electuary of treatment hepatitis B of the present invention.
Chronic hepatitis B patient because the course of disease is long, causes human righteousness's weakness, must take into account in treatment and set upright, and is simultaneously eliminating evil.In the past use the treatment by Chinese herbs chronic viral hepatitis B, set upright and how to start with from the spleen kidney, and the present invention is from the QI and blood staff, uses ginseng qi-tonifying, and pseudo-ginseng blood-circulation-invigovating nourishes blood, reach strong effect, simultaneously again must other Chinese medicine synergism, prevent that Radix Ginseng from having side effects, thereby when setting upright, eliminating evil again, set upright and do not stay heresy, just do not hinder by heresy.Cortex Moutan, Spica Prunellae, the Radix Paeoniae Alba, Herba Hedyotidis Diffusae and Fructus Forsythiae can directly suppress the hepatitis B virus in the human serum, in order to prevent prolonged application damage people's taste, so add the Rhizoma Atractylodis Macrocephalae, Poria etc.By traditional Chinese medical science mechanism, wet, heat, sick, heresy are two big contradictions, should damp eliminating heat clearing away again on treating, and this also is a pair of contradiction.The present invention adopts damp eliminatings such as Radix Clematidis, Rhizoma Zingiberis Recens, Poria, Semen Coicis and Herba Artemisiae Scopariae, with heat clearing away such as Spica Prunellae, Fructus Forsythiae, Herba Hedyotidis Diffusae and Cortex Moutans.Cortex Moutan, the Radix Paeoniae Alba are repaired impaired hepatocyte in addition, prevent the effect of hepatic necrosis.So medicament of the present invention has the effect of Fuzheng Jiedu, promoting flow of QI and blood, be used for the treatment of chronic viral hepatitis B and (comprise chronic active hepatitis, chronic persistent hepatitis, liver cirrhosis), 2 clinical observations through 5 years, 3-6 month course of treatment, the result shows, this medicine is to improving clinical symptoms and liver function has obvious curative effects, total effective rate reaches 74.52%, and cloudy commentaries on classics of hepatitis B virus duplication index also had effect preferably, HB
eAg, HBV-DNA negative conversion rate reach 51.6% and 51.5% respectively.Clinical and animal experiment shows no obvious toxic-side effects.Animal experiment and pharmacological evaluation show, this medical instrument has to be regulated immunologic function, fall enzyme, the turbid descending degree, promoting the function of the gallbladder to alleviate jaundice, antiinflammatory, fibrosis, the soft liver spleen that contracts, promote the effect of liver cell regeneration, rising plasma albumin.This medical instrument has advantages such as the medicine source is extensive, cheap, taking convenience, good effect, and bigger practical value is arranged.
The present invention will be described below in conjunction with embodiment.
Embodiment
Respectively 60g Radix Ginseng, 30g spring Radix Notoginseng, 60g Rhizoma Corydalis, 60g Semen Coicis, 60g Cortex Moutan, 60g Fructus Schisandrae Chinensis, 30g Endothelium Corneum Gigeriae Galli, 60g Poria are pulverized the back and cross 120 mesh sieves, it is standby to make fine powder.Other gets and decocts with water three times after 60g Radix Et Rhizoma Rhei, 60g Polyporus, 450g Spica Prunellae, 90 Rhizoma Atractylodis Macrocephalaes, 60g Herba Epimedii, 120g Fructus Forsythiae, 30g Radix Clematidis, 60g Fructus Hordei Germinatus, 15g Rhizoma Zingiberis Recens, 90g Radix Paeoniae Rubra, the 240g Radix Paeoniae Alba, 30g Radix Bupleuri, 90g Herba Artemisiae Scopariae and 180g Herba Hedyotidis Diffusae are cleaned, time was respectively 2 hours, 1.5 hours and 1 hour, filter one by one, merge three times filtrate, add ethanol precipitation behind the concentrating under reduced pressure once, left standstill the leaching supernatant 24 hours, decompression recycling ethanol is condensed into clear paste.Getting an amount of sucrose, dextrin and above-mentioned thin medicated powder again and place mixer to mix after ten minutes, pour clear paste into and continue to be mixed to evenly, is wetting agent with an amount of ethanol, makes granule, and drying, granulate, dress bag, sealing promptly obtain electuary of the present invention then.For further specifying effect of the present invention, compare below, the treatment group is taken electuary of the present invention, and every bag heavy 50g contains crude drug in whole 40g, and instructions about how to take medicine are every day 2 times, are grown up each half bag, each 1/4 bag of child, boiled water is taken after mixing it with water, the half a year course of treatment.
Matched group must be answered (Taonan associating pharmaceutical factory of Jilin University product) treatment, every day 3 times, each 2, warm water delivery service, the half a year course of treatment with liver.
Criterion of therapeutical effect is:
Produce effects: subjective symptoms disappears, and hepatosplenomegaly is stablized or dwindled, no percussion pain and tenderness, and liver function recovery is normal, HB
eAg or HBV-DNA turn out cloudy, and serum albumin detects normal, participates in general physical work state of an illness no change.
Effectively: cardinal symptom disappears, and hepatosplenomegaly is stable, does not have obvious tenderness and percussion pain, and liver function recovery is normal or approaching normal.
Invalid: as not have obviously before and after symptom, sign and the lab testing treatment and improve.
Can 3 diagnostic criterias of discussing revision be diagnosed as chronic active hepatitis 112 examples according to 1984 (Nanning) national viral hepatitis special topic is academic, chronic persistent hepatitis 192 examples are divided into treatment at random and organize 208 examples, matched group 96 examples.Male's 126 examples in the treatment group, women's 82 examples, 34 ± 4 years old mean age, average course of disease 4.5 years.Male's 57 examples in the matched group, women's 39 examples, 34.5 ± 4 years old mean age, average course of disease 4 years.
Through treatment half a year, treatment group produce effects 72 examples (34.62%) of taking electuary of the present invention, effective 83 examples (39.90%), invalid 53 examples (25.48%), total effective rate (74.52%).Take matched group produce effects 20 examples (20.83%) that liver must be answered, effective 38 examples (39.58%), invalid 38 examples (39.58%), total effective rate 60.42%.Two groups of curative effects have significant difference (P＜0.05).(table is seen the literary composition back)
Clinical data shows, electuary of the present invention obviously is better than liver aspect the clinical subjective symptoms and must answers improving, and is better than matched group as abdominal distention, hypochondriac pain, treatment group curative effect such as weak, and significant difference is arranged.But two groups of liver enlargement retraction effect no significant differences (P＞0.05).Two groups of case liver functions all have take a turn for the better in various degree (seeing Table) before and after the treatment.The negative case of HBV-M before treating was checked after treatment 3 months and half a year, and two groups of cases of result resist-HB
sHave 3 examples and change sun, treatment group HB
sAg and anti--HBc negative conversion rate are respectively 16.7% and 10.5%.Matched group HB
eAg and anti--HB
cNegative conversion rate is respectively 17.6% and 8.0%, and is anti--HB
eChange positive rate treatment group and matched group and be respectively 29.0% and 12.3%.Treatment group HB
eAg and HBV-DNA negative conversion rate are respectively 51.6% and 51.5%, matched group HB
eAg and HBV-DNA negative conversion rate are respectively 35.1% and 23.8%, and the treatment group is apparently higher than matched group (P＜0.05).Two groups of case changes of liver function before and after the tabulation expression treatment below 4
| Group | Before the treatment | Treated back 3 months | Treat later six months | |
| Glutamate pyruvate transaminase (reitman-frankel method IU) | Treatment group matched group | ????159.47±47.75 ????159.59±49.70 | ????42.03±17.34 ????54.33±18.28 | ????31.98±13.65 ????33.80±9.01 |
| Zinc sulfate group degree (IU) | Treatment group matched group | ????18.22±2.73 ????16.43±2.96 | ????12.03±2.44 ????12.01±5.36 | ????9.93±3.42 ????11.90±3.36 |
| Total bilirubin (mg/L) | Treatment group matched group | ????10.2±5.8 ????9.1±4.3 | ????8.3±2.7 ????6.6±3.9 | ????6.9±1.8 ????7.1±1.9 |
| Albumin (g/l) | Treatment group matched group | ????30.5±3.2 ????29.7±4.1 | ????32.6±2.8 ????31.3±3.3 | ????35.6±3.3 ????33.2±3.3 |
Claims (4)
1. Chinese medicine electuary for the treatment of hepatitis B is characterized in that being made by following proportion raw material (parts by weight):
Radix Ginseng 55-65, spring Radix Notoginseng 25-35,
Rhizoma Corydalis 55-65, Radix Et Rhizoma Rhei 55-65,
Semen Coicis 55-65, Polyporus 55-65,
Spica Prunellae 445-455, Herba Hedyotidis Diffusae 175-185,
Herba Epimedii 55-65, Fructus Forsythiae 115-125,
Fructus Schisandrae Chinensis 55-65, Rhizoma Atractylodis Macrocephalae 85-95,
Radix Clematidis 25-35, Endothelium Corneum Gigeriae Galli 25-35,
Fructus Hordei Germinatus 55-65, Rhizoma Zingiberis Recens 10-20,
Poria 55-65, Radix Paeoniae Rubra 85-95,
Radix Paeoniae Alba 235-245, Radix Bupleuri 25-35,
Herba Artemisiae Scopariae 85-95, Cortex Moutan 55-65,
2. electuary as claimed in claim 1 is characterized in that containing an amount of sucrose and dextrin.
3. preparation method of electuary as claimed in claim 1 or 2, it is characterized in that Radix Ginseng, spring Radix Notoginseng, Rhizoma Corydalis, Semen Coicis, Cortex Moutan, Fructus Schisandrae Chinensis, Endothelium Corneum Gigeriae Galli and Poria powder are broken into powder, decoct with water after Radix Et Rhizoma Rhei, Polyporus, Spica Prunellae, the Rhizoma Atractylodis Macrocephalae, Herba Epimedii, Fructus Forsythiae, Radix Clematidis, Fructus Hordei Germinatus, Rhizoma Zingiberis Recens, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Bupleuri, Herba Artemisiae Scopariae and Herba Hedyotidis Diffusae cleaned, add ethanol precipitation after after the filtration filtrate decompression being concentrated, the leaching supernatant, decompression recycling ethanol, be condensed into clear paste, with described medicated powder and clear paste mix homogeneously, make granule.
4. method as claimed in claim 3 is characterized in that sucrose and dextrin are mixed in the described medicated powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94105877A CN1052886C (en) | 1994-05-31 | 1994-05-31 | Chinese drug powder for curing hepatitis B and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94105877A CN1052886C (en) | 1994-05-31 | 1994-05-31 | Chinese drug powder for curing hepatitis B and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1113772A CN1113772A (en) | 1995-12-27 |
| CN1052886C true CN1052886C (en) | 2000-05-31 |
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ID=5032223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94105877A Expired - Fee Related CN1052886C (en) | 1994-05-31 | 1994-05-31 | Chinese drug powder for curing hepatitis B and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1052886C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1058623C (en) * | 1996-07-12 | 2000-11-22 | 王庆新 | Anti-hepatitis B capsule |
| CN103330882A (en) * | 2012-02-07 | 2013-10-02 | 张雨 | Traditional Chinese medicine tablet for treating chronic-hepatitis hepatic fibrosis and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1082905A (en) * | 1992-08-28 | 1994-03-02 | 兰春良 | A kind of processing method for the treatment of GANYAN KOUFUYE |
| CN1083712A (en) * | 1993-04-11 | 1994-03-16 | 孟福厚 | A kind of medicine of preventing and treating hepatitis B |
-
1994
- 1994-05-31 CN CN94105877A patent/CN1052886C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1082905A (en) * | 1992-08-28 | 1994-03-02 | 兰春良 | A kind of processing method for the treatment of GANYAN KOUFUYE |
| CN1083712A (en) * | 1993-04-11 | 1994-03-16 | 孟福厚 | A kind of medicine of preventing and treating hepatitis B |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1113772A (en) | 1995-12-27 |
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