CN105288078B - Prevent and treat the Chinese medicine composition and its preparation method and application that atherosclerosis merges cardiac insufficiency - Google Patents
Prevent and treat the Chinese medicine composition and its preparation method and application that atherosclerosis merges cardiac insufficiency Download PDFInfo
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Abstract
The invention discloses the Chinese medicine compositions that a kind of prevention and treatment atherosclerosis merges cardiac insufficiency.The Chinese medicine composition is the medicament being prepared by the bulk pharmaceutical chemicals of following weight parts: 9-15 parts of Radix Astragali, 6-12 parts of Snakegourd Fruit, 6-9 parts of Longstamen Onion Bulb, 6-9 parts of rhizoma acori graminei, 6-12 parts of pueraria lobata, 3-6 parts of ramulus cinnamomi, 6-12 parts of Radix Salviae Miltiorrhizae, 9-15 parts of motherwort, 6-12 parts of HERBA EPIMEDII, 6-12 parts of the fleece-flower root.In addition, the invention further relates to the preparation method of the Chinese medicine composition and purposes.
Description
Technical field
The present invention relates to the Chinese medicine compositions that a kind of prevention and treatment atherosclerosis merges cardiac insufficiency；The invention further relates to
The preparation method and purposes of the Chinese medicine composition.
Background technique
Modern society, with the continuous improvement of people's living standards, diet and living habit and the change of living environment,
The incidence of atherosclerosis (Atherosclerosis, AS) property disease also gradually increases, the heart, the cerebrovascular often involved
Deng and and make up one's mind, cerebrovascular accident and died account for the first place of mortality.Atherosclerosis is cardiovascular and cerebrovascular disease
The main pathological basis of disease, on this basis, plaque rupture, thrombosis, occluded blood vessel official jargon is to cause the instability mode heart to twist
Bitterly, the first cause of the acute coronary syndromes such as acute myocardial infarction AMI and sudden death.Arteria carotis is the good of atherosclerosis
Hair position is also the symbol location that whole body pathology starts, and position table is shallow, and ultrasonic wave, which is picked up to look into, to be easy to detect, carotid atherosclerosis
The earliest period performance of lesion is that Intima-media thickness thickens.Atherosclerosis not only involves arteria carotis, while also often tiring out the heart
Brain and artery of lower extremity blood vessel, wherein coronary atherosclerotic heart disease is gradually progressed to after involving angiocarpy, it is final most
Number all progresses to heart failure.Chronic heart failure (Chronic heart failure, CHF) is most of cardiovascular diseases
One of final home to return to, and most important cause of death clinical at present.Epidemiological study data shows, global heart failure
Number of patients is up to 22,500,000, newly promotes 2,000,000 every year.Chinese cardiovascular health multicenter joint study group in 2003 for the first time
The epidemiologic data for having studied population of China chronic heart failure obtains China's adult center force failure illness in 35-74 years old
Rate is about 0.9%, and has close association with the age.With current aging, the continuous improvement of living standard, by coronary heart disease, height
The disease incidence of chronic heart failure caused by blood pressure etc. gradually increases, and nearly 5 years death rates and malignant tumour are similar.Mental and physical efforts
Failure patients' epidemiology shows that the cause of disease first of heart failure in 2000 is coronary heart disease, accounts for 55.7%.
The prevention and treatment that traditional Chinese medicine merges cardiac insufficiency for atherosclerosis at present focuses mostly on mentioning in heart function curative effect
High and blood lipid improvement, does not still merge diastolic dysfunction carotid plaques, quality of life, anxiety to atherosclerosis
The influential drug of depressed mood obstacle.
Summary of the invention
For the above-mentioned deficiency of the prior art, according to an embodiment of the invention, wishing is that atherosclerosis merges heart function
Can not full patient one kind is provided can prevent and treat cardiac insufficiency, atherosclerosis and quality of making the life better, alleviate emotion barrier
The Chinese medicine composition hindered, and propose the preparation method and purposes of the Chinese medicine composition.
In order to solve the above technical problem, the present invention provides prevention and treatment atherosclerosis merge cardiac insufficiency Chinese medicine
Composition is the medicament being prepared by the bulk pharmaceutical chemicals of following weight parts: 9-15 parts of Radix Astragali, 6-12 parts of Snakegourd Fruit, 6-9 parts of Longstamen Onion Bulb,
6-9 parts of rhizoma acori graminei, 6-12 parts of pueraria lobata, 3-6 parts of ramulus cinnamomi, 6-12 parts of Radix Salviae Miltiorrhizae, 9-15 parts of motherwort, 6-12 parts of HERBA EPIMEDII, the fleece-flower root
6-12 parts.
Preferably, the parts by weight of the above-mentioned Chinese medicine composition of the present invention are respectively as follows: 12 parts of Radix Astragali, 9 parts of Snakegourd Fruit, 6 parts of Longstamen Onion Bulb, stone
6 parts of calamus, 9 parts of pueraria lobata, 3 parts of ramulus cinnamomi, 9 parts of Radix Salviae Miltiorrhizae, 12 parts of motherwort, 9 parts of HERBA EPIMEDII, 9 parts of the fleece-flower root.
Preferably, the above-mentioned medicament of the present invention is mixture.
Preferably, the above-mentioned medicament of the present invention is granule.
The above-mentioned Chinese medicine composition mixture of the present invention the preparation method is as follows: weigh bulk pharmaceutical chemicals 6-8 staggering amount in proportion, respectively plus
9-11 times of water amount is measured with 7-9 times, decocts two to three times, merging filtrate, filtrate is concentrated into every milliliter and is equivalent to 5 grams of crude drugs；Concentration
Liquid adds 2-4 times to measure ethyl alcohol, alcohol content 60%, and refrigeration stands 22-26 hours, filtration, filtrate recycling ethanol to no alcohol taste；Recycling
Liquid boils, and adds 2-4 grams of sodium benzoate, 0.23-0.27 grams of nipagin ethylester, and filtration is let cool, and is added water to 480-520ml, is filled while hot
It fills to obtain the final product.
In addition, the above-mentioned Chinese medicine composition mixture of the present invention also can be used following preparation method: weighing Longstamen Onion Bulb, stone Chang in proportion
Pu, ramulus cinnamomi 6-8 staggering amount, are crushed to 10-40 mesh, and it is spare to extract volatile oil using steam distillation or supercritical extraction；Chinese onion
White, rhizoma acori graminei, ramulus cinnamomi residue and remaining weighed bulk pharmaceutical chemicals in proportion add 5-10 times of water to measure respectively, decoct two to three times, close
And filtrate, filtrate are concentrated into every milliliter and are equivalent to 5 grams of crude drugs；Using flocculent precipitation, 22-26 hours are stood, centrifugal filtering, from
Heart speed be 4980-5020 revs/min, filtrate be added Longstamen Onion Bulb, rhizoma acori graminei, Ramulus Cinnamomi Volatile oil, mix, add 2-4 grams of sodium benzoate,
0.23-0.27 grams of nipagin ethylester, filtration is let cool, and adds water to 480-520ml, it is filling while hot to obtain the final product.
The above-mentioned Chinese medicinal composition granules of the present invention the preparation method is as follows: weighing bulk pharmaceutical chemicals 6-8 staggering amount in proportion, respectively
Add 9-11 times of water amount to measure with 7-9 times, decocts two to three times, merging filtrate, filtrate is concentrated into every milliliter and is equivalent to 5 grams of crude drugs；It is dense
Contracting liquid adds 2-4 times to measure ethyl alcohol, alcohol content 60%, and refrigeration stands 22-26 hours, filtration, and filtrate recycling ethanol to no alcohol taste returns
Receiving liquid and being concentrated into relative density is 1.25-1.30, and dextrin or appropriate starch is added, and wet granulation is dry, and particle 480- is made
It 520 grams, dispenses to obtain the final product.
In addition, the above-mentioned Chinese medicinal composition granules of the present invention also can be used following preparation method: weighing Longstamen Onion Bulb, stone in proportion
Calamus, ramulus cinnamomi 6-8 staggering amount, are crushed to 10-40 mesh, and it is spare to extract volatile oil using steam distillation or supercritical extraction；
Longstamen Onion Bulb, rhizoma acori graminei, ramulus cinnamomi residue and remaining weighed bulk pharmaceutical chemicals in proportion add 5-10 times of water to measure respectively, decoct two to three times,
Merging filtrate, filtrate are concentrated into every milliliter and are equivalent to 5 grams of crude drugs；Using the poly- soup flocculent precipitation of shell, 22-26 hours are stood, from
Heart filtration, it is 1.25-1.30 that mixed liquor, which is concentrated into relative density, and dextrin or appropriate starch is added and Longstamen Onion Bulb, rhizoma acori graminei, ramulus cinnamomi are waved
Hair oil beta cyclodextrin clathrate, wet granulation or marumerization granulation, low temperature or vacuum drying, are made 480-520 grams of particle,
It dispenses to obtain the final product.
The traditional chinese medicine composition of the invention with qi and activate blood circulation, activate yang that it is turbid for the rules for the treatment of to let out, by Radix Astragali, Snakegourd Fruit, Longstamen Onion Bulb, rhizoma acori graminei, Pueraria lobota
Root, ramulus cinnamomi, Radix Salviae Miltiorrhizae, motherwort, HERBA EPIMEDII, the fleece-flower root are drug composition.In this group of drug, Radix Astragali strengthening the spleen and replenishing qi, Radix Salviae Miltiorrhizae is lived
Blood disperse blood stasis and dredge collateral, the wide chest reducing phlegm and resolving masses of Snakegourd Fruit, Longstamen Onion Bulb, unobstructed whole body blood vessels, HERBA EPIMEDII, fleece-flower root nourishing liver and kidney, strengthening the bones and muscles, stone Chang
Pu is had one's ideas straightened out slit phlegm clearing damp, and pueraria lobata is supporing yang to promote the production of body fluid, motherwort activating blood and promoting diuresis, ramulus cinnamomi temperature yang transforming qi Li Shui, and full side's giving consideration to both the incidental and fundamental is taken into account
Gas, blood, phlegm, wet various aspects.Modern pharmacological research confirms that Radix Astragali, Radix Salviae Miltiorrhizae have improvement myocardial ischemia, expansion blood vessel, antithrombotic
It is formed, reduces blood viscosity, adjusts the effects of blood lipid；Snakegourd Fruit, Longstamen Onion Bulb, which have, to be inhibited platelet aggregation, adjusts blood lipid, improves antioxygen
Ability has the function that protect ischemic myocardial cells；The expansible blood vessel of ramulus cinnamomi adjusts blood circulation；Motherwort, HERBA EPIMEDII can be with
Increase hat blood flow, reduces myocardium cell necrosis amount, reduce vascular resistence, improve the effects of microcirculation；Pueraria lobata, the fleece-flower root all have
There is antithrombus formation, reduces blood viscosity, adjusts the pharmacological actions such as blood lipid.
The traditional chinese medicine composition of the invention significantly prevents and treats cardiac insufficiency and atherosclerosis clinical tests prove that having,
It makes the life better quality, alleviates the effect of the anxiety-depression disturbance of emotion.
Specific embodiment
Present invention will be further explained below with reference to specific examples.These embodiments are interpreted as being merely to illustrate this hair
It is bright rather than limit the scope of the invention.After having read the content of the invention recorded, those skilled in the art can
To make various changes or modifications to the present invention, these equivalence changes and modification equally fall into model defined by the claims in the present invention
It encloses.
Radix Astragali used in following embodiment of the present invention determines that the place of production is the Inner Mongol, is leguminous perennial herb astragalus mongolicus
The root of Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao.
Longstamen Onion Bulb used in following embodiment of the present invention determines place of production Jiangsu, is Liliaceae herbaceos perennial Allium macrostemon
The underground bulb of Allium macrostemon Bge. and Chinese onion Allium chinense G.Don.
Motherwort used in following embodiment of the present invention determines place of production Jiangsu, is that Labiatae is annual or biennial herb plant
The aerial part of motherwort Leonurus heterophyllus Sweet.
Rhizoma acori graminei used in following embodiment of the present invention determines place of production Hebei, perennial for Araeceae, Acorus graminoid
The rhizome of herbaceous plant rhizoma acori graminei Acorus tatarinowii..
Ramulus cinnamomi used in following embodiment of the present invention determines place of production Hebei, is lauraceae plant cortex cinnamomi Cinnamomum cassia
The dry twig of Presl.
HERBA EPIMEDII used in following embodiment of the present invention determines place of production Yunnan, is Berberidaceae plant Herba Epimedii Epimedium
Brevicornum Maxim, Epimedium sagittatum Epimedium sagittatum (Sieb.et Zucc.) Maxim, the excessive sheep of pubescence
Leaves of pulse plants Epimedium pubescens Maxim, E. wushanense T. S. Ying Epimedium wushanense T.S.Ying or Korea are excessive
The dry aerial parts of sheep leaves of pulse plants Epimedium koreanum Nakai.
The fleece-flower root used in following embodiment of the present invention, which is joined, determines place of production Hebei, is polygonum multiflorum thunb Polygonum
The dried root of multiflorum Thunb..
Radix Salviae Miltiorrhizae used in following embodiment of the present invention determines place of production Jiangsu, is Labiatae herbaceos perennial Radix Salviae Miltiorrhizae Salvia
The root and rhizome of miltiorrhiza Bge..
The tuber of pinellia processed used in following embodiment of the present invention determines place of production Anhui, is the Araeceae herbaceos perennial tuber of pinellia
The stem tuber of Pinellia ternate (Thunb.) Breit., is crossed with ginger juice system and is used as medicine.
Pueraria lobata used in following embodiment of the present invention determines place of production Jiangsu, is the perennial defoliation liana elegant jessamine of pulse family
The root of Pueraria lobata (Willd.) Ohwi or sweet kudzu Pueraria thomsonii Benth..
Whole Fructus Trichosanthis used in following embodiment of the present invention determines place of production Hebei, is Curcurbitaceae herbaceous perennial vine Trichosanthes kirilowii
The ripening fruits of Trichosanthes kirilowii Maxim. and trichosanthes rosthornii Harms T.rosthornii Harms.
Embodiment 1 (prepares mixture)
Above-mentioned 6 staggering amount of medicinal material is weighed in proportion and adds 9 times of water amounts and 7 times of amounts respectively, is decocted two and is arrived three times, merging filtrate, filter
Liquid is concentrated into every milliliter and is equivalent to 5 grams of crude drugs；Concentrate adds 2 times of amount ethyl alcohol, and alcohol content reaches 60% or so, and it is small that refrigeration stands 22
When, filtration, filtrate recycling ethanol to no alcohol taste；Recovered liquid boils, and adds 2 grams of sodium benzoate, and 0.23 gram of nipagin ethylester (has been dissolved in
In water), filtration is let cool, and adds water to 480ml, it is filling while hot to obtain the final product.
Embodiment 2 (prepares mixture)
Above-mentioned 7 staggering amount of medicinal material is weighed in proportion and adds 10 times of water amounts and 8 times of amounts respectively, is decocted two and is arrived three times, merging filtrate, filter
Liquid is concentrated into every milliliter and is equivalent to 5 grams of crude drugs；Concentrate adds 3 times of amount ethyl alcohol, and alcohol content reaches 60% or so, and it is small that refrigeration stands 24
When, filtration, filtrate recycling ethanol to no alcohol taste；Recovered liquid boils, and adds 3 grams of sodium benzoate, and 0.25 gram of nipagin ethylester (has been dissolved in
In water), filtration is let cool, and adds water to 500ml, it is filling while hot to obtain the final product.
Embodiment 3 (prepares mixture)
Above-mentioned 8 staggering amount of medicinal material is weighed in proportion and adds 11 times of water amounts and 9 times of amounts respectively, is decocted two and is arrived three times, merging filtrate, filter
Liquid is concentrated into every milliliter and is equivalent to 5 grams of crude drugs；Concentrate adds 4 times of amount ethyl alcohol, and alcohol content reaches 60% or so, and it is small that refrigeration stands 26
When, filtration, filtrate recycling ethanol to no alcohol taste；Recovered liquid boils, and adds 4 grams of sodium benzoate, and 0.27 gram of nipagin ethylester (has been dissolved in
In water), filtration is let cool, and adds water to 520ml, it is filling while hot to obtain the final product.
Embodiment 4 (prepares mixture)
Longstamen Onion Bulb, rhizoma acori graminei, 6 staggering amount of ramulus cinnamomi are weighed in proportion, is crushed to 10-40 mesh, using steam distillation or super are faced
It is spare that boundary's extraction extracts volatile oil；Longstamen Onion Bulb, rhizoma acori graminei, ramulus cinnamomi residue and remaining weighed bulk pharmaceutical chemicals in proportion add water respectively
5-10 times is measured, and decocts two to three times, merging filtrate, filtrate is concentrated into every milliliter and is equivalent to 5 grams of crude drugs；Using flocculent precipitation,
22 hours are stood, centrifugal filtering, centrifugal speed is 4980 revs/min, and Longstamen Onion Bulb, rhizoma acori graminei, Ramulus Cinnamomi Volatile oil is added in filtrate, is mixed
It is even, add 2 grams of sodium benzoate, 0.23 gram of nipagin ethylester, filtration is let cool, and adds water to 480ml, it is filling while hot to obtain the final product.
Embodiment 5 (prepares mixture)
Longstamen Onion Bulb, rhizoma acori graminei, 7 staggering amount of ramulus cinnamomi are weighed in proportion, is crushed to 10-40 mesh, using steam distillation or super are faced
It is spare that boundary's extraction extracts volatile oil；Longstamen Onion Bulb, rhizoma acori graminei, ramulus cinnamomi residue and remaining weighed bulk pharmaceutical chemicals in proportion add water respectively
5-10 times is measured, and decocts two to three times, merging filtrate, filtrate is concentrated into every milliliter and is equivalent to 5 grams of crude drugs；Using flocculent precipitation,
24 hours are stood, centrifugal filtering centrifugal speed is 5000 revs/min, and Longstamen Onion Bulb, rhizoma acori graminei, Ramulus Cinnamomi Volatile oil is added in filtrate, it mixes,
Add 3 grams of sodium benzoate, 0.25 gram of nipagin ethylester (having been dissolved in water), filtration is let cool, and adds water to 500ml, it is filling while hot to obtain the final product.
Embodiment 6 (prepares mixture)
Longstamen Onion Bulb, rhizoma acori graminei, 8 staggering amount of ramulus cinnamomi are weighed in proportion, is crushed to 10-40 mesh, using steam distillation or super are faced
It is spare that boundary's extraction extracts volatile oil；Longstamen Onion Bulb, rhizoma acori graminei, ramulus cinnamomi residue and remaining weighed bulk pharmaceutical chemicals in proportion add water respectively
5-10 times is measured, and decocts two to three times, merging filtrate, filtrate is concentrated into every milliliter and is equivalent to 5 grams of crude drugs；Using flocculent precipitation,
26 hours are stood, centrifugal filtering, centrifugal speed is 5020 revs/min, and Longstamen Onion Bulb, rhizoma acori graminei, Ramulus Cinnamomi Volatile oil is added in filtrate, is mixed
It is even, add 4 grams of sodium benzoate, 0.27 gram of nipagin ethylester, filtration is let cool, and adds water to 520ml, it is filling while hot to obtain the final product.
Embodiment 7 (prepares granule)
6 staggering amount of bulk pharmaceutical chemicals is weighed in proportion, respectively plus 9 times of water amounts are measured with 7 times, and it decocts two and arrives three times, merging filtrate, filtrate
It is concentrated into every milliliter and is equivalent to 5 grams of crude drugs；Concentrate adds 2 times of amount ethyl alcohol, alcohol content 60%, and refrigeration stands 22 hours, filtration,
For filtrate recycling ethanol to no alcohol taste, it is 1.25-1.30 (room temperature) that recovered liquid, which is concentrated into relative density, and dextrin is added or starch is suitable
Amount, wet granulation is dry, is made 480 grams of particle, dispenses to obtain the final product.
Embodiment 8 (prepares granule)
7 staggering amount of bulk pharmaceutical chemicals is weighed in proportion and adds 10 times of water amounts and 8 times of amounts respectively, is decocted two and is arrived three times, merging filtrate, filtrate
It is concentrated into every milliliter and is equivalent to 5 grams of crude drugs；Concentrate adds 3 times of amount ethyl alcohol, and alcohol content reaches 60% or so, and it is small that refrigeration stands 24
When, filtration, filtrate recycling ethanol to no alcohol taste, recovered liquid be concentrated into relative density be 1.25-1.30 (room temperature), addition dextrin or
Appropriate starch, wet granulation is dry, is made 500 grams of particle, dispenses to obtain the final product.
Embodiment 9 (prepares granule)
8 staggering amount of bulk pharmaceutical chemicals is weighed in proportion, respectively plus 11 times of water amounts are measured with 9 times, and it decocts two and arrives three times, merging filtrate, filter
Liquid is concentrated into every milliliter and is equivalent to 5 grams of crude drugs；Concentrate adds 4 times of amount ethyl alcohol, alcohol content 60%, and refrigeration stands 26 hours, filter
It crosses, for filtrate recycling ethanol to no alcohol taste, it is 1.25-1.30 (room temperature) that recovered liquid, which is concentrated into relative density, and dextrin or starch is added
In right amount, wet granulation, it is dry, it is made 520 grams of particle, dispenses to obtain the final product.
Embodiment 10 (prepares granule)
Longstamen Onion Bulb, rhizoma acori graminei, 6 staggering amount of ramulus cinnamomi are weighed in proportion, is crushed to 10-40 mesh, using steam distillation or super are faced
It is spare that boundary's extraction extracts volatile oil；Longstamen Onion Bulb, rhizoma acori graminei, ramulus cinnamomi residue and remaining weighed bulk pharmaceutical chemicals in proportion add water respectively
5-10 times is measured, and decocts two to three times, merging filtrate, filtrate is concentrated into every milliliter and is equivalent to 5 grams of crude drugs；It is heavy using the poly- soup flocculation of shell
Shallow lake method stands 22 hours, and centrifugal filtering mixes, and it is 1.25-1.30 (room temperature) that mixed liquor, which is concentrated into relative density, and dextrin is added
Or appropriate starch and Longstamen Onion Bulb, rhizoma acori graminei, Ramulus Cinnamomi Volatile oil beta cyclodextrin clathrate, wet granulation or marumerization are pelletized, low temperature
Or vacuum drying, it is made 480 grams of particle, dispenses to obtain the final product.
Embodiment 11 (prepares granule)
Longstamen Onion Bulb, rhizoma acori graminei, 7 staggering amount of ramulus cinnamomi are weighed in proportion, is crushed to 10-40 mesh, using steam distillation or super are faced
It is spare that boundary's extraction extracts volatile oil；Longstamen Onion Bulb, rhizoma acori graminei, ramulus cinnamomi residue and remaining weighed bulk pharmaceutical chemicals in proportion add water respectively
5-10 times is measured, and decocts two to three times, merging filtrate, filtrate is concentrated into every milliliter and is equivalent to 5 grams of crude drugs；It is heavy using the poly- soup flocculation of shell
Shallow lake method stands 24 hours, and centrifugal filtering mixes, and it is 1.25-1.30 (room temperature) that mixed liquor, which is concentrated into relative density, and dextrin is added
Or appropriate starch and Longstamen Onion Bulb, rhizoma acori graminei, Ramulus Cinnamomi Volatile oil beta cyclodextrin clathrate, wet granulation or marumerization are pelletized, low temperature
Or vacuum drying, it is made 500 grams of particle, dispenses to obtain the final product.
Embodiment 12 (prepares granule)
Longstamen Onion Bulb, rhizoma acori graminei, 8 staggering amount of ramulus cinnamomi are weighed in proportion, is crushed to 10-40 mesh, using steam distillation or super are faced
It is spare that boundary's extraction extracts volatile oil；Longstamen Onion Bulb, rhizoma acori graminei, ramulus cinnamomi residue and remaining weighed bulk pharmaceutical chemicals in proportion add water respectively
5-10 times is measured, and decocts two to three times, merging filtrate, filtrate is concentrated into every milliliter and is equivalent to 5 grams of crude drugs；It is heavy using the poly- soup flocculation of shell
Shallow lake method stands 26 hours, and centrifugal filtering mixes, and it is 1.25-1.30 (room temperature) that mixed liquor, which is concentrated into relative density, and dextrin is added
Or appropriate starch and Longstamen Onion Bulb, rhizoma acori graminei, Ramulus Cinnamomi Volatile oil beta cyclodextrin clathrate, wet granulation or marumerization are pelletized, low temperature
Or vacuum drying, it is made 520 grams of particle, dispenses to obtain the final product.
The beneficial effect of drug of the present invention is further illustrated below by test example, these tests use in the present invention
It states Chinese medicine composition mixture that embodiment 1-12 is prepared or granule is tested:
(qi and activate blood circulation activates yang and lets out facing for turbid side treatment atherosclerosis merging chronic cardiac insufficiency patient test example
Bed research)
1. subjects
In March, 2013 is in March, 2014 Longhua Hospital affiliated Shanghai University Of Chinese Traditional Medicine and Attached Tongji Hospital, Tongji Univ.
Cardiological outpatient service or 64, ward deficiency of vital energy phlegm-blood stasis deficiency of yang type atherosclerosis merge chronic cardiac insufficiency patient, wherein 32
It is included in treatment group, 32 are included in control group.
2. experimental design
Control group gives western medicine routine treatment, and appropriate rest, smoking cessation, low-salt and low-fat diet, mitigation mental burden, education refer to
It leads, basic pharmaceutical treatment includes diuretics, antiplatelet inhibitor, medicament for expanding vascellum, ARB, ACEI, beta-blocker, statin
Class, cardiotonic etc., other merge disease and select related drugs according to patient's actual conditions.Treatment group gives qi and activate blood circulation, activates yang and let out
Turbid side+western medicine routine treatment.Composition: unified by Longhua Hospital affiliated Shanghai University Of Chinese Traditional Medicine according to embodiment 1-12
Pharmacy is fabricated to granule or mixture.A packet or one every time, each 1 time of morning and evening daily, boiled water is taken after mixing it with water.Two groups of courses for the treatment of are 3
Month；Treatment group and control group, which are forbidden to use, can give benefit with the treatment-related other Chinese materia medica preparations of this disease, heart failure acute attack
The symptomatic treatments such as urine, heart tonifying.
3. observation index and detection method
Surpassed using NYHA cardiac functional grading, gait test in 6 minutes (6Minutes walk test, 6MWT), the heart, Type B sodium
It urinates peptide (Brain natriuretic peptide, BNP) and evaluates Cardiac Function of Patients.Pass through Carotid arterial IMT showed value, carotid plaques
Area, which subsides, evaluates patch curative effect.Using low density lipoprotein cholesterol (Low density lipoprotein
Cholesterol, LDL-C) or total cholesterol (Total cholesterol, TC) or triglycerides (Triglyceride, TG)
Rate of descent or high-density lipoprotein cholesterol (High density lipoprotein cholesterol, HDL-C) climbing
To evaluate blood lipid situation up to standard.Using Minnesota Living With Heart Failure quality of life scale (Minnesota living with heart
Failure questionnaire, LHFQ) evaluation patients ' life quality variation.Using Hamilton anxiety scale (Hamilton
Anxiety scale, HAMA) and Hamilton depressive scale (Hamilton depression scale, HAMD) evaluation patient
Disturbance of emotion variation.And all adverse reactions are recorded, and carry out correlation analysis, including general physical examination, electrocardiogram, blood urine
Stool routine, hepatic and renal function etc..
4. result
4.1 two groups of heart function curative effects compare
As shown in table 1, after treating March, treatment group's total effective rate is 81.25%, and control group total effective rate is 59.34%；
Compared with the control group, difference is statistically significant (P < 0.05) for treatment group's cardiac functional grading total effective rate.
1. two groups of cardiac functional grading curative effects of table compare n (%)
| Group | n | It is effective | Effectively | In vain | Deteriorate | It is total effective |
| Treatment group | 32 | 5(15.63) | 21(65.63) | 6(18.75) | 0(0.00) | 81.25%★ |
| Control group | 32 | 1(3.13) | 18(56.25) | 12(37.50) | 1(3.13) | 59.34% |
Note: compared with after control group treatment,★P<0.05。
4.2 two groups of 6 minutes walking distances compare
As shown in table 2, the first six minute walking distance of two groups of treatments compares no difference of science of statistics (P > 0.05), two groups after treatment
(P < 0.05) is improved before walking distance is relatively treated within 6 minutes, and treatment group's walking distance improves and is greater than control group (P < 0.05).
2. two groups of table pretherapy and post-treatment 6 minutes walking distances compare
| Group | n | Before treatment (m) | After treatment (m) |
| Treatment group | 32 | 292.38±12.03 | 355.94±34.60◆★ |
| Control group | 32 | 289.47±12.26 | 325.44±37.61◆ |
Note: compared with preceding with before the treatment of this group,◆P < 0.05, compared with after control group treatment,★P<0.05。
4.3 two groups of cardiac ultrasonics compare
As shown in table 3, the more equal no difference of science of statistics of EF, SV, LVEDD (P > 0.05) before two groups of treatments, is treated after treatment
Group EF value is improved (P<0.05) before relatively treating, no difference of science of statistics (P>0.05) before control group EF value is relatively treated, two after treatment
Group SV, LVEDD and treatment are preceding than no difference of science of statistics (P > 0.05).
3. two groups of table pretherapy and post-treatment cardiac ultrasonic Indexes Comparisons
Note: with this group before treatment,★P<0.05。
4.4 two groups of carotid plaques compare
4.4.1 two groups of Carotid arterial IMT showed values compare
As shown in table 4, two groups of more equal no difference of science of statistics of Carotid arterial IMT showed value (P > 0.05) before treatment, after treatment.Treatment
Bilateral IMT value declines (P < 0.05) before relatively treating after group treatment, and control group bilateral carotid arteries IMT value is before and after treatment without statistics
It learns difference (P > 0.05).
4. two groups of table pretherapy and post-treatment bilateral carotid arteries IMT compare
Note: with this group before treatment,★P<0.05。
4.4.2 two groups of carotid plaques areas compare
As shown in table 5, plaque area compares no difference of science of statistics (P > 0.05) between two groups before treatment, after treatment.After treatment
For two groups of plaque areas compared with before treatment, difference is not statistically significant (P > 0.05).
5. two groups of table pretherapy and post-treatment carotid plaques area logarithms compare
| Group | n | (mm before treatment2) | (mm after treatment2) |
| Treatment group | 32 | 3.79±0.79 | 3.69±0.79 |
| Control group | 32 | 3.81±0.86 | 3.88±0.77 |
4.5 two groups of lipids detections compare
As shown in table 6, the more equal no difference of science of statistics of preceding two groups of LDL-C, HDL-C, TC, TG (P > 0.05) is treated, treatment
Treatment group LDL-C, TC, TG declines (P < 0.05) compared with before treatment afterwards, the preceding decline of control group LDL-C, TG relatively treatment (P <
0.05), and treatment group LDL-C decline is higher than control group (P < 0.05).
6. two groups of pretherapy and post-treatment blood lipids index of table compare
Note: with this group before treatment,◆P<0.05；Compared with the control group,★P<0.05。
4.6 two groups of LFHQ, HAMA, HAMD integrals
As shown in table 7, the equal no difference of science of statistics of LFHQ, HAMA, HAMD integral contrast (P > 0.05) before two groups of treatments, treatment
Two groups of integrals are substantially reduced (P < 0.05) before relatively treating afterwards, and treatment group LFHQ, HAMA, HAMD integral decline are above control
Group (P < 0.05).
7. two groups of table pretherapy and post-treatment LFHQ, HAMA, HAMD integral contrasts
Note: with this group before treatment,◆P<0.05；Compared with after control group treatment,★P<0.05。
4.7 safety analysis
During this clinical observation, two groups do not occur obvious adverse reaction, blood, routine urinalysis and blood Liver and kidney function,
Electrocardiogram etc. has no obvious normal, two groups of no difference of science of statistics (P > 0.05).
Claims (5)
1. the Chinese medicine composition that a kind of prevention and treatment atherosclerosis merges cardiac insufficiency, characterized in that the Chinese medicine composition is
The medicament being prepared by the bulk pharmaceutical chemicals of following weight parts: 9-15 parts of Radix Astragali, 6-12 parts of Snakegourd Fruit, 6-9 parts of Longstamen Onion Bulb, rhizoma acori graminei 6-9
Part, 6-12 parts of pueraria lobata, 3-6 parts of ramulus cinnamomi, 6-12 parts of Radix Salviae Miltiorrhizae, 9-15 parts of motherwort, 6-12 parts of HERBA EPIMEDII, 6-12 parts of the fleece-flower root.
2. the Chinese medicine composition that prevention and treatment atherosclerosis according to claim 1 merges cardiac insufficiency, characterized in that
The parts by weight of each bulk pharmaceutical chemicals are respectively as follows: 12 parts of Radix Astragali, 9 parts of Snakegourd Fruit, 6 parts of Longstamen Onion Bulb, 6 parts of rhizoma acori graminei, 9 parts of pueraria lobata, 3 parts of ramulus cinnamomi, pellet
Join 9 parts, 12 parts of motherwort, 9 parts of HERBA EPIMEDII, 9 parts of the fleece-flower root.
3. prevention and treatment atherosclerosis according to claim 1 or 2 merges the Chinese medicine composition of cardiac insufficiency, feature
It is that the medicament is mixture.
4. prevention and treatment atherosclerosis according to claim 1 or 2 merges the Chinese medicine composition of cardiac insufficiency, feature
It is that the medicament is granule.
5. Chinese medicine composition of any of claims 1-4 merges cardiac insufficiency in preparation prevention and treatment atherosclerosis
Drug in purposes.
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|---|---|---|---|---|
| CN101433689A (en) * | 2008-12-15 | 2009-05-20 | 汝州市中医院 | Kudzu root and longstamen onion bulb oral liquid and preparation method |
| CN102114170A (en) * | 2010-01-05 | 2011-07-06 | 上海中医药大学附属龙华医院 | Traditional Chinese medicine composition for preventing and treating myocardial ischemia reperfusion injury and preparation method thereof |
| CN103099935A (en) * | 2011-11-11 | 2013-05-15 | 上海中医药大学附属龙华医院 | Traditional Chinese medicine composition for adjusting and controlling low-density lipoprotein level |
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| CN101433689A (en) * | 2008-12-15 | 2009-05-20 | 汝州市中医院 | Kudzu root and longstamen onion bulb oral liquid and preparation method |
| CN102114170A (en) * | 2010-01-05 | 2011-07-06 | 上海中医药大学附属龙华医院 | Traditional Chinese medicine composition for preventing and treating myocardial ischemia reperfusion injury and preparation method thereof |
| CN103099935A (en) * | 2011-11-11 | 2013-05-15 | 上海中医药大学附属龙华医院 | Traditional Chinese medicine composition for adjusting and controlling low-density lipoprotein level |
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