CN105286797B - A kind of vertical rotating fluorescent molecular tomography system and its imaging method - Google Patents
A kind of vertical rotating fluorescent molecular tomography system and its imaging method Download PDFInfo
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Abstract
The invention discloses a kind of vertical rotating fluorescent molecular tomography system and its imaging methods.The imaging system of the present invention includes：Excitation light source device, laser optical path device, fluorescence detection device, turntable, examination couch, translation stage, reel and computer；Laser optical path device allows bulky excitation light source device to be fixed on bottom plate without being rotated with system, can be with 360 ° of scanning inspected bodys by some row plane mirror exciting lights；The wavelength of exciting light can be as needed visible to infrared band unrestricted choice, it is convenient to the exciting light irradiation of different wave length is realized, so as to fulfill the imaging of multi-wavelength fluorescence probe；It is free to select dotted excitation light source, linear excitation light source or point face battle array excitation light source, the shape of exciting light be modulated according to experiment demand；Animal beds use open by design, and using non-transparent material, light leakage caused by solving animal beds and overexposure phenomenon improve the stability of data.
Description
Technical field
The present invention relates to biomedical optical fluorescent techniques, and in particular to a kind of vertical rotating fluorescent molecular tomography system
System and its imaging method.
Background technology
Fluorescent molecules imaging technology is to be widely used on a molecular scale carrying out the variation of organism physiology, pathology
In body, noninvasive qualitative and quantitative study image method, early diagnosis, drug action mechanism research and research and development and treatment in disease
Effect assessment etc. plays an important role.It is seen according to working method, fluorescent molecules imaging system can be divided into the anti-of plane formula
Penetrate the fluorescent molecular tomography (Fluorescence of formula fluorescence imaging (Epi-illumination Imaging) and chromatography type
Molecular Tomography, FMT) two kinds.FMT is a diffusion and absorbent properties according to light, using exciting light and by
The outgoing optical information of test sample sheet is to rebuild the technology of specificity fluorescent group position and concentration distributed in three dimensions information.FMT can be realized
Animal in body Non-invasive detection, there is low cost, high-throughput, highly sensitive, no ionising radiation can be detected quantitatively etc. many for a long time
Advantage.Relative to reflective fluorescence imaging, FMT can provide the space distribution situation of fluorescent material, detect the disease of deep tissues
Reason and functional information have more scientific researches and Diagnostic Superiority.
The method that the FMT systems of early stage immerse optical fiber contact measurement after matching fluid imaging chamber using animal.Harvard in 2007
University Medical College Deliolanis et al. is put forward for the first time 360 ° of non-contact fluorescence molecular tomography devices.Animal is placed on light
Between the imaging platform that source and CCD camera are formed.360 ° of relative rotation between animal and imaging system in imaging process.It but should
It is tested animal in device to be hung in vertical direction, relative rotation is realized by rotating animal, it is easily broken during the experiment
The original form of bad animal, it is difficult to control displacement of the animal in rotary course, while exacerbate the discomfort of animal.
With the development of fluorescent molecular tomography, there are more and more system designs, but be all difficult to take into account imaging
The factors such as effect, wavelength selection flexibility, animal fixation, there is obvious shortcoming and deficiency.The FMT of Perkin Elmer companies
Series is horizontal positioned using toy, and light source and detector are located at animal both sides.It uses the mode that array light source scans, and realizes
The three-dimensional fluorescence imaging of toy is realized in the case of not rotating animal, such product with compact structure, mechanical structure is simple, and
And the original form of animal will not be destroyed, but since acquisition direction is restricted seriously, extreme Dependent Algorithm in Precision is glimmering everywhere to mouse
The homogeneity of luminous point sensitivity response is poor, and imaging effect is poor.The BioFLECT products of Trifoil companies employ fixed excitation
Light source, detector surround the mechanical design structure of mouse rotation, and the mode of the irradiation of this single direction increases algorithm not
Accuracy, the individual difference of animal also large effect imaging results.
A kind of rotary fluorescent molecular tomography system of the propositions such as Luo Qing inscriptions later.The system puts toy level
It puts, experiment porch is rotated around toy, realizes 360 ° of data acquisition.The system source is semiconductor laser, is limited
The selection of wavelength can not adjust excitation wavelength, using being restricted according to the demand of experiment.If use halogen tungsten lamp, xenon lamp etc.
Light source is difficult to solve as exciting light, then instrument rotation twist problem of optical fiber and data line in rotary course.Jia Lifuni
The transmitting device that the fluorescent molecular tomography of sub- university Gultekin Gulsen laboratories and design employs drag chain type attempts
Circuit distortion problem is solved, Peking University appoints autumn reality lab design bobbin winoler and optical fiber switching device to attempt to solve circuit
Distortion and imaging pattern switching problem, but it is lengthy and jumbled in the presence of such as structure, and often rotating by a certain angle all must be by tool reset；Instrument
Ceaselessly twisted optical fiber is needed in device operation, declines optical fiber durability；The problems such as optic path inefficiency.
Meanwhile FMT is high-precision Experiments of Optics, carry the optical property of the animal beds of animal often influence experiment into
As effect.Animal beds can will introduce a large amount of noise signal to the reflection and refraction of light in imaging.In order to avoid noise
It introduces, usually used animal beds ensure that bed body is transparent, but effect is often undesirable as possible.Due to zoomorphism difference, at certain
Phenomena such as a little angles will appear overexposure, light leakage, affects the stability and repeatability of experiment.
Invention content
For more than problems of the prior art, the present invention proposes a kind of vertical rotating fluorescent molecular tomography system
System and its imaging method farthest maintain the form stable of detection body, simplify optical path transmission device, employ new-type
Animal beds mentality of designing.
For more than problems of the prior art, the present invention proposes a kind of vertical rotating fluorescent molecular tomography system
System, farthest maintains the form stable of inspected body, simplifies optical path transmission device, employ new-type animal beds and set
Count thinking.
An object of the present invention is to provide a kind of vertical rotating fluorescent molecular tomography systems.
The vertical rotating fluorescent molecular tomography system of the present invention includes：It is excitation light source device, laser optical path device, glimmering
Light detection device, turntable, examination couch, translation stage, reel and computer；Wherein, excitation light source device is fixed on bottom plate；
Turntable is mounted on bottom plate, and centre has through-hole, using the axis of through-hole for rotary shaft rotation during imaging；Laser optical path device and
Fluorescence detection device is installed on a spinstand respectively by respective connector；Examination couch is mounted on translation stage, with turntable
Through-hole in the same horizontal line, it is accessible in through-holes to pass through；Fluorescence detection device is connected to computer by data line, and
Power supply is connected to by power cord；Reel is coaxial with turntable, and data line and power cord are according to the direction of rotation with turntable
Opposite direction is wrapped on the outer wall of reel；Laser optical path device includes rotation synchronous plane mirror and plane of scanning motion mirror；Into
During picture, excitation light source device launches the exciting light of point light source；Exciting light passes through reel along rotary shaft, is incident to laser optical path
The rotation synchronous plane mirror of device；Through rotating the exciting light of synchronous plane mirror reflection and examination couch synchronous rotary；Exciting light is through rotation
The plane of scanning motion mirror of laser optical path device is incident to after turning the reflection of synchronous plane mirror, the exciting light of scanned plane mirror is to examination couch
It is scanned and the shape of exciting light is modulated, final exciting light is incident in the inspected body on examination couch, is generated glimmering
Light；Fluorescence detection device receives fluorescence；Fluorescence signal is converted into electric signal transmission to computer by fluorescence detection device.
Turntable includes swivel plate, motor and supporting rack；Wherein, motor is mounted on by supporting rack on bottom plate；Swivel plate
On motor, driven by motor and carry out 360 degree rotation；There is through-hole on swivel plate, with examination couch in a horizontal line
On, allow that examination couch is accessible in through-holes passes through.
Power supply and the routing device of data are using reel, and reel is fixed on a spinstand by connector, Huo Zhetong
Support plate is crossed to be fixed on bottom plate, reel is coaxial with turntable, by data line and power cord according to a direction be wrapped in around
On the outer wall of spool, during imaging the direction of rotation of turntable with direction of winding on the contrary, in this way in imaging, as turntable revolves
Turn, power cord and data line are decontroled, without the problem of circuit winds and combs occurs.One end of reel uses connector
It fixes on a spinstand, is rotated with turntable, the other end is connect by bearing with support plate, and support plate is fixed on pedestal
On；Alternatively, one end of reel is connect with the connector of fixed laser light path device by bearing, the other end is fixed on support plate
On, it is not rotated with turntable.The other end setting support plate of reel, so that the both ends uniform force of device.
Excitation light source device includes laser light source, luminous source optical fiber and filtering apparatus；Wherein, laser light source is fixed on bottom plate
Launch exciting light, exciting light is exported by luminous source optical fiber, sends out the high exciting light of the continuous collimation of spectrum, is incident to optical filtering dress
It puts；Exciting light is filtered into the preferable exciting light of monochromaticjty by filtering apparatus, and keeps collimation constant, is incident to laser optical path dress
It puts.
Laser optical path device includes rotation synchronous plane mirror and plane of scanning motion mirror；The exciting light of reel is passed through along rotary shaft
Be incident to rotation synchronous plane mirror, after reflection with examination couch synchronous rotary；The plane of scanning motion mirror of laser optical path device is incident to, is passed through
The exciting light of plane of scanning motion mirror is scanned examination couch and the shape of exciting light is modulated.It is incident to inspection as needed
The light source type selection plane of scanning motion mirror of bed, if the light source for being incident to examination couch is point light source, plane of scanning motion mirror is reflection
Mirror；If the light source for being incident to examination couch is line source, plane of scanning motion mirror is one-dimensional galvanometer；If it is incident to the light of examination couch
Source is array light source, then plane of scanning motion mirror is 2-D vibration mirror.Further, laser optical path device further includes the first speculum, fixed
On bottom plate, the exciting light that the excitation light source device that is arranged on bottom plate emits is after the reflection of the first speculum along rotary shaft
Across reel.Laser optical path device simplifies the system design at excitation end so that bulky excitation light source device no longer needs
The problems such as system for tracking rotation, exciting light is transmitted by a series of plane mirrors in laser optical path device, avoids Optical Fiber Winding,
And the light spot shape needed and lighting system can freely be adjusted according to experiment demand.
Examination couch includes fixing device, animal beds, gas anesthesia device and heating installation；Wherein, one end of fixing device
It is connect with translation stage, other end connection animal beds, internal there are vacancy；Gas anesthesia device and heating installation pass through fixing device
Interior vacancy provides numb gas and heating to animal beds respectively；Animal beds are arc-shaped or plate shaped；Animal beds are used in visible ray
The optical property of scattering and the absorption of the wave band and near infrared light wave band material consistent with inspected body.The thickness of animal beds and institute
The hardness of the material of use is related, and thickness is inversely proportional with hardness so that animal beds are enough to support inspected body.Animal beds use
Open by design, inspected body is lain directly on open animal beds, convenient for experimental implementation, while convenient for inspected body
Pick and place, the position and level of comfort of inspected body will not be influenced；Animal beds use the skin histology light of similar inspected body
The scattering medium of property is learned, caused by avoiding animal beds the problems such as overexposure, light leakage.
Translation stage is set on the base, and examination couch is arranged on translation stage, is moved horizontally along translation stage, so as to pass in and out rotation
Through-hole in turntable.
Fluorescence detection device sends out the side of fluorescence by connector fixation on a spinstand, receives fluorescence signal, and will
Fluorescence signal is converted into electric signal transmission to computer.Fluorescence detection device includes receiving filtering assembly, camera lens and detector.It visits
The power supply and data for surveying device are wound on a bobbin according to the direction opposite with the direction of rotation of turntable.
It is another object of the present invention to propose a kind of vertical rotating fluorescent molecular tomography method.
The vertical rotating fluorescent molecular tomography method of the present invention, includes the following steps：
1) attachment device：Fluorescence detection device is connected to computer by data line, and passes through power cord and be connected to power supply,
Reel is coaxial with turntable, and data line and power cord are wrapped in coiling according to the direction opposite with the direction of rotation of turntable
On the outer wall of cylinder；
2) excitation light source device launches the exciting light of point light source；
3) exciting light passes through reel along rotary shaft, is incident to the rotation synchronous plane mirror of laser optical path device；
4) exciting light through rotation synchronous plane mirror reflection after with examination couch synchronous rotary；
5) exciting light is incident to the plane of scanning motion mirror of laser optical path device after rotation synchronous plane mirror reflection, scanned flat
The exciting light of face mirror is scanned examination couch and the shape of exciting light is modulated；
6) exciting light is incident in the inspected body on examination couch, generates fluorescence；
7) fluorescence detection device receives fluorescence, and fluorescence signal is converted into electric signal, and be transmitted to computer；
8) computer receiving data rebuilds faultage image, and perform image display using fluorescence algorithm for reconstructing.
Advantages of the present invention：
1) laser optical path device allows bulky excitation light source device to be fixed on bottom plate without being rotated with system, leads to
Crossing some row plane mirrors causes exciting light can be with 360 ° of scanning inspected bodys；
2) wavelength of exciting light can be as needed visible to infrared band unrestricted choice, it is convenient to realize different waves
Long exciting light irradiation, so as to fulfill the imaging of multi-wavelength fluorescence probe；
3) it be free to select dotted excitation light source, linear excitation light source or point face battle array excitation light source, according to experiment
Demand is modulated the shape of exciting light；
4) animal beds use open by design, and using non-transparent material, light leakage and overexposure show caused by solving animal beds
As improving the stability of data；
5) without moving or removing inspected body, you can be adjusted to, as region, to pass through under the movement of translation stage
The system that turntable is transmitted to other mode, such as X-ray computer tomography X-ray CT, PET-Positron emission computed tomography
PET, single photon emission computerized tomography SPECT etc. are imaged, multi-modality imaging is carried out, farthest maintains examined
The form stable of body, while the step of simplify image registration.
Description of the drawings
Fig. 1 is the structure diagram of one embodiment of the vertical rotating fluorescent molecular tomography system of the present invention；
Fig. 2 is the schematic diagram of the turntable of the vertical rotating fluorescent molecular tomography system of the present invention；
Fig. 3 is the schematic diagram of the excitation light source device of the vertical rotating fluorescent molecular tomography system of the present invention；
Fig. 4 is one embodiment of the laser optical path device of the vertical rotating fluorescent molecular tomography system of the present invention
Schematic diagram；
Fig. 5 is the structure diagram of the fluorescence detection device of the vertical rotating fluorescent molecular tomography system of the present invention；
Fig. 6 is the schematic diagram of the vertical rotating fluorescent molecular tomography system animal beds of the present invention.
Specific embodiment
Below in conjunction with the accompanying drawings, by embodiment, the present invention will be further described.
As shown in Figure 1, the vertical rotating fluorescent molecular tomography system of the present embodiment includes：Excitation light source device 1 swashs
Light light path device 2, fluorescence detection device 3, turntable 4, examination couch 5, translation stage 8, reel 7 and computer；Wherein, exciting light
Source device 1 is fixed on bottom plate 6；Turntable 4 is mounted on bottom plate 6；Laser optical path device 2 and fluorescence detection device 3 lead to respectively
Respective connector is crossed on turntable 4；Examination couch 5 is mounted on translation stage 6, and the through-hole with turntable is in same level
It is accessible in through-holes to pass through on line；Fluorescence detection device 3 is connected to computer, and connect by power cord by data line
To power supply；Reel 7 is coaxial with turntable, and data line and power cord are wound according to the direction opposite with the direction of rotation of turntable
On the outer wall of reel 7；Exciting light is incident to the fluorescence generated after the inspected body of examination couch, by visiting after speculum reflects
Device 3 is surveyed to receive.
As shown in Fig. 2, turntable 4 includes swivel plate 41, motor 42 and supporting rack 43；Wherein, motor 42 passes through supporting rack
43 are mounted on bottom plate 6；Swivel plate 41 is mounted on motor 42, is driven by motor and is carried out 360 degree rotation；Have on swivel plate
Through-hole with examination couch on a horizontal line, allows that examination couch is accessible in through-holes passes through.
As shown in figure 3, excitation light source device 1 includes excitation light source 11, excitation filtering assembly 12, plane mirror 13 and anti-
Penetrate mirror support 14；Wherein, light source 11 sends out continuous exciting light, and into excitation filtering assembly 12, excitation filtering assembly 12 uses
Optical filter wheel, inside place a variety of optical filters, select the exciting light of suitable wavelength as needed, optical plane is excited after optical filtering
Speculum 13 reflects, and into laser optical path device 2, plane mirror 13 is arranged on reflector mount 14, and reflector mount 14 is installed
On bottom plate 6.
As shown in figure 4, laser optical path device 2 includes rotation synchronous plane mirror 22 and plane of scanning motion mirror 24；Rotation synchronizes flat
Face mirror 22 is mounted on by connecting plate 25 on swivel plate 41；Plane of scanning motion mirror 24 is mounted on swivel plate 41；From excitation light source 11
The exciting light sent out is incident to the first speculum 21 through the reflection of plane mirror 13, then after the reflection of the first speculum 21, along rotation
Shaft passes through reel 7, is incident to rotation synchronous plane mirror 22；Through rotating the exciting light of synchronous plane mirror 22 through the second plane mirror
Plane of scanning motion mirror 24 is incident to after 23 reflections, plane of scanning motion mirror is modulated exciting light shape.Laser optical path device 2 and rotation
The connector of platform uses connecting plate 25.
Reel 7 is mounted on connecting plate 25 together with rotation synchronous plane mirror 22, so as to fix on a spinstand, coiling
7 one end for being connect with connecting plate 25 of cylinder are fixed, rotated with turntable, the other end by bearing installation on the supporting plate 71,
So that the both ends uniform force of device.
It is installed as shown in figure 5, fluorescence detection device 3 includes reception filtering assembly 31, camera lens 32 and detector 33, camera lens 32
Before the detectors, filtering assembly 31 is installed, detector 33 is sleeved in pressure ring 34, and is fixed by block 35, mounted on fixation before
On plate 36.Fluorescence detection device is fixed on by connecting rod on the swivel plate 41 of turntable 4, at 45 ° by the fluorescence with sending out
Plane mirror reflection, receive fluorescence signal.Receive the data line and power cord of filtering assembly 31 and detector 33 respectively according to
The direction opposite with the direction of rotation of turntable is wrapped in the outer wall of reel.The connector of fluorescence detection device 3 and turntable
Using connecting rod.The fluorescence that inspected body generates is received after speculum 37 by fluorescence detection device.
As shown in fig. 6, examination couch 5 includes fixing device 51, animal beds 54, gas anesthesia device 52 and heating installation 53；
Wherein, one end of fixing device 51 is connect with translation stage, and other end connection animal beds 54, inside passes through 52 He of gas anesthesia device
The tracheae of heating installation 53；Gas anesthesia device 52 and heating installation 53 are separately mounted in fixing device 51；Animal beds are flat
Plate shape；Animal beds use the scattering medium of the optical property of similar animal skin tissue, and polyformaldehyde has been used in the present embodiment
(polyformaldehyde) as the material of animal beds, caused by avoiding animal beds the problems such as overexposure, light leakage.
It is finally noted that the purpose for publicizing and implementing mode is to help to further understand the present invention, but ability
The technical staff in domain is appreciated that：Without departing from the spirit and scope of the invention and the appended claims, it is various replacement and
Modification is all possible.Therefore, the present invention should not be limited to embodiment disclosure of that, the scope of protection of present invention with
Subject to the range that claims define.
Claims (10)
1. a kind of vertical rotating fluorescent molecular tomography system, which is characterized in that the imaging system includes：Excitation light source fills
It puts, laser optical path device, fluorescence detection device, turntable, examination couch, translation stage, reel and computer；Wherein, it is described to swash
Light emitting source apparatus is fixed on bottom plate；The turntable is mounted on bottom plate, and centre has through-hole, with the axis of through-hole during imaging
It is rotated for rotary shaft；The laser optical path device and fluorescence detection device are mounted on turntable by respective connector respectively
On；The examination couch is mounted on translation stage, with the through-hole of turntable in the same horizontal line, accessible in through-holes to pass through；
The fluorescence detection device is connected to computer by data line, and passes through power cord and be connected to power supply；The reel and rotation
Turntable is coaxial, and data line and power cord are wrapped according to the direction opposite with the direction of rotation of turntable on the outer wall of reel；
The laser optical path device includes rotation synchronous plane mirror and plane of scanning motion mirror；During imaging, excitation light source device launches light
The exciting light in source；Exciting light passes through reel along rotary shaft, is incident to the rotation synchronous plane mirror of laser optical path device；Through rotation
The exciting light of synchronous plane mirror reflection and examination couch synchronous rotary；Exciting light is incident to laser after rotation synchronous plane mirror reflection
The plane of scanning motion mirror of light path device, the exciting light of scanned plane mirror are scanned examination couch and the shape of exciting light are carried out
Modulation, final exciting light are incident in the inspected body on examination couch, generate fluorescence；The fluorescence detection device receives fluorescence；
Fluorescence signal is converted into electric signal transmission to computer by the fluorescence detection device.
2. imaging system as described in claim 1, which is characterized in that be incident to the light source type selection of examination couch as needed
Plane of scanning motion mirror, if the light source for being incident to examination couch is point light source, plane of scanning motion mirror is speculum；If it is incident to inspection
The light source of bed is line source, then plane of scanning motion mirror is one-dimensional galvanometer；If the light source for being incident to examination couch is array light source, sweep
Plane mirror is retouched as 2-D vibration mirror.
3. imaging system as described in claim 1, which is characterized in that further comprise the first speculum, be fixed on bottom plate；
The rotation synchronous plane mirror of the laser optical path device is installed on a spinstand by connecting plate；The plane of scanning motion mirror is mounted on
On turntable；From the exciting light that excitation light source device is sent out after the reflection of the first speculum, reel is passed through along rotary shaft, it is incident
To rotation synchronous plane mirror；Plane of scanning motion mirror is incident to after rotation synchronous plane mirror reflection.
4. imaging system as described in claim 1, which is characterized in that one end of the reel is fixed on rotation using connector
It on turntable, is rotated with turntable, the other end is connect by bearing with support plate, and the support plate is fixed on pedestal.
5. imaging system as described in claim 1, which is characterized in that one end of the reel and fixed laser light path device
Connector connected by bearing, the other end fix on the supporting plate, do not rotated with turntable, the support plate is fixed on pedestal
On.
6. imaging system as described in claim 1, which is characterized in that the excitation light source device includes laser light source, light source
Optical fiber and filtering apparatus；Wherein, the laser light source, which is fixed on bottom plate, launches exciting light, and exciting light is led by luminous source optical fiber
Go out, send out spectrum and continuously collimate exciting light, be incident to filtering apparatus；Exciting light is filtered into monochromatic excitation by the filtering apparatus
Light, and keep collimation constant, it is incident to laser optical path device.
7. imaging system as described in claim 1, which is characterized in that the examination couch includes fixing device, animal beds, gas
Anesthesia outfit and heating installation；Wherein, one end of the fixing device is connect with translation stage, other end connection animal beds, internal
There are vacancy；The gas anesthesia device and heating installation provide numb gas to animal beds respectively by the vacancy in fixing device
And heating.
8. imaging system as claimed in claim 7, which is characterized in that the animal beds are arc-shaped or plate shaped；It is described dynamic
Object bed is used in the optical property of scattering and the absorption of the visible light wave range and near infrared light wave band material consistent with inspected body.
9. a kind of vertical rotating fluorescent molecular tomography method, which is characterized in that the imaging method includes the following steps：
1) attachment device：Fluorescence detection device is connected to computer by data line, and passes through power cord and be connected to power supply, coiling
Cylinder is coaxial with turntable, and data line and power cord are wrapped in reel according to the direction opposite with the direction of rotation of turntable
On outer wall；
2) excitation light source device launches the exciting light of point light source；
3) exciting light passes through reel along rotary shaft, is incident to the rotation synchronous plane mirror of laser optical path device；
4) exciting light through rotation synchronous plane mirror reflection after with examination couch synchronous rotary；
5) exciting light is incident to the plane of scanning motion mirror of laser optical path device, scanned plane mirror after rotation synchronous plane mirror reflection
Exciting light examination couch is scanned and the shape of exciting light is modulated；
6) exciting light is incident in the inspected body on examination couch, generates fluorescence；
7) fluorescence detection device receives fluorescence, and fluorescence signal is converted into electric signal, and be transmitted to computer；
8) computer receiving data rebuilds faultage image, and perform image display using fluorescence algorithm for reconstructing.
10. imaging method as claimed in claim 9, which is characterized in that be incident to the light source type choosing of examination couch as needed
Plane of scanning motion mirror is selected, if the light source for being incident to examination couch is point light source, plane of scanning motion mirror is speculum；If it is incident to inspection
The light source for looking into bed is line source, then plane of scanning motion mirror is one-dimensional galvanometer；If the light source for being incident to examination couch is array light source,
Plane of scanning motion mirror is 2-D vibration mirror.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6208886B1 (en) * | 1997-04-04 | 2001-03-27 | The Research Foundation Of City College Of New York | Non-linear optical tomography of turbid media |
| CN101816552A (en) * | 2010-05-11 | 2010-09-01 | 天津大学 | Imitating CT scanning mode multispectral time domain fluorescence molecular tomography measuring system |
| CN102961122A (en) * | 2012-10-17 | 2013-03-13 | 北京航空航天大学 | Full-angle fluorescent molecular tomography imaging device and imaging method based on rotating mirror |
| CN104027071A (en) * | 2014-05-28 | 2014-09-10 | 北京大学 | Vertical rotating fluorescent molecule tomography imaging system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7383076B2 (en) * | 2000-11-27 | 2008-06-03 | The General Hospital Corporation | Fluorescence-mediated molecular tomography |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6208886B1 (en) * | 1997-04-04 | 2001-03-27 | The Research Foundation Of City College Of New York | Non-linear optical tomography of turbid media |
| CN101816552A (en) * | 2010-05-11 | 2010-09-01 | 天津大学 | Imitating CT scanning mode multispectral time domain fluorescence molecular tomography measuring system |
| CN102961122A (en) * | 2012-10-17 | 2013-03-13 | 北京航空航天大学 | Full-angle fluorescent molecular tomography imaging device and imaging method based on rotating mirror |
| CN104027071A (en) * | 2014-05-28 | 2014-09-10 | 北京大学 | Vertical rotating fluorescent molecule tomography imaging system |
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