CN105287920A - Medicinal composition for treating functional dyspepsia and preparation method thereof - Google Patents
Medicinal composition for treating functional dyspepsia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicinal composition for treating functional dyspepsia and a preparation method thereof. The medicinal composition is prepared by proportioning active ingredients such as daphne tangutica, medicago ruthenica, leucocyanidin, caragana and sciadopitysin and can be made into various dosage forms according to a conventional preparation process. The curative effect for treating the functional dyspepsia is remarkable.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of pharmaceutical composition for the treatment of functional dyspepsia and preparation method thereof.
Background technology
Functional dyspepsia refers to have the digestive system malaise symptoms such as abdominal distention, upper abdominal pain, belch, inappetence, acid regurgitation are heartburn, nausea and vomiting, get rid of one group of clinical syndrome of digestive tract organic disease on inspection, be modal functional gastrointestinal disorder clinically, symptom to be continued or recurrent exerbation.Its pathogenesis still imperfectly understands at present, and Modern medical therapy, mainly based on symptomatic treatment, uses acid suppression medicine, gastro-kinetic agent more, as domperidone, Trimebutine Maleate etc., have certain curative effect, but symptom easily repeatedly, brings more misery to patient.
Without " functional dyspepsia " name of disease in Chinese medicine, according to the clinical manifestation of common sympton, the category such as " gastric abscess ", " stomach painful abdominal mass ", " indigestion and loss of appetite " can be belonged to.Modern society, due to the raising of people's living standard, delicious food savoury takes in showed increased, and holding concurrently again, it is pungent not add the feed raw food of restraining, impairing the spleen and stomach, and transporting and transforming function of the spleen and stomach is too late, stops middle Jiao in water liquid, with the passing of time makes raw damp and hot.Middle burnt intrinsic heat, wet and accumulation of heat, steams and makes as suffering from, damp and hot middle resistance, functional activity of QI being not smooth therefore occur the symptoms such as gastralgia, early glutted full, belch, decreased food intake of receiving are few, nausea and vomiting, acid regurgitation are heartburn, dry mouth with bitter taste, feeling thirst but no desire to drink, tongue fur based on yellowish and greasy fur, many cunnings of arteries and veins or moisten.In recent years, Chinese medicine decoction is widely used in function of spleen and stomach regulating, treatment functional dyspepsia, and prescription used is based on traditional Chinese medical science traditional recipe, and clinical efficacy is remarkable.
ZANGJINJIER: this product is the woody part heartwood of leguminous plant Cortes seu Caulis Caraganae jubatae Caraganajubata (pall.) Poir. and Changdu caragana Caraganachangduensisfiauf.Cut and get maroon woody part, cut off, dry in the shade.[nature and flavor] are puckery, cold.[function with cure mainly] removing blood stasis, blood stasis dispelling, blood pressure lowering.For high mountain plethora, vascular hypertension and menoxenia.[character] this product is the heartwood of the many Ex-alls of appearance cork, cylindrical or irregular block sheet, slightly bending, and long 20 ~ 40cm, diameter can reach 5cm.There is cutter axe mark on surface, smoothly, has the cicatrix of the thin vertical of buckling or reticular texture and sprig, the aobvious yellow-white wood grain had.The endothelium of the visible yellow-white in stem branch residue place and dark-brown phellem layer.Matter is hard and fine and close, and difficulty fractures.The visible annual ring of section.Odorless, lightly seasoned micro-peppery.Record in health Tibetan medicine standard promulgated by the ministries or commissions of the Central Government (first), standard number: WS3-BC-0134-95.
Daphne tangutica: this product be the leaf of Isolated From Thymelaeaceae Species Daphne tangutica DaphnetanguticaMaxim., peel of stem, really, flower.Gather respectively at flower, fruit phase, remove impurity, dry.[nature and flavor] are puckery, flat.[function with cure mainly] damp eliminating, parasite killing.Fruit is used for dyspepsia, parasitosis; Leaf, branch are endured cream and are controlled parasitosis; Arthralgia chiefly caused by damp pathogen controlled by peel of stem cream, and yellow fluid is amassed in joint.[character] this product spends several to cluster on short floral axis, or comes off for single flower; Bract edge tool eyelashes; Calyx tube is thin, and tip four splits floweriness flap, and drying shrinkage bends, and long 2cm, surperficial yellowish-brown is to dark brown.Stem is pliable and tough, and tender skin is orange-yellow; The silver grey black of Lao Pi, has fine wrinkle and horizontal hole skin, easily peels off, inner face yellow green.Leaf keratin, focuses mostly under inflorescence, strip lanceolar or oval shape ellipse, and surperficial light green color tool fine wrinkle, the back side is light brown, and master pulse is obvious, edge warp.The black purple of drupe, drying shrinkage, fruit stem tool hair.Feeble QI is weak, sweet in the mouth, micro-pungent.Record in health Tibetan medicine standard promulgated by the ministries or commissions of the Central Government (first), standard number: WS3-BC-0024-95.
Herba Trigonellae Ruthenicae: this product is the dry herb of leguminous plant Herba Trigonellae Ruthenicae TrigonellaruthenicaL..6 ~ July gathers, and dries.[nature and flavor] are bitter, cool.[function with cure mainly] heat-clearing and toxic substances removing, kidney tonifying is healed skin ulcer.For skin ulcer rash, cough due to lung-heat.The shrinkage of [character] this product is curling.Root is elongated, few branch, faint yellow to brown.Nearly four ribs of stem, dredge by white hair, matter is crisp, easy to break.The many shrinkages of leaf, 3, lobule after wet exhibition, leaf green, obovate or wide ellipse, long 0.3 ~ 1cm, wide 2 ~ 8mm, tip nick, the irregular thin sawtooth of top edge tool.Flower butterfly, faint yellow, tool purple fringe.Pod is oval, and be about 1cm, there is band on surface, the short point of top tool; 2 ~ 4, seed, yellowish-brown.Feeble QI is fragrant.Record in health Tibetan medicine standard promulgated by the ministries or commissions of the Central Government (first), standard number: WS3-BC-0044-95.
7,4',4'''-Trimethylamentoflavone (Sciadopitysin): CAS 521-34-6, molecular weight 580.53766, molecular formula C
33h
24o
10, fusing point 296-298 DEG C.[ingredient origin] Semen Ginkgo Ginkgobiloba, Folium et Ramulus Cephalotaxi Cephalotaxusfortunei, Ramulus et folium taxi cuspidatae Taxuscuspidata.
Leucocianidol (Leucocyanidin): CAS 69256-15-1, molecular formula C
15h
14o
7, molecular weight 306.27.[pharmacological action] blood sugar lowering, suppresses eye aldose reductase.[ingredient origin] polygonaceae plant greater membrane mould root, halberd folic acid film; Pulse family babul flower, shield post bean; Annonaceae; The plants such as Myrtaceae.
2 crude drug chemical constitutions are as follows:
7,4',4'''-Trimethylamentoflavone (Sciadopitysin) leucocianidol (Leucocyanidin).
Summary of the invention
The object of the invention is the deficiency overcoming background technology, pharmaceutical composition of a kind of effective treatment functional dyspepsia and preparation method thereof is provided.
The present invention adopts following technical scheme to realize:
Composition and the weight portion of making the crude drug of the pharmaceutical composition of this treatment functional dyspepsia are:
Daphne tangutica 220-240 weight portion Herba Trigonellae Ruthenicae 180-210 weight portion leucocianidol 6-8 weight portion ZANGJINJIER 4-6 weight portion 7,4',4'''-Trimethylamentoflavone 2-4 weight portion.
Preferably be used for the treatment of the pharmaceutical composition of functional dyspepsia, be made up of the crude drug of following weight portion:
Daphne tangutica 230 weight portion Herba Trigonellae Ruthenicae 195 weight portion leucocianidol 7 weight portion ZANGJINJIER 5 weight portion 7,4',4'''-Trimethylamentoflavone 3 weight portion.
Treat a pharmaceutical composition for functional dyspepsia, it is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
Treat a pharmaceutical composition for functional dyspepsia, it is characterized in that the treatment functional dyspepsia medicine that pharmaceutical composition and chemical drugs or Chinese medicine form.
Treat a preparation method for the pharmaceutical composition of functional dyspepsia, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Daphne tangutica 220-240 weight portion Herba Trigonellae Ruthenicae 180-210 weight portion leucocianidol 6-8 weight portion ZANGJINJIER 4-6 weight portion 7,4',4'''-Trimethylamentoflavone 2-4 weight portion;
Preparation method: get Daphne tangutica by crude drug proportioning, Herba Trigonellae Ruthenicae, leucocianidol, ZANGJINJIER, 7,4',4'''-Trimethylamentoflavone, mixing, with weight percent concentration 17% ethanol as solvent, extract at 15 DEG C of warm macerating, extraction time is 3 times, each extraction time is 18 hours, each solvent load is 24 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by D807 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting D807 macroporous adsorptive resins of weight percent concentration 57% again, collect weight percent concentration 57% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
Preferably treat a preparation method for the pharmaceutical composition of functional dyspepsia, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Daphne tangutica 230 weight portion Herba Trigonellae Ruthenicae 195 weight portion leucocianidol 7 weight portion ZANGJINJIER 5 weight portion 7,4',4'''-Trimethylamentoflavone 3 weight portion;
Preparation method: get Daphne tangutica by crude drug proportioning, Herba Trigonellae Ruthenicae, leucocianidol, ZANGJINJIER, 7,4',4'''-Trimethylamentoflavone, mixing, with weight percent concentration 17% ethanol as solvent, extract at 15 DEG C of warm macerating, extraction time is 3 times, each extraction time is 18 hours, each solvent load is 24 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by D807 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting D807 macroporous adsorptive resins of weight percent concentration 57% again, collect weight percent concentration 57% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
Treat a preparation method for the pharmaceutical composition of functional dyspepsia, it is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
Treat a preparation method for the pharmaceutical composition of functional dyspepsia, it is characterized in that pharmaceutical composition and chemical drugs or Chinese medicine form and treat functional dyspepsia medicine.
Pharmaceutical composition determined curative effect, alleviates the symptom aspects such as stomachache, abdominal distention, belch, nausea and vomiting and is better than simple western medicine domperidone.
Detailed description of the invention
Embodiment 1: pharmaceutical composition for the treatment of functional dyspepsia and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of functional dyspepsia are: Daphne tangutica 230g Herba Trigonellae Ruthenicae 195g leucocianidol 7g ZANGJINJIER 5g 7,4',4'''-Trimethylamentoflavone 3g;
Preparation method: get Daphne tangutica by crude drug proportioning, Herba Trigonellae Ruthenicae, leucocianidol, ZANGJINJIER, 7,4',4'''-Trimethylamentoflavone, mixing, with weight percent concentration 17% ethanol as solvent, extract at 15 DEG C of warm macerating, extraction time is 3 times, each extraction time is 18 hours, each solvent load is 24 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by D807 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting D807 macroporous adsorptive resins of weight percent concentration 57% again, collect weight percent concentration 57% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
Embodiment 2: pharmaceutical composition for the treatment of functional dyspepsia and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of functional dyspepsia are: Daphne tangutica 220g Herba Trigonellae Ruthenicae 210g leucocianidol 6g ZANGJINJIER 6g 7,4',4'''-Trimethylamentoflavone 2g;
Preparation method: get Daphne tangutica by crude drug proportioning, Herba Trigonellae Ruthenicae, leucocianidol, ZANGJINJIER, 7,4',4'''-Trimethylamentoflavone, mixing, with weight percent concentration 17% ethanol as solvent, extract at 15 DEG C of warm macerating, extraction time is 3 times, each extraction time is 18 hours, each solvent load is 24 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by D807 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting D807 macroporous adsorptive resins of weight percent concentration 57% again, collect weight percent concentration 57% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
Embodiment 3: pharmaceutical composition for the treatment of functional dyspepsia and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of functional dyspepsia are: Daphne tangutica 240g Herba Trigonellae Ruthenicae 180g leucocianidol 8g ZANGJINJIER 4g 7,4',4'''-Trimethylamentoflavone 4g;
Preparation method: get Daphne tangutica by crude drug proportioning, Herba Trigonellae Ruthenicae, leucocianidol, ZANGJINJIER, 7,4',4'''-Trimethylamentoflavone, mixing, with weight percent concentration 17% ethanol as solvent, extract at 15 DEG C of warm macerating, extraction time is 3 times, each extraction time is 18 hours, each solvent load is 24 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by D807 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting D807 macroporous adsorptive resins of weight percent concentration 57% again, collect weight percent concentration 57% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
Embodiment 4: the preparation of tablet
Example 1 pharmaceutical composition 32g, adds starch 68g, mixing, granulates, dry, adds microcrystalline Cellulose 14g, magnesium stearate 0.8g, and mixing, is pressed into 1000, obtains medicinal composition tablets.
Embodiment 5: the preparation of capsule
Example 2 pharmaceutical composition 33g, adds starch 67g, mixing, granulates, and dry, granulate, adds appropriate magnesium stearate, and mixing, obtains medicament composition capsule by encapsulated 1000.
Embodiment 6: the preparation of drop pill
Taking polyethylene glycol 6000 143g water-bath (80 DEG C) heating boils molten, add embodiment 3 pharmaceutical composition 17g, stirring, is coolant with liquid paraffin, puts in glass tubing (4*80cm), chilling temperature is 6 DEG C, drip internal-and external diameter is 7.0/2.0 (mm/mm), and drip is 2.1cm apart from liquid level, drips speed with per minute 51 for optimum condition, blot the condensing agent on drop pill surface with cotton, obtain medicament composition dropping pills.
Embodiment 7: the pharmaceutical composition for the treatment of functional dyspepsia
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of functional dyspepsia are:
Daphne tangutica 120 weight portion ZANGJINJIER 14 weight portion 7,4',4'''-Trimethylamentoflavone 2 weight portion.
Embodiment 8: the pharmaceutical composition for the treatment of functional dyspepsia
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of functional dyspepsia are:
Leucocianidol 2 weight portion ZANGJINJIER 34 weight portion 7,4',4'''-Trimethylamentoflavone 6 weight portion.
Embodiment 9: the pharmaceutical composition for the treatment of functional dyspepsia
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of functional dyspepsia are:
Leucocianidol 5 weight portion ZANGJINJIER 30 weight portion 7,4',4'''-Trimethylamentoflavone 1 weight portion.
Experimental example 1: the experimental study for the treatment of functional dyspepsia
1. clinical data
42 routine cases all derive from hospital of city department of Chinese medicine outpatient clinic, are diagnosed as the patient of retention of damp-heat in the interior type functional dyspepsia.Adopt random digits table, patient is divided into 2 groups, often organize each 21 examples.Treatment group man 10 example, female 11 example; 37 ~ 75 years old age, average (55.2 ± 15.2) year; Individual month of average course of disease (17.8 ± 11.3); Syndrome integral (14.54 ± 2.88) point.Matched group man 11 example, female 10 example; 35 ~ 75 years old age, average (54.2 ± 14.8) year; Individual month of average course of disease (17.2 ± 10.9); Syndrome integral (14.33 ± 2.76) point.Two groups of patients statistical analysis in sex, age, average course of disease, syndrome integral, without significant difference, has comparability (P > 0.05).
2. diagnostic criteria
Western medicine diagnose standard: MethodsThe cases enrolled need meet Rome in 2005
standard: Upper abdominal pain or sense of discomfort, post-prandial fullness, early full sense, in 1 year continue or the recurrent exerbation time more than 1 month, with other gastrointestinal symptoms, as belch, Nausea and vomiting etc., can not explain the auxiliary examination evidence of the organic disease of above-mentioned symptom.
TCM syndrome diagnostic criteria: with reference to the related content in " new Chinese medicine guideline of clinical investigations " epigastric fullness.Damp-heat brewing internally primary symptom: gastral cavity abdomen feeling of fullness, lack of appetite is indigestion and loss of appetite, dry mouth with bitter taste, red tongue with yellowish and greasy fur.Secondary disease: heavy sensation of the body is sleepy, nausea and vomiting, oliguria with yellow urine, rolling pulse.
Inclusive criteria: 1. meet above-mentioned diagnostic criteria person; 2. 35 ~ 75 years old age; 3. Informed Consent Form is signed.
Exclusion standard: 1. previously have the organic disease medical histories such as gastric and duodenal ulcers erosion, tumor, esophagitis; 2. previously the disease medical histories such as liver and gall spleen pancreas are had; 3. the medical history such as diabetes, nephropathy, connective tissue disease; 4. psychological mental sickness person is had; 5. Previous abdominal surgery; 6. to drug allergy person used; 7. treatments period takes other digestants person; 8. the treatments period person that takes nonsteroidal antiinflammatory drug.
3. Therapeutic Method
Treatment group combination of oral medication (embodiment 1 pharmaceutical composition lot number 20100325), each 1.5g, warm water 200ml are oral after dissolving, and 1 day 2 times, ante cibum, 30min took.The oral domperidone tablet of matched group (the accurate word H10910003 of traditional Chinese medicines).Usage and dosage: each 10mg, 1 day 3 times, 30min is oral before the meal.
4. observation item
Formulate clinical observation table, the dyspeptic common sympton of overview function: abdominal distention, upper abdominal pain, belch, nausea and vomiting, acid regurgitation are heartburn.Be all 1 course for the treatment of with 4 weeks, after terminating the course for the treatment of, carry out efficacy evaluation.
5. criterion of therapeutical effect
According to the difference of above symptom frequency of occurrence and the order of severity, a point level Four is scored: 0 point: asymptomatic.1 point: symptom is slight, shows effect every day 1 time, Symptoms last, can spontaneous remission within 3h; 2 points: symptom is comparatively obvious, and show effect every day 1 time, Symptoms last, within 4h, needs drug administration to alleviate; 3 points: symptom is remarkable, and show effect every day 2 times or more, Symptoms last, need by agents alleviate at more than 4h.The total mark of record treatment front and back symptom respectively, according to integral and calculating therapeutic index.Symptom total mark × 100% before therapeutic index (%)=(before treatment the rear symptom total mark of symptom total mark-treatment)/treatment.
Clinical recovery: clinical symptoms, sign disappear or substantially disappear, therapeutic index >=90%; Effective: clinical symptoms, sign are obviously improved, therapeutic index >=70%; Effective: clinical symptoms, sign all take an evident turn for the better, therapeutic index >=30%; Invalid: clinical symptoms, sign are all not improved, even increase the weight of, therapeutic index < 30%.
6. statistical method
Adopt SPSS19.0 software to carry out data compilation and statistical analysis, measurement data mean ± standard deviation represents, measurement data adopts t inspection, and enumeration data adopts χ
2inspection, statistical test data adopts two-sided test, with P < 0.05 for difference has statistical significance.
7. therapeutic outcome
Treatment group and matched group effective percentage comparative result are in table 1.
Table 12 groups of effective percentage comparative examples (%)
| Group | n | Recovery from illness | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 21 | 5 | 6 | 8 | 2 | 19（90.48） |
| Matched group | 21 | 3 | 4 | 7 | 7 | 14（66.67） △ |
Note: medicine composite for curing group total effective rate is 90.48%, domperidone group total effective rate be 66.67%, two groups of effective percentage comparing differences have statistical significance (
△p < 0.05).
Treatment group compares in table 2 with individual event symptom score before and after treatment of control group.
Before and after table 2 liang group patient treatment, individual event symptom score compares (x ± s)
Note: treatment group and matched group before the treatment symptom integral compare, no significant difference (
△p > 0.05).Treatment group, in the improvement of abdominal distention, upper abdominal pain, belch, nausea and vomiting symptom, is better than matched group (P < 0.05).
Result shows, pharmaceutical composition determined curative effect, alleviates the symptom aspects such as stomachache, abdominal distention, belch, nausea and vomiting and is better than simple western medicine domperidone.
Claims (8)
1. treat a pharmaceutical composition for functional dyspepsia, it is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Daphne tangutica 220-240 weight portion Herba Trigonellae Ruthenicae 180-210 weight portion leucocianidol 6-8 weight portion ZANGJINJIER 4-6 weight portion 7,4',4'''-Trimethylamentoflavone 2-4 weight portion.
2. a kind of pharmaceutical composition for the treatment of functional dyspepsia according to claim 1, is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Daphne tangutica 230 weight portion Herba Trigonellae Ruthenicae 195 weight portion leucocianidol 7 weight portion ZANGJINJIER 5 weight portion 7,4',4'''-Trimethylamentoflavone 3 weight portion.
3. a kind of pharmaceutical composition for the treatment of functional dyspepsia according to claim 1, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
4. a kind of pharmaceutical composition for the treatment of functional dyspepsia according to claim 1, is characterized in that the treatment functional dyspepsia medicine that pharmaceutical composition and chemical drugs or Chinese medicine form.
5. treat a preparation method for the pharmaceutical composition of functional dyspepsia, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Daphne tangutica 220-240 weight portion Herba Trigonellae Ruthenicae 180-210 weight portion leucocianidol 6-8 weight portion ZANGJINJIER 4-6 weight portion 7,4',4'''-Trimethylamentoflavone 2-4 weight portion;
Preparation method: get Daphne tangutica by crude drug proportioning, Herba Trigonellae Ruthenicae, leucocianidol, ZANGJINJIER, 7,4',4'''-Trimethylamentoflavone, mixing, with weight percent concentration 17% ethanol as solvent, extract at 15 DEG C of warm macerating, extraction time is 3 times, each extraction time is 18 hours, each solvent load is 24 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by D807 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting D807 macroporous adsorptive resins of weight percent concentration 57% again, collect weight percent concentration 57% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
6. a kind of preparation method for the treatment of the pharmaceutical composition of functional dyspepsia according to claim 5, is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Daphne tangutica 230 weight portion Herba Trigonellae Ruthenicae 195 weight portion leucocianidol 7 weight portion ZANGJINJIER 5 weight portion 7,4',4'''-Trimethylamentoflavone 3 weight portion;
Preparation method: get Daphne tangutica by crude drug proportioning, Herba Trigonellae Ruthenicae, leucocianidol, ZANGJINJIER, 7,4',4'''-Trimethylamentoflavone, mixing, with weight percent concentration 17% ethanol as solvent, extract at 15 DEG C of warm macerating, extraction time is 3 times, each extraction time is 18 hours, each solvent load is 24 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.16, filter, medicinal liquid is by D807 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting D807 macroporous adsorptive resins of weight percent concentration 57% again, collect weight percent concentration 57% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
7. a kind of preparation method for the treatment of the pharmaceutical composition of functional dyspepsia according to claim 5, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
8. a kind of preparation method for the treatment of the pharmaceutical composition of functional dyspepsia according to claim 5, is characterized in that pharmaceutical composition and chemical drugs or Chinese medicine form and treats functional dyspepsia medicine.
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Application publication date: 20160203 |